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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Educational Impact of a 30-Minute Ultrasound Training Lecture on Medial Meniscus Extrusion Measurements: A Pilot Study of Intra- and Inter-rater Reliability Among Novice Students.

Tozawa R, Ishii N, Minamoto Y · 2026 · Cureus

Background Medial meniscus extrusion (MME) is a pivotal biomarker for knee osteoarthritis progression. Although ultrasonography offers a dynamic and cost-effective MME assessment, its clinical utility is often limited by the perceived high…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the validity and reliability of the Meloq EasyBase force platform for assessing jump performance and balance parameters.

Arslan SG, Gultekinler BD · 2026 · BMC sports science, medicine & rehabilitation

Background Force platforms are widely used to assess postural stability and vertical jump performance, yet their cost and limited portability restrict routine clinical and field-based use. The Meloq EasyBase force platform offers a…

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Negative / Null Result ReportOpen accessMedicine

Baseline Procalcitonin and C-Reactive Protein Levels in Asymptomatic Individuals From West Africa With and Without <i>P. falciparum</i> Parasitemia.

Strauss R, Wafula ST, Kobbe R et al. · 2026 · Open forum infectious diseases

We assessed baseline C-reactive protein (CRP) and procalcitonin levels in asymptomatic individuals from malaria-endemic West Africa. C-reactive protein remained unaffected by Plasmodium falciparum parasitemia, while procalcitonin (PCT) was…

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Negative / Null Result ReportMedicine

Intrinsically nonlocal metamaterials.

Ware A, LaMountain J, White RC et al. · 2026 · Nature communications

The electromagnetic response of materials serves as the foundation for a broad range of vital applications, from imaging, to sensing, to classical and quantum communications. Here we demonstrate, theoretically and experimentally, a…

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Negative / Null Result ReportOpen accessMedicine

Long-Term Clinical, Immunologic, and Viral Reservoir Outcomes in Children Treated With VRC01LS and 10-1074 Monoclonal Antibodies in the Tatelo Study.

Ajibola G, Nelson BS, Niesar A et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Broadly neutralizing antibodies (bNAbs) are a promising treatment option for children with HIV-1, but their long-term impact on virologic, immunologic, and clinical outcomes is unknown. Methods The Tatelo Study investigated dual…

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Negative / Null Result ReportOpen accessMedicine

Metformin

· 2006

Data from well-conducted studies indicate that metformin levels in milk are low and infants would receive less than 0.5% of their mother's weight-adjusted dosage. Milk metformin levels are relatively constant during maternal metformin use,…

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Negative / Null Result ReportOpen accessMedicine

Combustion and Heated Tobacco Cigarettes, but Not E-Cigarettes, Impair Aquaporin-Dependent H<sub>2</sub>O<sub>2</sub> Permeability in ATII-Like Cells.

Senise G, Bodega F, Porta C et al. · 2026 · Cells

Cigarette smoke is a major inducer of oxidative stress, promoting reactive oxygen species (ROS) accumulation and contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD) and lung cancer. Heated tobacco products…

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Negative / Null Result ReportOpen accessMedicine

Citalopram

· 2006

Infants receive citalopram in breastmilk, and it is detectable in low levels in the serum of some. The dosage that the infant receives and serum level achieved are probably related to the genetic metabolic capacity of the mother and…

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Negative / Null Result ReportOpen accessMedicine

Biomarker analysis of circulating tumor DNA in clinical stage III melanoma patients treated with neoadjuvant immunotherapy combined with targeted therapy.

Stoff R, Routman DM, Yalon M et al. · 2026 · Therapeutic advances in medical oncology

Background Circulating tumor DNA (ctDNA) is predictive of recurrence in resected stage III melanoma, yet its role in the neoadjuvant setting for clinical stage III (cSIII) is unclear. Objective Assess the association between ctDNA and…

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Negative / Null Result ReportMedicine

CRISPR/Cas9-Mediated Knockout of the NAD-Dependent Lactate Dehydrogenases for Altered Stereospecific Lactic Acid Production in Lacticaseibacillus paracasei NC4.

Chu NH, Le HD, Quach NT et al. · 2026 · Biochemical genetics

The optical purity of lactic acid is a critical parameter for producing high-performance polylactic acid (PLA). To investigate the genetic basis of stereospecific lactic acid biosynthesis, the present study aimed to functionally…

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Negative / Null Result ReportMedicine

High-risk human papillomavirus positivity and associated factors among women living with HIV in public health facilities of Mekelle, Northern Ethiopia.

Shfare MT, Kahsay H, Gebrehiwot GT et al. · 2026 · Infectious agents and cancer

Background Worldwide, it is believed that high-risk human papillomavirus (hr-HPV) strains are the root cause of many types of cancers, including cervical cancer, anorectal cancers, vaginal cancers, and penile cancers, with an estimated…

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Negative / Null Result ReportMedicine

Association of Torque Teno Virus DNA Load and Tacrolimus in Peripheral Blood Mononuclear Cells of Adult Kidney Transplant Patients.

Agergaard K, Thiesson HC, Carstens J et al. · 2026 · Therapeutic drug monitoring

Background Emerging strategies for tacrolimus dose optimization in kidney transplant recipients include measuring drug concentrations in peripheral blood mononuclear cells (PBMCs) and biomarkers of immunosuppression, such as torque teno…

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Negative / Null Result ReportMedicine

Risk of postpartum hemorrhage according to the ultrasound measurement of the lower uterine segment before delivery of women with a prior cesarean delivery: secondary exploratory research of the Lower Uterine Segment Trial.

Jeremy B, Rozenberg P · 2026 · American journal of obstetrics & gynecology MFM

Background Women with a previous cesarean delivery have a higher risk of postpartum hemorrhage, including after successful vaginal birth after cesarean. Mechanisms underlying this excess risk remain unclear and may involve impaired…

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Negative / Null Result ReportMedicine

Effects of shoulder rotation and table tilt maneuvers on the lumbar and thoracic paramedian acoustic window in older adults: a quasi-experimental study.

Nunes de Souza MV, Caetano AMM, Duarte NMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)

Background Shoulder rotation and table tilt have been reported to increase the acoustic window for spinal ultrasonography. However, evidence in older adults remains scarce. This study evaluated their anatomical effects on lumbar (L3-L4)…

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Negative / Null Result ReportMedicine

Short-term outcomes following reconstruction or direct repair of the ulnar collateral ligament.

Sribhashyam S, Talaski GM, Yazdanpanah S et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction Medial ulnar collateral ligament (UCL) injuries substantially impair athletic performance due to pain, instability, and diminished throwing capabilities. While UCL reconstruction is the primary surgical treatment due to its…

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Negative / Null Result ReportMedicine

Comparison of the illness perception between age-related macular degeneration and glaucoma patients living in a middle-income country.

Germano-Morrel CS, Tomishige KS, Macchione RM et al. · 2026 · Journal of health psychology

The aim of this cross-sectional study was to compare the cognitive and emotional representations of illness in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) living in a developing country. All…

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Negative / Null Result ReportMedicine

Bulimia Nervosa in Adolescents: Impact of Childhood and Adolescent Sexual Abuse History and the Mediating Role of Social Media.

Alvarez-Tueros EX, Alcántara-Obando MO, Caycho-Rodríguez T et al. · 2026 · The International journal of social psychiatry

The aim of this study was to analyze whether exposure to esthetic content aligned with beauty standards on social media mediates the relationship between a history of childhood/adolescent sexual abuse and bulimic symptomatology in…

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Negative / Null Result ReportMedicine

Effect of Continuous Theta-Burst Stimulation on Postoperative Delirium in Older Patients Who Undergo Cardiac Surgery.

Zhang J, Zhu Y, Yin Y et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

Objectives Postoperative delirium (POD) is a common complication after cardiac surgery in older patients, associated with higher mortality and prolonged stays. Continuous theta-burst stimulation (cTBS), a noninvasive neuromodulation…

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Negative / Null Result ReportMedicine

Oxidative DNA Damage as an Integrative Marker of Redox Dysfunction Associated with Doxorubicin-Induced Cardiotoxicity in Pediatric Leukemia.

Gándara-Mireles JA, Reyes Espinoza EA, Loera-Castañeda V et al. · 2026 · Current issues in molecular biology

Doxorubicin (Dox) is a cornerstone in the treatment of pediatric acute lymphoblastic leukemia (ALL), but its use is limited by dose-dependent cardiotoxicity. Oxidative stress, arising from mitochondrial dysfunction, enzymatic generation of…

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