e-ISSN: Pending

Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Investigating if changing the wording of a study invitation letter increased recruitment in a project promoting tobacco cessation in a town with high smoking rates.

Schell C, Godinho A, Cunningham JA · 2026 · Substance abuse treatment, prevention, and policy

BACKGROUND: Invitation letters can be the first point of contact between research staff and potential participants and a number of modifiable variables have been studied to improve their effectiveness. The aim of this analysis was to…

View details →
Negative / Null Result ReportOpen accessMedicine

Re-evaluating the Role of Partnership-Related Perceptions in Women's Preferences for Men with Masculine Face Shapes.

Dong J, Leger K, Lee AJ et al. · 2024 · Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior

Many researchers have proposed that women perceive men with masculine face shapes to be less suitable as parents and long-term partners than men with feminine face shapes, causing women to find masculine men more attractive for short-term…

View details →
Negative / Null Result ReportOpen accessMedicine

Effectiveness of an environmental nutrition and physical activity intervention in early childhood education and care settings (NAPSACC UK): a multicentre cluster randomised controlled trial.

Kipping R, Anne Simpson S, Hannam K et al. · 2026 · The Lancet regional health. Europe

Background Early childhood education and care (ECEC) provision is widespread. NAPSACC UK is an intervention in ECECs designed to improve nutrition and physical activity policies, practice and provision through ECEC staff workshops,…

View details →
Negative / Null Result ReportOpen accessMedicine

Opposing Roles of Testosterone and Cortisol in Prosocial Risk-Taking.

Huang S, Zhang D, Zhuang J · 2026 · Behavioral sciences (Basel, Switzerland)

Prosocial risk-taking is defined as engagement in altruistic behaviors that may have personal costs. Emerging research indicates that testosterone-a gonadal steroid hormone-is linked to behaviors aimed at promoting one's social status. In…

View details →
Negative / Null Result ReportOpen accessMedicine

Social identification and paranoia.

Greenburgh A, Zamperetti L, Bell V et al. · 2024 · Royal Society open science

Paranoia is associated with variation in social behaviour, such as lower inclination to trust others or to behave generously in economic game settings. Such variation may stem, in part, from a reduced tendency to socially identify with…

View details →
Negative / Null Result ReportMedicine

Effects of an Exercise Program to Reduce Falls in Older People Living in Long-Term Care: A Randomized Controlled Trial.

Taylor LM, Parsons J, Moyes SA et al. · 2024 · Journal of the American Medical Directors Association

Objectives To investigate the effect of an exercise program on falls in intermediate and high-level long-term care (LTC) residents and to determine whether adherence, physical capacity, and cognition modified outcomes. Design Randomized…

View details →
Negative / Null Result ReportOpen accessMedicine

The Effect of Transcranial Near-infrared Laser Therapy on Chronic Ischemic Stroke Patients: A Randomized, Single-blind, Sham-controlled Trial.

Hassan M, Al Balah O, Hegazy A et al. · 2026 · Journal of the Saudi Heart Association

Background Transcranial photobiomodulation (TPBM) using near-infrared (NIR) light is a novel, non-invasive neuromodulation strategy with potential to enhance neurorecovery. While preclinical studies are promising, clinical evidence in…

View details →
Negative / Null Result ReportOpen accessMedicine

Sneezing in response to naturalistic bright light exposure.

Bickerstaff L, Trinkl J, Munkwitz S et al. · 2025 · F1000Research

Background The photic sneeze reflex (PSR) is a common but underexplored phenomenon where bright light triggers sneezing, affecting ~30% of the population. This study aimed to characterise the light conditions inducing PSR. Methods One male…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of <i>Echinacea purpurea</i> on cytokine gene expression (IL10, IL1β, TNFα, IFNγ), telomere length, lipid peroxidation, and nitric oxide in broilers reared at high altitude.

Bahadoran S, Vaeznia S, Hassanpour H · 2026 · Veterinary and animal science

This study evaluated the effects of dietary Echinacea purpurea supplementation on immune regulation, oxidative stress, and cellular aging in broiler chickens reared at high altitude (2100 m). One hundred and eight day-old male Ross 308…

View details →
Negative / Null Result ReportOpen accessMedicine

Achievement (not effort) makes people feel entitled to rewards.

Cusimano C, Kim J, Wong J · 2025 · Proceedings of the National Academy of Sciences of the United States of America

It is common to say that people feel entitled to rewards-they think they have earned or deserve them-based on their effort and achievement. However, effort and achievement draw on different principles to justify reward. They can also…

View details →