e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Response of Atlantic salmon to long-term sustained aerobic training at suboptimum elevated temperature: Cardiac anatomy, aerobic performance, and growth implications

Foddai M, Carter CG, Wood AT et al. · 2025 · Comparative Biochemistry and Physiology, Part A

Sustained aerobic training is suggested to enhance cardiac performance and growth in farmed salmonids, but its effects under suboptimum elevated temperatures remain unclear. This study examined whether continuous training at different…

View details →
Negative / Null Result ReportMedicine

Synergistic interaction between nitrifying bacteria and Enterobacter ludwigii enhances PAHs biodegradation in coal mine dump soils.

Pulikova EP, Kotsarev VI, Demin KA et al. · 2025 · Journal of environmental management

Polycyclic aromatic hydrocarbons (PAHs) are one of the most widespread organic pollutants. The methods to restore the natural environments contaminated with these substances include bioremediation based on PAH-degrading microorganisms. In…

View details →
Negative / Null Result ReportMedicine

The telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): A randomized open-label phase 2 study.

Lorigan P, Medina TM, Nyakas M et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Purpose Immune checkpoint inhibitor (ICI) combinations have improved outcomes in patients with advanced melanoma; however, long term survival remains poor. The addition of therapeutic cancer vaccines to ICI combinations represents a…

View details →
Negative / Null Result ReportMedicine

Mapping the ABC transporter landscape in the human lung: A comprehensive characterisation of P-gp, MRP1 and BCRP expression and functional activity in human lung epithelial cells.

Simon S, Shanmugalingam T, Neu T et al. · 2025 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Active efflux transporters can play a substantial role in the drug disposition of their substrates in the human body. Efflux transporters like P-glycoprotein (P-gp), multidrug resistance associated protein 1 (MRP1) and breast cancer…

View details →
Negative / Null Result ReportMedicine

Antidepressant efficacy and safety of scopolamine in individuals with bipolar disorder (SCOPE-BD): A randomized double-blind placebo-controlled trial.

Miravalles C, Kane R, Rossier AT et al. · 2026 · Journal of affective disorders

Background Current treatments for depressive episodes in bipolar disorder are often limited by partial efficacy or delayed therapeutic response. Intravenous scopolamine, a pan-muscarinic antagonist, has shown rapid antidepressant effects…

View details →
Negative / Null Result ReportMedicine

Plane of nutrition through 92 days of age in beef × dairy hybrid steers influences subsequent finishing performance, feed efficiency, and carcass characteristics

Grote A, Genther-Schroeder O, Wilson BK et al. · 2025 · Applied Animal Science

Our objective was to determine the effect of plane of nutrition through 92 d of age on subsequent finishing performance, feed efficiency, and carcass characteristics in beef × dairy crossbred steers. Beef × dairy crossbred steers (n = 109)…

View details →
Negative / Null Result ReportMedicine

Clinical outcomes according to the location of graft retear after arthroscopy-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears.

Baek CH, Lim C, Kim JG et al. · 2025 · The bone & joint journal

Aims This study aimed to compare clinical outcomes according to the location of transferred graft retear in arthroscopy-assisted lower trapezius tendon transfer (aLTT) for posterosuperior irreparable rotator cuff tears (PSIRCTs). Methods…

View details →
Negative / Null Result ReportMedicine

Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial.

Pirracchio R, Fong N, Legrand M · 2025 · Intensive care medicine

Background The best blood pressure target in sepsis is a matter of debate. SEPSIS-PAM, a large multicenter pragmatic randomized controlled trial, compared two mean arterial pressure targets (65-70 mmHg vs 80-85 mmHg) in septic shock and…

View details →
Negative / Null Result ReportMedicine

Rabies immunoglobulin overdose in post-exposure prophylaxis.

Łukasik AJ, Podlasin RB · 2025 · Przeglad epidemiologiczny

Rabies is a zoonotic viral infection caused by an RNA virus from the Rhabdoviridae family, a Lyssavirus species with the highest mortality rate among all infectious diseases. Post-exposure propylahis (PEP) should be applied as soon as…

View details →
Negative / Null Result ReportOpen accessMedicine

Simulated brushing effects on surface roughness and color stability of coated additively manufactured dental resin: an in vitro study.

Alsalem Z, Alothemeen M, Alshehri D et al. · 2026 · Journal of medicine and life

This study aimed to evaluate the effect of a glaze coating on the surface roughness and color stability of 3D-printed temporary crown resin materials before and after simulated toothbrushing. Nano-filled ceramic resin specimens were…

View details →
Negative / Null Result ReportMedicine

Prediction of the digestibility and digestible energy content of hay for horses using an enzymatic degradability method.

Andueza D, Martin-Rosset W · 2025 · Animal : an international journal of animal bioscience

The nutritive value of forage for horses is closely dependent on the digestibility of organic matter (OMD), which is typically measured in vivo. Researchers have developed a variety of prediction methods to estimate the digestibility value…

View details →
Negative / Null Result ReportOpen accessMedicine

Variations in cow milk and teat skin microbiota across the lactation cycle with intramammary cephalosporin use at dry-off.

Van Beeck W, Lemos MLP, Niesen AM et al. · 2026 · Applied and environmental microbiology

Cephalosporins and other broad-spectrum antibiotics are frequently administered prophylactically into the udder when dairy cows end their lactation cycle, termed dry-off, to reduce mastitis risk. However, the use of antibiotics on cows…

View details →
Negative / Null Result ReportOpen accessMedicine

Improving Diagnostic Quality of Anogenital Photodocumentation in Emergency Department Evaluations for Acute Child Sexual Assault.

Miller ZE, Digirolamo SJ, Molnar J et al. · 2026 · Pediatric quality & safety

Introduction Emergency department evaluations for acute child sexual assault include anogenital photodocumentation as a standard of care, which has implications for accurate clinical care and forensic significance. If photodocumentation…

View details →
Negative / Null Result ReportMedicine

Alignment and early clinical outcomes following total knee arthroplasty using a handheld navigation system compared to conventional instruments.

Nishida C, Shimoda B, Weldon RH et al. · 2025 · Archives of orthopaedic and trauma surgery

Introduction Proper lower extremity alignment is important for success and longevity of total knee arthroplasty (TKA). Conventional instrumentation has demonstrated higher rates of mechanical axis (MA) malalignment compared to robotic or…

View details →
Negative / Null Result ReportOpen accessMedicine

The murine Irs1 knockout model, generated by the spontaneous Irs1<sup>S57X</sup> mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.

Fenerich BA, Fernandes JC, Silva CLA et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Insulin Receptor Substrate 1 (IRS1) is differentially expressed in hematological neoplasms suggesting a role in hematopoiesis and neoplastic transformation. Irs1 knockout mice represent a tool to investigate IRS1 function.…

View details →
Negative / Null Result ReportMedicine

Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on <i>Shewanella oneidensis</i> by Compromising Membrane Protein Functionality.

Zhang S, Jia B, Huang W et al. · 2025 · ACS nano

The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na + ,…

View details →
Negative / Null Result ReportMedicine

Combination of Exercise and Group Occupational Therapy for Behavioural and Psychological Symptoms of Dementia: A Pilot Randomised Controlled Trial.

Yoshiura K, Murata M, Hamasuna M et al. · 2025 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background The behavioural and psychological symptoms of dementia (BPSD) increase the burden for the caregiver, often leading to difficulties in maintaining home care and triggering psychiatric hospitalisation. Effective management of BPSD…

View details →
Negative / Null Result ReportMedicine

Oxidation of Platina(II)corrole to Platina(IV)corrole.

Kato S, Miwa K, Takano H et al. · 2025 · Inorganic chemistry

Recently, the aromaticity and antiaromaticity of organometallacycles have received much attention to understand the cyclic electronic delocalization through d orbitals on the metal center. Here, we prepared a Pd(II) platina(II)corrole…

View details →
Negative / Null Result ReportMedicine

Retrospective analysis of early functional and radiological outcomes between robotic, navigated and conventional total knee arthroplasty: A single Surgeon's series.

Leong JWK, Lee BH, Haniball J et al. · 2025 · Journal of clinical orthopaedics and trauma

Background Achieving a neutral mechanical axis alignment (MAA) in Total Knee Arthroplasty (TKA) is associated with increased implant longevity and patient satisfaction, and robot-assisted (robotic) TKA is touted to improve implant…

View details →