11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Scherer JS, Wu W, Wetmore JB et al. · 2026 · Kidney360
Background Legalization of cannabis across several US states may increase its use by individuals on hemodialysis, particularly among those with chronic pain. Contemporary data on frequency or factors associated with cannabis use by this…
View details →Men X, Taylor ZL, Marshe VS et al. · 2026 · Canadian journal of psychiatry. Revue canadienne de psychiatrie
BackgroundVenlafaxine is commonly prescribed for older adults with depression, yet the relationship between venlafaxine-related exposure and treatment outcomes remains unclear. We aimed to assess the association of exposure to venlafaxine,…
View details →Littmann J, Steiner N, Cabrejo-Jones K et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background A Moberg osteotomy is a dorsal closing wedge osteotomy of the base of the first proximal phalanx that is thought to augment the effect of cheilectomy by increasing dorsiflexion and ultimately improve patient outcomes in Hallux…
View details →Terentieva EI, Komleva PD, Antonova SM et al. · 2026 · International journal of molecular sciences
Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like…
View details →Ghazali M, Sele V, Sahuquillo A et al. · 2026 · Journal of hazardous materials
The increasing interest in seaweed as a potential feed and food source has prompted concerns regarding the presence of potentially toxic arsenic (As) species. Seaweed is known to contain the organic As species arsenosugars, but the…
View details →Daniloski D, Ibáñez RA, McCarthy NA et al. · 2026 · Journal of dairy science
Bovine β-casein (β-CN) is a major milk protein that exists as multiple genetic variants, distinguished by differences in their amino acid sequences. Among these, the A1 and A2 variants are the most extensively studied. They differ at…
View details →Noorman L, Bekebrede AF, de Vries S et al. · 2026 · Animal : an international journal of animal bioscience
In vitro and in situ experiments, primarily conducted using human cells, have demonstrated that metabolites produced during protein fermentation can negatively affect intestinal health. However, in vivo research on their impact on…
View details →Nass N, Sprung S, Ignatov A et al. · 2026 · Cancer treatment and research communications
In cancer, aerobic glycolysis predominantly used to provide energy. This high glycolytic flow results in the formation of reactive aldehydes such as glyoxal and methylglyoxal forming advanced glycation end products (AGEs) by reacting with…
View details →Willey CN, Bufi R, Takemon Y et al. · 2026 · American journal of physiology. Renal physiology
Increased concentrations of neuroblastoma suppressor of tumorigenicity 1 (NBL1) in the blood have been associated with disease progression in diabetic kidney disease (DKD) and IgA nephropathy. However, it is unclear whether NBL1 is a…
View details →Claus L, Zhang X, Ocasio L et al. · 2026 · Clinical radiology
Aim Computed tomography angiography (CTA) is essential for preprocedural assessment in transcatheter aortic valve replacement (TAVR), particularly as TAVR becomes the preferred treatment for high-risk patients with severe aortic stenosis.…
View details →Söröd M, Gyllencreutz E · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Introduction Cardiotocography (CTG) is used for fetal surveillance to prevent asphyxia related neonatal outcomes during pregnancy and delivery. In Sweden, all delivery wards have transitioned from CTG registered and printed on paper inside…
View details →Böhm M, Stegemann A, Wolnicka-Głubisz A et al. · 2026 · Aging and disease
Alpha-melanocyte-stimulating hormone (α-MSH) is a key endocrine mediator of photoprotection in the ultraviolet (UV)B-induced skin response. Its effects are mediated by the melanocortin-1 (MC1R) receptor and include increased eumelanin…
View details →Cabaret J, Guerrero Molina C, Martínez-Ortiz-de Montellano C et al. · 2026 · Pathogens (Basel, Switzerland)
Faecal egg counts (FECs) are used to assess the intensity of gastrointestinal nematode (GIN) infections in herbivores. FEC distribution is aggregated, meaning that approximately 20% of animals harbour 80% of infections. In times of…
View details →Santos de Oliveira N, Barbieri M, Moraes PA et al. · 2026 · Women & health
A prospective longitudinal study was conducted among 70 users of the etonogestrel contraceptive implant. World Health Organization Quality of Life (WHOQOL-BREF), Female Sexual Function Index (FSFI), and Birth Control Satisfaction…
View details →Nie Y, Staley A, Hinz TK et al. · 2026 · Clinical lung cancer
Background Although ALK-positive non-small cell lung cancer (NSCLC) derives limited benefit from immune checkpoint inhibitors, PD-L1 expression is frequently elevated at diagnosis. The clinical relevance of PD-L1 expression for the…
View details →Marcotte-Chénard A, Sandilands RE, Teixeira AA et al. · 2026 · American journal of physiology. Cell physiology
Beta-hydroxybutyrate (BHB) exerts anti-inflammatory effects in cell and animal models, but translational work in humans remains limited. We investigated how exogenous ketone monoester (KME) ingestion in vivo and BHB treatment of human…
View details →Effinger D, Hirschberger S, Arntjen T et al. · 2026 · Nutrients
Background/Objectives : The ketogenic diet (KD) has been shown to exert beneficial effects on human immunity by enhancing cytotoxic T lymphocyte function through metabolic reprogramming. However, strict dietary restrictions limit adherence…
View details →Vieira Y, Sobral M, Mateus V et al. · 2026 · International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Transcranial direct current stimulation (tDCS) has emerged as a promising tool to investigate and modulate emotional and social processes, including compassion. By targeting cortical regions implicated in empathy and prosocial behaviour…
View details →Jin Z, Li J, Thackray AE et al. · 2026 · Appetite
Oxyntomodulin (OXM) is a gut-derived peptide hormone with anorexigenic properties that reduce food intake and increase energy expenditure. This study investigated the effect of a single bout of moderate-intensity running on OXM…
View details →Harris MB, Milsom WK · 2025 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
During hibernation, golden-mantled ground squirrels (Spermophilus lateralis) breathe in distinct multi-breath episodes separated by prolonged periods of apnea. We hypothesized that vagal afferent feedback from pulmonary stretch receptors,…
View details →Liu Y, Sun J, Hu Y et al. · 2026 · Clinical and experimental reproductive medicine
Objective Previous studies have reported a higher rate of small for gestational age (SGA) newborns from fresh embryo transfers compared with frozen-thawed embryo transfers (FET), potentially due to the supraphysiologic serum estradiol…
View details →Flensted-Jensen M, Kleis-Olsen AS, Weinreich CM et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
Advanced glycation end-products (AGEs) accumulate with age and may contribute to skeletal muscle decline, yet their distribution within muscle compartments is unknown. Resistance training (RT) and high-intensity interval training (HIIT)…
View details →Park JK, Lee JE, Kim JS et al. · 2026 · Journal of hazardous materials
Microplastics (MPs) are emerging contaminants that disrupt development, physiology, and redox homeostasis in aquatic organisms. However, their detailed impacts on amphibians and the potential for antioxidant-based mitigation remain poorly…
View details →Bahabri M, Figueiredo JN, Kara Y et al. · 2026 · Nanotechnology
In this study, the growth of vertical graphene (VG) nanosheets on copper (Cu) substrates in a direct-current plasma-enhanced chemical vapor deposition (PECVD) system was studied. The plasma process during the VG growth was characterized…
View details →Lake J, Mariniello M, Schiano G et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points Lipocalin-2 upregulation paralleled intracellular uromodulin aggregates in mouse and cellular models of autosomal dominant tubulointerstitial kidney disease because of pathogenic uromodulin. The induction of lipocalin-2 was…
View details →Spry ER, Travis KB, Ragland KJ et al. · 2025 · Molecular and cellular endocrinology
Aims Semaglutide (SEMA) is a glucagon-like peptide-1 receptor agonist (GLP-1RA) that has recently emerged as a popular pharmacological treatment for type 2 diabetes and insulin resistance due to its weight loss properties. Previous studies…
View details →Bos MD, Ho CSL, Meyer NH et al. · 2026 · The Journal of surgical research
Introduction Epidemiological studies indicate that physical activity reduces cancer risk and mortality, while sedentary behavior exerts opposite effects. However, their impact on tumor metastasis remains unclear. This study investigated…
View details →Sogawa K, Funada M · 2026 · Toxicology letters
Cannabidiol (CBD) is a non-psychoactive cannabinoid with increasing global use, yet safety data during pregnancy remain limited. Preclinical studies suggest possible developmental neurotoxicity. Here, we examined the effects of CBD…
View details →Takata M, Nishikawa M, Hayashi H et al. · 2025 · Cureus
Background It remains unclear whether omecamtiv mecarbil, a cardiac myosin direct activator, enhances vascular smooth muscle myosin function at clinical and supra-clinical doses. Aims The current study evaluated the effect of omecamtiv…
View details →Day AS, Ballard TM, Benetti M et al. · 2026 · Journal of the Academy of Nutrition and Dietetics
Background The "gold standard" for successful blinding in controlled food-based dietary interventional trials includes a sham diet. Objective This study aimed to develop and evaluate a sham diet intended for use as a comparator in…
View details →