e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Rheological properties, microstructure, and encapsulation efficiency of inulin-type dietary fiber-based gelled emulsions at different concentrations.

Gomes A, Costa ALR, Fasolin LH et al. · 2025 · Carbohydrate polymers

Gelled emulsion systems offer promising matrices for encapsulating bioactive compounds, enhancing stability, bioavailability, and controlled release. Incorporating inulin-type dietary fibers into emulsion-filled gels can innovate food…

View details →
Negative / Null Result ReportOpen accessMedicine

Randomized Phase I/II Clinical Trial of a Melanoma Helper Peptide Vaccine with or without Systemic Agonistic Anti-CD27 Antibody (Varlilumab).

Ninmer EK, Petroni GR, Gaughan E et al. · 2026 · Cancer research communications

Purpose This randomized phase I/II clinical trial (NCT03617328) was designed to test whether administration of systemic agonistic anti-CD27 antibody (varlilumab) concurrent with a melanoma vaccine is safe and enhances vaccine…

View details →
Negative / Null Result ReportOpen accessMedicine

Long-Term Outcomes of Trauma Patients After Treatment With Prehospital Tranexamic Acid: A Subgroup Analysis From the PATCH-Trauma Trial.

Mitra B, MacKenzie S, Bourke EM et al. · 2026 · Journal of the American College of Emergency Physicians open

Objectives The aim of this study was to assess 24-month functional outcomes of patients randomly assigned to prehospital tranexamic acid (TXA) compared with those assigned to placebo. Methods The PATCH-Trauma trial assessed administration…

View details →
Negative / Null Result ReportMedicine

Targeting Oral Tissue Regeneration With Standardized Centella asiatica Extract: Experimental Insights From Human Fibroblast Cultures.

Değirmenci A, Bayar Muluk N, Budak Z et al. · 2026 · The Journal of craniofacial surgery

Objectives The possible cytotoxic effect of Centella asiatica extract on human dermal fibroblast cells was examined in this cell culture experiment. The main objective was to determine its basic safety for potential use in oral tissue…

View details →
Negative / Null Result ReportMedicine

The Effect of 6 Months of Dietary Counselling on Sleep Outcomes Among Patients With Cardiovascular Diseases: A Randomised Controlled Trial.

Verkaar AJCF, van Damme I, van Veldhuisen ER et al. · 2026 · Journal of sleep research

Sleep problems are highly prevalent among patients with cardiovascular diseases (CVD). We examined the effect of dietary counselling on sleep outcomes among patients with CVD. We performed secondary analyses within a previously conducted…

View details →
Negative / Null Result ReportMedicine

Volume-Stable Collagen Matrix With or Without Platelet-Rich Fibrin Impregnation for Multiple Gingival Recessions: A Randomized Clinical Trial.

Magrin GL, Michels R, Gil ACK et al. · 2026 · Journal of periodontal research

Aim This split-mouth randomized clinical trial aimed to assess whether incorporating platelet-rich fibrin (PRF) into a volume-stable collagen matrix results in superior reduction of recession depth after 6 months of healing in the…

View details →
Negative / Null Result ReportMedicine

Photobiomodulation for Pain, Healing, and Analgesic Use after Perineal Lacerations: A Double-Blind Randomized Controlled Trial.

de Castro T, Viana LH, Botelho S et al. · 2026 · International urogynecology journal

Introduction and hypothesis Approximately 60% of women experience some degree of perineal laceration following vaginal delivery. Although there is evidence supporting the use of photobiomodulation (PBM) for pain relief and wound healing in…

View details →
Negative / Null Result ReportMedicine

Rectus femoris graft harvest for anterior cruciate ligament reconstruction does not result in selective rectus femoris muscle volume loss or strength deficit at one year: quantitative magnetic resonance imaging, isokinetic and functional analyses.

Okutan AE, Kehribar L, Gürün E et al. · 2026 · International orthopaedics

Purpose To evaluate 1-year clinical and functional outcomes, as well as donor-site morbidity based on quadriceps muscle morphology, after primary single-bundle ACLR using a quadrupled RF tendon autograft. Methods Patients who underwent…

View details →
Negative / Null Result ReportOpen accessMedicine

From cool to non-cool: California's 'non-menthol' cigarettes in 2025.

Jabba SV, Erythropel HC, Anastas PT et al. · 2026 · Tobacco prevention & cessation

Since late 2022, the sale of most flavored tobacco products has been prohibited in California, including menthol cigarettes. Tobacco companies responded by introducing 'non-menthol' cigarettes in which menthol was replaced with WS-3, an…

View details →
Negative / Null Result ReportMedicine

The Influence of Heart Failure and Ventilatory Support Mode on Hospital Morbidity and Mortality in Patients With or at Risk of Obesity Hypoventilation Syndrome: Findings From the National Inpatient Sample.

Kaw R, Shekhar S, Mehra R et al. · 2026 · Chest

Background Heart failure (HF) is common in obesity hypoventilation syndrome (OHS). We explored the impact of HF on in-hospital outcomes of patients with or at risk of OHS who were treated with mechanical ventilation (MV), noninvasive…

View details →
Negative / Null Result ReportMedicine

Comparable 1-year results after arthroscopic Latarjet using screw or suture-button fixation.

Berge T, Vuletić F, Bøe B · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To compare clinical and radiological outcomes 1 year after Arthroscopic Latarjet procedure, using two different fixation techniques: screw or suture button fixation. Methods This retrospective comparative cohort study included 75…

View details →
Negative / Null Result ReportMedicine

A Twelve-Month Observation Analysis of Real-Time Contact Pressure-Controlled Powered Tooth Brushing as a Subgroup Analysis of a 36-Month RCT.

Graetz C, Löwe C, Übermuth S et al. · 2026 · International journal of dental hygiene

Objective Bristle splaying may be associated with reduced cleaning efficacy; however, the relationship between the bristle splaying index (BSI) and contact pressure (CP) during brushing with a powered toothbrush (PT) with real-time CP…

View details →
Negative / Null Result ReportMedicine

Cannabigerol and cannabidiol differ in their ability to affect the AhR/CYP1A pathway in vitro.

Vrba J, Havlasek J, Dostalova K et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Cannabidiol (CBD) is known to activate aryl hydrocarbon receptor (AhR) and expression of cytochromes P450 (CYP) 1A. This study examined the effect of cannabigerol (CBG) on the AhR/CYP1A pathway in HepG2 cells, human hepatocytes, and normal…

View details →
Negative / Null Result ReportMedicine

Comparative analysis of nucleic acid delivery systems based on benzimidazolium surfactants: impact of auxiliary lipids on lipoplex internalization and functional gene delivery in cancer cells.

Kuznetsova DA, Kuznetsov DM, Lyubina AP et al. · 2026 · Biochimica et biophysica acta. Biomembranes

The design of effective non-viral nucleic acid delivery systems based on cationic amphiphilic compounds remains a major challenge in biomedical research. In this study, cationic benzimidazolium surfactants (BI-n) and cationic liposomes…

View details →
Negative / Null Result ReportMedicine

Pimobendan in Heart Failure With Preserved Ejection Fraction and Right Ventricular-Pulmonary Arterial Uncoupling - A Randomized Clinical Trial.

Nakagawa A, Matsuoka Y, Seo M et al. · 2026 · Circulation journal : official journal of the Japanese Circulation Society

Background Patients with heart failure with preserved ejection fraction (HFpEF) and right ventricular (RV)-pulmonary arterial (PA) uncoupling, as assessed by a decrease ratio of tricuspid annular plane systolic excursion (TAPSE) to PA…

View details →
Negative / Null Result ReportMedicine

Simvastatin Treatment in Patients with Liver Cirrhosis: a Phase II Randomized Placebo Controlled Trial Shows Reduction in IL-6 Levels.

Hussain SK, Ayoub WS, Cruz-Correa M et al. · 2026 · Cancer prevention research (Philadelphia, Pa.)

Hepatocellular carcinoma (HCC) is a lethal cancer with rising burden. Few clinical trials have evaluated preventive strategies for HCC in high-risk patients with liver cirrhosis. Observational studies show statins are associated with…

View details →
Negative / Null Result ReportMedicine

Effects of Experimental Intermittent Theta Burst Stimulation on Negative Symptoms of Schizophrenia: A Double-Blind Sham-Controlled Study.

Kumar N, Prasad S, Srivastava MVP et al. · 2026 · The Journal of clinical psychiatry

Background: Negative symptoms remain among the most debilitating and treatment-resistant features of schizophrenia. Repetitive transcranial magnetic stimulation, particularly intermittent theta burst stimulation (iTBS), is emerging as a…

View details →
Negative / Null Result ReportMedicine

Inpatient Robotic Therapy for Stroke Survivors With Severe Upper Limb Impairments: A Randomized Controlled Trial.

Cowan C, Harmon EY, Melewski M et al. · 2026 · The American journal of occupational therapy : official publication of the American Occupational Therapy Association

Importance Understanding how upper extremity (UE) robotic therapy (RT) affects efficiency and effectiveness of inpatient rehabilitation is important to advancing poststroke treatment and recovery. Objective To determine whether UE RT…

View details →
Negative / Null Result ReportMedicine

Efficacy and tolerability of metformin as an adjuvant therapy in patients with relapse-remitting multiple sclerosis receiving interferon Beta 1a: A randomized pilot trial.

Abdelgaied MY, Abdelgawad O, Rashad MH et al. · 2026 · Journal of neuroimmunology

Background Neurodegeneration and inflammation can accelerate the demyelination process in multiple sclerosis (MS). We aimed to investigate the efficacy and tolerability of metformin as an add-on treatment to interferon Beta 1a (IFNβ-1a) in…

View details →
Negative / Null Result ReportOpen accessMedicine

Thermal Safety of Forced-Air Warming During Balloon Occlusion in Isolated Perfusion Chemotherapy: A Prospective Feasibility Study Using Multisite Temperature Monitoring.

Aust H, Kranke P, Torossian A et al. · 2026 · Cancers

Background Isolated Perfusion Chemotherapy (IPC) with balloon occlusion creates transient ischemic tissue compartments while patients remain exposed to significant perioperative heat loss. Active warming during these phases is commonly…

View details →
Negative / Null Result ReportMedicine

Enhancing Potato (Solanum tuberosum L.) Production in a Semi-arid Environment in Morocco Using Subsurface Drip Irrigation and Other Water-Saving Strategies

Kretzschmar HA, Abouabdillah A, Bouabid R et al. · 2026 · Potato Res..

The Fès-Meknès region in Morocco is characterized by a typical Mediterranean climate and the cultivation of water-demanding, locally well-established cash crops, such as potato (Solanum tuberosum L.). Therefore, this region is likely to…

View details →