11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Yang Y, Li Z, Zhu Y et al. · 2025 · Diagnostic pathology
Background Triple-negative breast cancer (TNBC) is aggressive and has limited therapeutic options due to the absence of targeted therapies, highlighting the urgent need for prognostic biomarkers linked to cancer stemness and…
View details →Kobayashi S · 2025 · World journal of hepatology
Carteri et al reaffirmed the value of the Child-Turcotte-Pugh score in predicting survival in patients with cirrhosis. However, the lack of association with nutritional markers warrants careful interpretation. In cirrhosis, complex…
View details →Yigit S, Nursal AF, Celik A et al. · 2024 · Revista da Associacao Medica Brasileira (1992)
Objective Coronary artery disease is the leading cause of death worldwide. Vascular endothelial growth factor is known to induce endothelial cell migration and proliferation, increase vascular permeability, and modulate thrombogenicity.…
View details →Takanaga S, Matsumoto N, Kadowaki T et al. · 2024 · Acta medica Okayama
Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a…
View details →Yang X, Liu W, Mao Z et al. · 2026 · GigaScience
Background Preeclampsia is a severe pregnancy complication that threatens maternal and neonatal health and well-being. Previous studies on epigenome-wide association studies (EWAS) of preeclampsia produced inconsistent results in cord…
View details →Alroba R, Alfakhri A, Badreldin H et al. · 2024 · Pharmacoepidemiology and drug safety
Purpose Previous research and pharmacovigilance monitoring activities have suggested a potential association between indapamide use and rhabdomyolysis. This study aims to investigate the potential causal relationship between the use of…
View details →Barcia Aguilar C, Amengual-Gual M, Brenton JN et al. · 2024 · Seizure
Purpose Evaluate the relationship between first and second-line medication dosing and progression to refractory status epilepticus (RSE) in children. Methods This is a retrospective analysis of prospectively collected data from September…
View details →Bhushan A, Dexter F, Brindeiro C et al. · 2026 · Anesthesiology and perioperative science
Purpose Earlier, patients developed surgical site infection for 2.0% of cases without Staphylococcus aureus transmission through anesthesia work areas, 11% with S. aureus transmitted susceptible to prophylactic antibiotic, and 18% with…
View details →Khoja R, Catuna TD, Gussin GM et al. · 2026 · Infection control and hospital epidemiology
Residual chlorhexidine gluconate (CHG) skin concentrations are thought to improve disease prevention. In the Changing Lives by Eradicating Antibiotic Resistance (CLEAR) trial, posthospitalization decolonization of MRSA carriers reduced…
View details →Ramazanzadeh S, Ashtari F · 2026 · Neurology research international
Background Cognitive impairment (CI) has been reported with wide variability in neuromyelitis optica spectrum disorder (NMOSD), but its impact on patients' quality of life (QoL) is not well understood. The aim of this study was to describe…
View details →Ngoie K, Kingsburgh C, Hamiwe T et al. · 2026 · World journal of microbiology & biotechnology
This study investigated the association between plasmid diversity, antibiotic resistance and virulence genes of Staphylococcus aureus (S. aureus) isolates from private hospitals in Gauteng, South Africa. Automated antibiotic susceptibility…
View details →Mendes C, Carvalho M, Gregório J et al. · 2026 · Obesity surgery
BACKGROUND: Bariatric surgery is an effective treatment for severe obesity, resulting in significant weight loss and remission of obesity-related diseases. However, weight gain remains a challenge, potentially impacting long-term outcomes.…
View details →Smadja DM, Roux de Bezieux J, Peronino C et al. · 2025 · ASAIO journal (American Society for Artificial Internal Organs : 1992)
This study aimed to assess platelet activation following implantation of the Aeson bioprosthetic total artificial heart (A-TAH). We monitored plasma levels of platelet activation markers in patients receiving A-TAH support (n = 16)…
View details →Mathew DE, Mathews DP, Wang D et al. · 2025 · Cureus
Agitation in inpatient psychiatric units is common and is an important area for research given its impact on staff and patients. This study explores the feasibility and utility of the Dynamic Appraisal of Situational Aggression (DASA) risk…
View details →Russell MW, Maatouk CM, Kim S et al. · 2024 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
Objective This study examines associations between lipoprotein(a) (Lp[a]), a low-density-like lipoprotein, and renal vein occlusion (RVO) in US cohorts to characterize its prognostic role in the setting of RVO. Design A two-phase…
View details →Bolvig I, Kloppenborg H, Lausten M · 2025 · Child abuse & neglect
Background Previous research has shown that young people in the child protection system experience different levels of participation in decision-making on important issues. Nonetheless, researchers agree that children's participation in…
View details →de Guzman SPC, Chavez LL, Abrilla AA · 2024 · Acta medica Philippina
Objective This study aimed to identify the effects of COVID-19 pandemic on radiation treatment delays, interruptions, and cancer outcomes if any, in a Philippine tertiary hospital. Methods A retrospective observational cohort study was…
View details →Mart MF, Jones MT, Raman R et al. · 2026 · Annals of the American Thoracic Society
Rationale How rurality may influence recovery after critical illness is unknown. Objectives To examine the association between rurality and disability, cognitive function, and health-related quality of life in ICU survivors and whether it…
View details →Szczuko M, Szmigiel O, Szczuko U et al. · 2026 · Journal of clinical medicine
Background : Hashimoto's thyroiditis (HT) is the result of a complex interplay between genetic, environmental, and epigenetic factors. The role of cellular and humoral immunity in the pathogenesis of the disease is well-established.…
View details →Corrêa Matias Pereira C, Najafi Moghaddam Gilani V, Nazif-Munoz JI · 2024 · Frontiers in psychiatry
Objectives Aiming to disseminate information related to suicide prevention in Brazil, the " Setembro Amarelo " campaign has been conducted since 2015. The objective of this study is to assess the association between this campaign and…
View details →Tabara Y, Matsumoto T, Murase K et al. · 2025 · Journal of cachexia, sarcopenia and muscle
Background Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general…
View details →Dadoo S, Vieider RP, Grandberg C et al. · 2026 · Orthopaedic journal of sports medicine
Background While quadriceps tendon (QT) autograft is being increasingly utilized for primary anterior cruciate ligament reconstruction (ACLR), there remains limited evaluation of how QT autograft diameter and the ratio of graft diameter to…
View details →Koerte IK, Wiegand TLT, Bonke EM et al. · 2026 · JAMA network open
Importance Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important. Objective To…
View details →Meza-Espinoza JP, Zavala-Rubio JD, Leal-Ugarte E et al. · 2025 · BMC research notes
Objective The CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic…
View details →Fleece H, Teglasi H · 2025 · Children (Basel, Switzerland)
Background/Objectives : Behavioral inhibition (BI) has been extensively studied as an early-appearing risk factor for adverse developmental outcomes. One pathway through which BI may confer risk is via reduced competence to interact…
View details →Nehme R, Sponchiado IM, Limirio LS et al. · 2025 · Clinical nutrition ESPEN
Background & aims Muscle strength is a key predictor of both quality of life and mortality. Although numerous studies have investigated the relationship between omega-3 (ω-3) intake and muscle strength, the evidence remains inconclusive.…
View details →Petre-Mandache B, Burada E, Cucu MG et al. · 2024 · Current oncology (Toronto, Ont.)
Colorectal cancer (CRC) is a major public health problem worldwide, currently ranking third in cancer incidence and second in mortality. Multiple genes and environmental factors have been involved in the complex and multifactorial process…
View details →Duvenci Birben O, Yenibertiz D, Akkurt ES et al. · 2025 · BMC pulmonary medicine
Background/aim Pneumonia is a significant cause of morbidity and mortality within the first year after autologous hematopoietic stem cell transplantation in patients with multiple myeloma (MM), and nutritional status may influence…
View details →Sæle RG, Aslaksen PM, Svartdal F et al. · 2026 · BMC psychology
BACKGROUND: Procrastination, the tendency to delay tasks despite negative consequences, is a widespread issue linked to poor mental health and reduced daily functioning. While often attributed to self-regulation failures, the specific…
View details →Akbar M, Avdagic E, Carlos C et al. · 2024 · Journal of pediatric ophthalmology and strabismus
Purpose To evaluate for an association between systemic hypertension and intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP) treatment, due to a 2020 case report of a neonate with ROP developing systemic hypertension and…
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