11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Szczupak M, Kobak J, Krupa-Nurcek S · 2026 · Frontiers in public health
Introduction Shift work is a recognized occupational risk factor for sleep disturbances, particularly among healthcare professionals. Nurses are especially vulnerable due to irregular work schedules, night duties, and the high physical and…
View details →Zhang Q, Yang T, Li L et al. · 2026 · Neurosurgical review
Chronic internal carotid artery occlusion (CICAO) is a significant cause of ischemic cerebrovascular events, with an annual stroke risk of up to 20%. Although the long-term efficacy of hybrid surgical revascularization (HSR) versus…
View details →Aslan T, AlShamrani M, Buck B et al. · 2026 · Stroke and vascular neurology
Background Stroke rates rise steeply with age but data on tenecteplase in patients ≥80 years remain limited. This post-hoc analysis of the AcT trial compared tenecteplase with alteplase in this population. Methods The analysis included all…
View details →Khan RB, Hanzlik E, Deokumar S et al. · 2026 · Pediatric blood & cancer
Background Hodgkin lymphoma is the most common cancer in adolescence and is treated with chemotherapy and/or radiation therapy. Little is known about neurologic symptoms, signs, and morbidity in long-term survivors of childhood Hodgkin…
View details →Qureshi S, Qureshi MA, Zehra SM et al. · 2026 · BMC cancer
Background Progastricsin/Pepsinogen C (PGC) is an aspartyl endoprotease predominantly expressed by gastric fundic and chief cells, with additional expression reported in select extragastric tissues. While increased PGC expression has been…
View details →Wang S, Miao J, Tang F et al. · 2026 · BMC cardiovascular disorders
Background The recurrence rate after ablation for atrial fibrillation (AF) remains high, and the predictive performance of existing predictors is limited. Left atrial dysfunction plays a key role in the occurrence and progression of AF.…
View details →Banerjee R, Kuruvilla C, Vega GL et al. · 2026 · The American journal of cardiology
While triglyceride-rich lipoproteins and small dense low-density lipoprotein (sdLDL) are associated with accelerated coronary atherosclerosis, their relationship with peripheral artery disease (PAD) is less clear. Fifty-five male subjects…
View details →Pyne AL, Uchida AM, Carlson M et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society
Background Eosinophilic esophagitis (EoE) shares several risk factors with other autoimmune diseases, but population-based studies in this field are limited. Methods Using the Swedish nationwide histopathology cohort Epidemiology…
View details →Ding X, Wang Y, Choi M et al. · 2026 · Clinical oral implants research
Objective The objective of this study is to evaluate the clinical efficacy of angulated single-implant crowns using the hybrid retention versus pure screw-retained restorations in the aesthetic area. Materials and methods A retrospective…
View details →Yang H, Gao J, Mo S et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Objective and background The optimal surgical strategy for patients with hepatocellular carcinoma (HCC) and liver fibrosis/cirrhosis presenting with a future liver remnant to standard liver volume (FLR/SLV) ratio of 30%-40% remains a…
View details →Süleyman S, Emin P, Hüseyin A et al. · 2026 · Journal of clinical medicine
Background/Objectives: Acute severe ulcerative colitis (ASUC) is a high-risk condition associated with intense inflammation and a substantial risk of early colectomy. Intravenous steroids (IVS) remain the first-line therapy; however,…
View details →Leizaola-Cardesa IO, Gómez-Moreno G, Hernando J et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery
Background To determine serum parathyroid hormone (PTH), vitamin D, and calcium levels in patients with medication related osteonecrosis of the jaw (MRONJ), compared with patients receiving similar medication but without MRONJ; also, to…
View details →Darroudi S, Ghazaee H, Babaei N et al. · 2026 · Scientific reports
Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has demonstrated cardioprotective effects beyond glycemic control. Empagliflozin has anti-inflammatory and antioxidant effects in long-term administration; however, current…
View details →Eslami M, Ermolaev N, Kronberger C et al. · 2026 · Scientific reports
Fibroblast growth factor 23 (FGF23), a bone-derived hormone, is emerging as a potential biomarker in cardiovascular disease. However, its role in transthyretin amyloid cardiomyopathy (ATTR-CM), a progressive infiltrative cardiomyopathy,…
View details →Marković F, Bojić Z, Stjepanović M et al. · 2026 · Cancers
Background: Immune checkpoint inhibitor monotherapy targeting the PD-1/PD-L1 axis is a standard first-line treatment option for patients with metastatic non-small cell lung cancer (NSCLC) and high PD-L1 expression. However, comparative…
View details →Chow SCW, Wang Y, Leung OLK et al. · 2026 · Journal of autism and developmental disorders
Purpose This study investigated the risk of ASD and ADHD in children who have survived hypoxic-ischemic encephalopathy (HIE), one of the common conditions during birth resulting in neonatal brain injury. Methods A population-based cohort…
View details →Çakır B, Polat F, Karataş MB et al. · 2026 · Acta diabetologica
Background Diabetic cardiomyopathy (DCM) frequently begins with diastolic dysfunction (DD), which leads to increased left ventricular filling pressures and subsequent left atrial enlargement, quantified by the left atrial volume index…
View details →García-Sáenz MR, Castro-Murillo JI, Mercado M et al. · 2026 · Archives of medical research
Introduction Predicting resistance to cabergoline in prolactinomas remains a challenge. While prolactin (PRL)-based ratios help differentiate prolactinomas from non-functioning pituitary adenomas (NFPAs), their role in forecasting…
View details →Aydın Güçlü Ö, Demirdöğen E, Hunutlu FÇ et al. · 2026 · BMC infectious diseases
Background Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality among immunocompromised patients, particularly those with hematologic malignancies. The present study aims to evaluate the clinical features,…
View details →Lee A, Higgins S, O'Driscoll D et al. · 2026 · Journal of autism and developmental disorders
OBJECTIVE: To examine the association between neonatal jaundice requiring hospital treatment and autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in offspring by age 14 years. METHODS: We used data from…
View details →Lan H, Ding Y, Liu M · 2026 · American journal of cancer research
Background Patients with high-risk diffuse large B-cell lymphoma (DLBCL) have poor prognoses, and the comparative efficacy between R-CHOP and R-DA-EPOCH regimens remains controversial. Objective To compare the efficacy and safety of R-CHOP…
View details →Yadav D, Ghuman NK, Kathuria P et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Objective To study the effect of intrauterine instillation of Hyaluronan enriched media on reproductive outcomes of intrauterine insemination treatment. Design and participants 100 couples with unexplained infertility were approached and…
View details →Losiewicz S, Collis B, El-Dalati S et al. · 2026 · Open forum infectious diseases
This single-center retrospective study evaluated 218 patients with injection drug use-associated infective endocarditis, 169 of whom received medications for opioid use disorder (MOUD). Initiation of MOUD was associated with a…
View details →Premkumar A, Arellano E, Heo KY et al. · 2026 · The Journal of arthroplasty
Background The use of short-term postoperative corticosteroid regimens has been reported to improve pain control and decrease opioid consumption following total knee arthroplasty (TKA). The purpose of this study was to evaluate the effect…
View details →Altavilla S, Di Pietro N, Loconsole D et al. · 2026 · Antibiotics (Basel, Switzerland)
Background Carbapenem-resistant Enterobacterales (CRE) require early identification and appropriate patient placement to prevent in-hospital transmission. Bed Management plays a key organizational role in coordinating screening results and…
View details →Zhang Y, Zhao J, Gao Q et al. · 2026 · Virchows Archiv : an international journal of pathology
Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25-30% of non-small cell lung cancer (NSCLC) patients. Pooled analyses in previous research have largely focused on the prognostic and predictive value of overall or…
View details →Yan L, Yin H, Shi L et al. · 2026 · Drug design, development and therapy
Purpose To evaluate the efficacy and safety of PHPV in the treatment of persistent high-risk papillomavirus (hrHPV) infection of the cervix. Patients and methods A randomized controlled trial (RCT) was conducted on patients with persistent…
View details →Guan J, Chen Y, Ye J et al. · 2026 · Annali italiani di chirurgia
Aim Rotator cuff tears and long head of the biceps tendon (LHBT) injuries are primary causes of shoulder pain. During rotator cuff repair, concurrent LHBT injuries are frequently identified. Surgical management of LHBT injuries can…
View details →Phyo AP, Hoglund RM, Saito M et al. · 2026 · Tropical medicine & international health : TM & IH
Background HIV co-infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first-line anti-TB drugs and clinical outcomes in patients with and without HIV co-infection.…
View details →Nicklas A, Bienger K, Rudari M et al. · 2026 · Burns : journal of the International Society for Burn Injuries
Background Split-thickness skin grafting (STSG) remains the standard for deep second-degree burns, but grafted skin often shows suboptimal biomechanical properties. The dermal substitute MatriDerm® may improve elasticity, structural…
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