11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Adeva-Andany MM · 2025 · World journal of nephrology
Sodium-glucose cotransporter-2 (SGLT2) inhibitors suppress glucose reabsorption in the kidney proximal tubule through the SGLT2 protein, leading to glucosuria and osmotic diuresis. Randomized placebo-controlled clinical trials show that…
View details →Chommaux T, Renault PO, Godard P et al. · 2026 · ACS applied materials & interfaces
The electrical and mechanical behaviors of 400 nm thick indium tin oxide (ITO) thin films on polyimide substrates were investigated by means of electrical resistivity and synchrotron X-ray diffraction (XRD) measurements during equibiaxial…
View details →Vaidie J, Demiselle J, Gabriel A et al. · 2025 · Intensive care medicine
Purpose Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. This study aimed to evaluate the impact of a temporary suspension strategy (interruption of…
View details →Gröning M, Smerup MH, Nissen H et al. · 2026 · Pediatric cardiology
To assess temporal changes in the timing of pulmonary valve replacement (PVR) among patients with tetralogy of Fallot and to determine whether temporal shifts toward earlier PVR were accompanied by differences in ventricular volumes,…
View details →Pascoe B, Cocks K, Clarke N et al. · 2026 · Schizophrenia research
Cognitive impairment associated with schizophrenia (CIAS) is a fundamental symptom of the disorder, which significantly affects individuals' daily functioning and overall quality of life. Currently available antipsychotic drugs have little…
View details →Thimmesch M, Cheping Simo C, Boulay M et al. · 2026 · Revue medicale de Liege
Cystic fibrosis, the most common genetic disorder in Caucasian populations, is caused by mutations in the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator), which disrupts chloride ion transport and leads to the production of…
View details →Kloura C, Jensen MM, Ekblond TS et al. · 2026 · Diabetes research and clinical practice
Aim The aim of this exploratory analysis was to investigate effects of time-restricted eating (TRE) on glycemic control and variability in adults with prediabetes. Methods This study utilized data from the Restricted Eating Time (RESET)…
View details →Mommers I, Mubarik S, van Boven JFM et al. · 2025 · BMJ open respiratory research
Background Antibiotics are widely used to manage acute asthma exacerbations, despite little evidence for their effectiveness. This study assesses the added value of antibiotics alongside oral corticosteroids (OCSs) in treating asthma…
View details →Toraño P, Balmaseda A, Bordons A et al. · 2025 · Food Microbiology.
Oenococcus oeni is the main species of lactic acid bacteria (LAB) responsible for malolactic fermentation (MLF) in winemaking. MLF development can present difficulties because of the harsh, stressful conditions of wine. Yeast mannoproteins…
View details →Holzhauer CG, Bickar L · 2026 · Alcohol, clinical & experimental research
Background The associations of stress and negative emotion with alcohol use are well established. These associations are mediated by cognitive and psychological mechanisms that may be sex-dependent. This pilot study examined sex…
View details →Kobayashi Y, Hosoda C, Kohda M et al. · 2026 · Journal of ethology
Parental care has a direct and beneficial effect on parental fitness. An important question regarding the evolution of parental care is why parental roles and the amount of care invested are characterized by sexual bias. In species that…
View details →Bourgeois J, Domange C, Celie B · 2026 · International journal of environmental research and public health
Sleep is a fundamental aspect of physiological and psychological functioning, and the beneficial effect of exercise on sleep quality and quantity, depending on training modality, remains underexplored. This study compared the effects of…
View details →Kolli RD, Kasireddy B, Iuspa MA et al. · 2026 · British poultry science
1. This 42 d study further examined the physiological mechanisms underlying responses to a precision biotic (PB) on growth performance and ileal amino acid digestibility. It focussed on fermentation profile, caecal soluble protein levels,…
View details →Fransisca S, Sitepu BRE, Delfi · 2026 · Frontiers in medicine
Background Visual disturbances are a common and often debilitating complication following stroke, significantly impairing patients' functional independence and quality of life. Among various neuroprotective agents, Citicoline…
View details →Omae K, Luo Y, Sahker E et al. · 2026 · World journal of urology
PURPOSE: The smallest worthwhile difference (SWD) represents the minimal beneficial effect of an intervention that patients consider valuable when weighed against its burdens, including potential harms, costs, and inconveniences. We aimed…
View details →Zhiping N, Yuanyuan Y, Qichun Z et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
With the acceleration of China's aging society, how to enhance the subjective well-being of older adults has become a core issue of concern. This study aims to explore the influence mechanisms of socioeconomic status, health, recreation,…
View details →Lamb CJ, Biedermann BM, Lin EH et al. · 2025 · JSES international
Background Spin in scientific literature is defined as bias that overstates efficacy and/or underestimates harms of an experimental treatment. Glenoid augmentation is a technique used to correct glenoid bone deficiency during shoulder…
View details →Bkaily G, Jazzar A, Jacques D · 2026 · Canadian journal of physiology and pharmacology
Generation of reactive oxygen species (ROS) is a physiological product of cell activity that is mainly generated by the mitochondria as well as by transmembrane NADPH oxidases (NOX1-5) present at the plasma and nuclear envelope membranes.…
View details →Zhou HY, Xin ZM, Lu YY · 2026 · Journal of clinical psychology
Objective Theory of mind (ToM), the ability of mental state attribution, is an important aspect of social cognition. The autism-psychosis diametrical model suggests that there is an opposite impact of autistic traits and psychotic-like…
View details →Feola M, Landra F, Greco CA et al. · 2026 · Journal of clinical medicine
Cardiac arrest is a way of demise of patients who are affected by heart failure (HF), being more frequent in those with HF with a reduced left ventricular ejection fraction (HFrEF), and is, as such, responsible for 30-50% of cardiac death.…
View details →Noël A, Picard L · 2025 · Emotion (Washington, D.C.)
Numerous studies have highlighted the beneficial effect of humor on memory in younger adults. While older adults are known to preferentially process positive information and appreciate humor, no study has investigated whether the effect of…
View details →Wei Y, Meade ML, Soderstrom NC · 2025 · Memory (Hove, England)
The present study replicated and extended prior research by comparing the effects of reviewing notes in groups vs. reviewing notes individually on individual final test performance. We also examined the potential interaction between…
View details →Silva AT, Ferreira NM, Vaz F et al. · 2025 · Journal of biomechanical engineering
Pelvic organ prolapse (POP) is a common pelvic floor disorder resulting from weakened supportive muscles and ligaments. Although the demand for surgeries involving surgical meshes is expected to increase, current options remain limited. In…
View details →Wang C, Ren J, Cui Y et al. · 2025 · Journal of Applied Ecology.
Grassland carbon storage depends on microbial‐mediated interactions between grazing and nitrogen (N) addition, which regulates the balance between soil organic carbon (SOC) retention and priming effects. However, uncertainties regarding…
View details →Panopoulos S, Poulia V, Vlachogiannis N et al. · 2026 · Rheumatology international
Randomized trials have demonstrated that nintedanib is beneficial for Systemic Sclerosis-associated interstitial lung disease (SSc-ILD) with an acceptable safety profile. We evaluated the long-term safety and efficacy of nintedanib in a…
View details →Cai Y, Ren X, Ding C · 2026 · Intensive & critical care nursing
Objectives To assess the effects of various non-pharmacological interventions on long-term outcomes associated with Post-Intensive Care Syndrome (PICS) in intensive care unit (ICU) survivors, based on existing systematic reviews and…
View details →Pietersen LC, Broekman N, Broekman N et al. · 2025 · Clinical transplantation
Acute kidney injury (AKI) is a common complication following liver transplantation (LT), with multifactorial etiology. It is believed that perioperative hemodynamic instability could lead to AKI. A temporary portocaval shunt (TPCS) could…
View details →Drost M, Fuhrmann G · 2026 · ACS infectious diseases
Pseudomonas aeruginosa is a notorious bacterial pathogen causing chronic pulmonary infections in people with cystic fibrosis (CF) due to its high tolerance to antibiotics and ability to form recalcitrant biofilms. A newer approach to…
View details →Cheng J, Li F, Zhang B et al. · 2025 · Bulletin of experimental biology and medicine
We compared the therapeutic effects of dietary adjustment and fish oil in rats with experimental non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. The NAFLD rats were either maintained on high-fat diet, or transferred…
View details →Clarke JG, Dutta N, Nickel MS et al. · 2026 · ACS medicinal chemistry letters
Semisynthetic modification of mycothiazole ( 1 ) with Meerwein's salt to generate a more stable and/or potent analog than 8- O -acetylmycothiazole ( 2 ) unexpectedly yielded diastereomers devoid of the diene. Analysis of NMR, HR-LCMS, and…
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