11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Szczuko M, Szmigiel O, Szczuko U et al. · 2026 · Journal of clinical medicine
Background : Hashimoto's thyroiditis (HT) is the result of a complex interplay between genetic, environmental, and epigenetic factors. The role of cellular and humoral immunity in the pathogenesis of the disease is well-established.…
View details →Corrêa Matias Pereira C, Najafi Moghaddam Gilani V, Nazif-Munoz JI · 2024 · Frontiers in psychiatry
Objectives Aiming to disseminate information related to suicide prevention in Brazil, the " Setembro Amarelo " campaign has been conducted since 2015. The objective of this study is to assess the association between this campaign and…
View details →Tabara Y, Matsumoto T, Murase K et al. · 2025 · Journal of cachexia, sarcopenia and muscle
Background Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general…
View details →Dadoo S, Vieider RP, Grandberg C et al. · 2026 · Orthopaedic journal of sports medicine
Background While quadriceps tendon (QT) autograft is being increasingly utilized for primary anterior cruciate ligament reconstruction (ACLR), there remains limited evaluation of how QT autograft diameter and the ratio of graft diameter to…
View details →Koerte IK, Wiegand TLT, Bonke EM et al. · 2026 · JAMA network open
Importance Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important. Objective To…
View details →Meza-Espinoza JP, Zavala-Rubio JD, Leal-Ugarte E et al. · 2025 · BMC research notes
Objective The CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic…
View details →Fleece H, Teglasi H · 2025 · Children (Basel, Switzerland)
Background/Objectives : Behavioral inhibition (BI) has been extensively studied as an early-appearing risk factor for adverse developmental outcomes. One pathway through which BI may confer risk is via reduced competence to interact…
View details →Nehme R, Sponchiado IM, Limirio LS et al. · 2025 · Clinical nutrition ESPEN
Background & aims Muscle strength is a key predictor of both quality of life and mortality. Although numerous studies have investigated the relationship between omega-3 (ω-3) intake and muscle strength, the evidence remains inconclusive.…
View details →Petre-Mandache B, Burada E, Cucu MG et al. · 2024 · Current oncology (Toronto, Ont.)
Colorectal cancer (CRC) is a major public health problem worldwide, currently ranking third in cancer incidence and second in mortality. Multiple genes and environmental factors have been involved in the complex and multifactorial process…
View details →Duvenci Birben O, Yenibertiz D, Akkurt ES et al. · 2025 · BMC pulmonary medicine
Background/aim Pneumonia is a significant cause of morbidity and mortality within the first year after autologous hematopoietic stem cell transplantation in patients with multiple myeloma (MM), and nutritional status may influence…
View details →Sæle RG, Aslaksen PM, Svartdal F et al. · 2026 · BMC psychology
BACKGROUND: Procrastination, the tendency to delay tasks despite negative consequences, is a widespread issue linked to poor mental health and reduced daily functioning. While often attributed to self-regulation failures, the specific…
View details →Akbar M, Avdagic E, Carlos C et al. · 2024 · Journal of pediatric ophthalmology and strabismus
Purpose To evaluate for an association between systemic hypertension and intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP) treatment, due to a 2020 case report of a neonate with ROP developing systemic hypertension and…
View details →Lanzarin JVM, Sabage LE, Louro MD et al. · 2024 · Journal of pediatric endocrinology & metabolism : JPEM
Objectives Seasonal environment at birth may influence diabetes incidence in later life. We sought evidence for this effect and analyzed the association between the month of birth and the risk of developing type 1 diabetes mellitus (T1DM).…
View details →Yigit S, Nursal AF, Ozsoy F et al. · 2024 · Nucleosides, nucleotides & nucleic acids
Major depressive disorder (MDD), which is a prevalent psychiatric disorder, is characterized by sleep-wake disturbances. An underlying circadian rhythm disorder mainly may cause these disturbances. The study presented here was designed to…
View details →Abdelgalil KAA, Fathi N, El Nouby FH et al. · 2025 · BMC rheumatology
BACKGROUND: Rheumatoid Arthritis (RA) is a prevalent autoimmune disease affecting approximately 84,338 individuals in Egypt. Genetic predispositions, such as the PTPN22 and PADI4 genes, are linked to RA risk. PTPN22, a protein tyrosine…
View details →de Oliveira CAF, Amaral LMB, Micheleto JPC et al. · 2024 · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Introduction Diabetes, obesity, and CKD collectively impact musculoskeletal health and increase the risk of severe coronavirus disease 2019 (COVID-19) outcomes. Methods This cross-sectional study included 32 dialysis patients, categorized…
View details →Meins IA, van der Stouwe ECD, Aan Het Rot M et al. · 2026 · Schizophrenia research. Cognition
Background Empathy as a key component of social cognition may be impaired in individuals at ultra-high risk (UHR) for psychosis. The Empathic Accuracy Task (EAT) was designed to address the dynamic and interactive nature of real-world…
View details →Joseph J, Chandranaath A, Louis J et al. · 2025 · Cureus
Background Wound healing relies on a balance between extracellular matrix remodelling by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Among all the MMPs, elevated MMP-9 levels are implicated in…
View details →Alharazy S · 2024 · Pakistan journal of medical sciences
Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…
View details →Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America
Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…
View details →Gu Y, Zhang W, Zhou J et al. · 2025 · International journal of nephrology
Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients…
View details →Agbektas T, Genc HC, Zontul C et al. · 2025 · International journal of molecular sciences
(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls)…
View details →Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…
View details →Nasirzadeh A, Mohammadzadeh F, Kazeminia S et al. · 2025 · Scientific reports
The presence of a known labor companion was shown to improve childbirth satisfaction. However, a companion's anxiety might affect the satisfaction of laboring women. Therefore, this study aimed to evaluate the relationship between the…
View details →Veenman F, Tibbertsma S, Wolvius EB et al. · 2025 · Caries research
Introduction Asthma and dental caries may be linked through frequent mouth breathing and the use of inhaled asthma medication. However, the current literature is inconclusive on whether asthma or asthma medications increase the risk of…
View details →Whelton SP, Yao J, Clish C et al. · 2026 · Journal of the American Heart Association
Background Aortic valve calcification (AVC) is the primary process leading to aortic stenosis. We examined whether polygenic risk scores (PRS) are associated with AVC beyond traditional atherosclerotic cardiovascular disease risk factors.…
View details →Isaacs Q, Sofianos C, Muganza A et al. · 2026 · European burn journal
Background: Timely admission to a specialised burn unit is considered crucial for optimising outcomes in burn patients. However, the impact of delayed admission on hospital length of stay and clinical outcomes remains unclear, particularly…
View details →Zhao J, Li W, Chen L et al. · 2024 · Frontiers in endocrinology
Objective Despite several observational studies attempting to investigate the potential association between type 1 diabetes mellitus (T1DM) and the risk of digestive cancers, the results remain controversial. The purpose of this study is…
View details →Pietraszko P, Żórawski M, Bielecka-Richter E et al. · 2025 · International journal of molecular sciences
Mid-regional pro-adrenomedullin (MR-proADM) has emerged as a promising biomarker reflecting endothelial dysfunction and systemic inflammation. Its prognostic role in cardiovascular complications, particularly in the context of COVID-19…
View details →Weber J, Heming M, Apolinário-Hagen J et al. · 2024 · Biological psychology
Valid approaches to conveniently measure stress reactivity are needed due to the growing evidence of its health-impairing effects. This study examined whether the Perceived Stress Reactivity Scale (PSRS) predicts cardiovascular and…
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