11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Gatterer C, Allmer D, Beitzke D et al. · 2026 · Journal of clinical medicine
Background/Objectives: Fabry disease (FD) is a lysosomal storage disorder characterized by progressive renal and cardiac involvement and an increased burden of cardiovascular and cerebrovascular events. While cardiac magnetic resonance…
View details →Kamian S, Azadeh P, Anbiaee R et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Anthracyclines are widely used in the treatment of breast cancer but are associated with myocardial injury that may progress to cardiac dysfunction. Surveillance has traditionally relied on left ventricular ejection fraction…
View details →Kim H, Kipp K · 2025 · Computer methods in biomechanics and biomedical engineering
The purpose of this study was to calculate and compare (1) knee loads, (2) muscle-specific contributions to knee loads, and (3) effects of knee flexion angle on knee loads and muscle-specific load contributions during a forward…
View details →Nakamura T, Hatanaka KC, Kawamoto Y et al. · 2025 · Journal of cancer research and clinical oncology
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Despite the use of aggressive combination chemotherapy regimens, outcomes remain unsatisfactory. Schlafen family member 11 (SLFN11) has been reported to regulate the DNA…
View details →Tsui ST, Zhou N, Tan KS et al. · 2025 · JTCVS open
Objectives The study objectives were to determine whether diagnostic laparoscopy improves staging accuracy in selected patients with distal esophageal adenocarcinoma and to identify clinicopathologic features associated with positive…
View details →Tabara Y, Shoji-Asahina A, Ogawa A et al. · 2024 · International journal of obesity (2005)
Background Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy…
View details →Tseng YT, Chen II, Wang CH · 2025 · Healthcare (Basel, Switzerland)
Background : The long-term effects of hormone replacement therapy (HRT) on inflammatory bowel disease (IBD) remain unclear, necessitating further investigations of the association between HRT and the development of ulcerative colitis and…
View details →Schiff DM, Wheeler A, Lewis D et al. · 2026 · Journal of substance use and addiction treatment
Objective Identify sociodemographic and substance use characteristics associated with pregnancy intention and explore the relationship between pregnancy intent and postpartum contraception interest among pregnant individuals with opioid…
View details →Reda B, Zanon G, Contardo L et al. · 2025 · Orthodontics & craniofacial research
Objective Orthodontic treatment is a common approach for correcting malocclusion but is often associated with discomfort. The aim of this study was to assess the longitudinal changes in oral behaviours, temporomandibular disorder…
View details →Kholili U, Hidayat AA, Bintoro UY et al. · 2026 · Cancers
Introduction Mounting evidence indicates that the p53 Pro72Arg single-nucleotide polymorphisms (SNPs) may play a role in modulating hepatocarcinogenesis in the setting of chronic HBV infection. However, there is currently a lack of studies…
View details →Petzke TM, Köteles F, Pohl A et al. · 2024 · Journal of psychosomatic research
Objective (Cardiac) interoception was long considered a key mechanism behind symptom perception in persistent somatic symptoms (PSS). In this study, we aimed to extend earlier findings to clarify this potential interoceptive mechanisms of…
View details →Kohno C, Higuchi A, Miyagawa E et al. · 2026 · Modern rheumatology
Objectives Low-dose aspirin (LDA) is widely recommended to prevent hypertensive disorders of pregnancy (HDP). However, the evidence of its effectiveness in pregnancies with systemic lupus erythematosus (SLE) remains limited. This study…
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Lurasidone is more than 99% bound to plasma proteins, so it is unlikely that the drug would be excreted into milk in sufficient amounts to affect a breastfed infant. Data from one mother-infant pair appears to support the poor excretion…
View details →Kishinevsky M, Ferrer-Suay M, Ives AR · 2026 · Biol Invasions.
The enemy release hypothesis—that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range—can be an important explanation for successful invasions. Testing this…
View details →Neal RA, Corbett J, Costello JT et al. · 2026 · European journal of sport science
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterised by chronic hyperglycaemia, whereas obesity is a major risk factor which increases morbidity and mortality. Treatments that alter white adipose tissue to express a…
View details →Abbasi H, Ashtiani MN · 2026 · Journal of motor behavior
This study investigated the impact of real-time laser-guided visual cues on spatiotemporal gait parameters during initiation and termination in people with Parkinson's (PwP). Fifteen PwP walked a 5-m path under uncued and laser-cued…
View details →DeGrado J, Devlin JW · 2025 · Critical care clinics
Antipsychotics are an attractive option for adjunctive sedation in critically ill adults given their sedating effects, short duration of action, lack of effect on respiratory drive, and multiple routes of administration but high-quality…
View details →Singier A, Jarne Munoz A, Maumus-Robert S et al. · 2025 · JAMA network open
Importance Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further…
View details →Ellis K, Moss J, Dziwisz M et al. · 2025 · Oxford open neuroscience
It has been suggested that mentalizing abilities underlie the distinct profiles of autism characteristics observed between Cornelia de Lange (CdLS) and fragile X syndromes (FXS) and autistic people without a genetic syndrome. However,…
View details →Turmanbayeva A, Sadykova K, Nuskabayeva G et al. · 2026 · Journal of clinical medicine
Background : Metabolic syndrome (MetS) is influenced by behavioral and genetic factors, yet evidence on eating behavior patterns and related genetic polymorphisms in Central Asian populations remains limited. Aim: The aim of this study was…
View details →Santamaria-Guzman K, Holmes H, Kosek J et al. · 2026 · Archives of orthopaedic and trauma surgery
Introduction Visual processing speed and cognitive interference control are critical for athletic performance and Anterior Cruciate Ligament (ACL) injury risk. However, how these cognitive functions relate to biomechanical performance…
View details →Matsumoto N · 2024 · Memory & cognition
Autobiographical memory specificity is known to contribute to better mental health, social problem-solving, and episodic future thinking. While numerous studies have addressed variables that affect autobiographical memory specificity,…
View details →Masal TA, Kholinne E · 2026 · Cureus
Background Fractures are a major public health concern among the elderly and contribute substantially to morbidity and disability. Sedentary behavior has been proposed as a modifiable risk factor for fractures; however, evidence regarding…
View details →Khalil E, Yüksel B · 2026 · Archives of medical sciences. Atherosclerotic diseases
Introduction Perioperative atrial fibrillation (POAF) remains the most common arrhythmic complication occurring in the setting of isolated coronary artery bypass grafting (CABG), and it is now being increasingly recognised as a marker of…
View details →Beesiga B, Litunya J, Nakato JZ et al. · 2026 · AIDS and behavior
Alcohol-serving venues in East Africa are high-risk environments for HIV transmission but few studies in sub-Saharan Africa (SSA) have examined perceived HIV risk and sexual risk behaviors by alcohol use levels on a broader population of…
View details →Shinde SS, Naik NS, Adhyapak SU et al. · 2025 · Journal of pharmacy & bioallied sciences
Background Emotional hyporexia, a form of intentional food avoidance triggered by emotional distress, presents a growing health concern among adolescent girls. Addressing this behavior through psychological intervention is essential for…
View details →Wang Y, Xu P, Wang K et al. · 2024 · Neurological research
Objective The association between herpes zoster (HZ) and stroke has been the subject of much previous research. Nevertheless, the connection remains ambiguous. A two-sample Mendelian randomisation study was conducted to explore the…
View details →Randall B, Leković A, Nikolić S et al. · 2025 · Lipids in health and disease
The role of omega-3 fatty acids in the atherosclerotic process remains unclear. Early studies demonstrated a profound anti-atherogenic effect of cod liver oil in a pig model, and autopsy reports from Alaska Natives consuming omega-3 rich…
View details →Sharpe AR, Richardson K, Stanton M et al. · 2023 · The Journal of emergency medicine
Background Cardiac arrest occurs in approximately 350,000 patients outside the hospital and approximately 30,000 patients in the emergency department (ED) annually in the United States. When return of spontaneous circulation (ROSC) is…
View details →Zanetto A, Campello E, Spiezia L et al. · 2024 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Introduction Factor XI (FXI) is associated with thrombosis in patients without liver disease, but it alterations and prognostic value in cirrhosis are uncertain. Patients and methods We studied a prospective cohort of cirrhosis patients…
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