11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Jorgensen E, Modahl L, Noll A et al. · 2026 · The Journal of the Acoustical Society of America
This study investigated how hearing loss and hearing aid use affect environmental sound ratings in laboratory and real-world contexts using the soundscape framework. Forty-four participants (17 normal hearing, 14 with unaided hearing loss,…
View details →Parrish BP, McCool BA · 2026 · Neuropharmacology
Acute ethanol modulates an incredibly diverse number of neurotransmitter receptors and intracellular pathways. Presynaptic modulation by acute ethanol has been identified at some GABAergic synapses; but descriptions of acute ethanol…
View details →Straszewski A, Troyer S, Boyer MI et al. · 2026 · The Journal of hand surgery
Purpose Routine practices without a clear impact on patient care merit continuous reassessment. This retrospective study evaluated the value of routine histopathologic and culture analysis in patients who underwent flexor or extensor…
View details →Fang SH, Chiang MR, Li CY et al. · 2026 · Journal of muscle research and cell motility
Physical activity induces rapid myokine and metabolic responses in skeletal muscle, yet the immediate cellular adaptations to short-duration contractile activity remain incompletely defined. C2C12 myotubes were exposed to electrical pulse…
View details →Wong R, Robertson R, Meylakh N et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology
Objectives Electroencephalographic (EEG) studies suggest chronic migraine (CM) is associated with increased global power, especially in somatosensory cortex. Furthermore, recent studies suggest chronic pain is associated with a reduced…
View details →Lopes FM, Bantounas I, Sarov A et al. · 2026 · Nephron
Introduction Human fetal kidneys contain macrophages, innate immune cells postulated to enhance their development. Macrophages have also been implicated in the pathobiology of human kidney malformations and Wilms tumour. Human pluripotent…
View details →Prins PJ, Buga A, Storoschuk K et al. · 2026 · Journal of the American Nutrition Association
Background Exogenous ketone supplementation acutely elevates circulating beta-hydroxybutyrate ( R -BHB), but the impact of chronic repeated dosing on exercise performance, cognition, mood, and cardiometabolic health remains unclear.…
View details →Lee HW, Harris AN, Wall SM et al. · 2026 · American journal of physiology. Renal physiology
Hypokalemia activates intercalated cell acid secretion, but because hypokalemia is typically associated with metabolic alkalosis, this activation cannot be ascribed to extracellular pH. Metabolic acidosis induces responses similar to those…
View details →King JL, Effinger DP, Basquez-Pfeifer C et al. · 2026 · Translational psychiatry
The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT 2A R activation. Here, we examine how the polypharmacological agonists lisuride and lysergic…
View details →Donate APG, Cousijn J, Rømer Thomsen K · 2026 · Psychopharmacology
Rationale People who use cannabis often report using it to improve sleep and/or manage mental health symptoms. Cannabis products differ in their typical cannabinoid composition, particularly in their relative THC and CBD content, which may…
View details →Brown KA, Max LNF, Struble SE et al. · 2026 · American journal of veterinary research
Objective Determine the acute effects of xylazine and detomidine on concentrations of selected growth factors, cytokines, and α2-macroglobulin (A2M) in platelet-rich plasma (PRP) and autologous protein solution (APS) and the long-term…
View details →Calder AE, Diehl VJ, Lietz MP et al. · 2026 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Preclinical studies suggest that lysergic acid diethylamide (LSD) may induce lasting changes in brain function and learning ability, but evidence in humans is uncertain. Motor learning, in particular, has clinical relevance but has not…
View details →Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayon F · 2026 · Psychopharmacology
Rationale Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive avoidance (no…
View details →Abrahams M, Bunting BP, Frewer LJ et al. · 2026 · Food & function
Although personalised nutrition is more effective than generic approaches to dietary health promotion, effect sizes tend to be small. Behaviour change theory implies the importance of goal setting to successful health intervention. This…
View details →Ben-Zeev T, Levi C, Ratamess NA et al. · 2026 · Hormones and behavior
This study examined the effects of resistance training (RT) and supraphysiological nandrolone decanoate (ND) administration on hippocampal neurogenesis, neurotrophic signaling, and behavior. Forty 3-month-old male C57BL/6 J mice were…
View details →Ceccatto Andrade VP, Araujo Júnior E, Callado GY et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Objective The transdermal administration of testosterone is a promising alternative to improve sexual health in postmenopausal women with decreased sexual desire, although its use remains off-label in Brazil and several other countries.…
View details →Miftakhov R, Fortygina P, Zuzina A et al. · 2026 · Scientific reports
Astrocytes communicate bidirectionally with neurons by releasing various signaling molecules. This astrocyte-neuron "dialogue" is essential for long-term processes in the nervous system, and its disruption correlates with various…
View details →Wu J, Li G, Pen J et al. · 2026 · Journal of environmental management
Saline-alkali grassland ecosystems are essential methane (CH 4 ) sinks, playing a significant role in global CH 4 budgets. However, our understanding of the CH 4 uptake potential in saline-alkali grasslands and its response to climate…
View details →Fang YJ, Gonzalez K, Konecny F et al. · 2026 · American journal of physiology. Heart and circulatory physiology
Maternal exercise may influence long-term cardiovascular health in offspring, yet its effects on intrinsic myocardial performance and mitochondrial metabolism remain incompletely defined. We investigated whether maternal voluntary wheel…
View details →Plouhinec L, Maresca M, Saget J et al. · 2026 · Applied microbiology and biotechnology
As demand for sustainable and welfare-conscious food production increases, reducing the environmental and health impacts of animal feed has become a key challenge. Soybean meal (SBM) is widely used in poultry diets for its high protein…
View details →Ki SY, Jeong YT · 2026 · Biochemical and biophysical research communications
Peripheral sensory nerve injury triggers Wallerian degeneration, a process characterized by axonal fragmentation, myelin breakdown, and robust macrophage infiltration. While macrophages are widely implicated in debris clearance and repair…
View details →Schmid JA, Hogue M, Aguilar-Cardoza J et al. · 2026 · Environmental toxicology and chemistry
Agricultural run-off is one of the leading sources of environmental pollution in the United States. Insecticides and neonicotinoids have become the most used insecticide class across the world and act as an agonist on the nicotinic…
View details →Saiz-Gonzalo G, Drouin G, Rao Y et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Non-nutritive sweeteners (NNS) are increasingly consumed during pregnancy, yet their distinct metabolic fates obscure a unified mechanism for developmental programming. We tested whether maternal NNS exposure acts upstream of metabolism by…
View details →Magsi FH, Ullah A, Ma Y et al. · 2026 · Journal of chemical ecology
Fall armyworm (Spodoptera frugiperda) has emerged as a major pest of maize across the Americas, Africa and Asia. Current management relies heavily on synthetic insecticides, which are environmentally unsustainable. However, pheromone-based…
View details →Rajhansa S, Crump NT, Khoo HM et al. · 2026 · Experimental hematology
A major challenge in cancer therapeutics has been the identification of targets that are selectively toxic to cancer cells while displaying limited effects on healthy counterparts. Toxicities related to blood production from hematopoietic…
View details →Hajj-Boutros G, Faust A, Mastrandrea C et al. · 2026 · Experimental physiology
Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head-down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure…
View details →Cuadro R, Borrajo CI, Marino MA et al. · 2026 · European Journal of Agronomy.
Nitrogen (N) and phosphorus (P) deficiencies commonly limit plant growth in agroecosystems. While critical N concentration (Nc) dilution curves are widely used to assess the N status of crops and pastures, it remains unclear whether Nc…
View details →Zhao Y, Ma Y, Fan Y et al. · 2023 · Lung cancer (Amsterdam, Netherlands)
Purpose This study aimed to evaluate the efficacy and safety of cadonilimab (anti PD-1 and CTLA-4 bispecific antibody) in patients with previously treated metastatic non-small-cell lung cancer (NSCLC). Methods In this multicenter,…
View details →Karavia EA, Pittaras A, Andreopoulou O et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives: Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), represents a growing global health burden closely linked to obesity, insulin…
View details →Limon D, Bokstein F, Blumenthal DT et al. · 2026 · Neuro-oncology advances
Background Tumor-treating fields (TTFields) have demonstrated efficacy in newly diagnosed glioblastoma (ndGBM) when combined with adjuvant temozolomide (TMZ). Preclinical studies suggest that TTFields enhance the therapeutic effect of…
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