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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

A case-control study on the diagnostic role of Omega-3 fatty acid levels in erythrocyte membranes of critically ill patients.

Dorchin M, Nasiri-Jounaghani M, Hashemi-Javaheri FS et al. · 2025 · Scientific reports

This study aimed to investigate the erythrocyte Omega-3 fatty acid index as a potential biomarker for clinical severity, nutritional status, and mortality risk in critically ill patients admitted to the intensive care unit (ICU). Using a…

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Negative / Null Result ReportMedicine

Effectiveness of a School-Based Substance Use Prevention Program in Reducing Primary School Students' Intentions to Use Tobacco, Alcohol or Other Drugs in the Future.

Hodder RK, O'Brien KM, Wolfenden L et al. · 2026 · Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

Issue addressed Tobacco, alcohol and other drug use contribute significantly to the global burden of disease, with initiation typically occurring during childhood and adolescence. School-based substance use prevention interventions are…

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Negative / Null Result ReportMedicine

Age-related changes and lack of effect of midlife resistance wheel exercise on afferent connectivity of lumbar alpha motor neurons in ageing mouse spinal cord.

S Krishnan V, Hodgetts SI, Harvey AR et al. · 2025 · Biogerontology

This two part study on the afferent connectivity of lumbar spinal motor neurons in normal ageing mice investigates; Study 1: time course analysis of age-related changes in the synaptic coverage of lumbar spinal cords of male C57BL/BJ mice…

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Negative / Null Result ReportMedicine

Percutaneous gastrostomy, mechanical ventilation and survival in amyotrophic lateral sclerosis: an observational study in an incident cohort.

Borghero G, Pierri V, Pili F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration

Objective To analyze disease-modifying effects of percutaneous endoscopic gastrostomy (PEG) insertion for supporting nutrition, noninvasive ventilation (NIV), and tracheostomy-assisted ('invasive') ventilation (TIV) in amyotrophic lateral…

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Negative / Null Result ReportMedicine

Triiodothyronine supplementation in a sheep model of intensive care.

Maiden MJ, Torpy DJ, Ludbrook GL et al. · 2024 · Experimental and therapeutic medicine

Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is…

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Negative / Null Result ReportMedicine

Preloading With Nicotine Replacement Therapy in People With HIV Who Smoke: A Pilot Randomized Controlled Trial.

Cioe PA, Stang GS, Azam D et al. · 2025 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Introduction Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of…

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Negative / Null Result ReportMedicine

Whole cottonseed and palmitic and oleic acid supplementation improve production responses during the immediate postpartum in multiparous dairy cows.

Parales-Girón JE, Dos Santos Neto JM, Lock AL · 2026 · Journal of dairy science

We evaluated the effects of whole cottonseed (WCS) and fatty acid (FA) supplementation on the production responses of early-lactation cows. Fifty-two multiparous cows were used in a randomized complete block design with a 2 × 2 factorial…

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Negative / Null Result ReportMedicine

Two-year real-world retrospective safety evaluation with onabotulinumtoxinA across multiple therapeutic indications: Findings from the SYNCHRONIZE study.

Forde G, Ifantides KB, Mayadev A et al. · 2026 · Toxicon : official journal of the International Society on Toxinology

OnabotulinumtoxinA (onabotA) is approved for the treatment of various therapeutic indications, which require retreatment. In clinical practice, many patients receive onabotA for multiple therapeutic indications concomitantly over extended…

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Negative / Null Result ReportMedicine

Combined Effects of Fish, Light and Allochthonous Dissolved Organic Carbon on Interactions Between Green and Brown Food Webs: An Aquatic Mesocosm Experiment

Quévreux P, Zou K, Barot S et al. · 2025 · Freshwater Biology

The classical concepts of top‐down and bottom‐up cascading effects in ecosystems are challenged by the interactions between green and brown food webs. The green food web relies on photosynthesis and the brown food web relies on the…

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Negative / Null Result ReportMedicine

Challenges and lessons learned in attempts to develop in vitro models for ultrasound neuromodulation using local field potential measurements in hippocampal tissue.

Prieto ML, Madison DV, Maduke M · 2025 · Biophysical journal

Ultrasound neuromodulation is a rapidly developing tool for noninvasive control of brain activity. An in vitro model recapitulating the effects of ultrasound on neural tissue in vivo would be extremely valuable in guiding the development…

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Negative / Null Result ReportMedicine

Pumping Behaviors of Breast Pump-Dependent Mothers of Preterm Infants in the Neonatal Intensive Care Unit (NICU): Importance of the First Five Postpartum Days.

Medina Poeliniz C, Hoban R, Janes J et al. · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

Objective: To determine if cumulative measures of pumping behaviors over the first 5 days postpartum predicted lactation outcomes by postpartum days 7 (achievement of secretory activation [SA] and pumped milk volume) and 14 (achievement of…

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Negative / Null Result ReportMedicine

Targeting synaptic plasticity and acetylcholine dysregulation in the medial prefrontal cortex: Rosmarinic acid attenuates Autism-like phenotypes in Shank3B<sup>-/-</sup> mice via the CREB/BDNF pathway.

Shi J, Chen M, Zhang Y et al. · 2026 · Psychopharmacology

Rationale Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B -/- ) mouse model displays ASD-related…

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Negative / Null Result ReportOpen accessMedicine

No light, no problem: provision of light during simulated transport does not alter broiler chick performance or welfare outcomes.

McGregor D, Shynkaruk T, Adler CAB et al. · 2026 · Poultry science

Commercial transport of newly hatched poultry species typically occurs under darkness. The impact of providing light during chick transportation has not been investigated and previous research suggests blue light may have a calming effect…

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Negative / Null Result ReportMedicine

Role of beta-blocker therapy on the sympathetic effects in stroke heart syndrome.

Prandin G, Naccarato M, Furlanis G et al. · 2025 · Clinical autonomic research : official journal of the Clinical Autonomic Research Society

Background Sympathetic activation, inflammation, and neuro-endocrine response after an ischemic stroke contribute to the development of the stroke heart syndrome (SHS). One marker of SHS is a troponin "rise and fall pattern" > 30%. Among…

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Negative / Null Result ReportMedicine

Recommendations on the health outcomes of infant formula supplemented with biotics by the ESPGHAN Special Interest Group on Gut Microbiota and Modifications.

Dinleyici EC, Indrio F, Szajewska H et al. · 2026 · Journal of pediatric gastroenterology and nutrition

For many years, biotics (including probiotics, prebiotics, human identical milk oligosaccharides, synbiotics, and postbiotics) have been added to infant formula to influence the gut microbiota of formula-fed infants, aiming to bring it…

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Negative / Null Result ReportOpen accessMedicine

GABA<sub>B</sub> receptor-mediated modulation of sensory neuron excitability: Roles of Ca<sub>V</sub>2.2, G-protein-coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels in human and mouse nociception.

Brizuela M, Bony AR, Garcia-Caraballo S et al. · 2026 · Experimental physiology

Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage-gated calcium and potassium channels by G protein-coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the…

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Negative / Null Result ReportMedicine

Subcutaneous zilucoplan: Evaluation of reproductive toxicology.

Lemper M, Luetjens CM, Fuchs A et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)

To further understand the safety profile of zilucoplan, reproductive toxicology studies in non-human primates (NHPs) were performed, including a male fertility study and a combined embryo-foetal development (EFD) and enhanced pre- and…

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Negative / Null Result ReportOpen accessMedicine

Connexin-43-Mediated Gap Junction Coupling Between Adipocytes Regulates Norepinephrine-Induced Ca<sup>2+</sup> Responses in Perivascular Adipose Tissue.

Kim AR, Jamka J, Jackson WF et al. · 2026 · Cells

Anticontractile factors secreted by perivascular adipose tissue (PVAT) play an important role in regulating vascular tone. This process is driven by the neurotransmitter norepinephrine (NE), but recent data show that adrenergic innervation…

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Negative / Null Result ReportMedicine

Alpha-secretase inhibition impairs Group I metabotropic glutamate receptor-mediated protein synthesis, long-term potentiation and long-term depression.

Mockett BG, Davies JWT, Mills ZB et al. · 2024 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Group I metabotropic glutamate receptors (Gp1-mGluRs) exert a host of effects on cellular functions, including enhancement of protein synthesis and the associated facilitation of long-term potentiation (LTP) and induction of long-term…

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Negative / Null Result ReportOpen accessMedicine

Pin1 promotes human Ca V 2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2.

Fu SJ, Cheng KM, Hsiao CT et al. · 2024 · Cell communication and signaling : CCS

Loss-of-function mutations in the human gene encoding the neuron-specific Ca 2+ channel Ca V 2.1 are linked to the neurological disease episodic ataxia type 2 (EA2), as well as neurodevelopmental disorders such as developmental delay and…

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