11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kaabi YA, Abdelmola AA, Abdelwahab SI et al. · 2024 · Clinical laboratory
Background Type 2 diabetes mellitus (T2DM) is common in Saudi Arabia and represents a major health concern. Silent information regulator of transcription-1 (SIRT1) positively influences insulin sensitivity and might contribute to the…
View details →Chiarelli PA, Chapman N, Flyer BE et al. · 2024 · Journal of neurosurgery. Pediatrics
Objective The optimal timing of ventricular shunt placement in low-weight and preterm infants remains an unresolved topic in modern pediatric neurosurgery. Shunt placement for hydrocephalus is performed over a wide range of infant weights,…
View details →Boucher V, Frenette J, Neveu X et al. · 2023 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Approximately 15 % of individuals who sustained a mild Traumatic Brain Injury (TBI) develop persistent post-concussion symptoms (PPCS). We hypothesized that blood biomarkers drawn in the Emergency Department (ED) could help predict PPCS.…
View details →Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer
Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…
View details →Seizer L, Löchner J, Renner TJ · 2026 · Brain, behavior, & immunity - health
The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This…
View details →Howard KA, Witrick B, Clark A et al. · 2026 · The Journal of surgical research
Introduction Implicit bias can influence behavior and decision-making, such as treatment decisions in clinical settings. Given documented Black-White disparities in vascular care, the purpose of this study was to describe the prevalence…
View details →Pires S, Freitas M, Pinho F et al. · 2025 · Sensors (Basel, Switzerland)
Objective We aimed to quantify the mechanical pressure required to reach the deep cervical and thoracolumbar fasciae, to examine its association with pressure pain threshold (PPT) and adipose tissue thickness, and to determine whether PPT…
View details →Haahr Vad O, Önnestam L, Bengtsson Boström K et al. · 2025 · PloS one
Aims The aim of the study was to investigate the association between breastfeeding duration and body mass index (BMI), overweight and obesity in children during follow-up until 16 years of age. Methods Observational cohort study of mothers…
View details →Montoya-Delgado IB, Ochoa-García IV, Escobedo-Salcedo ZL et al. · 2026 · International journal of molecular sciences
Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and…
View details →Sacre H, Haddad C, Rizk R et al. · 2025 · Frontiers in public health
Objectives To investigate the association between food insecurity (FI), eating disorders (EDs), and orthorexia nervosa (ON) among Lebanese university students. Methods This cross-sectional study, conducted between 2021 and 2022, enrolled…
View details →Wistrand H, Kaartinen NE, Jousilahti P et al. · 2024 · Integrated blood pressure control
Purpose The complex pathogenesis of hypertension, potentially involving inflammatory pathways, remains elusive. This study aimed to evaluate the relationship between 24-hour urinary sodium excretion and inflammatory cytokines alongside…
View details →Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives
We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…
View details →Kayode GA, Zagkos L, Oboli G et al. · 2025 · PloS one
Background Subarachnoid haemorrhage (SAH) poses a life-threatening risk, contributing to half of all haemorrhagic strokes, with aneurysmal SAH (aSAH) affecting approximately 6 individuals per 100,000 annually. Following aSAH, the influx of…
View details →Rodrigues CAS, Albano TR, Pereira Melo AK et al. · 2024 · Journal of bodywork and movement therapies
Background Y-Balance Test (YBT) assesses postural stability. When is applied to patients after anterior cruciate ligament reconstruction (ACLR), it is not clear which variables influence its result. Objective To connect YBT and postural…
View details →Harik L, Gregg AC, Wu Y et al. · 2026 · Journal of the American Heart Association
Background Patient-surgeon sex concordance influences postoperative outcomes in general surgery, but its relevance in cardiac surgery is unknown. Methods This was a cohort study of 223 065 Medicare beneficiaries undergoing coronary artery…
View details →Lee SE, Kim CW, Bae JE et al. · 2025 · Epidemiology and health
Objectives This study investigated the associations between usual source of care (USC) characteristics, which incorporate primary care functions, and medication adherence and healthy behaviors in Korean adults with diabetes. Methods We…
View details →Jiang W, Cheng A, Wang J et al. · 2025 · Frontiers in neurology
Background Febrile seizures (FSs) are a common neurological manifestation in children, affecting 2%-5% of children worldwide. While acute-phase recurrences during the same febrile illness are frequent, their risk factors and implications…
View details →Wakayama T, Saita Y, Uchino S et al. · 2025 · Journal of clinical medicine
Objective: Platelet-rich plasma (PRP) therapy has become a popular treatment for knee osteoarthritis. We aimed to determine the outcomes of knee osteoarthritis patients following PRP therapy using magnetic resonance imaging (MRI) findings…
View details →Nagao-Sato S, Kushida O, Kurita Y et al. · 2025 · Nutrients
Background/Objectives : Low masticatory function has been proposed as a risk factor for sarcopenia. This study investigated its potential association with body composition and physical performance in community-dwelling older adults.…
View details →Wu J, Guo J, Wang A et al. · 2023 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Background The association between nonalcoholic fatty liver disease (NAFLD) and intracerebral hemorrhage (ICH) remains unclear. This study aimed to investigate whether NAFLD and its severity predict incident ICH. Methods Participants free…
View details →Malindisa EK, Dika H, Rehman AM et al. · 2025 · European journal of clinical nutrition
Background The diabetes burden in sub-Saharan Africa is rising, but there is little African data on associations between diet, insulin resistance, and beta-cell dysfunction. Objective We investigated the association between dietary…
View details →Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine
Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…
View details →Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…
View details →Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine
Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…
View details →Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal
Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…
View details →Meyer DB, Gifford A, Bradley T et al. · 2026 · Journal of gastrointestinal oncology
Background Prior studies have reported solid organ transplant (SOT) recipients have increased rates of colorectal cancer (CRC). While this increased incidence is established, the recurrence risk following curative-intent treatment for…
View details →Huber A, Pasquier T, Demarchi M et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is…
View details →Sanghvi K, Todorova B, Sepil I · 2025 · Ecology and evolution
Sexual selection operates across pre- and post-mating episodes, driven by intra-sexual competition and inter-sexual choice for mates or gametes. While these episodes can act in the same direction, this is not always the case; for example,…
View details →Al Shboul S, Abu Al Karsaneh O, Alrjoub M et al. · 2025 · International journal of immunopathology and pharmacology
Objective The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introduction Cellular senescence and its secretory phenotype (the SASP) are implicated in…
View details →Arato CVB, Guerra LM, Probst LF et al. · 2025 · Revista de saude publica
Objective To investigate the impact of prenatal care on the reduction of maternal-child mortality in Brazilian municipalities following the new primary health care financing model, the Previne Brasil program. Methods This study comprised a…
View details →