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Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effect of final irrigation protocols on the bond strength and dentinal tubule penetration of root canal sealers: an ex vivo laboratory study.

Örs SA, Yılmaz GA, Şengül N et al. · 2026 · BMC oral health

BACKGROUND: Effective disinfection and sealing of the root canal system are essential for the long-term success of endodontic treatment. Final irrigation solutions can influence the interactivity between dentin and sealers. This study…

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Negative / Null Result ReportMedicine

Matrigel-encapsulated articular cartilage derived fibronectin adhesion assay derived chondroprogenitors for enhanced chondrogenic differentiation: An in vitro evaluation.

Parasuraman G, Rani J MS, Zachariah MM et al. · 2025 · Tissue & cell

Purpose In cartilage research, three-dimensional (3D) culture models are pivotal for assessing chondrogenic differentiation potential. Standard pellet cultures, despite their utility, pose challenges like uneven differentiation and…

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Negative / Null Result ReportMedicine

Arthroscopic Microdrilling for Full-Thickness Trochlear Cartilage Defects in Patients Undergoing High Tibial Osteotomy Confers Improved Cartilage Status at 1 Year and Rate of Minimal Clinically Important Difference at Short-Term Follow-Up.

Jung SH, Jung M, Chung K et al. · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purpose To compare the patient-reported outcome (PRO) improvements and cartilage status of trochlear cartilage defects (TCDs) after additional arthroscopic microdrilling versus no treatment for TCDs during medial open-wedge high tibial…

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Negative / Null Result ReportMedicine

Assessment of coated orthodontic miniscrews with chlorhexidine hexametaphosphate antimicrobial nanoparticles: A randomized clinical trial.

Al-Hilaly AA, Alhuwaizi AF · 2025 · Journal of the World federation of orthodontists

Background Using miniscrews to control anchorage made the application of force for various orthodontic treatment approaches easier and increased their effectiveness. Some problems may occur during the use of miniscrews, such as…

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Negative / Null Result ReportMedicine

Training Effects of Traditional versus Cluster Set Configuration with and without Blood Flow Restriction.

Cornejo-Daza PJ, Sánchez-Valdepeñas J, Rodiles-Guerrero L et al. · 2025 · Medicine and science in sports and exercise

Purpose This study compared the effects of four different resistance training (RT) programs that differed in the set configuration (cluster vs traditional) and the blood flow condition (free-flow [FF] vs blood flow restriction [BFR]) on…

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Negative / Null Result ReportMedicine

Chelating agents desorb soil acid-soluble and iron‑manganese oxide-bound Cd into dissolved Cd-chelate complexes yet with low phytoavailability.

Dong Q, Tang W, Wang X et al. · 2025 · Journal of hazardous materials

The use of chelating agents in remediation of cadmium (Cd)-contaminated soils by leaching has gained popularity. However, the environmental risks associated with this practice, particularly its impact on soil Cd phytoavailability, remain…

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Negative / Null Result ReportOpen accessMedicine

Should Microhematuria Be Incorporated into the 2023 Duke-International Society for Cardiovascular Infectious Diseases Minor Immunological Criteria?

Regina J, Stavart L, Guery B et al. · 2025 · Antibiotics (Basel, Switzerland)

Background/Objectives : Microhematuria is common in patients with infective endocarditis (IE). The present study aims to assess whether the addition of microhematuria in the 2023 Duke-International Society for Cardiovascular Infectious…

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Negative / Null Result ReportMedicine

Comparing letters written by humans and ChatGPT: A preliminary study.

Matsubara S · 2025 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective There are no criteria for what type of manuscript and to what extent ChatGPT use is permissible in writing manuscripts. I aimed to determine which, human or ChatGPT, writes more readable letters to the editor and whether ChatGPT…

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Negative / Null Result ReportMedicine

Malate or Not? Acute Effects of L-Citrulline Versus Citrulline Malate on Neuromuscular Performance in Young, Trained Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.

Martín-Olmedo JJ, Miras-Moreno S, Cuadra-Montes K et al. · 2025 · International journal of sport nutrition and exercise metabolism

L-citrulline (CIT) supplementation seems to improve resistance training performance; yet, whether malate has additive ergogenic effects when combined with CIT is unknown. This randomized, double-blind, placebo-controlled crossover trial…

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Negative / Null Result ReportMedicine

Effect of Cold Stress on Field Performance, Chlorophyll Fluorescence, Electrolyte Leakage and Leaf Gas Exchange Parameters of Potato (Solanum tuberosum L.) Genotypes

Angmo D, Sharma SP, Kalia A et al. · 2024 · Potato Res..

North-western parts of the Indo-Gangetic Plains are prone to occasional frost incidences which may result in 40–60% loss of tuber yield in potato. The overall aim of this study was to identify the morpho-physiological responses of two…

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Negative / Null Result ReportMedicine

Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency.

Xu Y, Sawamoto T, Sun R et al. · 2024 · Bioscience, biotechnology, and biochemistry

Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection against…

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Negative / Null Result ReportMedicine

Challenge for Deep Learning: Protein Structure Prediction of Ligand-Induced Conformational Changes at Allosteric and Orthosteric Sites.

Olanders G, Testa G, Tibo A et al. · 2024 · Journal of chemical information and modeling

In the realm of biomedical research, understanding the intricate structure of proteins is crucial, as these structures determine how proteins function within our bodies and interact with potential drugs. Traditionally, methods like X-ray…

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Negative / Null Result ReportMedicine

Senescence in Alveolar Epithelial Type II Cells Promotes Acute Lung Injury and Impairs Regeneration.

Hirsch MS, Hildebrand CB, Geltinger F et al. · 2024 · American journal of respiratory cell and molecular biology

The mortality associated with acute lung injury (ALI) increases with age. Alveolar epithelial type II (AEII) cells are the progenitor cells of the alveolar epithelium and are crucial for repair after injury. We hypothesize that telomere…

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Negative / Null Result ReportOpen accessMedicine

Sex Differences in Force, Velocity, and Power Percent Changes During Countermovement Jump Performance Following a Dynamic Warm-Up.

Sanders GJ, Bennett M, Kollock RO et al. · 2026 · Muscles (Basel, Switzerland)

Background : The study examined sex differences in countermovement jump (CMJ) force plate metrics and neuromuscular responses to a standardized dynamic warm-up in physically active college students. Methods : Forty-one participants (21…

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Negative / Null Result ReportOpen accessMedicine

Virtual Reality Body Exposure and Attentional Bias Modification in the Treatment of Adolescents With Anorexia Nervosa.

Ascione M, Carulla-Roig M, Meschberger-Annweiler FA et al. · 2026 · Clinical psychology & psychotherapy

Anorexia nervosa (AN) is a severe psychiatric disorder characterized by intense fear of gaining weight and persistent body image disturbance. Virtual reality-based mirror exposure therapy (VR-MET) may reduce body-related fear through…

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Negative / Null Result ReportMedicine

Wildflower strips enhance pest regulation services in citrus orchards

Mockford A, Urbaneja A, Ashbrook K et al. · 2024 · Agriculture, Ecosystems and Environment.

Contemporary approaches to agriculture must be reimaged to include ecological techniques that maximise ecosystem services, so that food can be produced sustainably whilst simultaneously meeting yield demands. Pest regulation services,…

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Negative / Null Result ReportOpen accessMedicine

Effects of supplementing crude protein to feedlot bison heifers using canola meal or wheat-based distillers' grains with solubles on feed intake, performance and carcass traits.

Alcivar de Lucca J, McKinnon JJ, Feist MS et al. · 2025 · Translational animal science

This study evaluated how varying crude protein levels in rations that incorporated canola meal or wheat-based dried distillers' grains with solubles as alternative protein sources affected growth performance, carcass traits, and liver…

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Negative / Null Result ReportOpen accessMedicine

A Phase 2a Study of the Early Bactericidal Activity of Rifampicin in Combination With Meropenem Plus Amoxicillin/Clavulanate Among Adults With Rifampicin-Resistant Pulmonary Tuberculosis.

de Jager V, Mockeliunas L, You H et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background In vitro, meropenem is shown to restore the activity of rifampicin in rifampicin-resistant Mycobacterium tuberculosis strains. This phase 2a trial aimed to determine if addition of rifampicin increases the early bactericidal…

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Negative / Null Result ReportMedicine

Extended Reichardt's Dye-Synthesis and Solvatochromic Properties.

Franzese S, Saker Neto N, Wong WWH · 2024 · Chemistry (Weinheim an der Bergstrasse, Germany)

Three new pyridinium-phenolate dyes based on the benchmark solvatochromic dye Betaine 30 were synthesised. The dyes contained phenylene spacers between the donor and acceptor groups. Their UV-Vis absorption spectra were measured, with the…

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Negative / Null Result ReportMedicine

Investigating the impact of surface treatments on tensile bond strength between pediatric prefabricated zirconia crowns and primary maxillary incisors with various types of luting cement: an in vitro study.

Chinadet W, Pengpue P, Chaijareenont P · 2024 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Purpose This study aimed to evaluate the effects of two surface treatments on the tensile bond strength of prefabricated zirconia crowns (PZCs) using bioactive and resin cements. Methods Forty extracted human primary maxillary incisors…

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