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Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Pilot Testing a Narrative Psychoeducational Video to Reduce Stigma and Improve Mental Health Literacy and Help-Seeking Among Latinx Adults: Examining Gender Differences and Contextual Insights.

Saravia DH, Silvan YA, Martinez JI · 2026 · Community mental health journal

Despite similar rates of mental illness, non-Latinx Whites (NLW) received care at higher rates compared to Latinxs (National Institute of Mental Health, 2024). Latinx adults report lower mental health literacy (MHL) and higher stigma…

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Negative / Null Result ReportMedicine

Behavioral Incentives for Exercise and Intra-Articular Glucocorticoids for Knee Osteoarthritis: Results From a Factorially Designed Pragmatic Randomized Clinical Trial.

Baker JF, Wysham KD, Quinones M et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)

Objective The purpose of this study was to determine the benefit of a behaviorally designed incentive program and glucocorticoid injections in reducing symptoms and promoting physical activity in patients with knee osteoarthritis (KOA).…

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Negative / Null Result ReportMedicine

Use of Er:YAG Laser for Disinfection of Infected Carious Dentin: Microbiological Evaluation and Scanning Electron Microscopy Analysis.

Marcondes Pinto MO, Arana-Chavez VE, Trevelin LT et al. · 2026 · Photobiomodulation, photomedicine, and laser surgery

Objective To evaluate the antimicrobial efficacy of Er:YAG laser for disinfection of softened carious dentin using subablative parameters. Background Current literature lacks robust scientific evidence supporting the use of Er:YAG laser…

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Negative / Null Result ReportMedicine

Impact of Running Shoe Midsole Properties on Energy Cost of Running: Insights Into Midsole Stiffness and Resilience Properties.

Rodrigo-Carranza V, Alda-Blanco A, Kuzmeski J et al. · 2026 · International journal of sports physiology and performance

Purpose The mechanisms behind improvements in running economy (RE) from shoes with supercritical foams (SCF) compared with a traditional midsole material (ethylene vinyl acetate [EVA]) remain only partially understood. This study aimed to…

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Negative / Null Result ReportMedicine

'Sawa Aqwa' (Stronger Together): A multi-site randomized controlled trial of a brief family systemic intervention for adolescent mental health in Lebanon.

Bosqui T, Brown FL, Farah S et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background There are no evaluated family-based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole-family interventions in low- and middle-income…

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Negative / Null Result ReportMedicine

Treatment with elexacaftor/tezacaftor/ivacaftor does not alter SpiroNose-derived electronic breath profiles in children with cystic fibrosis.

Seidl E, Zikic A, Micic S et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Background Breath profile analysis of volatile organic compounds (VOCs) by electronic nose (eNose) technology can distinguish between healthy individuals and people with cystic fibrosis (pwCF). It remains, however, unclear whether CFTR…

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Negative / Null Result ReportMedicine

Effect of Successive Bleaching Treatments Followed by Staining on Color, Whiteness, and Translucency of Polymer-Based CAD-CAM Materials.

Ramos AC, Mascaro BA, Dos Santos Nunes Reis JM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To evaluate differences in color, whiteness, and translucency of CAD-CAM materials after successive bleaching treatments and coffee immersion. Materials and methods Lava Ultimate (LU) and VITA Enamic (VE) were divided into four…

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Negative / Null Result ReportMedicine

Evaluation of an Immune-guided Prevention Strategy Against CMV Among Intermediate-risk Kidney Transplant Recipients: A Quasi-experimental Study.

Caso JM, Fernández-Ruiz M, González E et al. · 2026 · Transplantation

Background Observational studies have shown that kidney transplant (KT) recipients who are cytomegalovirus (CMV)-seropositive (R+) but lack effective CMV-specific cell-mediated immunity (CMV-CMI) are at increased risk of CMV infection.…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis.

Ali R, Yazdi A, Collins K et al. · 2026 · International journal of critical illness and injury science

Background Thiamine is a vitamin that plays a role in lactate clearance. Patients with sepsis may present with elevated lactate, and also in cirrhosis, as lactate is hepatically metabolized. Prior studies showed mixed results regarding the…

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Negative / Null Result ReportMedicine

Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy (MIP) for Primary Hyperparathyroidism With Concordant Localisation.

Chew BMH, Lim SSA, Gan TRX et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective There is increasing use of intraoperative parathyroid hormone (ioPTH) in minimally invasive parathyroidectomy (MIP). While ioPTH has improved cure rate, there is little evidence to suggest effectiveness in primary…

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Negative / Null Result ReportMedicine

Impact of eravacycline on fibrinogen.

Stevenson E, Ponder M, Daniels L et al. · 2026 · The Journal of antimicrobial chemotherapy

Objectives While tigecycline has been associated with hypofibrinogenaemia, limited data with eravacycline suggest this may also occur with this agent. However, the incidence and clinical significance of this finding are not well defined.…

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Negative / Null Result ReportMedicine

There Is No Clinical and Radiological Difference between Suspensory and Cortical Button Fixation at the Treatment of Medial Meniscus Posterior Root Tear.

Sarikaya G, Paksoy AE, Karaşahin Ö et al. · 2026 · Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Purpose of the study The purpose of this prospective study was to compare the two surgical techniques; (Transosseous Fixation with the Suspensory Fixation System technique and Pull Out Suture Repair) for clinical and radiologic scores and…

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Negative / Null Result ReportMedicine

Vasopressors or Fluids in Early Septic Shock.

Peake SL, Macdonald SPJ, Howe BD et al. · 2026 · The New England journal of medicine

Background The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy along with smaller…

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Negative / Null Result ReportMedicine

The influence of verbalization versus imagery on trauma memory.

Rupietta AE, Meyer T, Margraf J et al. · 2026 · Journal of behavior therapy and experimental psychiatry

Background Cognitive theories on trauma memory postulate that trauma-related intrusions are associated with more data-driven and less contextual processing. However, contextualisation can be enhanced via verbalization, suggesting that…

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Negative / Null Result ReportMedicine

Safety, Immunogenicity of Co-Administered Vaccines, and Lot-to-Lot Consistency of a 14-Valent Pneumococcal Conjugate Vaccine (PNEUBEVAX 14<sup>®</sup>) Administered at 6-10-14 Weeks in Healthy Infants: A Multicenter, Phase IV Trial.

Thuluva S, Gunneri S, Ningaiah S et al. · 2026 · Vaccines

Background: Pneumococcal conjugate vaccines (PCVs) have substantially reduced pneumococcal disease in children; however, serotype distribution varies geographically, and residual disease due to non-PCV13 serotypes persists. Biological E's…

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Negative / Null Result ReportMedicine

DNA recovery from 3D printed firearms.

Oltrogger FT, Howe G, McNevin D et al. · 2026 · Science & justice : journal of the Forensic Science Society

Over the last few years, additive manufacturing, by means of fused deposition modelling 3D printing, has become increasingly popular and accessible due to the relative low costs, flexibility, and continually lowering barriers for entry.…

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