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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Dietary Diversity Score and Its Sociodemographic Determinants in School-Aged Children: Cross-Sectional Baseline Findings From a Quasi-experimental Study.

Singh T, Kumar S, Sinha S et al. · 2025 · Cureus

Background Dietary diversity is an essential component of nutritional adequacy, particularly for school-aged children who are undergoing rapid physical and cognitive development. Inadequate dietary diversity can lead to micronutrient…

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Negative / Null Result ReportMedicine

Place of Death, Care Intensity, Symptom Prevalence, and Symptom Management for Patients With Stroke at End-of-Life.

Ramsburg H, Hinkle JL, MacKenzie Greenle M · 2026 · The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

Background Each year in the United States, 795,000 people are diagnosed with a new or recurrent stroke, resulting in 165,393 deaths. However, little is known about the quality of end-of-life (EOL) care in this population, including the…

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Negative / Null Result ReportMedicine

Intrapartum Glycemic Control and Clinical Outcomes.

Bitar G, Fishel Bartal M · 2025 · Diabetes spectrum : a publication of the American Diabetes Association

Current recommendations encourage strict intrapartum glycemic control for individuals with diabetes in pregnancy to optimize maternal and neonatal outcomes. However, established evidence is limited in providing a strong association between…

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Negative / Null Result ReportOpen accessMedicine

The effect of centralized care on the management of postoperative fluctuations in plasma sodium concentration after pediatric suprasellar brain tumor surgery.

Hulsmann SC, Zaal DC, van Gestel JPJ et al. · 2026 · Pituitary

PURPOSE: Children undergoing neurosurgery for (supra)sellar tumors are at risk of developing arginine vasopressin-deficiency (AVP-D), which can cause severe sodium fluctuations and associated neurological complications, prolonged…

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Negative / Null Result ReportOpen accessMedicine

A Longitudinal Observational Study on Lactation-Associated Changes in Procalcitonin, Protein Carbonyl Content, Asymmetric Dimethylarginine, and Symmetric Dimethylarginine in Dairy Cattle.

Sala G, Castelli M, Orsetti C et al. · 2025 · Veterinary sciences

Procalcitonin (PCT), protein carbonyl content (PCC), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) have been proposed as promising biomarkers for detecting diseases in cattle. Their concentrations could…

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Negative / Null Result ReportOpen accessMedicine

Influence of Coagulation Factor VIII on Ischemic Stroke.

Martínez-Salmerón MDM, Amaya-Pascasio L, Martínez-Sánchez P et al. · 2026 · Revista de neurologia

Background There is considerable interest in the underlying mechanisms of cryptogenic stroke, with hypercoagulable states being widely studied. An elevated level of Factor VIII has been proposed as a potential prothrombotic marker…

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Negative / Null Result ReportOpen accessMedicine

Influence of Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism in Conditioned Pain Modulation in Women with Migraine.

Cigarán-Méndez M, de-la-Llave-Rincón AI, Pacho-Hernández JC et al. · 2026 · International journal of molecular sciences

The role of the catechol-O-methyltransferase (COMT) Val158Met rs4680 polymorphism in altered pain processing in headaches is controversial. The aim of this study was to investigate the influence of the Val158Met rs4680 polymorphism in…

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Negative / Null Result ReportMedicine

Impact of metabolism-related markers on outcomes in ovarian cancer patients: Findings of the MITO16A/MaNGO-OV2 trial.

Indraccolo S, Signoriello S, Piga I et al. · 2024 · The International journal of biological markers

Introduction In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation of markers mapping to distinct metabolic…

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Negative / Null Result ReportOpen accessMedicine

Performance of Early Therapeutic Paracentesis in Spontaneous Bacterial Peritonitis and Its Effect on Clinical Outcomes.

Wentworth BJ, Shwetar M, Mallawaarachchi I et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology

Background and aims Spontaneous bacterial peritonitis (SBP) is common in decompensated cirrhosis and often accompanied by large volume ascites. However, the safety of early therapeutic paracentesis is unknown and may lead to unnecessary…

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Negative / Null Result ReportMedicine

Assessment of the impact of microplastic ingestion in striped red mullets from an Eastern Mediterranean coastal area (Zakynthos Island, Ionian Sea).

Patsiou D, Digka N, Galli M et al. · 2024 · Marine environmental research

Monitoring microplastics (MPs) in the marine environment is an ongoing process, and our understanding of their impact on marine organisms is limited. The present study evaluates the effects of ingested MPs on the marine MP pollution…

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Negative / Null Result ReportOpen accessMedicine

Parent substance use and child-to-parent violence: A brief report.

Curtis A, Skvarc D, Brittain N et al. · 2025 · Drug and alcohol review

Introduction Substance use has been associated with child-to-parent violence (CPV), yet little is known about the contributing factors. This study investigated the association between parental substance use and substance involved child to…

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Negative / Null Result ReportOpen accessMedicine

Feeding Therapy and its Relationship to Timing of Independent Oral Feeding for Preterm Infants in the Neonatal Intensive Care Unit.

Nguyen TT, Pineda R, Reynolds S et al. · 2026 · Physical & occupational therapy in pediatrics

Aim To examine the relationship between feeding therapy and the timing of independent oral feeding (IOF) in preterm infants in the neonatal intensive care unit (NICU). Study design A retrospective analysis of 536 preterm infants ( Results…

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Negative / Null Result ReportOpen accessMedicine

The value of transpulmonary thermodilution parameters in predicting hemodynamic instability in intensive care patients undergoing continuous renal replacement therapy.

Keser CS, Erdemir M, Yilmaz M et al. · 2025 · BMC nephrology

Background Hemodynamic instability related to renal replacement therapy (HIRRT) is a serious complication of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), significantly increasing…

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Negative / Null Result ReportOpen accessMedicine

Neighborhood Physical Disinvestment and Incident Diabetes between visits 1 and 2 of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Smith CM, Spalt EW, Gallo LC et al. · 2026 · Journal of urban health : bulletin of the New York Academy of Medicine

Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and…

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Negative / Null Result ReportOpen accessMedicine

Burden of atherosclerosis, cardiovascular risk factors and atrial fibrillation in individuals with covert brain infarcts in late midlife: the Akershus Cardiac Examination 1950 Study.

Ihle-Hansen H, Walle-Hansen MM, Berge T et al. · 2026 · BMJ open

Background Current expert consensus statements generally suggest cardiovascular risk assessment, including atrial fibrillation (AF) screening, on detection of covert brain infarctions (CBIs). However, evidence to guide management of CBI…

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Negative / Null Result ReportMedicine

Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.

O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…

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Negative / Null Result ReportOpen accessMedicine

Stable bloodstream infection rates despite rising colonization: insights from a hospital system using in-house polymerase chain reaction screening for <i>Candidozyma auris</i>.

Rosa R, Rosello G, Manzanillo K et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE

Following the implementation of in-house Candidozyma auris ( C. auris ) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C. auris already present at hospital…

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Negative / Null Result ReportOpen accessMedicine

Ki67 and Lymphovascular Invasion as Histopathological Predictors of Residual Cancer Burden After Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Study.

Carabas BA, Țǎpoi DA, Costache M · 2026 · Diagnostics (Basel, Switzerland)

Background: Neoadjuvant chemotherapy (NAC) is widely used in the management of stage I-III breast cancer, with tumor regression serving as an important surrogate for long-term outcome. Identifying reliable pathological biomarkers…

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Negative / Null Result ReportOpen accessMedicine

Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation.

Lee CC, Miller AA, Tallman PS et al. · 2025 · American journal of human biology : the official journal of the Human Biology Council

Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological…

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Negative / Null Result ReportOpen accessMedicine

Circulating Levels of Soluble α-Klotho and FGF23 in Childhood Cancer Survivors: Lack of Association with Nephro- and Cardiotoxicity-A Preliminary Study.

Kozłowski K, Konończuk K, Muszyńska-Rosłan K et al. · 2024 · Journal of clinical medicine

Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood cancer survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and…

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Negative / Null Result ReportOpen accessMedicine

Dietary Fiber Intake Was Inversely Associated with All-Cause Mortality but Not with Cancer and Cardiovascular Disease Mortalities in the US.

Akbar Z, Fituri S, Shi Z et al. · 2025 · Diseases (Basel, Switzerland)

Background Evidence linking dietary fiber intake with cancer risk and mortality is equivocal. Objective We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US…

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