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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Enhanced serodiagnosis of opisthorchiasis using a multi-epitope dot-ELISA: comparative evaluation of visual and imageJ-assisted analysis of IgG and IgM responses.

Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases

Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…

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Negative / Null Result ReportOpen accessMedicine

Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: A Phase II Study.

Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine

Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…

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Negative / Null Result ReportMedicine

Phase 2 Single-arm Trial of Primary Retroperitoneal Lymph Node Dissection in Patients with Seminomatous Testicular Germ Cell Tumors with Clinical Stage IIA/B (PRIMETEST).

Hiester A, Che Y, Lusch A et al. · 2023 · European urology

Background Primary retroperitoneal lymph node dissection (RPLND) for clinical stage (CS) IIA/B seminoma without adjuvant treatment is an experimental treatment to avoid radiotherapy- or chemotherapy-related toxicity from standard…

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Negative / Null Result ReportMedicine

No evidence of influenza A virus infection in marine mammals stranded in Basque Country coast (Northern Spain) in the context of H5N1 clade 2.3.4.4b expansion.

López-Morales A, Benito D, Gerrikagoitia X et al. · 2026 · Canadian journal of microbiology

Influenza A infection is frequently detected in marine mammals causing mortality events of different magnitude. In recent years, the highly pathogenic avian influenza (HPAI) H5N1 virus (clade 2.3.4.4b) has been rapidly expanding and…

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Negative / Null Result ReportMedicine

Unmet HIV and STI Prevention Needs and Limited Linkage to Care Among Gay, Bisexual, and Other Men Who Have Sex with Men in Southern Spain: A Community-Based Intervention Study.

Corma-Gómez A, Santos M, Martín-Carmona J et al. · 2026 · AIDS patient care and STDs

To evaluate the proportion of gay, bisexual, and other men who have sex with men (GBMSM) with ongoing high-risk sexual practices not engaged in care, and to assess linkage to and retention in care following a community-based intervention.…

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Negative / Null Result ReportOpen accessMedicine

Machine says go, doctor says no: an ecological momentary assessment analysis examining clinicians' perceptions of, and their antibiotic prescribing behaviour when using rapid molecular diagnostic tests in intensive care.

Stewart SF, Enne VI, Pandolfo AM et al. · 2026 · Antimicrobial resistance and infection control

Background Rapid molecular diagnostics such as the BioFire FilmArray Pneumonia Panel (the Pneumonia Panel) can improve antibiotic stewardship by supporting doctors to make more targeted antibiotic prescribing decisions faster compared to…

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Negative / Null Result ReportMedicine

Evaluating causal links between retinal thickness, Alzheimer's disease, and circulating total-tau: evidence from Mendelian randomization and colocalization analysis.

Sheng D, Wang S, Xiao Z et al. · 2026 · European archives of psychiatry and clinical neuroscience

BACKGROUND: Observational studies have reported associations between retinal thickness and Alzheimer’s disease (AD); however, the causal relationship remains uncertain. OBJECTIVE: To investigate the potential causal relationships between…

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Negative / Null Result ReportMedicine

Innovation in Personal Protective Equipment Decontamination During the COVID-19 Pandemic: The Powered-Air Purifying Respirator Hood Optimal Decontaminant Distribution System.

Schwartz A, Mikati S, Knipper F et al. · 2025 · Applied biosafety : journal of the American Biological Safety Association

Background The COVID-19 pandemic highlighted critical shortages in personal protective equipment (PPE), particularly respirators, which limited healthcare workers' safety worldwide. Decontamination and reuse of PPE, including powered-air…

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Negative / Null Result ReportOpen accessMedicine

The accuracy of recording malaria rapid diagnostic test (RDT) results in public health facilities in Benin; results from the MaCRA project.

Ahogni I, Avanon H, Hueha C et al. · 2026 · Malaria journal

Background Accurate interpretation and recording of malaria rapid diagnostic tests (RDTs) are critical for case management and surveillance in malaria-endemic settings. In Benin, where over 90% of malaria diagnoses rely on RDTs, concerns…

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Negative / Null Result ReportMedicine

Performance of five mpox antigen-based rapid diagnostic tests tested on lesion swabs from patients with suspected mpox from the Kinshasa province of DR Congo: a diagnostic accuracy study.

Kavunga-Membo H, Chi HF, Emperador DM et al. · 2026 · The Lancet. Infectious diseases

Background Mpox has spread to 36 countries in Africa, yet many face challenges achieving nationwide PCR-based testing due to cost and limited access in remote and rural areas. Point-of-care antigen-based rapid diagnostic tests (RDTs) might…

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Negative / Null Result ReportOpen accessMedicine

Hit-and-run hypothesis: revisiting the impact of EBV in malignancies.

Mangiaterra T, Chabay P, Bellan C et al. · 2026 · Frontiers in immunology

Epstein-Barr virus (EBV) infects more than 90% of the global population and is etiologically linked to a wide spectrum of lymphoid and epithelial malignancies. Although its role as an oncogenic virus is well established, the mechanisms…

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Negative / Null Result ReportOpen accessMedicine

Assessing the Effectiveness of the Human Immunodeficiency Virus Point-of-Care Proficiency Testing Scheme: Analysis of the Data From 2021 to 2022 in South Africa.

Blasich NP, Adelekan AM · 2026 · Health science reports

Background Point-of-care rapid diagnostic testing plays a critical role in HIV detection and timely linkage to care, particularly in decentralized healthcare settings. To support testing reliability, the National Health Laboratory Service…

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Negative / Null Result ReportOpen accessMedicine

Clinical Relevance and Methodological Comparison of Anti-MDA5 Antibody Detection: A Five-Year Retrospective and Exploratory Pilot Study.

Mogyoróssy S, Nagy G, Griger Z et al. · 2026 · Biomolecules

Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibodies are critical biomarkers in myositis, associated with distinct clinical features and prognosis. This study aimed to evaluate the proportion of anti-MDA5 positivity and…

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Negative / Null Result ReportOpen accessMedicine

Diagnostic Accuracy of Blood Cytology and Conventional PCR Using Universal Primers for Detecting Haemoplasma Infection in Cats and Pigs of Thailand.

Thongmeesee K, Aung A, Bui TTH et al. · 2026 · Veterinary medicine and science

Background Haemoplasma (haemotropic Mycoplasma sp.) is an aetiological agent of infectious anaemia in several mammals, including cats and pigs. Blood cytology lacks sensitivity for detecting this infection, and information regarding its…

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Negative / Null Result ReportMedicine

[Diagnostic value of whole exome sequencing for fetuses undergone induced labor due to structural abnormalities].

Cao Y, Wang L, Wang R et al. · 2025 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To assess the diagnostic value of whole exome sequencing (WES) for fetuses undergone induced abortion due to structural abnormalities. Methods A retrospective analysis was carried out on 43 aborted fetuses with negative results…

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Negative / Null Result ReportMedicine

Managing demand for the direct antiglobulin test with a big data-derived predictive equation.

Ceacero-Marín D, Puig-Pey Comas I, Nieto-Moragas J et al. · 2026 · Scandinavian journal of clinical and laboratory investigation

Background The direct antiglobulin test (DAT) is a key diagnostic tool in evaluating autoimmune haemolytic anaemia. However, indiscriminately ordering this test, together with certain methodological limitations, can compromise the…

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Negative / Null Result ReportMedicine

Discovery of IS1515 transposition into the Spn9802 fragment of Streptococcus pneumoniae and its implications for PCR-based diagnostic assays.

Toorop MMA, Kraakman MEM, Claas ECJ et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

This study investigates a diagnostic challenge in detecting Streptococcus pneumoniae using a Spn9802-targeted PCR assay. Four S. pneumoniae isolates tested lytA-positive but Spn9802-negative due to an insertion sequence (IS1515) within…

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Negative / Null Result ReportOpen accessMedicine

Campylobacter Fetus Periprosthetic Joint Infection: A Case Report and Review of Literature from the Past Three Decades.

Hunkár A, Prinz G, Pongrácz J et al. · 2026 · Journal of orthopaedic case reports

Introduction Periprosthetic joint infection (PJI) is a serious complication following total joint arthroplasty. It can be potentially limb- or life-threatening, often necessitating complex surgical intervention and prolonged antimicrobial…

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Negative / Null Result ReportOpen accessMedicine

Letter to the Editor: Three questions to be answered when evaluating a super obese patient for urgent liver transplant.

Baggio L, Gianni S, De Carlis R et al. · 2026 · World journal of transplantation

We read with interest the study by Cigrowsky et al published in the World Journal of Transplantation . Obesity is a common and serious health issue worldwide. Its incidence has been rapidly and continuously increasing. Obesity causes…

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Negative / Null Result ReportOpen accessMedicine

Treatment of posttraumatic stress disorder (PTSD).

Bandelow B · 2026 · Dialogues in clinical neuroscience

The present review summarises recommendations for the management of posttraumatic stress disorder (PTSD) based on a consensus among international experts in the field.Cognitive-behavioural therapy (CBT) has the best evidence base as a…

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