11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Doneddu PE, Collet-Vidiella R, Gallo C et al. · 2026 · Journal of the peripheral nervous system : JPNS
Background and aims Rituximab has been proposed as a potential treatment in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but formal evidence regarding its clinical effectiveness is weak. The CIDPRIT trial found no…
View details →Tajika A, Toyomoto R, Sakata M et al. · 2026 · BMJ mental health
Background Depression is a leading cause of global disability, and subthreshold cases contribute substantially to the burden. Cognitive behavioural therapy (CBT) is effective for depressive symptoms, but its impact on social functioning in…
View details →Miletić M, Kovač V, Barišić L et al. · 2025 · Pharmaceutics
Background/Objectives : Resveratrol (RSV) and curcumin (CRC) have antioxidant, anti-inflammatory, photoprotective, and cell-repairing properties. We selected them to investigate the potential role involved in human keratinocyte protection.…
View details →Charles AL, Tetsi L, Quiring G et al. · 2026 · Muscles (Basel, Switzerland)
Peripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia-reperfusion (IR) settings, but whether PDE 4 inhibition protects…
View details →Li J, Yang C, Li K · 2026 · BMC pregnancy and childbirth
BACKGROUND: Restricted gestational weight gain (GWG) following lifestyle interventions for gestational diabetes mellitus (GDM) has been observed in clinical trials but not been explicitly confirmed in real-world clinical settings.…
View details →Stanley M, Huang K, Garlich J et al. · 2025 · Journal of orthopaedic trauma
Objectives To compare time, fluoroscopic utilization, and number of misses for placement of far interlocking screws in tibial and femoral nails using a targeting arm (Targeter) versus perfect circle technique (Control). Methods . Design…
View details →Gewiss C, Gehrdau K, Hischke S et al. · 2025 · Journal of wound care
Objective The application of cold atmospheric plasma (CAP) has been described as a promising therapeutic approach for wound healing. Its use in immunologically mediated wounds such as pyoderma gangrenosum (PG) has not yet been sufficiently…
View details →Avetisian H, Mathew K, Myers A et al. · 2026 · Global spine journal
Study DesignCross-sectional.ObjectivesLaminoplasty (LP) and laminectomy with fusion (LF) are surgical approaches for degenerative cervical myelopathy (DCM), but their comparative effectiveness remains controversial. Systematic reviews and…
View details →Lee J, Sun J, Lee HW · 2025 · Annals of the American Thoracic Society
Rationale: In patients with lung cancer, the impact of chronic obstructive pulmonary disease (COPD) diagnosis and subsequent management on mortality remains uncertain, because evidence supporting the efficacy of inhaled therapies in…
View details →Tamber MS, Jensen H, Reeder R et al. · 2025 · Journal of neurosurgery. Pediatrics
Objective The Hydrocephalus Clinical Research Network-Quality (HCRNq) was established to encourage adoption of evidence-based best practices for the care of children with hydrocephalus. A shunt infection prevention initiative is ongoing…
View details →Pearson AC, Yampolsky LY · 2025 · Biogerontology
NAD + homeostasis is an important determinant of lifespan and may be a key mechanism of caloric restriction (CR) expansion of lifespan. Ketone bodies such as beta-hydroxybutyrate (BHB) that regulate NAD + abundance and NAD + precursors…
View details →Valiensi SM, Vera VA, Folgueira AL et al. · 2025 · Brain sciences
Background . Although melatonin is widely used in Sleep Medicine for its chronobiological action, its potent antioxidant and mitochondrial regulatory effects, as well as its immunomodulatory and anti-inflammatory functions, make it of…
View details →El Hajjaji A, Akasbi N, El Mezouar I et al. · 2025 · Cureus
Introduction Knee osteoarthritis (KO) is a major public health issue, that significantly affects patients' quality of life. Metabolic comorbidities, particularly dyslipidemia, have been shown to influence the incidence and progression of…
View details →de Souza EDF, E Silva LO, Vieira LM et al. · 2026 · Theriogenology
The aim was to evaluate the effects of administering long-acting injectable progesterone (iP4) and/or hCG 3 days after timed artificial insemination (TAI) on luteal dynamics, circulating progesterone (P4) concentrations, and fertility…
View details →Lindhard K, Hansen HP, Gliese K et al. · 2026 · The journal of vascular access
Introduction Improved arteriovenous fistula (AVF) maturation is crucial for reducing the dependency on central venous catheters in patients undergoing hemodialysis (HD). Far-infrared radiation (FIR) is a treatment modality that may enhance…
View details →Kwieciński M, Kwiatkowski B, Ziomek W et al. · 2026 · Molecular biology reports
Despite major advances in medicine, cancer treatment remains a considerable challenge. The rising incidence of new cases and the frequent resistance to cytostatics suggest that standard therapies may be insufficient. This highlights the…
View details →Harcęko-Zielińska E, Górska A, Romantowski J et al. · 2025 · Journal of asthma and allergy
Background The influence of intestinal microorganisms on the development and course of allergic diseases has recently been the subject of intensive research, but studies describing changes in the intestinal microbiome of asthma patients in…
View details →Toraño P, Balmaseda A, Bordons A et al. · 2025 · Food microbiology
Oenococcus oeni is the main species of lactic acid bacteria (LAB) responsible for malolactic fermentation (MLF) in winemaking. MLF development can present difficulties because of the harsh, stressful conditions of wine. Yeast mannoproteins…
View details →Roberts E, Francesconi M, Flouri E · 2025 · Stress (Amsterdam, Netherlands)
Prenatal stress has been associated with poor cognitive outcomes in offspring, but the evidence about the role of exact timing of exposure is mixed and that about causal mechanisms is limited. Using the Avon Longitudinal Study of Parents…
View details →Pec J, Nigl M, Fox H et al. · 2026 · Journal of cardiovascular development and disease
(1) Background: Early treatment of sleep-disordered breathing (SDB) with adaptive servo-ventilation (ASV) after acute myocardial infarction (AMI) has been shown to improve myocardial salvage. This analysis evaluates nocturnal…
View details →Hansen EK, Hansen D, Schalkwijk C et al. · 2026 · Blood purification
Introduction Far infrared radiation may improve arteriovenous fistula maturation and patency rates in patients on hemodialysis (HD). The mechanism is proposed to involve anti-inflammatory and vasodilatory effects in the arteriovenous…
View details →Siffredi V, Liverani MC, Fernandez NB et al. · 2025 · Child: care, health and development
Background Very preterm (VPT) adolescents show executive and socio-emotional difficulties that persist into adulthood. Beneficial effect of mindfulness-based intervention (MBI) has been found in VPT young adolescents immediately after the…
View details →Weeks JJ, Johnson PA, Garcia-Tomas V · 2025 · Current opinion in anaesthesiology
Purpose of the review Regional anesthesia is valuable in peripheral vascular surgery, either as the primary anesthetic or as an adjuvant to general anesthesia. Patients presenting for vascular surgery often have associated comorbidities…
View details →Conteduca J, Longo D, Casto A et al. · 2025 · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
Purpose The objective of this study was to assess the benefits of utilizing a silicone ring tourniquet in relation to traditional pneumatic cuff tourniquets and scenarios without any tourniquet intervention. The tested hypothesis…
View details →Ricigliano VA, Szejko N, Camera V et al. · 2026 · Multiple sclerosis and related disorders
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neuronal loss, with significant public health impact. Despite important therapeutic advances, major unmet needs remain, mainly in…
View details →Terakawa H, Kawata C, Kurokawa Y et al. · 2025 · Gan to kagaku ryoho. Cancer & chemotherapy
Oncotype DX is performed to predict prognosis and the added benefit of chemotherapy in hormone receptor-positive, HER2-negative breast cancer, with the goal of individualizing chemotherapy decisions. Here, we report 2 cases of early- stage…
View details →Dravigney L, Chartier C, Grelaud P et al. · 2026 · Journal of helminthology
Anthelmintic resistance (AR) in gastrointestinal nematodes is insufficiently studied in cattle in many European regions, including France, where only three studies have been conducted in the north-west. This study evaluated the efficacy of…
View details →Granda D, Szmidt MK, Jarmuzek-Orska P et al. · 2026 · Scientific reports
To date, only a few studies have examined the relationship between dietary patterns and premenstrual syndrome (PMS), and these have been limited to Asian populations with inconclusive results, while studies in European populations are…
View details →De Silva DTN, Hamilton AJ, Strunk T et al. · 2026 · European journal of hospital pharmacy : science and practice
Objective To investigate the chemical and visual compatibility of dexmedetomidine injection with 44 secondary intravenous (IV) drugs and six 2-in-1 parenteral nutrition (PN) solutions used in neonatal intensive care unit settings. Methods…
View details →Giulia C, Simona M, Monia M et al. · 2026 · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Background and aims The current diagnostic approach to inherited cardiac conditions (ICCs) is primarily focused on the analysis of single-nucleotide variants (SNVs) and small insertions/deletions (InDels). However, as recommended for other…
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