e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic reactivity during…

View details →
Negative / Null Result ReportOpen accessMedicine

Trained immunity agonists given to neonatal mice fail to protect against leptospiral infection in adulthood and may cause adverse effects.

Fernandez M, Vernel-Pauillac F, Pezier T et al. · 2026 · Innate immunity

Background and ObjectivesTrained immunity (TI) refers to a non-specific, long-lasting protective immune response that occurs following initial stimulation of the immune system and thought to be largely mediated by functional reprogramming…

View details →
Negative / Null Result ReportMedicine

Will a co-created program enhance implementation of injury prevention training in youth handball in Sweden? A cluster-randomized controlled trial.

Ageberg E, Donaldson A, Lucander K et al. · 2025 · Journal of science and medicine in sport

Objectives To compare the implementation of a co-created evidence-based injury prevention intervention with an existing program in youth team handball. Design Pragmatic two-armed cluster-randomized controlled trial, conducted…

View details →
Negative / Null Result ReportMedicine

The metal-organic framework MIL-100(Fe) and ferric citrate as potential counteracting biomaterials against osteoarthritis-induced articular inflammation and fibrosis.

Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…

View details →
Negative / Null Result ReportMedicine

Added value of a balloon-based mucosal exposure device in computer-aided detection-assisted colonoscopy: a randomized controlled trial (COMBAT study).

Rocchetto S, Rondonotti E, Alicante S et al. · 2025 · Endoscopy

Both computer-aided detection (CADe) systems and mucosal exposure devices can enhance adenoma detection during colonoscopy. This research investigates whether combining a CADe system with a balloon-based mucosal exposure device increases…

View details →
Negative / Null Result ReportMedicine

The role of social and emotional experience in representing abstract words.

Goriachun D, Strijkers K, Gala N et al. · 2025 · Journal of experimental psychology. General

words challenge embodied cognition theories due to their lack of direct connections to the sensory and bodily world. To address this, some theories propose that abstract words are represented through emotional and social information. We…

View details →
Negative / Null Result ReportMedicine

PcrV in an intranasal adjuvanted tobacco mosaic virus conjugate vaccine mediates protection from Pseudomonas aeruginosa via an early Th1/Th17 skewed localized and systemic immune response.

Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine

Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…

View details →
Negative / Null Result ReportMedicine

Cost does not prevent pigeons from investing in the future.

Cowie S, Davison M · 2025 · Behavioural processes

One of the simplest forms of behavior, operant behavior, appears fundamentally prospective, implying potential similarity to 'sophisticated' prospective behaviors like planning in terms of underlying mechanisms. But differences between…

View details →
Negative / Null Result ReportOpen accessMedicine

Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial.

Ratajczak M, Bilska A, Musialik K et al. · 2026 · Frontiers in endocrinology

Background Metformin is widely used as a first-line therapy for type 2 diabetes and increasingly prescribed off-label in women with elevated HOMA-IR indices, including those at risk of metabolic disorders. However, its clinical use is…

View details →
Negative / Null Result ReportMedicine

Mesenchymal Stem Cell Therapy Fails to Improve Fat Graft Retention: Cryopreserved and Cultured Syngeneic and Allogeneic Mesenchymal Stem Cells in a Rat Model.

Alstrup T, Pedersen JO, Kjær EM et al. · 2025 · Plastic and reconstructive surgery

Background Fat grafting is a gentle technique used to correct soft-tissue defects, but it is challenged by low graft survival rates. To enhance retention, mesenchymal stromal cells (MSCs) have been explored. Autologous MSC therapy has…

View details →
Negative / Null Result ReportOpen accessMedicine

Evidence that SmTetX is not a tetracycline resistance determinant.

Beech MJ, Trush MM, Toma EC et al. · 2026 · Microbiology spectrum

SmTetX, a flavin-dependent monooxygenase from the opportunistic pathogen Stenotrophomonas maltophilia , is structurally related to the tetracycline-degrading Tet(X) resistance enzymes, though displays substantial divergence in active site…

View details →
Negative / Null Result ReportOpen accessMedicine

Non-visualization of the fetal gallbladder with ultrasound in the second trimester in a Chinese cohort: prognosis and clinical consultation.

Ding H, Wang Y, He F et al. · 2026 · BMC pregnancy and childbirth

BACKGROUND: To investigate the prenatal characteristics and clinical outcomes of fetuses with non-visualization of the fetal gallbladder (NVFGB) with ultrasound during the second trimester and to promote prenatal consultations based on…

View details →
Negative / Null Result ReportOpen accessMedicine

Acute beetroot juice ingestion fails to improve sprint performance and neuromuscular function in trained male sprinters: a randomized, double-blind, placebo-controlled study.

López-Samanes Á, Moreno-Pérez D, Aguilar-Navarro M et al. · 2026 · Journal of the International Society of Sports Nutrition

Introduction The aim of this study was to evaluate the acute effect of beetroot juice ingestion on sprint performance and neuromuscular properties of male trained sprinters. Methods Twelve male sprinters (24.3 ± 4.8 years) participated in…

View details →
Negative / Null Result ReportMedicine

Criteria for knee flexion range of motion and quadriceps strength to ascend and descend stairs 1 year after bilateral total knee arthroplasty: A cross-sectional study.

Nanjo K, Ikeda T, Kaneyama R et al. · 2025 · Journal of back and musculoskeletal rehabilitation

BackgroundStair ascent/descent pose significant challenges after total knee arthroplasty (TKA); however, the exact knee flexion range of motion (ROM) and quadriceps strength requirements remain unclear.ObjectiveTo establish criteria for…

View details →
Negative / Null Result ReportMedicine

Local Recurrence and Survival Outcomes after Portal Vein/Superior Mesenteric Vein Separation without Resection Preceding Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma.

Inoue K, Mizuma M, Motoi F et al. · 2025 · Pancreas

Objectives In patients with pancreatic ductal adenocarcinoma (PDAC) and portal vein/superior mesenteric vein (PV/SMV) contact, we can often separate the tumor from the PV/SMV and avoid PV/SMV resection (VR) owing to the favorable efficacy…

View details →
Negative / Null Result ReportOpen accessMedicine

Quercetin Enhances Gastric Nitric Oxide Formation and Potentiates the Antihypertensive Effects of Oral Nitrite Administration.

Silva-Cunha M, Conde-Tella SO, Rebelo MA et al. · 2026 · Basic & clinical pharmacology & toxicology

Oral nitrite supplementation enhances nitric oxide (NO) bioavailability and lowers blood pressure. Quercetin may facilitate the reduction of nitrite to NO. However, the combined effects of nitrite and Quercetin on gastric NO formation and…

View details →
Negative / Null Result ReportOpen accessMedicine

Dafadine Does Not Promote Dauer Development in Pristionchus pacificus .

Carstensen HR, Hong RL · 2025 · microPublication biology

In response to unfavorable conditions, nematodes develop into the stress-resistant dauer larvae. Under favorable conditions, many nematodes are known to synthesize dafachronic acids (DAs) that bind to the conserved nuclear hormone receptor…

View details →
Negative / Null Result ReportMedicine

Exploring mechanisms underlying the beneficial effect of whey protein isolate on the biocompatibility of the thermally obtained curdlan-based hydrogel.

Klimek K, Kierys A, Matwijczuk A et al. · 2025 · Carbohydrate polymers

This work aimed to compare the biomedical potential of thermally obtained hydrogels consisting of curdlan and a curdlan-whey protein isolate mixture. The purpose of this paper was also to investigate and explain the mechanisms responsible…

View details →
Negative / Null Result ReportMedicine

Investigating the role of ketogenic diet and high-dose vitamin C in modulating doxorubicin toxicity in a murine breast cancer model.

Al-Jada DN, Takruri HR, Talib WH et al. · 2025 · Biochemical and biophysical research communications

In this study, we investigated the effectiveness of combining the ketogenic diet (KD) with high-dose vitamin C (VitC) as adjuvant nutritional therapy to mitigate doxorubicin (DOX) toxicity, with a focus on cardiotoxicity, while enhancing…

View details →
Negative / Null Result ReportOpen accessMedicine

Myeloid Cell Targeting Strategies Show Limited Durable Activity in the Breast Cancer Tumor Microenvironment and Do Not Enhance the Activity of Thermally Ablative Focused Ultrasound.

Van Wagoner CM, Kitelinger LE, DeWitt MR et al. · 2026 · Cells

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BrCa), owing to its lack of targetable receptors and resistance to chemical and molecularly targeted therapeutic approaches. While chemotherapy and…

View details →
Negative / Null Result ReportMedicine

Irradiation with Ultraviolet-C Light-Emitting Diodes: Evaluation of the potential and limitations in controlling the spread of mobile genetic elements.

Duering H, Westerhoff T, Kipp F et al. · 2025 · Environment international

Background Recent reports of multispecies outbreaks show that, in addition to multidrug-resistant bacteria, the accumulation and spread of antibiotic resistance-conferring genes (ARGs) in clinical settings is a growing concern.…

View details →