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Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Efficacy and safety of cannabidiol oil in psoriasis: a randomized, double-blind, placebo-controlled trial.

Roongpisuthipong W, Klangjareonchai T, Kurathong S et al. · 2026 · The Journal of dermatological treatment

Background The management of psoriasis presents challenges, prompting many patients to seek alternative treatments. Cannabidiol (CBD) has demonstrated potential antioxidant and anti-inflammatory properties which may offer therapeutic…

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Negative / Null Result ReportMedicine

Effects of ultralow oxygen treatments at low temperature on survival of spotted wing drosophila, Drosophila suzukii (Diptera: Drosophilidae), in blueberries and sweet cherries.

Liu YB · 2025 · Journal of economic entomology

Controlled atmosphere with ultralow oxygen (ULO) treatments were conducted to determine effects against eggs and larvae of spotted wing drosophila, Drosophila suzukii (Diptera: Drosophilidae), in blueberries and cherries at 3 °C in 19…

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Negative / Null Result ReportMedicine

Administration of EAPCI patient video animation versus standard patient information leaflets in the catheterization laboratory: Impact on patient experience assessed using the PATCATH questionnaire.

Rai H, Byrne KK, O'Callaghan D et al. · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background The Patient Experience in the Catheterization Laboratory (PATCATH) Questionnaire was developed by the European Association of Percutaneous Cardiovascular Intervention (EAPCI) to evaluate patient understanding of coronary…

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Negative / Null Result ReportMedicine

Cavernous ganglioneuroma of the thoracic spine: surgical nuances and outcomes following limited anterior resection.

Yılmaz MC, Tezer P, Olgaç G et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Background Spinal tumors constitute approximately 15% of all primary central nervous system neoplasms, with extradural tumors accounting for the majority. Ganglioneuromas are rare, benign tumors of neural crest origin, most often located…

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Negative / Null Result ReportMedicine

Dry Needling Plus Manual Therapy and Exercise for Subacromial Pain Syndrome: A Sham-Controlled Randomized Clinical Trial.

Hando BR, Rhon DI, Barker D et al. · 2026 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To determine the effect on Shoulder Pain and Disability Index (SPADI) scores of adding dry needling to a program of exercise and manual therapy in individuals with subacromial pain syndrome (SAPS). DESIGN: Three-arm randomized…

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Negative / Null Result ReportMedicine

Harvesting of peroneus longus tendon autograft

Liang C, He J · 2025 · Journal of Visualized Experiments

Autografts are always used in anterior cruciate ligament (ACL) reconstruction. Traditional sources, such as hamstring tendons, bone-patellar tendon-bone, and quadriceps tendon, are popular choices but may result in muscle imbalances and…

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Negative / Null Result ReportMedicine

Effect of Local Cold Application on Nausea and Vomiting in Early Postoperative Period-A Randomized Controlled Trial.

Türkiş NA, Taşdemir N · 2026 · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

Purpose Postoperative nausea and vomiting (PONV) is one of the most common complications in surgical patients during the first 24 hours after general anesthesia. This research aimed to evaluate the effect of cold application on early PONV…

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Negative / Null Result ReportMedicine

Cytogenotoxic effects of polycyclic aromatic hydrocarbons complex mixture in human peripheral blood, lung A549 and liver HepG2 cells: Translation of a real-scenario exposure to in vitro.

Kazensky L, Lovrić Štefiček MJ, Kašuba V et al. · 2026 · Environmental research

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous air pollutants, where their genotoxic potential raises significant public health concerns. This study evaluated the cytotoxic and genotoxic effects of an environmentally relevant…

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Negative / Null Result ReportMedicine

Verification of the protective effect of transfecting brain-derived neurotrophic factor and B-cell lymphoma 2 genes on retina ganglion cells in a rat model of optic nerve injury.

Zhao Z, Fang Y, Xu G et al. · 2026 · Drug discoveries & therapeutics

This pilot study investigated the protective effect of transfecting brain-derived neurotrophic factor (BDNF) and B-cell lymphoma 2 (bcl-2) genes in retinal ganglion cells (RGCs) using in vivo electroporation in an adult rat optic nerve…

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Negative / Null Result ReportMedicine

Short-term Treatment with Metformin During Puberty Mitigates Metabolic Dysfunctions Programmed by Neonatal Overfeeding in Male Rats.

Raposo SR, Lopes RP, Barbosa LF et al. · 2026 · Archives of medical research

Objective To address the major public health problems of increased body weight and obesity, causing conditions such as hypertension and diabetes. Early obesity in childhood and adolescence has more severe long-term health consequences. The…

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Negative / Null Result ReportMedicine

4-year overall survival after the introduction of adjuvant therapy for patients with stage III melanoma: A population-based study.

Janssen JC, Schurink AW, Verhoef C et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Background Adjuvant systemic therapy for resected stage III melanoma was introduced in clinical practice following the improved recurrence free survival in randomized controlled trials. However, after ten years of follow-up, adjuvant…

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Negative / Null Result ReportMedicine

Harvesting of Peroneus Longus Tendon Autograft.

Liang C, He J · 2025 · Journal of visualized experiments : JoVE

Autografts are always used in anterior cruciate ligament (ACL) reconstruction. Traditional sources, such as hamstring tendons, bone-patellar tendon-bone, and quadriceps tendon, are popular choices but may result in muscle imbalances and…

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Negative / Null Result ReportMedicine

Medial Patellofemoral Ligament Reconstruction in Adolescent Patellofemoral Instability With High Tibial Tubercle-Trochlear Groove Intervals: A Comparison of With or Without Tibial Tubercle Osteotomy.

Grewal RS, Berger GK, Pennock AT et al. · 2026 · Journal of pediatric orthopedics

Background Patellofemoral instability is common in adolescent patients and is frequently associated with increased tibial tuberosity-trochlear groove (TT-TG) distances. Medial patellofemoral ligament (MPFL) reconstruction is a standard…

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Negative / Null Result ReportMedicine

Efficacy of a Phase III Cardiac Rehabilitation Program on Physical Exercise in Patients with Ischemic Heart Disease: A Cluster Randomized Controlled Trial.

Santaularia N, Arnau A, Torà N et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention

Purpose Our purpose was to assess the efficacy of a phase III cardiac rehabilitation (CR) program, based on counseling in the maintenance of physical exercise, on the time spent on physical exercise per week in patients with ischemic heart…

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Negative / Null Result ReportMedicine

Rediscovering a Neotropical anuran fluke: a morphological and phylogenetic study of <i>Rauschiella proxima</i> (Trematoda: Plagiorchioidea).

Queiroz MS, López-Hernández D, Anjos LA et al. · 2025 · Journal of helminthology

Species of the genus Rauschiella are trematodes of frogs and snakes in the Americas. The taxonomy of the group is complex, and most of the 18 currently valid species are known only from the original description. Moreover, genetic data are…

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Negative / Null Result ReportMedicine

Outcomes of Pars Plana Vitrectomy in Inherited Retinal Degenerations.

Al-Moujahed A, Lu ES, Zhou HW et al. · 2026 · Ophthalmology. Retina

Purpose To describe the management and outcomes of pars plana vitrectomy (PPV) for common surgical retinal conditions, including epiretinal membrane (ERM), full-thickness macular hole (FTMH), and retinal detachment, in patients with…

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Negative / Null Result ReportMedicine

Procedural eptifibatide administration as an alternative to preprocedural dual antiplatelet therapy for patients undergoing flow diversion procedures: case series and review of the literature.

Mosallami Aghili SM, Santori D, Denice C et al. · 2025 · Journal of neurointerventional surgery

Introduction Pretreatment with dual antiplatelet agents (DAPT) has been standard practice for patients undergoing aneurysm treatment with flow diversion (FD). Rates of periprocedural diffusion lesions observed after FD procedures remain…

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