11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Demcsák A, Hegyi E, Hegyi P et al. · 2025 · Pancreas
Objectives CTRB2-del, a commonly occurring loss-of-function deletion variant in the CTRB2 gene encoding chymotrypsinogen B2 was shown to induce endoplasmic reticulum (ER) stress and increase risk for pancreatic cancer but not for chronic…
View details →Gao Z, Yuan Y, Oleson JJ et al. · 2026 · Ear and hearing
Objectives This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users. Design Study…
View details →Kim HK, Jones BDM, Hahn MK et al. · 2026 · Journal of psychiatric research
Being overweight is commonly observed in patients with major depressive disorder (MDD). However, the relationship between body weight and treatment outcomes in MDD is less clear. In this context, we examined the association between BMI and…
View details →Jinchang K, Jarunratanakul P · 2025 · Body image
Expanding conceptualizations of beauty can promote positive body image and reduce appearance-related concerns. In collectivist cultures, beauty is often perceived through both appearance and inner or social qualities. This study examined…
View details →Lee M, Sulica L · 2026 · The Laryngoscope
Objectives/hypotheses To compare symptom characteristics between benign vocal fold lesions for insight into pathophysiology. Study design Cross-sectional study. Methods Adults who were diagnosed with a benign vocal fold lesion between June…
View details →Suzuki K, Sato H, Sorimachi T et al. · 2025 · Neurosurgical review
Older age and Fisher group scores predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, among aging societies, treatment indications and decisions in older patients with severe-grade aSAH (World…
View details →Xie S, Chen Q, Huang J et al. · 2025 · Translational pediatrics
Background Venous malformations (VMs) are a common congenital vascular anomaly. The long non-coding RNA (lncRNA) HOTTIP , associated with the HOXA gene cluster, modulates the expression of multiple HOXA genes, which are crucial for…
View details →Zanardo V, Polver S, Zanardo B et al. · 2025 · European journal of obstetrics, gynecology, and reproductive biology
Objective This study aimed to investigate the relationship between GWG and postpartum depressive symptoms among high income women with 'low and late fertility', combined into a single category. Methods We examined the impact of low and…
View details →Ouattara A, Adams M, Niangaly A et al. · 2026 · BMC infectious diseases
Although overall malaria incidence has decreased sharply over the past two decades, progress has stalled since 2015. The human host maintains a complex set of interactions with Plasmodium falciparum, the parasite species causing most…
View details →Brolin KA, Bäckström D, Wallenius J et al. · 2025 · Parkinsonism & related disorders
Variants in GBA1 are important genetic risk factors in Parkinson's disease (PD). GBA1 T369M has been linked to an ∼80 % increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A…
View details →Viktorsson C, Astor K · 2026 · Scientific reports
Infants’ tendency to focus on socially relevant cues is commonly referred to as ‘social attention’ and is often conceptualized as a unified construct. However, few studies have examined the concordance among measures that fall under this…
View details →Mohamed RA, Peronard Mayntz S, Møller JK et al. · 2025 · European journal of preventive cardiology
Aims This study assessed the relationship between air pollution exposure, fine particulate matter ≤2.5 µm (PM2.5) and nitrogen dioxide (NO2), and coronary calcium score (CCS) in a cohort of 60-75-year-old men from the Danish Cardiovascular…
View details →Gendron MP, El-Haouly A · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada
Introduction The majority (97.5%) of men with prostate cancer (PCa) live for at least five years after diagnosis. The health-related quality of life (HRQoL) of such men is affected by the adverse effects of treatment. Men living in remote…
View details →Park JS, Kang DH, Lee CS et al. · 2025 · Spine
Study design Retrospective study using prospectively collected data. Objective To investigate the impact of the lordosis distribution index (LDI) on proximal junctional kyphosis (PJK) and clinical outcomes in patients with degenerative…
View details →Khan KN, Fujishita A, Hiraki K et al. · 2024 · The journal of obstetrics and gynaecology research
Aim We investigated the association between the length of anogenital distance (AGD) and intra-vaginal pH, an indicator of vaginal eubiosis or dysbiosis, in women with endometriosis. Methods A prospective cohort study was performed…
View details →Hosoda KK, Shiroma KY, Lee PM et al. · 2026 · Hawai'i journal of health & social welfare
The Medical School Hotline of the University of Hawai'i John A. Burns School of Medicine was founded in 1993, by Satoru Izutu PhD (former vice-dean of UH JABSOM). It is edited by Kathleen Kihmm Connolly PhD, HJH&W Contributing Editor.…
View details →Franco D, Leite CBG, Schmidt S et al. · 2026 · The journal of knee surgery
This retrospective study investigates whether the degree of infrapatellar fat pad (IFP) fibrosis influences postoperative pain 6 months following patellofemoral arthroplasty (PFA). Furthermore, this study explores whether sex and patellar…
View details →Aziz-Ahari S, Aminian M, Rahimian A et al. · 2026 · Iranian journal of allergy, asthma, and immunology
Anti-recombinant human acid α-glucosidase (anti-rhGAA) antibody formation is a major challenge in patients with Pompe disease receiving enzyme replacement therapy (ERT). The clinical significance of these antibodies and their detection…
View details →Kardon A, Ren H, Gerard E et al. · 2026 · Neurocritical care
Background Headache is nearly ubiquitous in the immediate aftermath of nontraumatic, aneurysmal pattern subarachnoid hemorrhage (SAH); however, pain experiences vary significantly throughout the intensive care unit (ICU) course across…
View details →Itou J, Kuwasawa A, Nihei K et al. · 2026 · Archives of orthopaedic and trauma surgery
Purpose This study investigated the clinical outcomes of robotic-assisted unicompartmental knee arthroplasty (UKA) performed using a surface-matching kinematic technique that restores native joint morphology without alignment constraints.…
View details →Emiralioglu Cakır Z, Ankara Aktaş H, Gercik Arzık I et al. · 2026 · Medicina (Kaunas, Lithuania)
Backgroud and Objectives : To evaluate conventional Doppler indices and the novel middle cerebral artery (MCA) diastolic deceleration area (DDA) in pregnancies complicated by gestational diabetes mellitus (GDM), and to explore their…
View details →Polat T, Yılmaz ÖÖ, Önem Özbilen E et al. · 2025 · Genes
Background/objectives Anterior open bite is a multifact orial malocclusion influenced by genetic and environmental factors. Variants in the Collagen type I, alpha 1 ( COL1A1 ) gene, particularly rs1800012, have been implicated in bone…
View details →Presley CA, Butera NM, Krause-Steinrauf H et al. · 2025 · The science of diabetes self-management and care
PurposeThe purpose of this study is to evaluate whether higher emotional distress (depressive symptoms or diabetes distress) was associated with a lower likelihood of basal or rapid-acting insulin initiation among participants enrolled in…
View details →Marcoux V, Mondal P, Adegunsoye A et al. · 2025 · ERJ open research
Background The impact of applying different lung function reference equations and interpretation methods in fibrotic interstitial lung disease (ILD) is poorly understood. We aimed to evaluate disease severity classification, trajectories…
View details →Längle A, Reyes Del Paso GA, Ettinger U et al. · 2025 · Psychophysiology
Adult attention-deficit/hyperactivity disorder (ADHD) is associated with substantial impairments in well-being and quality of life. In addition to cognitive and behavioral symptoms, emotional dysregulation characterizes the disorder. This…
View details →Neenan A, Byrd M · 2026 · Journal of psychosocial oncology
Background There are nearly 500,000 childhood cancer survivors in the United States, and emerging evidence suggests at least 25% of these survivors have lost a peer to cancer. The current study investigated the nature of peer loss in a…
View details →Houghton JSM, Black I, Meffen A et al. · 2026 · Annals of vascular surgery
Background The wound, ischemia and foot infection (WIfI) classification system has been widely adopted in chronic limb-threatening ischemia (CLTI) management. Primary aim was to prospectively investigate the association of WIfI stage with…
View details →da Silva JC, Caetano AR, Mendonça ACDF et al. · 2025 · The journal of applied laboratory medicine
Background Exploring polymorphisms in vitamin D-related genes (VDR) within the Brazilian population provides a valuable model to contribute to the influence of the host genetic variants on chronic viral hepatitis B (CHB). Methods 126 CHB…
View details →Bergin K, Leibner L, Roger S et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective Prolactin (PRL) secretion during breastfeeding suppresses gonadotropin releasing hormone and ovulation. While PRL receptors are present in the endometrium, it is unknown whether transient rises in secretion during breastfeeding…
View details →Afaya A, Awunyo W, Udeoha MA et al. · 2026 · PloS one
Background Cervical cancer screening remains vital in the early detection of precancerous lesions and promotes better treatment outcomes. Though evidence suggested multiple sexual partners and HIV infection as risk factors for cervical…
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