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Browse the failure-mode index

11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of continuous vs. intermittent transcutaneous electrical stimulation of the auriculotemporal nerve on nociceptive processing: a pilot randomized controlled double-blind crossover trial in asymptomatic volunteers.

Barone M, Guli L, Centurión J et al. · 2026 · Cranio : the journal of craniomandibular practice

Objective To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of the auriculotemporal nerve on nociceptive processing. Methods Twelve asymptomatic volunteers received…

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Negative / Null Result ReportMedicine

Comparative analysis of PTH Washout and 99mTc-MIBI SPECT/CT in presurgical localization for patients with primary hyperparathyroidism.

Cieślewicz M, Szczepanek-Parulska E, Witowska A et al. · 2026 · Journal of endocrinological investigation

Purpose Our study aimed to evaluate the performance and concordance of parathyroid hormone wash-out (PTHw) and 99m Tc-MIBI+SPECT/CT (MIBI) in preoperative localization for patients with primary hyperparathyroidism (PHPT), and assess…

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Negative / Null Result ReportMedicine

'White autopsies': an overview of cases with inconclusive results of post-mortem examinations in the Department of Forensic Medicine of the Jagiellonian University Medical College in Kraków, Poland.

Zwierzewicz Z, Szpakowska A, Bistroń D et al. · 2025 · Archiwum medycyny sadowej i kryminologii

The aim of the study The aim of the study was to accurately determine the incidence of white autopsies and to identify possible conditions responsible for such autopsies by means of analyzing confirmed causes of death in the same age…

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Negative / Null Result ReportMedicine

COMPARING THE ABILITY OF GENETIC TESTING TO PROVIDE A DEFINITIVE DIAGNOSIS IN PATIENTS WITH PERIPHERAL AND MACULAR INHERITED RETINAL DISEASE.

Dones AM, Bou Ghanem G, Kessler C et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose We performed a retrospective cross-sectional study to determine whether there is a significant difference in the percentage of patients with diagnosed inherited macular or peripheral disease who receive more definitive genetic…

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Negative / Null Result ReportMedicine

Robotic arm-assisted <sup>18</sup>F-FDG PET/CT-guided biopsy in febrile patients with biopsy accessible FDG-avid lesions: a single-centre experience.

Aggarwal P, Singh H, Kumar R et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose Fever of unknown origin (FUO) is a prolonged fever with unknown etiology after an extensive outpatient or inpatient workup. 18 F-Flurodeoxyglucose (FDG) positron emission tomography (PET) with computed tomography (CT) has shown a…

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Negative / Null Result ReportMedicine

Development and validation of a nomogram model for predicting negative/indeterminate HIV-1 antibody confirmation: a strategy to streamline the diagnostic pathway.

Liao G, Zhang S, Wei Y et al. · 2026 · BMC medical informatics and decision making

Background The standard HIV diagnostic algorithm comprises sequential serological screening, confirmatory antibody testing, and nucleic acid confirmation when necessary. This multi-step process often causes diagnostic delays, particularly…

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Negative / Null Result ReportMedicine

Changes in Attitudes After Suicide Prevention Media Campaigns in Three Norwegian Regions.

Mohn C, Haga E, Nilsson HSW et al. · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research

Background In a recent Norwegian regional suicide prevention media campaign, we found small and inconclusive results regarding changes in attitudes to suicide and help-seeking. In this exploratory study we add the data from two other…

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Negative / Null Result ReportMedicine

Biomagnetism of oral tissues and external magnetic field interactions with cell membranes, oral microflora, and orthodontic magnetic therapies: A review.

Itabaiana Sobrinho S, Meira-Belo LC, Mohallem NDS · 2026 · Progress in biophysics and molecular biology

Various rare earth magnets have been successfully applied in clinical orthodontics; however, their interactions with the oral environment remain only partially understood. Various controversies remain regarding magnetic fields (MFs) in…

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Negative / Null Result ReportMedicine

Effects of Glucagon-Like Peptide-1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review.

Vieira FT, Deng Z, Muller MJ et al. · 2026 · Obesity reviews : an official journal of the International Association for the Study of Obesity

Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat-free mass and fat mass losses) and mass-independent adaptations in EE (e.g., hormones). Glucagon-like peptide-1 receptor…

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Negative / Null Result ReportMedicine

Intraoperative biopsy challenges: Cavernous sinus meningioma mimic.

Pérez Serena A, Martínez Betancourt DP · 2026 · Neurocirugia

We report the case of a 56-year-old female patient with controlled Human Immunodeficiency Virus (HIV) who presented with binocular diplopia and a known sixth cranial nerve palsy. Imaging revealed a lesion centered in the right cavernous…

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Negative / Null Result ReportMedicine

Lost in submission? Investigating publication bias in regional anaesthesia: A pilot case study of the erector spinae plane block.

De Cassai A, Dost B, Karapinar YE et al. · 2026 · Revista espanola de anestesiologia y reanimacion

Background The Erector Spinae Plane (ESP) block is a regional anaesthesia technique with a growing range of clinical applications due to its short learning curve, low complication rate, and effectiveness. However, publication bias can…

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Negative / Null Result ReportOpen accessMedicine

Glomerular Yield in Ultrasound-Guided Native Kidney Biopsies in Pediatric and Adult Populations With Age-Stratified Subgroups.

Ravizzini PC, Lino HA, de Faria Castro Fleury E et al. · 2025 · Cureus

Background This study compares the glomerular yield, mean number of biopsy cores, and complication rates between pediatric and adult populations undergoing ultrasound-guided native kidney biopsies. Additionally, the adult population was…

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Negative / Null Result ReportMedicine

Association between hemodynamically significant patent ductus arteriosus and fluid intake in the first week of life in a cohort of very low birth weight preterm infants: the COOL study.

Mayer A, Bresesti I, Francescato G et al. · 2025 · European journal of pediatrics

The amount of fluid to give in preterm infants with patent ductus arteriosus (PDA) is still highly debated, with no robust evidence that fluid restriction provides a clear benefit. The aim of the study is to evaluate if spontaneous closure…

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Negative / Null Result ReportMedicine

Assessing Blood Pressure, Mental Health, and HRV Responses to Integrated Acupuncture in Hypertensive Patients: A Pilot Randomized Controlled Trial.

Singh D, Kodali PB, Sharma G et al. · 2025 · Medical acupuncture

Abstract This study aimed to investigate the effects of an integrated acupuncture (IA) protocol on blood pressure (BP), depression, anxiety, stress scores, and heart rate variability (HRV) in hypertensive patients. Abstract The study was a…

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Negative / Null Result ReportMedicine

Serum 25-Hydroxyvitamin D Levels and Longitudinal Changes in Muscle Mass and Function in Peritoneal Dialysis Patients: A Prospective Cohort Study.

Wang L, Xue C, Zhu B et al. · 2026 · Journal of nutritional science and vitaminology

Data regarding to how serum 25 hydroxyvitamin D (25(OH)D) levels affect muscle mass and function in end-stage renal disease (ESRD) patients have led to inconclusive results. The main goal of this research was to examine the relationship…

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Negative / Null Result ReportOpen accessMedicine

Capsule Endoscopy-Guided Diagnosis of Small Bowel Lymphoma Presenting as Protein-Losing Enteropathy: Complementary Role of Peripheral Blood Flow Cytometry.

Abdulrasak M, Axler O, Kapás B et al. · 2026 · Diagnostics (Basel, Switzerland)

Protein-losing enteropathy (PLE) is an uncommon and often underrecognized manifestation of lymphoproliferative disorders and may be difficult to diagnose when conventional gastrointestinal investigations are unrevealing. We present an…

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