11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Jens Theysohn, Oliver Kraff, Stefan Maderwald et al. · 2011 · Journal of Magnetic Resonance Imaging
PURPOSE: To evaluate 7T MRI in the assessment of cerebrovascular alterations as seen in vascular dementia by means of detection of cerebral microbleeds (CMB) and depiction of white matter lesions (WML). 7T imaging was evaluated with…
View details →Klaus Wirth, Hagen Hartmann, André Sander et al. · 2015 · The Journal of Strength and Conditioning Research
Strength training-induced increases in speed strength seem indisputable. For trainers and athletes, the most efficient exercise selection in the phase of preparation is of interest. Therefore, this study determined how the selection of…
View details →Balaji Rangarathnam, Gary H. McCullough, Hylan Pickett et al. · 2015 · American Journal of Speech-Language Pathology
PURPOSE: The purpose of this study was to investigate the utility of telepractice for delivering flow phonation exercises to persons with primary muscle tension dysphonia (MTD). METHOD: Fourteen participants with a diagnosis of primary MTD…
View details →Britt Clynick, Tamera J. Corte, Helen E. Jo et al. · 2021 · European Respiratory Journal
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in which circulatory biomarkers have the potential for guiding management in clinical practice. We assessed the prognostic role of serum biomarkers in three…
View details →James Holland, David Langton, Munawar Hashmi · 2012 · Journal of Bone and Joint Surgery - British Volume
We present the clinical results and survivorship of consecutive 100 Birmingham Hip Resurfacings in 90 patients at a minimum follow-up of ten years. All procedures were carried out by an independent surgeon who commenced a prospective study…
View details →Jody Tversky, Andrew P. Lane, Antoine Azar · 2021 · Clinical & Experimental Allergy
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) can be a severe and debilitating disease associated with significant morbidity, loss of smell, sinus pressure and asthma exacerbations. Eosinophils play a role in the majority…
View details →Hiroto Inaba, Yinmei Zhou, Oussama Abla et al. · 2015 · Blood
Comprehensive clinical studies of patients with acute megakaryoblastic leukemia (AMKL) are lacking. We performed an international retrospective study on 490 patients (age ≤18 years) with non-Down syndrome de novo AMKL diagnosed from 1989…
View details →Christopher W. Lewis, Jamiluddin Qazi, Daniel S. Hippe et al. · 2019 · Cancer Medicine
Approximately one-third of Merkel cell carcinoma (MCC) patients eventually develop distant metastatic disease. Little is known about whether the location of the primary lesion is predictive of initial distant metastatic site, or if survival likelihood differs depending on the metastatic site. Such data could inform imaging/surveillance practices and improve prognostic accuracy. Multivariate and competing-risk analyses were performed on a cohort of 215 MCC patients with distant metastases, 31% of whom had two or more initial sites of distant metastasis. At time of initial distant metastasis in
View details →Scott A. Asher, Hilliary N. White, Alexandra E. Kejner et al. · 2013 · Otolaryngology
OBJECTIVE: An increasing number of head and neck surgeons have begun using transoral robotic-assisted surgery. Our objective was to examine the postoperative bleeding complications we have encountered to determine risk factors and to…
View details →Katherine D. LaClair, Kebreten F. Manaye, Dexter L. Lee et al. · 2013 · Molecular Neurodegeneration
BACKGROUND: Though the precise cause(s) of Alzheimer's disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies to promote natural Aβ clearance mechanisms, such as the protein apolipoprotein-E (APOE), hold promise for the treatment of AD. The amount of APOE in the brain is regulated by nuclear receptors including retinoid X receptors (RXRs). Drugs that activate RXRs, including bexarotene, can increase APOE and ABCA1 production, and have been shown to decrease the Aβ burden and improve c
View details →Felice Nava, Irene Tramacere, Veronica Andrea Fittipaldo et al. · 2014 · Neuro-Oncology
BACKGROUND: Prospective follow-up studies of large cohorts of patients with glioblastoma (GBM) are needed to assess the effectiveness of conventional treatments in clinical practice. We report GBM survival data from the Brain Cancer…
View details →Young-Hyo Ryu, Yong-Hee Kim, Jin‐Young Lee et al. · 2013 · PLoS ONE
Non-thermal plasma at atmospheric pressure has been actively applied to sterilization. However, its efficiency for inactivating microorganisms often varies depending on microbial species and environments surrounding the microorganisms. We investigated the influence of environmental factors (surrounding media) on the efficiency of microbial inactivation by plasma using an eukaryotic model microbe, Saccharomyces cerevisiae, to elucidate the mechanisms for differential efficiency of sterilization by plasma. Yeast cells treated with plasma in water showed the most severe damage in viability and ce
View details →Mirko S. Gilardino, Mihiran Karunanayake, Taghreed Alhumsi et al. · 2015 · Journal of Craniofacial Surgery
BACKGROUND: Cranioplasty can be performed either with gold-standard, autologous bone grafts and osteotomies or alloplastic materials in skeletally mature patients. Recently, custom computer-generated implants (CCGIs) have gained popularity…
View details →Abha A. Gupta, James R. Anderson, Alberto S. Pappo et al. · 2011 · Cancer
BACKGROUND: Patients aged >10 years with rhabdomyosarcoma have an inferior outcome compared with patients ages 1 to 9 years, which may be explained by toxicities (adverse events [AEs]) that result in chemotherapy dose reductions. METHODS:…
View details →Bahaa Aba Alkhail · 2015 · Medical Teacher
INTRODUCTION: A near-peer-assisted learning term (NPAL) is "a trainee one or more years senior to another trainee". The current study is aiming to determine the pattern of NPAL activities, to compare its effect on student's course…
View details →Yasin Çınar, Abdullah Kürşat Cingü, Fatih Mehmet Türkçü et al. · 2013 · Cutaneous and Ocular Toxicology
PURPOSE: To compare outcomes of accelerated and conventional corneal cross-linking (CXL) for progressive keratoconus (KC). MATERIALS AND METHODS: Patients were divided into two groups as the accelerated CXL group and the conventional CXL…
View details →Maya Williams, Sandra V. Mayer, William L. Johnson et al. · 2014 · American Journal of Tropical Medicine and Hygiene
During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years.…
View details →Yoshimi Kubota, Hiroyasu Iso, Chigusa Date et al. · 2011 · Stroke
BACKGROUND AND PURPOSE: Only a few reports have dealt with the association of antioxidant vitamin intakes with mortality or morbidity from cardiovascular disease in Asia. We investigated the relation of dietary vitamins A, E, and C intake…
View details →Davide Castagno, Mark C. Petrie, Brian Claggett et al. · 2012 · European Heart Journal
AIMS: The importance of heart rate in the pathophysiology of heart failure with reduced LVEF has recently attracted attention. In particular, the findings of the Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial…
View details →Marcos Hortes Nisihara Chagas, José Alexandre S. Crippa, Antônio Waldo Zuardi et al. · 2013 · Journal of Psychopharmacology
UNLABELLED: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle. OBJECTIVE: The objective of this paper is to assess the effects on sleep of acute…
View details →Katherine Andrinopoulos, Gretchen Clum, Debra A. Murphy et al. · 2011 · AIDS Education and Prevention
In this study HIV health-related quality of life (HIV-HRQOL) is examined among 179 behaviorally infected adolescent and young adult women. Modifiable psychosocial variables including depression, stigma, social support, and illness…
View details →Selma Kronsteiner-Gicevic, Audrey J. Gaskins, Teresa T. Fung et al. · 2018 · PLoS ONE
BACKGROUND: Dietary diversity scores (DDS) are considered as metrics for monitoring the implementation of the UN's Sustainable Development Goals, but they need to be rigorously evaluated. OBJECTIVE: To examine two DDS, the Food Groups Index (FGI), and the Minimum Dietary Diversity-Women (MDD-W), alongside two dietary quality scores, the Alternate Healthy Eating Index (AHEI-2010) and the Prime Diet Quality Score (PDQS), with risks of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDPs). DESIGN: The analysis included 21,312 (GDM) and 19,917 (HDPs) singleton births r
View details →Catherine Townsend, Julie Laffy, Bryan Wu et al. · 2016 · Frontiers in Immunology
Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 light chain variable region sequences from IgM-transcribing, newly f
View details →Konstantinos A. Toulis, Brian H Willis, Tom Marshall et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes mellitus (T2DM) and a prior cardiovascular disease (CVD) event. Objectives: To establish whether these benefits can be replicated in a real-world…
View details →Oded Zmora, Khaled Madbouly, Hagit Tulchinsky et al. · 2010 · Diseases of the Colon & Rectum
PURPOSE: Urinary bladder drainage for several days after pelvic surgery is a common surgical practice, despite insufficient evidence supporting its routine use. The aim of this study was to prospectively evaluate the utility of urinary…
View details →Sushmita Pamidi, Isabelle Marc, Gabrielle Simoneau et al. · 2016 · Thorax
OBJECTIVE: It is unclear whether objectively measured maternal sleep-disordered breathing (SDB) leads to poor fetal outcomes. In this study, we prospectively assessed whether polysomnography-based diagnosis of SDB in the third trimester is…
View details →Jan Krhút, Vladimír Borovička, Karolína Bílková et al. · 2018 · Neurourology and Urodynamics
AIMS: To assess the efficacy and safety of mirabegron in the treatment of neurogenic detrusor overactivity. METHODS: This prospective, multicenter, randomized, double-blind, placebo-controlled study was conducted in three tertiary centers,…
View details →Murat Gedikoğlu, Levent Oğuzkurt, Serkan Gür et al. · 2013 · Catheterization and Cardiovascular Interventions
OBJECTIVES: To compare the success and complication rates of ultrasound-guided or palpation-guided punctures of the common femoral artery in a prospective randomized study. BACKGROUND: Percutaneous femoral arterial access is sometimes…
View details →Mary Carmelle Philogene, Serena M. Bagnasco, Edward S. Kraus et al. · 2016 · Transplantation
BACKGROUND: This is a cross-sectional study designed to evaluate the histologic characteristics of graft injury in the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (AECA). METHODS:…
View details →Daqing Hong, Jeong Jin Min, Jeongwon Kim et al. · 2010 · Anaesthesia and Intensive Care
In several recent clinical trials on cardiac surgery patients, remote ischaemic preconditioning (RIPC) showed a powerful myocardial protective effect. However the effect of RIPC has not been studied in patients undergoing off-pump coronary…
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