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Browse the failure-mode index

11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Understanding caffeine's impact on sustained attention in early phase psychosis: Unveiling cognitive insights through the use of EEG.

Francis AM, Anderson TJ, McKearney KJ et al. · 2025 · Psychiatry research. Neuroimaging

Cognitive impairment, particularly in attention and working memory, is a notable feature of schizophrenia (SZ). Individuals with SZ frequently consume high levels of caffeine, often exceeding 550 mg daily, yet the cognitive effects of this…

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Negative / Null Result ReportMedicine

Quantitative analysis of 'virtual' SSP assessment clinics in the NHS bowel cancer screening programme in England.

Nickerson C, Wright S, Pickering L et al. · 2025 · Journal of public health (Oxford, England)

Background Bowel cancer screening in England is initially carried out using a home testing kit, with those who require further testing first being referred to an assessment clinic. During COVID-19, these assessment clinics became 'virtual'…

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Negative / Null Result ReportMedicine

The association between maternal diabetes, antidiabetic medication use, and severe ADHD requiring inpatient care: A registry-based cohort study.

Damtie Y, Betts K, Dachew BA et al. · 2025 · Journal of psychosomatic research

Background Limited evidence exists on the association between maternal use of antidiabetic medications and neurodevelopmental outcomes in children. This study examined the link between maternal diabetes, antidiabetic medication use, and…

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Negative / Null Result ReportMedicine

Neurocognitive passport: A novel feedback tool for pediatric patients with sickle cell disease.

Karst J, Miller M, Simpson P et al. · 2026 · Journal of child health care : for professionals working with children in the hospital and community

Sickle Cell Disease (SCD) is associated with neurocognitive impairment, and routine cognitive and academic screening is recommended. Traditional reports following testing are often not health literate, limiting the usefulness of…

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Negative / Null Result ReportOpen accessMedicine

Ocular Findings in Women with Cervical HPV Positivity and Cervical Dysplasia Undergoing Loop Electrosurgical Excision Procedure: A Prospective Cross-Sectional Study.

Vural NA, Mergen B, Güler S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : To evaluate ocular findings in women with cervical HPV positivity undergoing loop electrosurgical excision procedure (LEEP) for cervical dysplasia and to assess conjunctival/eyelid papilloma and other ocular…

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Negative / Null Result ReportMedicine

Impact of preoperative use of biologics on 30-day surgical morbidity and mortality in patients with Crohn's disease undergoing ileocolectomy: National Surgical Quality Improvement Program database analysis.

Daniel F, El Kouzi Z, Mrad J et al. · 2025 · Updates in surgery

Preoperative use of biologics has been inconsistently reported to be associated with increased frequency of infectious and surgical anastomotic complications in inflammatory bowel disease patients. We aimed to evaluate the rates of 30-day…

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Negative / Null Result ReportMedicine

Psychological mechanisms of change in reducing co-occurring social anxiety and alcohol use: A causal mediation analysis of the online Inroads intervention.

Gückel T, Prior K, Newton NC et al. · 2025 · Behaviour research and therapy

Background Research has documented the prevalence and treatment of co-occurring anxiety and alcohol use, but the mechanisms underlying treatment efficacy, especially in online interventions, remain unclear. This study investigated the…

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Negative / Null Result ReportOpen accessMedicine

Immune dysregulation in gestational diabetes mellitus: placental downregulation of CXCL9 and IL1RL1 and altered immune cell infiltration.

Zhou Z, Huang L, Sheng L et al. · 2026 · Frontiers in cell and developmental biology

Background Immune dysregulation is implicated in pregnancy complications, particularly gestational diabetes mellitus (GDM). This study aimed to identify immune-related genes and characterize immune cell infiltration in GDM placentas.…

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Negative / Null Result ReportMedicine

Comparative Phylogenetic Study on Host Newts (Caudata: Salamandridae) and Parasitic Mites (Acariformes: Hydrachnidia: Hygrobatidae) in East and Southeast Asia.

Shen Y, Nishikawa K, Hiruta SF et al. · 2025 · Zoological science

The water mite genus Hygrobates and the newt family Salamandridae are distributed widely in the northern hemisphere. However, only in Eastern and Southeastern Asia a host-parasite association developed, with several Hygrobates species,…

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Negative / Null Result ReportMedicine

Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial.

Ala-Jaakkola R, Forssten SD, Cheng J et al. · 2025 · Molecular nutrition & food research

Functional constipation (FC) is characterized by difficult, infrequent, or incomplete bowel movements without clear physiological cause. Daily intake of Bifidobacterium lactis HN019 has been shown to reduce colonic transit time or…

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Negative / Null Result ReportMedicine

Supportive Environmental Features at Home as Proactive/Reactive Associates of Disability and Mortality Status in Older Adults.

Barbakoff D, Glennie K, Yan M et al. · 2026 · Journal of applied gerontology : the official journal of the Southern Gerontological Society

Supportive environmental features (SEFs) are attributes of homes that help people overcome activity limitations. Evidence suggests that SEFs may facilitate aging in place. However, real-life SEF implementation patterns are not fully…

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Negative / Null Result ReportMedicine

Sensorimotor dysfunction does not predict pain-related cognition, but proprioception is associated with pain catastrophizing and pain self-efficacy in people with lower limb tendinopathy: A cross-sectional study.

Mest J, Flood A, Preston P et al. · 2026 · Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

Objectives To investigate if sensorimotor function predicts pain-related cognition in people with lower limb tendinopathy. Design Single-cohort, cross-sectional study. Setting Sports and exercise research laboratory. Participants…

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Negative / Null Result ReportOpen accessMedicine

Adolescent binge drinking causes sex-specific deficits in behavioral reactivity, endocrine recovery from stress and altered expression of hypothalamic KCC2 in males.

Büyükdemirtaş B, Benn M, Kwon HB et al. · 2026 · Psychopharmacology

Rationale Binge drinking during adolescence is associated with a higher risk of developing Alcohol Use Disorders and impaired stress reactivity in adulthood. The hypothalamic-pituitary-adrenal axis matures during adolescence and is under…

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Negative / Null Result ReportMedicine

Linking overstory relative density to light availability and understory plant community composition in disturbance-dependent, Pinus rigida -dominated forests of the mid-Atlantic coastal plain, USA

Isaacson BN, Serbin SP, Grabosky JC · 2025 · Forest Ecology and Management.

There is a vigorous debate around whether and how to manage forests for climate mitigation or for other goals such as biodiversity. To achieve any of these goals it is necessary to define the parameters within which they can exist;…

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Negative / Null Result ReportOpen accessMedicine

Subclinical peripheral nerve demyelination without overt symptoms in a family with neuronal intranuclear inclusion disease harboring biallelic repeat expansions.

Zhang H, Zhao T, Zheng H et al. · 2026 · BMC neurology

Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disorder caused by abnormal GGC repeat expansions in the NOTCH2NLC gene, leading to multisystem involvement. Electrophysiological abnormalities in NIID…

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Negative / Null Result ReportMedicine

Insufficient Evidence for Load as the Primary Cause of Nonspecific (Chronic) Low Back Pain. A Scoping Review.

de Bruin LJE, Hoegh M, Greve C et al. · 2024 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To assess the causal role of the relationship between loading and the onset of nonspecific low back pain (NSLBP) and persistence of NSLBP (chronic low back pain [CLBP]). DESIGN : Scoping review. LITERATURE SEARCH : We searched…

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