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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Viniferin-Rich Phytocomplex from <i>Vitis vinifera</i> L. Plant Cell Culture Mitigates Neuroinflammation in BV2 Microglia Cells.

Videtta G, Sasia C, Quadrino S et al. · 2026 · Molecules (Basel, Switzerland)

Activation of microglia and resulting neuroinflammation are central processes that significantly contribute to neurodegenerative disease progression. Treatments capable of attenuating neuroinflammation are therefore an urgent medical need.…

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Negative / Null Result ReportOpen accessMedicine

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio.

Nguyen AP, Hadi DL, Todd DA et al. · 2026 · Clinical pharmacology and therapeutics

Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5-fold…

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Negative / Null Result ReportOpen accessMedicine

SYNCHRONIZE: Real-World Retrospective Safety Analysis of Patients Treated with OnabotulinumtoxinA for More than One Therapeutic Indication.

Forde G, Brucker BM, Becker Ifantides K et al. · 2024 · Toxins

OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the…

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Negative / Null Result ReportMedicine

Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance.

Goettel M, Werner C, Honarvar N et al. · 2024 · Toxicology

The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500 and 3000 ppm and in female rats at a dietary level of 3000 ppm via a non-genotoxic…

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Negative / Null Result ReportOpen accessMedicine

Body composition and muscle health changes after providing vascular imaging results in older adults: secondary analysis of a randomised controlled trial.

Dalla Via J, Radavelli-Bagatini S, Sim M et al. · 2026 · Aging clinical and experimental research

Background Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim This secondary analysis of a 12-week…

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Negative / Null Result ReportMedicine

Theory-guided process evaluation of a multicomponent, technology-based 'SMART Eating' trial among Indian adults: an embedded mixed-methods study.

Kaur J, Kaur M, Chakrapani V et al. · 2023 · Health education research

We report process evaluation findings from the 'SMART Eating' intervention trial, which significantly improved fat, sugar and salt (FSS), and fruits and vegetables (FVs) intake among adults. Intervention used information technology [short…

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Negative / Null Result ReportOpen accessMedicine

The impact of CYP2D6 on donepezil concentration and its lack of effect on the treatment response and adverse effect in Korean patients with Alzheimer's disease.

Kim TE, Bae JW, Hong S et al. · 2025 · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Donepezil, an acetylcholinesterase inhibitor, is widely used for managing the symptoms of Alzheimer's disease (AD), yet its clinical response varies widely among individuals. This study aims to investigate the influence of CYP2D6 genetic…

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Negative / Null Result ReportOpen accessMedicine

MG53's non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues.

Lee KE, Nishi M, Kim J et al. · 2024 · Frontiers in endocrinology

Rationale MG53's known function in facilitating tissue repair and anti-inflammation has broad applications to regenerative medicine. There is controversy regarding MG53's role in the development of type 2 diabetes mellitus. Objective This…

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Negative / Null Result ReportOpen accessMedicine

Autoactivation of the HeLa 9903 test system during a full moon.

Krakowian D, Lach M, Żemła P et al. · 2025 · Cytotechnology

The HeLa 9903 cell line is used in the in vitro endocrine disruption assay (OECD 455). After treatment with an estrogen receptor agonist, the luminescence of these cells increases. However, some autoactivation of this test system may…

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Negative / Null Result ReportMedicine

Liquid feeding does not suppress drinking motivation in heavy pigs

Nannoni E, Martelli G, Militerno G et al. · 2024 · Animal Feed Science and Technology.

The experiment aimed to obtain information on the water requirements, drinking behavior and drinking motivation of liquid-fed pigs and was conducted during the hot season. Eighty castrated male pigs (initial body weight: 36 kg) fed a…

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Negative / Null Result ReportMedicine

Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.

Schumacher JD, van Holstein M, Zhou P et al. · 2025 · The Journal of neuroscience : the official journal of the Society for Neuroscience

Converging evidence suggests that orbitofrontal cortex (OFC) subregions subserve distinct roles in decision-making across a variety of tasks. Cost/benefit decisions can require an organism to choose between options based on information…

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Negative / Null Result ReportOpen accessMedicine

Association Between Routine Patient-Reported Outcome Measure Utilization Among Total Joint Arthroplasty Surgeons and Clinically Meaningful Outcome Achievement.

Dekhne MS, Kunze KN, Chiu YF et al. · 2025 · Arthroplasty today

Background Patient-reported outcome measures (PROMs) assess quality of care after total joint arthroplasty (TJA) and will be mandatory for reporting by 2027 under the Center for Medicare and Medicare Services. This study evaluated the…

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Negative / Null Result ReportMedicine

Differential effects of acute versus repeated chemogenetic activation of the mesocorticolimbic dopamine pathway on cocaine choice in male and female TH:Cre rats.

Robinson HL, Banks ML · 2026 · ASPET discovery

Rationale Mesocorticolimbic dopamine neurotransmission is hypothesized to play a central role in both cocaine reinforcement and amphetamine maintenance-induced decreases in cocaine self-administration. One method to selectively modulate…

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Negative / Null Result ReportOpen accessMedicine

Effects of Beet-Vinasse (Condensed Molasses Soluble) Addition on the Performance, Milk Fatty Acid Profile, Digestibility, Blood Parameters, and Ruminal Fermentation of Early Lactating Holstein Cows.

Rahimi A, Fatehi F, Rafiee H et al. · 2026 · Veterinary medicine and science

Background Beet vinasse (VIN), a by-product of sugar beet processing, is rich in non-protein nitrogen (NPN), potassium, and prebiotic compounds, offering potential as a feed additive to enhance dairy cow performance while reducing…

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Negative / Null Result ReportOpen accessMedicine

Extracellular Vesicles from Poor-Outcome Intracerebral Hemorrhage Patients Reveal Limited Reparative Potential in a Preclinical Model.

Laso-García F, Díaz-Gamero N, Gallego-Ruiz R et al. · 2025 · International journal of molecular sciences

Extracellular vesicles (EVs) have emerged as potential therapeutic agents for neurological disorders. Their molecular cargo may reflect the clinical status of the donor and has been identified as a biomarker for the cellular damage and…

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