11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Fosstveit SH, Feron J, Lohne-Seiler H et al. · 2026 · BMC sports science, medicine & rehabilitation
Background High-intensity interval training (HIIT) was originally designed to improve athletic performance, but a growing body of research over the past decade has highlighted its positive impact on various other health outcomes. However,…
View details →Lemos C, Vargas F, Donald EM et al. · 2026 · Journal of cardiac failure
Background Women, racial and ethnic minority groups, and patients of low socioeconomic status (SES) face barriers linked to adverse outcomes after heart transplantation (HT). Data are lacking regarding the association of these demographics…
View details →Sahlan RN, Frietchen R, Billman Miller MG et al. · 2025 · Suicide & life-threatening behavior
Objective Although previous research has established bidirectional links between many eating disorder (ED) symptoms and suicidal ideation (SI), no research has examined how symptoms of avoidant/restrictive food intake disorder (ARFID)…
View details →Hauser N, Sommerfield D, Nguyen J et al. · 2026 · Anaesthesia
Introduction Peri-operative respiratory adverse events remain a major cause of morbidity and mortality in children undergoing general anaesthesia; those with asthma are at higher risk. The aim of this feasibility study was to determine…
View details →Li M, He H, Dong L et al. · 2026 · Journal of psychosomatic research
Background Patients post hepatocellular carcinoma (HCC) surgery encounter physiological challenges as well as psychological and social adaptation problems，yet the trajectory and predictors of their psychosocial adjustment (PSA) remain…
View details →Tezanos KM, Simeone A, Gerson R et al. · 2026 · Child psychiatry and human development
Youth are presenting to Emergency Departments (EDs) following a suicide-related crisis at higher rates and younger ages. Clinicians lack tools to effectively discern suicide risk in younger patients. The present investigation examines how…
View details →Joshi S, Jahn KN · 2026 · Ear and hearing
Objectives Cochlear implants (CIs) enable people with moderate-to-profound sensorineural hearing loss to perceive sounds, but perceptual outcomes with a CI remain highly variable from person to person. Individuals who wear their CI…
View details →Ciriello GD, Colonna D, Morelli C et al. · 2026 · Indian pacing and electrophysiology journal
Fetal echocardiography plays a pivotal role in the diagnosis and management of fetal arrhythmias, allowing evaluation of the electrophysiological mechanism and guiding appropriate medical therapy. Herein, we describe our ten-year…
View details →Chan ACY, Stephan AT, Sneed RS · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives While the intensity of grandparent caregiving has been linked to older adults' health, limited research has examined the bidirectional associations between grandparenting intensity and health, particularly within grandparent…
View details →Kula O, Machluf Ruttner R, Shahar B et al. · 2026 · Psychotherapy (Chicago, Ill.)
The primary proposed change process in emotion-focused therapy models for couples involves partners accessing and revealing vulnerable emotions and responding to such disclosures with empathy and compassion. Therapists often use enactments…
View details →Chawner LR, Kidby S, Filippetti ML · 2026 · Appetite
Parental feeding practices, child temperament, and poor emotion regulation abilities are central factors associated with Emotional Eating (EE) during childhood (3–10 years). Yet, it is poorly understood how children develop EE behaviours…
View details →Özden HÖ, Çelik FND, Üstüner FŞ et al. · 2026 · Diagnostics (Basel, Switzerland)
Background: Abrupt cessation of deep brain stimulation (DBS) in Parkinson's disease (PD), most commonly due to implantable pulse generator (IPG) battery depletion, may lead to DBS withdrawal syndrome (DBS-WDS). However, withdrawal syndrome…
View details →Morel M, Mitchell L, Stienen E et al. · 2026 · Proceedings. Biological sciences
The post-fledging period is a critical phase for inexperienced birds, who must navigate and explore unfamiliar environments to locate essential resources for survival. Successful foraging during this stage relies on acquiring spatial…
View details →O'Shaughnessy J, Brufsky AM, Layeequr Rahman R et al. · 2026 · JCO precision oncology
Purpose Randomized trials have not demonstrated clear benefit from anthracyclines for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (EBC). The MammaPrint 70-gene…
View details →Xiao H, Warner E, Ryan J et al. · 2026 · Cancer causes & control : CCC
Purpose Cancer-related cognitive impairment (CRCI) is a common concern among breast cancer (BC) patients receiving chemotherapy, yet predictors of short-term cognitive change remain unclear. This study examined whether baseline…
View details →William JB, Chieng D, Crowley R et al. · 2026 · JACC. Clinical electrophysiology
Background Left atrial (LA) enlargement is commonly used in patient selection for catheter ablation. However, its role in predicting postablation outcomes in persistent atrial fibrillation (AF) remains uncertain. Objectives The study goal…
View details →Alpert E, Kaplan A, Nelson D et al. · 2026 · Psychological trauma : theory, research, practice and policy
Objective Among patients with co-occurring posttraumatic stress disorder (PTSD) and substance use disorders (SUDs), little is known about early PTSD treatment processes, including treatment preference and outcome expectancy. This study…
View details →Cohen H, Toro D, Zuluaga D et al. · 2026 · Clinical transplantation
Introduction To evaluate donor-stratified graft and patient survival following kidney transplantation (KT) for lithium-associated end-stage kidney disease (ESKD). Methods This retrospective analysis utilized the Organ Procurement and…
View details →Yang L, Zhang H, Wei Y et al. · 2026 · American journal of hematology
Immunosuppressive therapy (IST) is the standard treatment for acquired pure red cell aplasia (aPRCA), but predictors of treatment response and long-term prognosis remain unclear. The clinical significance of somatic mutations in aPRCA is…
View details →Vellore AJ, Bhatia S, Kann MR et al. · 2026 · JMIR XR and spatial computing
Background Augmented reality (AR) can provide risk-free training for medical trainees, yet little is known about which learner characteristics facilitate adoption or inform training design. Objective We aimed to identify which learner…
View details →Denfeld QE, Hiatt SO, Dieckmann NF et al. · 2026 · The Journal of cardiovascular nursing
Many adults with heart failure (HF) are physically frail, and HF self-care behaviors, especially symptom monitoring and management (SMM), may affect physical frailty; however, the association between SMM behaviors and physical frailty has…
View details →Gefferie SR, Jiménez-Jiménez D, Visser GH et al. · 2026 · Epilepsia open
Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB…
View details →Heidari N, Maroufi A, Shams-Alizadeh N · 2026 · Clinical neuropharmacology
Objective Neuroinflammation, reflected in hematological and inflammatory biomarkers, plays a role in bipolar disorder. Electroconvulsive therapy (ECT) is effective for treatment-resistant bipolar disorder, but its impact on these…
View details →Sweeney L, Schapira L, Webster S et al. · 2026 · Pain
Abstract Chronic cancer-related pain affects up to 40% of cancer survivors, yet why pain persists after cancer treatment has ended is not well-understood. The Cancer Threat Interpretation (CTI) model proposes that fear of cancer recurrence…
View details →Kikut-Stein A, Jesch E, Dhawan D et al. · 2026 · Journal of health communication
In the wake of the COVID-19 pandemic, a critical question for health communication is whether misinformation exposure and misperceptions about one health topic have far-reaching, or "spillover," effects on health behavior in general. The…
View details →Fasting A, Simensen MV, Sele P et al. · 2026 · Journal of affective disorders
Background This retrospective quality-control study examined whether patients with posttraumatic stress disorder (PTSD) at a specialized Norwegian inpatient hospital exhibited high levels of interpersonal problems before treatment and…
View details →Raha SJ, Bhatia P, Bansal D et al. · 2026 · Cancer chemotherapy and pharmacology
Background High‑dose methotrexate (HD‑MTX) is a cornerstone of pediatric acute lymphoblastic leukaemia (ALL) therapy. However, deviations from protocol-mandated infusion durations need regular monitoring as part of standard quality care.…
View details →Hunter M, Skippen P, Templio SL et al. · 2026 · Cognitive, affective & behavioral neuroscience
Risk-taking in young people is often attributed to a mismatch between slowly maturing cognitive control networks and overactive reward networks, leading to impulsive actions. However, evidence is inconsistent, and these models do not…
View details →Pizzi A, Cotrufo PP, Farinaro G et al. · 2026 · Stereotactic and functional neurosurgery
Introduction Gamma knife radiosurgery (GKRS) is an established effective treatment for medically intractable trigeminal neuralgia (TN), but outcome predictors remain controversial. Notably, the influence of neurovascular conflict (NVC)…
View details →Lustermans H, Bruinhof N, Beijers R et al. · 2026 · Appetite
During the perinatal period, mental health issues and poor diet quality can adversely affect maternal and infant outcomes. Previous studies described associations between perinatal mental health and diet quality, but the direction of these…
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