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Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Beyond Gram-Negative and Gram-Positive Bacteria: Virulence as a Determinant of Clinical Outcome in Periprosthetic Joint Infections.

Achatz V, Sebastian S, Mitterer JA et al. · 2026 · The Journal of arthroplasty

Background Gram-negative (GN) periprosthetic joint infections (PJIs) are still less frequent than gram-positive (GP) PJIs. There is only little data available on a direct comparison of GP- and GN-associated PJIs. Therefore, we investigated…

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Negative / Null Result ReportMedicine

Natural versus GnRHa-HRT cycle for FET in tubal infertility with prior failed natural cycles: a propensity score-matched retrospective cohort study.

Li L, Gao S, Zhu H et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Introduction Frozen embryo transfer offers improved cumulative pregnancy rates and reduces complications compared to fresh cycles. Successful outcomes depend on both embryonic potential and endometrial receptivity, necessitating…

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Negative / Null Result ReportMedicine

The Effect of Contrast Media Formulations with Different Iodine Preparation Concentrations at a Constant Iodine Delivery Rate in Low-kV CT Angiography: An Experimental Animal Study.

Holtkamp M, Jost G, Salhöfer L et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

Purpose The effect of iodine preparation concentration on vascular attenuation during computed tomography angiography (CTA) is a topic of controversy. Iodine-based contrast media (CM) formulations are used in different iodine preparation…

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Negative / Null Result ReportMedicine

Light at the End of the Tunnel! Effects of 405 nm Visible Light Disinfection on Surgical Site Infection: A Prospective Randomized Cohort Study.

Bauerle WB, Allsbrook A, Green A et al. · 2026 · Surgical infections

Introduction Surgical site infections (SSIs) are a substantial contributor to morbidity and mortality rates. 405 nm visible light disinfection (VLD) has been shown to reduce bacterial burden in operating rooms (ORs); however, its effect on…

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Negative / Null Result ReportMedicine

The Cost-Utility of a Workplace Mental Health Program for Employees with Common Mental Disorders (FRIAA Project).

Mulfinger N, Waldmann T, Herold R et al. · 2026 · The journal of mental health policy and economics

Background Common mental disorders (CMDs) are a leading cause of sickness absence and early retirement due to health problems. Early identification and treatment of CMDs may have a positive impact on prognosis and associated economic…

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Negative / Null Result ReportMedicine

Contribution of oilseed waste on the development of the edible insect species Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae): From trash to cash.

Baliota GV, Rumbos CI, Athanassiou CG · 2026 · The Science of the total environment

The lesser mealworm, Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae), has attracted considerable commercial interest as an authorized insect species for use as food and feed, thanks to many important features that enable its…

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Negative / Null Result ReportMedicine

Simulation of lung volume and SPECT count errors due to mismatch between SPECT and CT during free-breathing in lung perfusion scintigraphy.

Nojima Y, Yamazaki Y · 2026 · Biomedical physics & engineering express

Respiratory phase mismatch between single-photon emission computed tomography (SPECT) and computed tomography (CT) acquisition phases presents a challenge in lung perfusion scintigraphy using SPECT/CT. This study simulated lung volume and…

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Negative / Null Result ReportMedicine

Effects of wood ash, nitrogen, and biosolids fertilisation on the growth and soil properties of Scots pine and Norway spruce stands

Mäkinen H, Ilvesniemi H, Lindroos AJ et al. · 2025 · Forest Ecology and Management.

The recycling of wood ash back to forests has the potential to restore nutrients that are removed during the harvesting of wood chips for bioenergy. Biosolids are nutrient-rich organic residual materials derived from biowaste and sewage…

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Negative / Null Result ReportMedicine

Exploitation of Saccharomyces cerevisiae as an alternative microencapsulation strategy of thymol via β-glucan based matrix for the development of multilayer LDPE active packaging films – comparison with zeolite- and activated carbon-based carriers

Giotopoulou I, Stamatis H, Barkoula NM · 2025 · International Journal of Biological Macromolecules

In the current study Saccharomyces cerevisiae (S. cerevisiae) was exploited as an alternative carrier of thymol with the aim of developing multilayer low-density polyethylene (LDPE) films with advanced bioactivity over time. The results…

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Negative / Null Result ReportOpen accessMedicine

Dimensional Stability of SLA 3D-Printed Surgical Guide Resin After Steam Sterilization (121 °C and 134 °C) and Isopropyl Alcohol Disinfection: An In Vitro Study.

Sîrbu I, Custura A, Radu A et al. · 2026 · Dentistry journal

Background : Additively manufactured surgical guides require post-processing and subsequent decontamination prior to intraoral use. Steam sterilization and chemical disinfection protocols may influence the dimensional stability of…

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Negative / Null Result ReportMedicine

Effects of hypocaloric wholegrain rye vs refined wheat diets on weight loss, cardiometabolic risk factors and gut microbiota: A 12-week randomized controlled trial.

Åberg S, Nordin E, Iversen KN et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background and aims Wholegrain rye foods have shown promising effects on metabolic regulation and weight-loss, which may be mediated via gut microbiota and derived metabolites. This study aimed to investigate effects of hypocaloric diets…

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Negative / Null Result ReportMedicine

Transmucosal detomidine gel induces emesis in approximately half of cats presenting for dietary indiscretion.

Neufeld MR, Hanson KR, Mochel JP et al. · 2026 · Journal of the American Veterinary Medical Association

Objective To evaluate the efficacy and safety of transmucosal administration of detomidine gel to induce emesis in cats. Methods Cats presenting on an emergency basis due to dietary indiscretion were eligible for enrollment at 2 emergency…

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Negative / Null Result ReportOpen accessMedicine

Unplanned hospital presentations in oncology patients receiving chemotherapy: a secondary analysis of a randomized controlled trial to explore opportunities for improving supportive care.

Kim B, Boustany C, Fethney J et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Purpose This study aimed to report the incidence, common reasons, and associated risk factors for unplanned hospital presentations during chemotherapy treatment. Methods A secondary analysis using data from a randomized controlled trial…

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Negative / Null Result ReportMedicine

Acute dysfunction of granular-based anaerobic reactor triggered by short-term exposure to colloid-containing wastewater: from irreversible sludge flotation to systemic failure.

Xie L, Lian H, Yin H et al. · 2026 · Bioresource technology

Inert colloidal substances (ICS) are ubiquitous in industrial wastewater; however, their effects on the stability of anaerobic granular sludge beds remain insufficiently understood. Using polyacrylamide as a model ICS, this study…

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Negative / Null Result ReportMedicine

Efficacy and safety of cannabidiol oil in psoriasis: a randomized, double-blind, placebo-controlled trial.

Roongpisuthipong W, Klangjareonchai T, Kurathong S et al. · 2026 · The Journal of dermatological treatment

Background The management of psoriasis presents challenges, prompting many patients to seek alternative treatments. Cannabidiol (CBD) has demonstrated potential antioxidant and anti-inflammatory properties which may offer therapeutic…

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Negative / Null Result ReportMedicine

Effects of ultralow oxygen treatments at low temperature on survival of spotted wing drosophila, Drosophila suzukii (Diptera: Drosophilidae), in blueberries and sweet cherries.

Liu YB · 2025 · Journal of economic entomology

Controlled atmosphere with ultralow oxygen (ULO) treatments were conducted to determine effects against eggs and larvae of spotted wing drosophila, Drosophila suzukii (Diptera: Drosophilidae), in blueberries and cherries at 3 °C in 19…

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Negative / Null Result ReportMedicine

Administration of EAPCI patient video animation versus standard patient information leaflets in the catheterization laboratory: Impact on patient experience assessed using the PATCATH questionnaire.

Rai H, Byrne KK, O'Callaghan D et al. · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background The Patient Experience in the Catheterization Laboratory (PATCATH) Questionnaire was developed by the European Association of Percutaneous Cardiovascular Intervention (EAPCI) to evaluate patient understanding of coronary…

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Negative / Null Result ReportMedicine

Cavernous ganglioneuroma of the thoracic spine: surgical nuances and outcomes following limited anterior resection.

Yılmaz MC, Tezer P, Olgaç G et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Background Spinal tumors constitute approximately 15% of all primary central nervous system neoplasms, with extradural tumors accounting for the majority. Ganglioneuromas are rare, benign tumors of neural crest origin, most often located…

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