11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Jochen B. Fiebach, Yasir Al‐Rawi, Max Wintermark et al. · 2012 · Stroke
BACKGROUND AND PURPOSE: Desmoteplase is a novel and highly fibrin-specific thrombolytic agent. Evidence of safety and efficacy was obtained in 2 phase II trials (Desmoteplase In Acute Ischemic Stroke [DIAS] and Desmoteplase for Acute…
View details →Ted Wun, Denis Soulières, Andrew L. Frelinger et al. · 2013 · Journal of Hematology & Oncology
BACKGROUND: Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet agent, in adult patients with SCD, we conducted a double-blind, randomized, placebo-controlled study. METHODS: The primary endpoint, safety, was measured by hemorrhagic events requiring medical intervention. Patients were randomized to prasugrel 5 mg daily (n = 41) or placebo (n = 21) for 30 days. Platelet function by VerifyNow® P2Y12 and vasodilator-stimulated phosphoprotein as
View details →Ignácio F. Mata, Dora Yearout, Victoria Álvarez et al. · 2011 · Movement Disorders
Recent genome-wide association studies of Parkinson's disease have nominated 3 new susceptibility loci (PARK16-18) and confirmed 2 known risk genes (MAPT and SNCA) in populations of European ancestry. We sought to replicate these findings.…
View details →Marianna Adamo, Matteo Pagnesi, Giulia Ghizzoni et al. · 2022 · European Journal of Heart Failure
AIM: To evaluate short-term changes in tricuspid regurgitation (TR) after transcatheter edge-to-edge mitral valve repair (M-TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality. METHODS AND RESULTS: This…
View details →Zahra Shahrokh, Louise Royle, Radka Saldova et al. · 2010 · Molecular Pharmaceutics
Recombinant human erythropoietin has been used to treat anemia associated with chronic renal disease. This paper provides a comprehensive comparative analysis of Dynepo and three other commercial erythropoiesis stimulating agents, Eprex,…
View details →Bart A. Mulder, Dirk J. van Veldhuisen, Harry J.G.M. Crijns et al. · 2012 · European Journal of Heart Failure
AIMS: Beneficial effects of beta-blockade remain unclear in heart failure patients who have atrial fibrillation (AF), especially in the elderly. We evaluated the effect of nebivolol on cardiovascular outcomes in elderly patients with heart…
View details →Monica Rydén‐Aulin, Dimitrios T. Boumpas, Irene E. M. Bultink et al. · 2016 · Lupus Science & Medicine
OBJECTIVES: Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the off-label use of RTX in Europe and compare the characteristics of patients…
View details →Ahmed M Abou-Setta, Brett L. Houston, Hesham Al-Inany et al. · 2013 · Cochrane Database of Systematic Reviews
BACKGROUND: Various options exist for treating endometriosis, including surgical, medical, such as ovarian suppression, or a combination of these strategies. Surgical treatment of endometriosis aims to remove visible areas of…
View details →Dylan J. Jester, Ellen Rozek, Ryan A. McKelley · 2018 · Aging & Mental Health
OBJECTIVES: Two decades of heart rate variability (HRV) biofeedback research have focused on adolescent and adult populations with a variety of symptoms and conditions at the exclusion of older adults. This study explores HRV biofeedback…
View details →Nikolaos A. Trikalinos, Amy Zhou, Maria B. Majella Doyle et al. · 2018 · Journal of the National Comprehensive Cancer Network
Background: Combined hepatocellular-cholangiocarcinoma tumors (cHCC-CCA) are a heterogeneous group of rare malignancies that have no established optimal treatment. Patients and Methods: We identified patients with cHCC-CCA treated at a…
View details →Yun‐Ming Tian, Mingzhu Liu, Lei Zeng et al. · 2018 · Head & Neck
PURPOSE: To analyze the long-term outcome and pattern of failure for patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS: Patients with NPC after IMRT from 2001 to 2008 were…
View details →Pénélope Paradis‐Deschênes, Denis R. Joanisse, François Billaut · 2017 · Frontiers in Physiology
Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs between sexes, it is relevant to examine the impact of sex in response to IPC to determine whether it is also ergogenic in females. In a randomized, crossover, single-blind study, we investigated muscle performance, hemodynamic and O2 uptake in strength-trained males (n=9) and femal
View details →Dorothea Buck, Sabine Cepok, Steve Hoffman et al. · 2011 · Archives of Neurology
OBJECTIVE: To determine relevant HLA-DRB1 alleles associated with the susceptibility of anti-interferon beta antibody development in a large patient cohort. DESIGN: In a case-control study, HLA-DRB1 genotyping was performed in a discovery…
View details →Ara Cho, Yoosoo Chang, Jiin Ahn et al. · 2018 · British Journal of Cancer
BACKGROUND: We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS: We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years. RESULTS: During 511,052.9 person-years of follow-up, 1,250 participants developed thyroid cancer. In men, we observed a dose-dependent inverse association between current smoking, pack-years, and thyroid cancer. After adjustment for confounders, adjusted hazard ratios (95% conf
View details →Christopher R Romero, Daniela S Herzig, A.O. Etogo et al. · 2010 · Journal of Leukocyte Biology
Several studies indicate that IFN-γ facilitates systemic inflammation during endotoxin-induced shock. However, the pathobiology of IFN-γ in clinically relevant models of septic shock, such as CLP, is not well understood. In this study, the…
View details →Scott L. Zuckerman, Gary S. Solomon, Jonathan A. Forbes et al. · 2012 · Journal of Neurosurgery Pediatrics
OBJECT: Several studies have suggested a gender difference in response to sports-related concussion (SRC). The Concussion in Sport group did not include gender as a modifying factor in SRC, concluding that the evidence at that point was…
View details →Yoshiyuki Konishi, Yoshihiro Muragaki, Hiroshi Iseki et al. · 2012 · Neurologia medico-chirurgica
The present retrospective study evaluated the recurrence patterns after aggressive surgical removal of intracranial glioblastomas in 43 consecutive adult patients. The resection rate of the enhanced lesion on magnetic resonance imaging was…
View details →Adam de Belder, Aung Myat, Jonathan Blaxill et al. · 2021 · EuroIntervention
BACKGROUND: Historically the elderly have been under-represented in non-ST-elevation myocardial infarction (NSTEMI) management trials. AIMS: The aim of this trial was to demonstrate that an intervention-guided strategy is superior to optimal medical therapy (OMT) alone for treating NSTEMI in elderly individuals. METHODS: Patients (≥80 years, chest pain, ischaemic ECG, and elevated troponin) were randomised 1:1 to an intervention-guided strategy plus OMT versus OMT alone. The primary endpoint was a composite of all-cause mortality and non-fatal myocardial reinfarction at 1 year. Ethics approval
View details →Eisaku Fujimoto, Yoshiaki Sasashige, Yasuji Masuda et al. · 2012 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: The intra-operative femorotibial joint gap and ligament balance, the predictors affecting these gaps and their balances, as well as the postoperative knee flexion, were examined. These factors were assessed radiographically after…
View details →Claudia Trenkwalder, Fabrizio Stocchi, Werner Poewe et al. · 2016 · Movement Disorders
BACKGROUND: Two phase 2 randomized, double-blind studies were designed to evaluate efficacy and safety of immediate-release (study 1) and modified-release (study 2) mavoglurant formulations in PD l-dopa-induced dyskinesia. METHODS:…
View details →Daniel Alcolea, Constance Delaby, Laia Muñoz et al. · 2021 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: All categories included in the AT(N) classification can now be measured in plasma. However, their agreement with cerebrospinal fluid (CSF) markers is not fully established. A blood signature to generate the AT(N) classification…
View details →Olga Karginova, Marni B. Siegel, Amanda E.D. Van Swearingen et al. · 2015 · Molecular Cancer Therapeutics
Patients with breast cancer brain metastases have extremely limited survival and no approved systemic therapeutics. Triple-negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis. TNBC frequently…
View details →Yngvar Krukhaug, Stein Atle Lie, Leif I Havelin et al. · 2014 · Journal of Hand Surgery (European Volume)
In this study we report the results of thumb carpometacarpal (CMC) joint replacements in the Norwegian population over a 17-year period. In total, 479 primary replacements performed from 1994 to 2011 were identified in the Norwegian…
View details →Donald C. Hood, Emmanouil Tsamis, Nikhil Bommakanti et al. · 2019 · Investigative Ophthalmology & Visual Science
Purpose: To assess the agreement between structural (optical coherence tomography [OCT]) and functional (visual field [VF]) glaucomatous damage with an automated method and deviation/probability maps, and to compare this method to a metric method. Methods: Wide-field spectral-domain OCT scans, including the disc and macula, and 24-2 and 10-2 VFs were obtained from 45 healthy control (H) eyes/individuals, and 53 eyes/patients with 24-2 mean deviation (MD) better than -6 dB diagnosed as "definite glaucoma" (DG) by experts. Abnormal structure-abnormal function (aS-aF) agreement was assessed with
View details →Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty et al. · 2019 · PLoS ONE
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion of anti-tumor CD8+ T cells from cancer cells, upregulation of immune checkpoint ligand expression, immunosuppressive cytokine production, and polarization of tumor infiltrating inflammatory cells. FAP is a post-proline peptidase selectively expressed during tissue remodeling and repair, such as with wound healing, and in the tumor
View details →Yi‐Hsuan Huang, Meei‐Shyuan Lee, Yu-Sheng Lou et al. · 2019 · PLoS ONE
BACKGROUND: Breast cancer is the most common cancer in women and several perioperative factors may account for tumor recurrence and metastasis. The anesthetic agents employed during cancer surgery might play a crucial role in cancer cell survival and patient outcomes. We conducted a retrospective cohort study to investigate the relationship between the type of anesthesia and overall survival in patients who underwent breast cancer surgery performed by one experienced surgeon. METHODS: All patients who underwent breast cancer surgery by an experienced surgeon between January 2006 and December 2
View details →Martin D. Hoffman, Kristin J. Stuempfle, Ian R. Rogers et al. · 2012 · International Journal of Sports Physiology and Performance
PURPOSE: To determine the incidence of exercise-associated hyponatremia (EAH), the associated biochemical measurements and risk factors for EAH, and whether there is an association between postrace blood sodium concentration ([Na+]) and…
View details →Constantine Mavroudis, Tiffany S. Ko, Ryan W. Morgan et al. · 2020 · Critical Care
BACKGROUND: Despite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenation, possibly potentiating neurological injury during CPR. We investigated the cerebrovascular effects of intravenous epinephrine in a swine model of pediatric in-hospital cardiac arrest. The primary objectives of this study were to determine if (1) epinephrine doses have a significant acute effect on CBF and cerebral tissue oxygenation during CPR and (2) if the effect of each
View details →Nahdiya Zainal Abidin, Mohd Bakri Adam · 2013 · PubMed
BACKGROUND: Vertical jump is an index representing leg/kick power. The explosive movement of the kick is the key to scoring in martial arts competitions. It is important to determine factors that influence the vertical jump to help…
View details →P T W Kim, Alice C. Wei, Eshetu G. Atenafu et al. · 2013 · British journal of surgery
BACKGROUND: The management of portal vein (PV) involvement by pancreatic adenocarcinoma during pancreaticoduodenectomy (PD) is controversial. The aim of this study was to compare the outcomes of unplanned and planned PV resections as part…
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