11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Szczupak M, Kobak J, Krupa-Nurcek S · 2026 · Frontiers in public health
Introduction Shift work is a recognized occupational risk factor for sleep disturbances, particularly among healthcare professionals. Nurses are especially vulnerable due to irregular work schedules, night duties, and the high physical and…
View details →Zhang Q, Yang T, Li L et al. · 2026 · Neurosurgical review
Chronic internal carotid artery occlusion (CICAO) is a significant cause of ischemic cerebrovascular events, with an annual stroke risk of up to 20%. Although the long-term efficacy of hybrid surgical revascularization (HSR) versus…
View details →Aslan T, AlShamrani M, Buck B et al. · 2026 · Stroke and vascular neurology
Background Stroke rates rise steeply with age but data on tenecteplase in patients ≥80 years remain limited. This post-hoc analysis of the AcT trial compared tenecteplase with alteplase in this population. Methods The analysis included all…
View details →Khan RB, Hanzlik E, Deokumar S et al. · 2026 · Pediatric blood & cancer
Background Hodgkin lymphoma is the most common cancer in adolescence and is treated with chemotherapy and/or radiation therapy. Little is known about neurologic symptoms, signs, and morbidity in long-term survivors of childhood Hodgkin…
View details →Qureshi S, Qureshi MA, Zehra SM et al. · 2026 · BMC cancer
Background Progastricsin/Pepsinogen C (PGC) is an aspartyl endoprotease predominantly expressed by gastric fundic and chief cells, with additional expression reported in select extragastric tissues. While increased PGC expression has been…
View details →Wang S, Miao J, Tang F et al. · 2026 · BMC cardiovascular disorders
Background The recurrence rate after ablation for atrial fibrillation (AF) remains high, and the predictive performance of existing predictors is limited. Left atrial dysfunction plays a key role in the occurrence and progression of AF.…
View details →Banerjee R, Kuruvilla C, Vega GL et al. · 2026 · The American journal of cardiology
While triglyceride-rich lipoproteins and small dense low-density lipoprotein (sdLDL) are associated with accelerated coronary atherosclerosis, their relationship with peripheral artery disease (PAD) is less clear. Fifty-five male subjects…
View details →Pyne AL, Uchida AM, Carlson M et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society
Background Eosinophilic esophagitis (EoE) shares several risk factors with other autoimmune diseases, but population-based studies in this field are limited. Methods Using the Swedish nationwide histopathology cohort Epidemiology…
View details →Kikumoto T, Kobayashi M, Hori S et al. · 2026 · International journal of sports physical therapy
The Functional Movement Screen™ (FMS™) is widely used to evaluate movement quality and attempt to identify athletes at risk of injury. However, the predictive value of the total score is inconsistent, and it remains unclear whether…
View details →Wang D, Dong X, Feng T · 2026 · Scientific reports
Brainstem auditory evoked potentials (BAEP) provide an objective assessment of brainstem functional integrity. However, their characteristic profiles and clinical significance in patients with prolonged disorders of consciousness (pDOC)…
View details →Resnick E, Travers C, Griffin R et al. · 2026 · Pediatric nephrology (Berlin, Germany)
Background Extremely low gestational age neonates (ELGANs) remain at high risk for morbidity and mortality. Acute kidney injury (AKI) is increasingly recognized, but data in the most immature neonates, especially those born at 22-23 weeks,…
View details →Yılmaz U, Buzdağlı Y, Bilgin S et al. · 2026 · Journal of strength and conditioning research
Abstract Yılmaz, U, Buzdağlı, Y, Bilgin, S, Sepil, Y, Ozan, M, Bağaçlı, UH, Şıktar, E, Baygutalp, F, and Kılıç Baygutalp, N. Multidimensional physiologic adaptations to a 14-day detraining period in elite powerlifters: Neuromuscular,…
View details →Benli O, Avşar MK · 2026 · Pediatric cardiology
Isolated (IHV) drainage can prevent uniform delivery of hepatic venous effluent to the pulmonary circulation after Fontan completion, predisposing to pulmonary arteriovenous malformations (PAVMs), hypoxemia, and thrombosis. Comparative…
View details →Rochlin DH, Chen J, Cole-Price A et al. · 2026 · Plastic and reconstructive surgery
Background The objectives of this study were to determine if financial considerations affect reconstructive decision-making, and conversely if reconstructive choice affects downstream financial burden. Methods We conducted mixed-methods…
View details →Avcı EA, Bülbül GA, Tsakır B et al. · 2026 · BMC pregnancy and childbirth
Background Accessory renal arteries (ARAs) are recognized as an extrinsic cause of hydronephrosis in children; however, their relationship with prenatally detected hydronephrosis remains unclear. This prospective study aimed to evaluate…
View details →Okur KT, Abdulaliyev F, Yalçın S et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Acetabular fracture surgery is associated with substantial perioperative blood loss and prolonged operative time. Routine preoperative pelvic computed tomography (CT) carries information about body composition…
View details →Connor CH, Katsnelson JY, Paul BJ et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Periprosthetic infection is a frequent complication of implant-based breast reconstruction, often resulting in implant removal, additional surgery, and increased costs. This study evaluated whether polymethyl methacrylate (PMMA) discs…
View details →Schibler D, Hinkelmann MA, Frei F et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society
INTRODUCTION: Hook plates remain controversial in the management of lateral clavicle fractures despite their biomechanical advantages. Concerns include implant-related complications, subacromial irritation, and the need for routine implant…
View details →Ding X, Wang Y, Choi M et al. · 2026 · Clinical oral implants research
Objective The objective of this study is to evaluate the clinical efficacy of angulated single-implant crowns using the hybrid retention versus pure screw-retained restorations in the aesthetic area. Materials and methods A retrospective…
View details →Yang H, Gao J, Mo S et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Objective and background The optimal surgical strategy for patients with hepatocellular carcinoma (HCC) and liver fibrosis/cirrhosis presenting with a future liver remnant to standard liver volume (FLR/SLV) ratio of 30%-40% remains a…
View details →Süleyman S, Emin P, Hüseyin A et al. · 2026 · Journal of clinical medicine
Background/Objectives: Acute severe ulcerative colitis (ASUC) is a high-risk condition associated with intense inflammation and a substantial risk of early colectomy. Intravenous steroids (IVS) remain the first-line therapy; however,…
View details →Leizaola-Cardesa IO, Gómez-Moreno G, Hernando J et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery
Background To determine serum parathyroid hormone (PTH), vitamin D, and calcium levels in patients with medication related osteonecrosis of the jaw (MRONJ), compared with patients receiving similar medication but without MRONJ; also, to…
View details →Darroudi S, Ghazaee H, Babaei N et al. · 2026 · Scientific reports
Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has demonstrated cardioprotective effects beyond glycemic control. Empagliflozin has anti-inflammatory and antioxidant effects in long-term administration; however, current…
View details →Eslami M, Ermolaev N, Kronberger C et al. · 2026 · Scientific reports
Fibroblast growth factor 23 (FGF23), a bone-derived hormone, is emerging as a potential biomarker in cardiovascular disease. However, its role in transthyretin amyloid cardiomyopathy (ATTR-CM), a progressive infiltrative cardiomyopathy,…
View details →Marković F, Bojić Z, Stjepanović M et al. · 2026 · Cancers
Background: Immune checkpoint inhibitor monotherapy targeting the PD-1/PD-L1 axis is a standard first-line treatment option for patients with metastatic non-small cell lung cancer (NSCLC) and high PD-L1 expression. However, comparative…
View details →Chow SCW, Wang Y, Leung OLK et al. · 2026 · Journal of autism and developmental disorders
Purpose This study investigated the risk of ASD and ADHD in children who have survived hypoxic-ischemic encephalopathy (HIE), one of the common conditions during birth resulting in neonatal brain injury. Methods A population-based cohort…
View details →Çakır B, Polat F, Karataş MB et al. · 2026 · Acta diabetologica
Background Diabetic cardiomyopathy (DCM) frequently begins with diastolic dysfunction (DD), which leads to increased left ventricular filling pressures and subsequent left atrial enlargement, quantified by the left atrial volume index…
View details →Kilavuz A, Zorbozan O, Yildirim Simsir I et al. · 2026 · BMC nutrition
Background Recent evidence suggests that the gut microbiota plays a crucial role in the development and progression type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of multi-strain probiotic supplementation on…
View details →Tajima Y, Kubota M, Yoshida Y et al. · 2026 · World neurosurgery
Objective This study aimed to evaluate the impact of embolic protection strategies on outcomes in asymptomatic patients undergoing carotid artery stenting (CAS). Methods We retrospectively analyzed 312 consecutive asymptomatic patients…
View details →Feigin L, Feigin E, Bronstein Y · 2026 · The American journal of medicine
Background This study was conducted to examine whether a "weekend effect" exists in internal medicine departments of a large tertiary medical center in Israel. Methods We conducted a retrospective cohort study of patients > 18 admitted to…
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