Negative / Null Result ReportOpen accessMedicine
Simone Riis Porsborg, Allan Stensballe, Jeppe Emmersen et al. · 2016 · Stem Cell Research & Therapy
BACKGROUND: Adipose-derived stem cells (ASCs) are being increasingly recognized for their potential to promote tissue regeneration and wound healing. These effects appear to be partly mediated by paracrine signaling pathways, and are enhanced during hypoxia. Mass spectrometry (MS) is a valuable tool for proteomic profiling of cultured ASCs, which may help to reveal the identity of the factors secreted by the cells under different conditions. However, serum starvation which is essentially required to obtain samples compatible with secretome analysis by MS can have a significant influence on ASC
View details →Negative / Null Result ReportMedicine
Erik C. Olsson, Meghan Jobson, Moe R. Lim · 2015 · Orthopedics
Dysphagia is a relatively common complication of anterior cervical spine surgery. Smoking has not been definitively assessed as a risk factor for dysphagia. This study examined risk factors for dysphagia, including smoking and pain…
View details →Negative / Null Result ReportOpen accessMedicine
Jennifer E. Nyland, Nazia Raja‐Khan, Kerstin Bettermann et al. · 2021 · Diabetes
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of severe coronavirus disease 2019 (COVID-19) outcomes possibly because of dysregulated inflammatory responses. Glucose-regulating medications, such as glucagon-like…
View details →Negative / Null Result ReportOpen accessMedicine
Karol Sadowski, Adrianna Jażdżewska, Jan Kozłowski et al. · 2024 · International Journal of Molecular Sciences
Glioblastoma is the most common malignant primary brain tumor in the adult population, with an average survival of 12.1 to 14.6 months. The standard treatment, combining surgery, radiotherapy, and chemotherapy, is not as efficient as we would like. However, the current possibilities are no longer limited to the standard therapies due to rapid advancements in biotechnology. New methods enable a more precise approach by targeting individual cells and antigens to overcome cancer. For the treatment of glioblastoma, these are gamma knife therapy, proton beam therapy, tumor-treating fields, EGFR and
View details →Negative / Null Result ReportOpen accessMedicine
Junyi Xin, Xia Jiang, Shuai Ben et al. · 2022 · BMC Medicine
BACKGROUND: The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive. Here, we aimed to evaluate the causal effect of circulating vitamin E on the risk of ten common cancers, including bladder, breast, colorectal, esophagus, lung, oral and pharynx, ovarian, pancreatic, prostate, and kidney cancer. METHODS: A Mendelian randomization (MR) analytic framework was applied to data from a cancer-specific genome-wide association study (GWAS) comprising a total of 297,699 cancer cases and 304,736 controls of European a
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Jochen B. Fiebach, Yasir Al‐Rawi, Max Wintermark et al. · 2012 · Stroke
BACKGROUND AND PURPOSE: Desmoteplase is a novel and highly fibrin-specific thrombolytic agent. Evidence of safety and efficacy was obtained in 2 phase II trials (Desmoteplase In Acute Ischemic Stroke [DIAS] and Desmoteplase for Acute…
View details →Negative / Null Result ReportOpen accessMedicine
Ted Wun, Denis Soulières, Andrew L. Frelinger et al. · 2013 · Journal of Hematology & Oncology
BACKGROUND: Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet agent, in adult patients with SCD, we conducted a double-blind, randomized, placebo-controlled study. METHODS: The primary endpoint, safety, was measured by hemorrhagic events requiring medical intervention. Patients were randomized to prasugrel 5 mg daily (n = 41) or placebo (n = 21) for 30 days. Platelet function by VerifyNow® P2Y12 and vasodilator-stimulated phosphoprotein as
View details →Negative / Null Result ReportOpen accessMedicine
Ignácio F. Mata, Dora Yearout, Victoria Álvarez et al. · 2011 · Movement Disorders
Recent genome-wide association studies of Parkinson's disease have nominated 3 new susceptibility loci (PARK16-18) and confirmed 2 known risk genes (MAPT and SNCA) in populations of European ancestry. We sought to replicate these findings.…
View details →Negative / Null Result ReportOpen accessMedicine
Marianna Adamo, Matteo Pagnesi, Giulia Ghizzoni et al. · 2022 · European Journal of Heart Failure
AIM: To evaluate short-term changes in tricuspid regurgitation (TR) after transcatheter edge-to-edge mitral valve repair (M-TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality. METHODS AND RESULTS: This…
View details →Negative / Null Result ReportMedicine
Zahra Shahrokh, Louise Royle, Radka Saldova et al. · 2010 · Molecular Pharmaceutics
Recombinant human erythropoietin has been used to treat anemia associated with chronic renal disease. This paper provides a comprehensive comparative analysis of Dynepo and three other commercial erythropoiesis stimulating agents, Eprex,…
View details →Negative / Null Result ReportOpen accessMedicine
Bart A. Mulder, Dirk J. van Veldhuisen, Harry J.G.M. Crijns et al. · 2012 · European Journal of Heart Failure
AIMS: Beneficial effects of beta-blockade remain unclear in heart failure patients who have atrial fibrillation (AF), especially in the elderly. We evaluated the effect of nebivolol on cardiovascular outcomes in elderly patients with heart…
View details →Negative / Null Result ReportOpen accessMedicine
Monica Rydén‐Aulin, Dimitrios T. Boumpas, Irene E. M. Bultink et al. · 2016 · Lupus Science & Medicine
OBJECTIVES: Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the off-label use of RTX in Europe and compare the characteristics of patients…
View details →Negative / Null Result ReportMedicine
Ahmed M Abou-Setta, Brett L. Houston, Hesham Al-Inany et al. · 2013 · Cochrane Database of Systematic Reviews
BACKGROUND: Various options exist for treating endometriosis, including surgical, medical, such as ovarian suppression, or a combination of these strategies. Surgical treatment of endometriosis aims to remove visible areas of…
View details →Negative / Null Result ReportMedicine
Dylan J. Jester, Ellen Rozek, Ryan A. McKelley · 2018 · Aging & Mental Health
OBJECTIVES: Two decades of heart rate variability (HRV) biofeedback research have focused on adolescent and adult populations with a variety of symptoms and conditions at the exclusion of older adults. This study explores HRV biofeedback…
View details →Negative / Null Result ReportOpen accessMedicine
Nikolaos A. Trikalinos, Amy Zhou, Maria B. Majella Doyle et al. · 2018 · Journal of the National Comprehensive Cancer Network
Background: Combined hepatocellular-cholangiocarcinoma tumors (cHCC-CCA) are a heterogeneous group of rare malignancies that have no established optimal treatment. Patients and Methods: We identified patients with cHCC-CCA treated at a…
View details →Negative / Null Result ReportMedicine
Yun‐Ming Tian, Mingzhu Liu, Lei Zeng et al. · 2018 · Head & Neck
PURPOSE: To analyze the long-term outcome and pattern of failure for patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS: Patients with NPC after IMRT from 2001 to 2008 were…
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Pénélope Paradis‐Deschênes, Denis R. Joanisse, François Billaut · 2017 · Frontiers in Physiology
Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs between sexes, it is relevant to examine the impact of sex in response to IPC to determine whether it is also ergogenic in females. In a randomized, crossover, single-blind study, we investigated muscle performance, hemodynamic and O2 uptake in strength-trained males (n=9) and femal
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Dorothea Buck, Sabine Cepok, Steve Hoffman et al. · 2011 · Archives of Neurology
OBJECTIVE: To determine relevant HLA-DRB1 alleles associated with the susceptibility of anti-interferon beta antibody development in a large patient cohort. DESIGN: In a case-control study, HLA-DRB1 genotyping was performed in a discovery…
View details →Negative / Null Result ReportOpen accessMedicine
Ara Cho, Yoosoo Chang, Jiin Ahn et al. · 2018 · British Journal of Cancer
BACKGROUND: We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS: We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years. RESULTS: During 511,052.9 person-years of follow-up, 1,250 participants developed thyroid cancer. In men, we observed a dose-dependent inverse association between current smoking, pack-years, and thyroid cancer. After adjustment for confounders, adjusted hazard ratios (95% conf
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Christopher R Romero, Daniela S Herzig, A.O. Etogo et al. · 2010 · Journal of Leukocyte Biology
Several studies indicate that IFN-γ facilitates systemic inflammation during endotoxin-induced shock. However, the pathobiology of IFN-γ in clinically relevant models of septic shock, such as CLP, is not well understood. In this study, the…
View details →Negative / Null Result ReportOpen accessMedicine
Scott L. Zuckerman, Gary S. Solomon, Jonathan A. Forbes et al. · 2012 · Journal of Neurosurgery Pediatrics
OBJECT: Several studies have suggested a gender difference in response to sports-related concussion (SRC). The Concussion in Sport group did not include gender as a modifying factor in SRC, concluding that the evidence at that point was…
View details →Negative / Null Result ReportOpen accessMedicine
Yoshiyuki Konishi, Yoshihiro Muragaki, Hiroshi Iseki et al. · 2012 · Neurologia medico-chirurgica
The present retrospective study evaluated the recurrence patterns after aggressive surgical removal of intracranial glioblastomas in 43 consecutive adult patients. The resection rate of the enhanced lesion on magnetic resonance imaging was…
View details →Negative / Null Result ReportOpen accessMedicine
Adam de Belder, Aung Myat, Jonathan Blaxill et al. · 2021 · EuroIntervention
BACKGROUND: Historically the elderly have been under-represented in non-ST-elevation myocardial infarction (NSTEMI) management trials. AIMS: The aim of this trial was to demonstrate that an intervention-guided strategy is superior to optimal medical therapy (OMT) alone for treating NSTEMI in elderly individuals. METHODS: Patients (≥80 years, chest pain, ischaemic ECG, and elevated troponin) were randomised 1:1 to an intervention-guided strategy plus OMT versus OMT alone. The primary endpoint was a composite of all-cause mortality and non-fatal myocardial reinfarction at 1 year. Ethics approval
View details →Negative / Null Result ReportMedicine
Eisaku Fujimoto, Yoshiaki Sasashige, Yasuji Masuda et al. · 2012 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: The intra-operative femorotibial joint gap and ligament balance, the predictors affecting these gaps and their balances, as well as the postoperative knee flexion, were examined. These factors were assessed radiographically after…
View details →Negative / Null Result ReportMedicine
Claudia Trenkwalder, Fabrizio Stocchi, Werner Poewe et al. · 2016 · Movement Disorders
BACKGROUND: Two phase 2 randomized, double-blind studies were designed to evaluate efficacy and safety of immediate-release (study 1) and modified-release (study 2) mavoglurant formulations in PD l-dopa-induced dyskinesia. METHODS:…
View details →Negative / Null Result ReportMedicine
Daniel Alcolea, Constance Delaby, Laia Muñoz et al. · 2021 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: All categories included in the AT(N) classification can now be measured in plasma. However, their agreement with cerebrospinal fluid (CSF) markers is not fully established. A blood signature to generate the AT(N) classification…
View details →Negative / Null Result ReportOpen accessMedicine
Olga Karginova, Marni B. Siegel, Amanda E.D. Van Swearingen et al. · 2015 · Molecular Cancer Therapeutics
Patients with breast cancer brain metastases have extremely limited survival and no approved systemic therapeutics. Triple-negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis. TNBC frequently…
View details →Negative / Null Result ReportMedicine
Yngvar Krukhaug, Stein Atle Lie, Leif I Havelin et al. · 2014 · Journal of Hand Surgery (European Volume)
In this study we report the results of thumb carpometacarpal (CMC) joint replacements in the Norwegian population over a 17-year period. In total, 479 primary replacements performed from 1994 to 2011 were identified in the Norwegian…
View details →Negative / Null Result ReportOpen accessMedicine
Donald C. Hood, Emmanouil Tsamis, Nikhil Bommakanti et al. · 2019 · Investigative Ophthalmology & Visual Science
Purpose: To assess the agreement between structural (optical coherence tomography [OCT]) and functional (visual field [VF]) glaucomatous damage with an automated method and deviation/probability maps, and to compare this method to a metric method. Methods: Wide-field spectral-domain OCT scans, including the disc and macula, and 24-2 and 10-2 VFs were obtained from 45 healthy control (H) eyes/individuals, and 53 eyes/patients with 24-2 mean deviation (MD) better than -6 dB diagnosed as "definite glaucoma" (DG) by experts. Abnormal structure-abnormal function (aS-aF) agreement was assessed with
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Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty et al. · 2019 · PLoS ONE
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion of anti-tumor CD8+ T cells from cancer cells, upregulation of immune checkpoint ligand expression, immunosuppressive cytokine production, and polarization of tumor infiltrating inflammatory cells. FAP is a post-proline peptidase selectively expressed during tissue remodeling and repair, such as with wound healing, and in the tumor
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