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Browse the failure-mode index

11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Biomarker analysis of circulating tumor DNA in clinical stage III melanoma patients treated with neoadjuvant immunotherapy combined with targeted therapy.

Stoff R, Routman DM, Yalon M et al. · 2026 · Therapeutic advances in medical oncology

Background Circulating tumor DNA (ctDNA) is predictive of recurrence in resected stage III melanoma, yet its role in the neoadjuvant setting for clinical stage III (cSIII) is unclear. Objective Assess the association between ctDNA and…

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Negative / Null Result ReportMedicine

CRISPR/Cas9-Mediated Knockout of the NAD-Dependent Lactate Dehydrogenases for Altered Stereospecific Lactic Acid Production in Lacticaseibacillus paracasei NC4.

Chu NH, Le HD, Quach NT et al. · 2026 · Biochemical genetics

The optical purity of lactic acid is a critical parameter for producing high-performance polylactic acid (PLA). To investigate the genetic basis of stereospecific lactic acid biosynthesis, the present study aimed to functionally…

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Negative / Null Result ReportMedicine

High-risk human papillomavirus positivity and associated factors among women living with HIV in public health facilities of Mekelle, Northern Ethiopia.

Shfare MT, Kahsay H, Gebrehiwot GT et al. · 2026 · Infectious agents and cancer

Background Worldwide, it is believed that high-risk human papillomavirus (hr-HPV) strains are the root cause of many types of cancers, including cervical cancer, anorectal cancers, vaginal cancers, and penile cancers, with an estimated…

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Negative / Null Result ReportMedicine

Association of Torque Teno Virus DNA Load and Tacrolimus in Peripheral Blood Mononuclear Cells of Adult Kidney Transplant Patients.

Agergaard K, Thiesson HC, Carstens J et al. · 2026 · Therapeutic drug monitoring

Background Emerging strategies for tacrolimus dose optimization in kidney transplant recipients include measuring drug concentrations in peripheral blood mononuclear cells (PBMCs) and biomarkers of immunosuppression, such as torque teno…

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Negative / Null Result ReportMedicine

Risk of postpartum hemorrhage according to the ultrasound measurement of the lower uterine segment before delivery of women with a prior cesarean delivery: secondary exploratory research of the Lower Uterine Segment Trial.

Jeremy B, Rozenberg P · 2026 · American journal of obstetrics & gynecology MFM

Background Women with a previous cesarean delivery have a higher risk of postpartum hemorrhage, including after successful vaginal birth after cesarean. Mechanisms underlying this excess risk remain unclear and may involve impaired…

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Negative / Null Result ReportMedicine

Effects of shoulder rotation and table tilt maneuvers on the lumbar and thoracic paramedian acoustic window in older adults: a quasi-experimental study.

Nunes de Souza MV, Caetano AMM, Duarte NMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)

Background Shoulder rotation and table tilt have been reported to increase the acoustic window for spinal ultrasonography. However, evidence in older adults remains scarce. This study evaluated their anatomical effects on lumbar (L3-L4)…

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Negative / Null Result ReportMedicine

Short-term outcomes following reconstruction or direct repair of the ulnar collateral ligament.

Sribhashyam S, Talaski GM, Yazdanpanah S et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction Medial ulnar collateral ligament (UCL) injuries substantially impair athletic performance due to pain, instability, and diminished throwing capabilities. While UCL reconstruction is the primary surgical treatment due to its…

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Negative / Null Result ReportMedicine

Comparison of the illness perception between age-related macular degeneration and glaucoma patients living in a middle-income country.

Germano-Morrel CS, Tomishige KS, Macchione RM et al. · 2026 · Journal of health psychology

The aim of this cross-sectional study was to compare the cognitive and emotional representations of illness in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) living in a developing country. All…

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Negative / Null Result ReportMedicine

Bulimia Nervosa in Adolescents: Impact of Childhood and Adolescent Sexual Abuse History and the Mediating Role of Social Media.

Alvarez-Tueros EX, Alcántara-Obando MO, Caycho-Rodríguez T et al. · 2026 · The International journal of social psychiatry

The aim of this study was to analyze whether exposure to esthetic content aligned with beauty standards on social media mediates the relationship between a history of childhood/adolescent sexual abuse and bulimic symptomatology in…

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Negative / Null Result ReportMedicine

Effect of Continuous Theta-Burst Stimulation on Postoperative Delirium in Older Patients Who Undergo Cardiac Surgery.

Zhang J, Zhu Y, Yin Y et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

Objectives Postoperative delirium (POD) is a common complication after cardiac surgery in older patients, associated with higher mortality and prolonged stays. Continuous theta-burst stimulation (cTBS), a noninvasive neuromodulation…

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Negative / Null Result ReportMedicine

Oxidative DNA Damage as an Integrative Marker of Redox Dysfunction Associated with Doxorubicin-Induced Cardiotoxicity in Pediatric Leukemia.

Gándara-Mireles JA, Reyes Espinoza EA, Loera-Castañeda V et al. · 2026 · Current issues in molecular biology

Doxorubicin (Dox) is a cornerstone in the treatment of pediatric acute lymphoblastic leukemia (ALL), but its use is limited by dose-dependent cardiotoxicity. Oxidative stress, arising from mitochondrial dysfunction, enzymatic generation of…

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Negative / Null Result ReportMedicine

Predictive value of peak left atrial reservoir strain combined with left atrial appendage flow velocity for atrial fibrillation recurrence after pulsed field ablation.

Wang S, Miao J, Tang F et al. · 2026 · BMC cardiovascular disorders

Background The recurrence rate after ablation for atrial fibrillation (AF) remains high, and the predictive performance of existing predictors is limited. Left atrial dysfunction plays a key role in the occurrence and progression of AF.…

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Negative / Null Result ReportOpen accessMedicine

Association Between Individual Functional Movement Screen™ Tasks and Sports Injury Occurrence in University Basketball Players: A Prospective Cohort Study.

Kikumoto T, Kobayashi M, Hori S et al. · 2026 · International journal of sports physical therapy

The Functional Movement Screen™ (FMS™) is widely used to evaluate movement quality and attempt to identify athletes at risk of injury. However, the predictive value of the total score is inconsistent, and it remains unclear whether…

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