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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Lack of association between month of birth and risk of developing type 1 diabetes in Brazil: a 40-year analysis.

Lanzarin JVM, Sabage LE, Louro MD et al. · 2024 · Journal of pediatric endocrinology & metabolism : JPEM

Objectives Seasonal environment at birth may influence diabetes incidence in later life. We sought evidence for this effect and analyzed the association between the month of birth and the risk of developing type 1 diabetes mellitus (T1DM).…

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Negative / Null Result ReportMedicine

Lack of association between VNTR variant of the circadian gene (PER3) and major depressive disorder in a sample of a Turkish population.

Yigit S, Nursal AF, Ozsoy F et al. · 2024 · Nucleosides, nucleotides & nucleic acids

Major depressive disorder (MDD), which is a prevalent psychiatric disorder, is characterized by sleep-wake disturbances. An underlying circadian rhythm disorder mainly may cause these disturbances. The study presented here was designed to…

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Negative / Null Result ReportMedicine

Post-COVID-19 inflammation and sarcopenia in obese diabetic dialysis patients.

de Oliveira CAF, Amaral LMB, Micheleto JPC et al. · 2024 · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

Introduction Diabetes, obesity, and CKD collectively impact musculoskeletal health and increase the risk of severe coronavirus disease 2019 (COVID-19) outcomes. Methods This cross-sectional study included 32 dialysis patients, categorized…

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Negative / Null Result ReportOpen accessMedicine

Empathic accuracy in individuals at ultra-high risk for psychosis: Using a task with dynamic real-life emotional stimuli.

Meins IA, van der Stouwe ECD, Aan Het Rot M et al. · 2026 · Schizophrenia research. Cognition

Background Empathy as a key component of social cognition may be impaired in individuals at ultra-high risk (UHR) for psychosis. The Empathic Accuracy Task (EAT) was designed to address the dynamic and interactive nature of real-world…

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Negative / Null Result ReportOpen accessMedicine

Genetic Variants in Vitamin-D Metabolism Genes (rs1155563, rs12785878 and rs10500804) among Females with Type-2 Diabetes Mellitus in Saudi Arabia.

Alharazy S · 2024 · Pakistan journal of medical sciences

Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…

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Negative / Null Result ReportOpen accessMedicine

Computationally efficient whole-genome quantile regression at biobank scale.

Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America

Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…

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Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Intraoperative Hypotension and Postoperative Acute Kidney Injury in Patients Undergoing Pancreaticoduodenectomy: A Retrospective Cohort Study.

Gu Y, Zhang W, Zhou J et al. · 2025 · International journal of nephrology

Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients…

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Negative / Null Result ReportOpen accessMedicine

<i>XPO5</i> Polymorphism in Colon Cancer Patients: A Cross-Sectional Study.

Agbektas T, Genc HC, Zontul C et al. · 2025 · International journal of molecular sciences

(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls)…

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Negative / Null Result ReportMedicine

Comparison of susceptibility of Pseudomonas aeruginosa isolated from keratitis to antibiotics and multipurpose disinfecting solutions.

Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…

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Negative / Null Result ReportOpen accessMedicine

A Single-Centre Review of Outcomes of Delayed Admission to a Burns Unit.

Isaacs Q, Sofianos C, Muganza A et al. · 2026 · European burn journal

Background: Timely admission to a specialised burn unit is considered crucial for optimising outcomes in burn patients. However, the impact of delayed admission on hospital length of stay and clinical outcomes remains unclear, particularly…

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Negative / Null Result ReportOpen accessMedicine

Cardiovascular Disease and COVID-19: Is There a Place for Mid-Regional Pro-Adrenomedullin? Preliminary Data from a Clinical Cohort.

Pietraszko P, Żórawski M, Bielecka-Richter E et al. · 2025 · International journal of molecular sciences

Mid-regional pro-adrenomedullin (MR-proADM) has emerged as a promising biomarker reflecting endothelial dysfunction and systemic inflammation. Its prognostic role in cardiovascular complications, particularly in the context of COVID-19…

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Negative / Null Result ReportMedicine

Comparison of the Perceived Stress Reactivity Scale with physiological and self-reported stress responses during ecological momentary assessment and during participation in a virtual reality version of the Trier Social Stress Test.

Weber J, Heming M, Apolinário-Hagen J et al. · 2024 · Biological psychology

Valid approaches to conveniently measure stress reactivity are needed due to the growing evidence of its health-impairing effects. This study examined whether the Perceived Stress Reactivity Scale (PSRS) predicts cardiovascular and…

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Negative / Null Result ReportMedicine

Shunt timing in low-weight infants in the treatment of hydrocephalus.

Chiarelli PA, Chapman N, Flyer BE et al. · 2024 · Journal of neurosurgery. Pediatrics

Objective The optimal timing of ventricular shunt placement in low-weight and preterm infants remains an unresolved topic in modern pediatric neurosurgery. Shunt placement for hydrocephalus is performed over a wide range of infant weights,…

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Negative / Null Result ReportMedicine

Lack of association between four biomarkers and persistent post-concussion symptoms after a mild traumatic brain injury.

Boucher V, Frenette J, Neveu X et al. · 2023 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Approximately 15 % of individuals who sustained a mild Traumatic Brain Injury (TBI) develop persistent post-concussion symptoms (PPCS). We hypothesized that blood biomarkers drawn in the Emergency Department (ED) could help predict PPCS.…

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Negative / Null Result ReportMedicine

Lack of Association Between Immunotherapy and Improvement of Survival for Non-small Cell Lung Cancer Patients With Hemodialysis: A Nationwide Retrospective Cohort Study.

Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer

Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…

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Negative / Null Result ReportOpen accessMedicine

Peripheral immune system activity in young psychiatry patients.

Seizer L, Löchner J, Renner TJ · 2026 · Brain, behavior, & immunity - health

The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This…

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Negative / Null Result ReportOpen accessMedicine

Implicit Bias and Recognition of Biases Among Vascular Surgeons.

Howard KA, Witrick B, Clark A et al. · 2026 · The Journal of surgical research

Introduction Implicit bias can influence behavior and decision-making, such as treatment decisions in clinical settings. Given documented Black-White disparities in vascular care, the purpose of this study was to describe the prevalence…

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Negative / Null Result ReportOpen accessMedicine

Mechanosensitivity and Adipose Thickness as Determinants of Pressure to Reach Deep Fasciae in Cervical and Thoracolumbar Regions.

Pires S, Freitas M, Pinho F et al. · 2025 · Sensors (Basel, Switzerland)

Objective We aimed to quantify the mechanical pressure required to reach the deep cervical and thoracolumbar fasciae, to examine its association with pressure pain threshold (PPT) and adipose tissue thickness, and to determine whether PPT…

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Negative / Null Result ReportOpen accessMedicine

Lack of association between breastfeeding duration and body mass index in children and adolescents - A Swedish cohort study.

Haahr Vad O, Önnestam L, Bengtsson Boström K et al. · 2025 · PloS one

Aims The aim of the study was to investigate the association between breastfeeding duration and body mass index (BMI), overweight and obesity in children during follow-up until 16 years of age. Methods Observational cohort study of mothers…

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Negative / Null Result ReportOpen accessMedicine

<i>IL4</i> Gene Variants rs2243250 and rs2243248 and Their Association with Clinical Phenotypes of Severe Asthma in the Mexican Population: In Silico Functional Analysis and Regulatory Implications.

Montoya-Delgado IB, Ochoa-García IV, Escobedo-Salcedo ZL et al. · 2026 · International journal of molecular sciences

Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and…

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Negative / Null Result ReportOpen accessMedicine

Lack of association between food insecurity, eating disorders, and orthorexia nervosa: findings from a cross-sectional study in Lebanon.

Sacre H, Haddad C, Rizk R et al. · 2025 · Frontiers in public health

Objectives To investigate the association between food insecurity (FI), eating disorders (EDs), and orthorexia nervosa (ON) among Lebanese university students. Methods This cross-sectional study, conducted between 2021 and 2022, enrolled…

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Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Sodium Intake and Cytokine Levels.

Wistrand H, Kaartinen NE, Jousilahti P et al. · 2024 · Integrated blood pressure control

Purpose The complex pathogenesis of hypertension, potentially involving inflammatory pathways, remains elusive. This study aimed to evaluate the relationship between 24-hour urinary sodium excretion and inflammatory cytokines alongside…

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Negative / Null Result ReportOpen accessMedicine

Accounting for Time-Varying Confounding in a Self-Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen-Related Events.

Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives

We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…

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