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Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Dry Needling Plus Manual Therapy and Exercise for Subacromial Pain Syndrome: A Sham-Controlled Randomized Clinical Trial.

Hando BR, Rhon DI, Barker D et al. · 2026 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To determine the effect on Shoulder Pain and Disability Index (SPADI) scores of adding dry needling to a program of exercise and manual therapy in individuals with subacromial pain syndrome (SAPS). DESIGN: Three-arm randomized…

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Negative / Null Result ReportMedicine

Harvesting of peroneus longus tendon autograft

Liang C, He J · 2025 · Journal of Visualized Experiments

Autografts are always used in anterior cruciate ligament (ACL) reconstruction. Traditional sources, such as hamstring tendons, bone-patellar tendon-bone, and quadriceps tendon, are popular choices but may result in muscle imbalances and…

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Negative / Null Result ReportMedicine

Effect of Local Cold Application on Nausea and Vomiting in Early Postoperative Period-A Randomized Controlled Trial.

Türkiş NA, Taşdemir N · 2026 · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

Purpose Postoperative nausea and vomiting (PONV) is one of the most common complications in surgical patients during the first 24 hours after general anesthesia. This research aimed to evaluate the effect of cold application on early PONV…

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Negative / Null Result ReportMedicine

Cytogenotoxic effects of polycyclic aromatic hydrocarbons complex mixture in human peripheral blood, lung A549 and liver HepG2 cells: Translation of a real-scenario exposure to in vitro.

Kazensky L, Lovrić Štefiček MJ, Kašuba V et al. · 2026 · Environmental research

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous air pollutants, where their genotoxic potential raises significant public health concerns. This study evaluated the cytotoxic and genotoxic effects of an environmentally relevant…

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Negative / Null Result ReportMedicine

Verification of the protective effect of transfecting brain-derived neurotrophic factor and B-cell lymphoma 2 genes on retina ganglion cells in a rat model of optic nerve injury.

Zhao Z, Fang Y, Xu G et al. · 2026 · Drug discoveries & therapeutics

This pilot study investigated the protective effect of transfecting brain-derived neurotrophic factor (BDNF) and B-cell lymphoma 2 (bcl-2) genes in retinal ganglion cells (RGCs) using in vivo electroporation in an adult rat optic nerve…

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Negative / Null Result ReportMedicine

Short-term Treatment with Metformin During Puberty Mitigates Metabolic Dysfunctions Programmed by Neonatal Overfeeding in Male Rats.

Raposo SR, Lopes RP, Barbosa LF et al. · 2026 · Archives of medical research

Objective To address the major public health problems of increased body weight and obesity, causing conditions such as hypertension and diabetes. Early obesity in childhood and adolescence has more severe long-term health consequences. The…

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Negative / Null Result ReportMedicine

4-year overall survival after the introduction of adjuvant therapy for patients with stage III melanoma: A population-based study.

Janssen JC, Schurink AW, Verhoef C et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Background Adjuvant systemic therapy for resected stage III melanoma was introduced in clinical practice following the improved recurrence free survival in randomized controlled trials. However, after ten years of follow-up, adjuvant…

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Negative / Null Result ReportMedicine

Harvesting of Peroneus Longus Tendon Autograft.

Liang C, He J · 2025 · Journal of visualized experiments : JoVE

Autografts are always used in anterior cruciate ligament (ACL) reconstruction. Traditional sources, such as hamstring tendons, bone-patellar tendon-bone, and quadriceps tendon, are popular choices but may result in muscle imbalances and…

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Negative / Null Result ReportMedicine

Medial Patellofemoral Ligament Reconstruction in Adolescent Patellofemoral Instability With High Tibial Tubercle-Trochlear Groove Intervals: A Comparison of With or Without Tibial Tubercle Osteotomy.

Grewal RS, Berger GK, Pennock AT et al. · 2026 · Journal of pediatric orthopedics

Background Patellofemoral instability is common in adolescent patients and is frequently associated with increased tibial tuberosity-trochlear groove (TT-TG) distances. Medial patellofemoral ligament (MPFL) reconstruction is a standard…

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Negative / Null Result ReportMedicine

Efficacy of a Phase III Cardiac Rehabilitation Program on Physical Exercise in Patients with Ischemic Heart Disease: A Cluster Randomized Controlled Trial.

Santaularia N, Arnau A, Torà N et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention

Purpose Our purpose was to assess the efficacy of a phase III cardiac rehabilitation (CR) program, based on counseling in the maintenance of physical exercise, on the time spent on physical exercise per week in patients with ischemic heart…

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Negative / Null Result ReportMedicine

Rediscovering a Neotropical anuran fluke: a morphological and phylogenetic study of <i>Rauschiella proxima</i> (Trematoda: Plagiorchioidea).

Queiroz MS, López-Hernández D, Anjos LA et al. · 2025 · Journal of helminthology

Species of the genus Rauschiella are trematodes of frogs and snakes in the Americas. The taxonomy of the group is complex, and most of the 18 currently valid species are known only from the original description. Moreover, genetic data are…

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Negative / Null Result ReportMedicine

Outcomes of Pars Plana Vitrectomy in Inherited Retinal Degenerations.

Al-Moujahed A, Lu ES, Zhou HW et al. · 2026 · Ophthalmology. Retina

Purpose To describe the management and outcomes of pars plana vitrectomy (PPV) for common surgical retinal conditions, including epiretinal membrane (ERM), full-thickness macular hole (FTMH), and retinal detachment, in patients with…

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Negative / Null Result ReportMedicine

Procedural eptifibatide administration as an alternative to preprocedural dual antiplatelet therapy for patients undergoing flow diversion procedures: case series and review of the literature.

Mosallami Aghili SM, Santori D, Denice C et al. · 2025 · Journal of neurointerventional surgery

Introduction Pretreatment with dual antiplatelet agents (DAPT) has been standard practice for patients undergoing aneurysm treatment with flow diversion (FD). Rates of periprocedural diffusion lesions observed after FD procedures remain…

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Negative / Null Result ReportMedicine

Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.

Richter J, Hamm AO, Lang T et al. · 2026 · Behaviour research and therapy

The efficacy of exposure-based cognitive behavioral therapy (eCBT) for panic disorder and agoraphobia (PD/AG) is well established, but the mechanisms of action are still under debate. Here we investigated whether increased fear activation…

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Negative / Null Result ReportMedicine

Improvements in pharmacokinetics, bleeding control, and cost analysis after PK-guided transition to extended-half-life factor IX in hemophilia B: A multicentric study.

Chovi-Trull M, Megías-Vericat JE, Palanques-Pastor T et al. · 2026 · Thrombosis research

Introduction Extended half-life factor IX concentrates (FIX-EHL) have been shown to improve clinical outcomes and reduce treatment burden in patients with hemophilia B (HB). Objectives To analyze the differences in pharmacokinetic (PK) and…

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Negative / Null Result ReportMedicine

Exploring Dynamic Brain Oscillations in Motor Imagery and Low-frequency Sound.

Dupont W, Poulin-Charronnat B, Madden-Lombardi C et al. · 2025 · Journal of cognitive neuroscience

Although both motor imagery (MI) and low-frequency sound listening have independently been shown to modulate brain activity, the potential synergistic effects that may arise from their combined application remains unexplored. Any further…

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Negative / Null Result ReportMedicine

Long-Term Survival of Cronobacter sakazakii, Salmonella enterica, Listeria monocytogenes, and Enterobacter spp. in Powdered Infant Formula Based on Relative Humidity.

Fay ML, Khouja BA, Newkirk R et al. · 2025 · Journal of food protection

Powdered infant formula (PIF) has previously been shown to support the survival of bacterial foodborne pathogens including Cronobacter sakazakii, Listeria monocytogenes, and Salmonella enterica at various storage temperatures. However, the…

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Negative / Null Result ReportOpen accessMedicine

Investigating the Antioxidant and Immunomodulatory Effects of Quercetin Using Porcine PBMCs as an Inflammatory In Vitro Model.

Somogyi F, Pézsa NP, Jerzsele Á et al. · 2026 · Antioxidants (Basel, Switzerland)

As the human population continues to grow, the demand for pork increases, and the management of infectious diseases in swine from a One Health standpoint is becoming more important than ever. To prevent antimicrobial use as much as…

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