11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Rabbi F, Gulacha P, Thabane L et al. · 2026 · Nutrition bulletin
Asthma affects over 850,000 Canadian children under 14, ranking among the top chronic childhood diseases. Prenatal dietary factors are hypothesised to influence its development. We examined associations between maternal prenatal dietary…
View details →Kocamış Ö · 2026 · BMC ophthalmology
BACKGROUND: Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible central vision loss in elderly individuals. Increasing evidence indicates that systemic inflammation contributes to nAMD pathogenesis.…
View details →Gonçalves TR, Cunha DB, Mediano MFF et al. · 2025 · BMC public health
Background Low back pain (LBP) is a leading cause of years lived with disability. However, the association of non-chronic LBP with levels of daily physical activity (PA) remains poorly explored. This study investigated the association…
View details →Wierzbiński P, Henzler M, Hubska J · 2022 · Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Suicidal behaviour is a major public health problem in Poland. There is compelling evidence that genetic factors contribute to the risk for suicidal behavior. Studies suggest a link between single nucleotide polymorphism (SNP) rs1049353…
View details →Gümüş CY, Özer Y, Kaşko Arıcı Y · 2026 · Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND Vitamin D deficiency is common in pediatric obesity and has been proposed to contribute to metabolic-associated fatty liver disease (MAFLD). This retrospective study aimed to evaluate serum 25-hydroxyvitamin D (25[OH]D) levels…
View details →Barber LE, Maliniak ML, Moubadder L et al. · 2024 · JAMA network open
Importance Neighborhood deprivation has been associated with increased breast cancer mortality among White women, but findings are inconsistent among Black women, who experience different neighborhood contexts. Accounting for interactions…
View details →Xin Y, Qian X, Yang Y · 2025 · BMC public health
Background This study aimed to prospectively assess the relationship between systolic blood pressure (SBP) trajectories and successful aging in middle-aged and elderly Chinese individuals. Methods A total of 1,960 participants from the…
View details →Rabizadeh S, Seyedi SA, Nabipoorashrafi SA et al. · 2023 · Chronic diseases and translational medicine
Background High concentrations of low-density lipoprotein cholesterol (LDL-C) have been a known risk factor for cardiovascular diseases. Also, the role of oxidized LDL (ox-LDL) in forming atherosclerosis plaque has been proven. However, it…
View details →Lange AV, Hess E, Barón AE et al. · 2026 · Journal of palliative medicine
Background Providing and measuring goal-concordant care is a priority. Objective Determine the effect of a nurse and social worker palliative telecare team intervention on goal concordance and participants' understanding of care focus.…
View details →Soeda K, Komaba H, Nakagawa Y et al. · 2024 · Journal of nephrology
Background Hyponatremia is implicated in pathological bone resorption and has been identified as a risk factor for bone fracture in the general population. However, there are limited data on the association between serum sodium levels and…
View details →Lampousi AM, Zeng J, Löfvenborg JE et al. · 2026 · Diabetologia
Aims/hypothesis The role of red meat in type 1 diabetes risk remains unclear. We examined whether maternal and early-life red meat intake is associated with the development of type 1 diabetes and whether such associations are modified by…
View details →Bowler SA, Premeaux TA, Ratzan L et al. · 2025 · AIDS (London, England)
A segment of people with HIV on effective antiretroviral therapy (ART) continue to experience poor immune recovery, leaving them at heightened risk of non-AIDS-defining events (NAEs). The production of anti-CD4 IgG autoreactive antibodies…
View details →Dorchin M, Nasiri-Jounaghani M, Hashemi-Javaheri FS et al. · 2025 · Scientific reports
This study aimed to investigate the erythrocyte Omega-3 fatty acid index as a potential biomarker for clinical severity, nutritional status, and mortality risk in critically ill patients admitted to the intensive care unit (ICU). Using a…
View details →Franco Vega I · 2026 · Journal of sex research
This study assessed the effects of condom types and brands on use in a free condom distribution intervention in hostales (love hotels). New policies are needed to overcome the low levels of contraceptive use in Perú. Hostales could serve…
View details →Hodder RK, O'Brien KM, Wolfenden L et al. · 2026 · Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals
Issue addressed Tobacco, alcohol and other drug use contribute significantly to the global burden of disease, with initiation typically occurring during childhood and adolescence. School-based substance use prevention interventions are…
View details →Sundarakrishnan A, Siek B, Clarke PBS · 2026 · Behavioural brain research
The sucrose preference test is the primary measure of anhedonia in rat models of depression, but it does not specifically assess anticipatory anhedonia, a deficit commonly observed in patients. Anticipatory 50-kHz ultrasonic vocalizations…
View details →S Krishnan V, Hodgetts SI, Harvey AR et al. · 2025 · Biogerontology
This two part study on the afferent connectivity of lumbar spinal motor neurons in normal ageing mice investigates; Study 1: time course analysis of age-related changes in the synaptic coverage of lumbar spinal cords of male C57BL/BJ mice…
View details →Borghero G, Pierri V, Pili F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Objective To analyze disease-modifying effects of percutaneous endoscopic gastrostomy (PEG) insertion for supporting nutrition, noninvasive ventilation (NIV), and tracheostomy-assisted ('invasive') ventilation (TIV) in amyotrophic lateral…
View details →Maiden MJ, Torpy DJ, Ludbrook GL et al. · 2024 · Experimental and therapeutic medicine
Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is…
View details →Nygaard B, Jensen CZ, Jorsal M et al. · 2025 · European thyroid journal
Objective Patients are increasingly using and requesting LT4/LT3 combination treatment for persistent hypothyroid symptoms, but the efficacy and side effects of long-term therapy remain largely unexplored. This study aimed to describe the…
View details →Cioe PA, Stang GS, Azam D et al. · 2025 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Introduction Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of…
View details →Parales-Girón JE, Dos Santos Neto JM, Lock AL · 2026 · Journal of dairy science
We evaluated the effects of whole cottonseed (WCS) and fatty acid (FA) supplementation on the production responses of early-lactation cows. Fifty-two multiparous cows were used in a randomized complete block design with a 2 × 2 factorial…
View details →Martin EL, Adarve-Rengifo I, Siddons SR et al. · 2026 · Ecology and evolution
Terrestrial leaf litter can release chemical compounds into the water, creating a solution called "leachate" that can have direct and indirect impacts on freshwater organisms. In this study, we investigated the direct effects of leaf…
View details →Forde G, Ifantides KB, Mayadev A et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
OnabotulinumtoxinA (onabotA) is approved for the treatment of various therapeutic indications, which require retreatment. In clinical practice, many patients receive onabotA for multiple therapeutic indications concomitantly over extended…
View details →Anderbrant O, Huynh H, Isaksson A et al. · 2025 · Journal of Applied Entomology
Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran…
View details →Quévreux P, Zou K, Barot S et al. · 2025 · Freshwater Biology
The classical concepts of top‐down and bottom‐up cascading effects in ecosystems are challenged by the interactions between green and brown food webs. The green food web relies on photosynthesis and the brown food web relies on the…
View details →Amindarolzarbi A, Satcowitz K, Khalil A et al. · 2025 · Nuclear medicine communications
Objective The appropriate clinical management of indeterminate small renal masses can be improved based on accurate risk stratification. This study aimed to investigate the impact of renal function on the uptake of technetium-99m ( 99m…
View details →Prieto ML, Madison DV, Maduke M · 2025 · Biophysical journal
Ultrasound neuromodulation is a rapidly developing tool for noninvasive control of brain activity. An in vitro model recapitulating the effects of ultrasound on neural tissue in vivo would be extremely valuable in guiding the development…
View details →Medina Poeliniz C, Hoban R, Janes J et al. · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
Objective: To determine if cumulative measures of pumping behaviors over the first 5 days postpartum predicted lactation outcomes by postpartum days 7 (achievement of secretory activation [SA] and pumped milk volume) and 14 (achievement of…
View details →Prasifka JR, Fugate KK, Hulke BS · 2025 · Crop Science.
Variation in the quality, quantity, or accessibility of nectar and pollen within plant species is a potential target for plant breeding, both to enhance pollination and to support nutritional needs of pollinators. A biparental population…
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