11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mattar D, Cheewasopit W, Samir M et al. · 2023 · Reproduction & fertility
Kisspeptin, a hypothalamic neuropeptide encoded by the KISS1 gene, has a pivotal role in promoting GnRH secretion in mammals. Kisspeptin and its receptor (KISS1R) are also expressed in certain peripheral tissues including gonads,…
View details →Ivanov YV, Ivanova AI, Kartashov AV et al. · 2026 · Biology
Manganese (Mn) is a crucial micronutrient for plants. The impaired function of the oxygen-evolving complex in Photosystem II (PSII) due to Mn deficiency is believed to result in the overproduction of reactive oxygen species and the…
View details →Fondevila G, Fatmi H, Fernando P et al. · 2025 · Insects
The effects of Lys and Ile supplementation in a barley-based substrate on growth performance and nutrient deposition in Tenebrio molitor larvae were evaluated. Six trays per treatment containing sixty larvae were assigned to five…
View details →Lindig A, Mannagottera L, Hahlweg P et al. · 2024 · Health expectations : an international journal of public participation in health care and health policy
Background There is a need for better implementation of patient-centred (PC) communication and shared decision-making (SDM) in routine cancer care. Objective The aim of this study was to assess whether a programme to implement SDM in…
View details →Peverill RE, Narayan O, Cameron JD · 2023 · Scandinavian cardiovascular journal : SCJ
Background Dobutamine effects on the relationships of the peak velocity of left ventricular (LV) long-axis systolic motion (s') with systolic excursion (SExc), systolic duration (SDur) and heart rate, of LV long-axis early diastolic…
View details →Totsch SK, Sorge RE · 2024 · Behavioural brain research
Background and aims In rodents, placebo analgesia is often investigated through direct conditioning of stimuli, but humans can experience placebo analgesia through expectation without experience. In this study, we sought to determine…
View details →Lopez-Alonso V, López-Bermúdez G, Pagaduan JC et al. · 2025 · Sensors (Basel, Switzerland)
Transcranial direct current stimulation (tDCS) modulates cortical excitability, thus inducing improvements in motor learning of simple tasks. In this study, we aimed to evaluate the effect of different tDCS conditions-anodal stimulation…
View details →Lewandowski K, Kaniewska M, Tulewicz-Marti E et al. · 2024 · Journal of clinical medicine
Background : Oncological anxiety associated with biological therapy is a particular challenge in inflammatory bowel disease (IBD), and it has raised questions about the need for the dermatological assessment of the skin before starting…
View details →Okada M, Tran TTT · 2024 · IBRO neuroscience reports
We have previously shown that a single dose of a TREK-1 channel activator, ostruthin, exhibited antidepressant and anxiolytic effects in acute behavioral test models in mice. To assess the potential clinical application, it is essential to…
View details →Strickland JA, Austen JM, Sprengel R et al. · 2024 · Hippocampus
The hippocampus has been implicated in temporal learning. Plasticity within the hippocampus requires NMDA receptor-dependent glutamatergic neurotransmission. We tested the prediction that hippocampal NMDA receptors are required for…
View details →Stoddart K, Davies M, Oughton J et al. · 2025 · Addiction biology
Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro-drug, N-acetyl-cysteine (NAC), is a promising glutamatergic agent that…
View details →Bonne TC, Arthemalle V, Doherty CS et al. · 2025 · Physiological reports
Athletes use creatine monohydrate (CM) to enhance high-intensity exercise performance by increasing creatine phosphate availability. While CM supplementation is known to raise muscle creatine levels in vegans and vegetarians, its impact on…
View details →Barranco I, Spinaci M, Nesci S et al. · 2024 · Theriogenology
Porcine seminal plasma (SP) is loaded with a heterogeneous population of extracellular vesicles (sEVs) that modulate several reproductive-related processes. This study investigated the effect of two sEV subsets, small (S-sEVs) and large…
View details →Brongers K, Hoekstra T, Wilming L et al. · 2024 · Disability and rehabilitation
Purpose As the effect evaluation of our randomized controlled trial the "Comprehensive Approach of Reintegration for clients with Multiple problems" (CARm) showed no superior effect on re-integration into paid employment of the clients…
View details →Hoevenaar-Blom MP, Shourick J, van Dalen JW et al. · 2025 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction We explored which dementia risk factors in two multidomain prevention trials mediate beneficial, neutral, or counteracting effects on dementia incidence. Methods We pooled data from the multidomain MAPT (Multidomain Alzheimer…
View details →Pizarro J, Walker MC, Sheybani L · 2025 · Epilepsia
Generalized epileptiform discharges (GEDs) in idiopathic generalized epilepsy (IGE) are classically considered symmetrical in amplitude, although this has not been formally tested. This is a major knowledge gap, since asymmetry is…
View details →Mogensen DG, Aanaes K, Andersen IB et al. · 2025 · The Laryngoscope
Objectives Olfactory training is a recommended treatment in patients with olfactory dysfunction after COVID-19. However, the effectiveness of olfactory training in COVID-19-induced olfactory dysfunction has been studied; only a few studies…
View details →Sehgal I, Eells K, Hudson I · 2024 · Pharmacy (Basel, Switzerland)
Small interfering RNA (siRNA)-based medications offer the ability to target previously undruggable targets and have now received FDA approval in five instances for orphan or uncommon diseases. The current siRNA "-sirans" are directed…
View details →Boss M, Pels F, Kleinert J · 2023 · PsyCh journal
The purpose of this study was to analyze whether the social compensation of performance drops in a team setting depends on the relationship quality. Two experiments were conducted. Experiment 1: In a team-building condition, the…
View details →Başeğmez M, Eryavuz A, Demirel HH · 2025 · Journal of biochemical and molecular toxicology
This study aims to determine the effect of orally administered vitamin C (Vit C) supplementation on physiological and histopathological changes in aged rats of different genders. A total of 28 Sprague-Dawley aged male and female rats were…
View details →Scott MB, Kammermeier PJ · 2024 · Pharmaceuticals (Basel, Switzerland)
The gabapentenoids such as gabapentin (GP) and pregabalin are approved for the treatment of chronic pain, but their utility is limited by persistent side effects. These adverse effects result from GPs affecting many types of neurons and…
View details →Choneva M, Delchev S, Hrischev P et al. · 2024 · International journal of molecular sciences
Diabetic cardiomyopathy is a major etiological factor in heart failure in diabetic patients, characterized by mitochondrial oxidative metabolism dysfunction, myocardial fibrosis, and marked glycogen elevation. The aim of the present study…
View details →Ebrahimi F, Kangari H, Akbarzadeh-Bagheban A et al. · 2025 · International journal of ophthalmology
Aim To evaluate the effects of polarized and non-polarized sunglasses on visual functions, including distance and near visual acuity, phoria, stereopsis and contrast sensitivity across five spatial frequencies (1.5, 3, 6, 12, 18…
View details →Zeng X, Chen Y, Lin S et al. · 2026 · Frontiers in surgery
Purpose This study aimed to investigate the influence of previous percutaneous renal procedures on the outcome of ultrasound (US)-guided percutaneous nephrolithotomy (PCNL) in patients with upper urinary tract stones. Patients and methods…
View details →Kazmi S, Sanford E, Rammaha ZA et al. · 2025 · International journal of molecular sciences
Oral squamous cell carcinoma (OSCC) is marked by profound differences in survival between the localized and disseminated disease, estimated to result in a 70% and less than a 40% five-year survival rate with surgical and/or radiation…
View details →Dicker D, Tamir O, Lieberman-Segal G et al. · 2023 · The Israel Medical Association journal : IMAJ
Background In 2019, 1 mg subcutaneous semaglutide was registered for the treatment of diabetes in Israel. Recognition of its effect on weight has led to its use as a treatment for obesity. Objectives To explore physicians' pre-therapy…
View details →Goldschmied N, Lambrecht J, Castro A et al. · 2023 · Scandinavian journal of medicine & science in sports
Hockey is a sport known for its violent nature. Specifically, hockey fights have consistently been an integral part of the National Hockey League. Past research has demonstrated that players are likely to be involved in fighting as a…
View details →Riise HS, Simpson MR, Espnes KA et al. · 2026 · Headache
Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real-world setting. Background Oral migraine preventives are previously mainly explored in…
View details →Sonnhoff M, Oyur M, Becker JN et al. · 2026 · Radiation oncology (London, England)
BACKGROUND: Despite the favorable toxicity profiles of whole breast radiotherapy, there are subgroups that tend to experience high toxicity. This study examines anatomical and physiological characteristics that can predict the induction of…
View details →Hunter-Cooper SD, Rahimi M, Millet P et al. · 2026 · European journal of nutrition
Introduction High sodium intake has been associated with greater pressor responses in Black compared with White adults. While the acute effects of sodium on BP have been studied in Black adults, to our knowledge, no studies have explored…
View details →