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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Results from a Phase 2 Study of Induction Docetaxel and Carboplatin Followed by Maintenance Rucaparib in the Treatment of Patients with Metastatic Castration-resistant Prostate Cancer with DNA Homologous Recombination Repair Deficiency.

Raychaudhuri R, Cheng HH, Gulati R et al. · 2026 · European urology oncology

Background and objective Our aim was to determine whether induction chemotherapy followed by PARP inhibitor (PARPi) maintenance improves outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC) harboring…

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Negative / Null Result ReportMedicine

Early worsening of diabetic retinopathy after simultaneous pancreas and kidney transplantation-Myth or reality?

Voglová B, Hladíková Z, Nemétová L et al. · 2020 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Early worsening of diabetic retinopathy due to sudden glucose normalization is a feared complication of pancreas transplantation; however, its rate or severity has not been studied prospectively. We followed up 43 pancreas and kidney…

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Negative / Null Result ReportOpen accessMedicine

Final report on North Central Cancer Treatment Group N0877 (alliance): A phase II randomized, placebo-controlled trial of chemoradiotherapy with or without dasatinib for glioblastoma.

Breen WG, Dixon JG, Anderson SK et al. · 2025 · Neuro-oncology

Background Dasatinib is an oral inhibitor of the Src kinase family, with preclinical data indicating impact on gliomagenesis, tumor invasion, and radiosensitivity. Methods North Central Cancer Treatment Group N0877 is a phase 1 dose…

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Negative / Null Result ReportMedicine

Results of TRIO-15, a multicenter, open-label, phase II study of the efficacy and safety of ganitumab in patients with recurrent platinum-sensitive ovarian cancer.

Davidson TM, Lebreton CL, Hendricksen AEW et al. · 2023 · Gynecologic oncology

Background IGF signaling has been implicated in the pathogenesis and progression of ovarian carcinoma (OC). Single agent activity and safety of ganitumab (AMG 479), a fully human monoclonal antibody against IGF1R that blocks binding of…

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Negative / Null Result ReportMedicine

Phase II Study of Palbociclib in Patients with Tumors with CDK4 or CDK6 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1C.

O'Hara MH, Jegede O, Dickson MA et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose Amplification of cyclin-dependent kinase 4 (CDK4) and CDK6 is a feature of a variety of malignancies, and preclinical evidence suggests that inhibition of CDK4/6 is a plausible treatment strategy in these tumors. Subprotocol Z1C of…

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Negative / Null Result ReportMedicine

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.

Bateman RJ, Li Y, McDade EM et al. · 2025 · The Lancet. Neurology

Background Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for delaying the onset of clinical symptoms in asymptomatic people is unknown. The…

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Negative / Null Result ReportOpen accessMedicine

Medium-term oncological outcomes of totally laparoscopic colectomy with intracorporeal anastomosis for right-sided and left-sided colon cancer: propensity score matching analysis.

Hamamoto H, Suzuki Y, Takano Y et al. · 2022 · BMC surgery

Background This retrospective study aimed to compare long-term oncological outcomes between laparoscopic-assisted colectomy (LAC) with extracorporeal anastomosis (EA) and totally laparoscopic colectomy (TLC) with intracorporeal anastomosis…

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Negative / Null Result ReportOpen accessMedicine

The role of hemostatic markers as venous stenosis or occlusion predictors following first transvenous cardiac device implantation.

Cacko A, Kozyra-Pydyś E, Gawałko M et al. · 2021 · Cardiology journal

Background Among patients with an implanted cardiac implantable electronic device (CIED), ipsilateral upper extremity vein stenosis or occlusion (VSO) is observed more frequently than in the general population. However, there are no data…

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Negative / Null Result ReportMedicine

Tivozanib plus nivolumab versus tivozanib monotherapy in patients with renal cell carcinoma following an immune checkpoint inhibitor: results of the phase 3 TiNivo-2 Study.

Choueiri TK, Albiges L, Barthélémy P et al. · 2024 · Lancet (London, England)

Background Immune checkpoint inhibitors (ICIs) and vascular endothelial growth factor receptor tyrosine kinase inhibitors are cornerstones of first-line treatment for advanced renal cell carcinoma; however, optimal treatment sequencing…

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Negative / Null Result ReportOpen accessMedicine

Prognostic significance of para-aortic node metastasis in endometrial cancer: Japanese Gynecologic Oncology Group Study JGOG2043 post hoc analysis.

Konno Y, Mayama M, Takehara K et al. · 2025 · Journal of gynecologic oncology

Objective This study aimed to assess the prognostic significance of para-aortic lymphadenectomy (PALX) and para-aortic lymph node metastasis in endometrial cancer (EC) patients at risk of post-operative recurrence. Methods Japanese…

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Negative / Null Result ReportMedicine

Immediate-release/extended-release amantadine (OS320) to treat Parkinson's disease with levodopa-induced dyskinesia: Analysis of the randomized, controlled ALLAY-LID studies.

Rascol O, Tönges L, deVries T et al. · 2022 · Parkinsonism & related disorders

Background Immediate-release (IR) amantadine has been used for treatment of levodopa induced dyskinesia (LID). The immediate-release/extended-release (IR/ER) amantadine formulation OS320 (OSMOLEX ER®) contains an IR outer layer and ER core…

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Negative / Null Result ReportMedicine

EXPRESS: Lack of Association Between Inner Ear FLAIR Suppression on MRI and Laterality of Clinical Signs in Feline Idiopathic Vestibular Syndrome.

Putzer M, De Decker S, Gutierrez Quintana R et al. · 2026 · Journal of feline medicine and surgery

ObjectivesThe underlying aetiology of feline idiopathic vestibular syndrome (IVS) remains unclear. In humans, specific magnetic resonance imaging (MRI) sequences are used to demonstrate differences in endolymph composition between…

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Negative / Null Result ReportMedicine

Lack of association between donor left ventricular hypertrophy and graft survival in the contemporary era of heart transplantation.

Mahar JH, Wayda B, Weng Y et al. · 2026 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Donor heart left ventricular hypertrophy (LVH) is a common reason for organ discard in the United States, despite limited contemporary data on its impact on transplant outcomes. Using Scientific Registry of Transplant Recipients data…

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Negative / Null Result ReportMedicine

Lack of association between cytomegalovirus infection and liver fibrosis in patients with biliary atresia after the Kasai procedure.

Lucas A, Novebri NA, Heros PAI et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Background Biliary atresia (BA) is a serious condition and the leading cause for liver transplantation in children. The exact cause for BA is currently unknown, with one suggested mechanism being a viral infection. Cytomegalovirus (CMV) is…

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Negative / Null Result ReportMedicine

The role of IgM anti-acetylated protein antibodies and B cells in the origin of anti-modified protein autoimmunity in rheumatoid arthritis.

Athanasiadou A, Kroos S, van de Wetering R et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)

Objective Rheumatoid arthritis (RA) is characterized by anti-modified protein antibodies (AMPAs), including anti-citrullinated (ACPA), anti-carbamylated (anti-CarP), and anti-acetylated (AAPA) protein antibodies. In contrast to other…

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Negative / Null Result ReportMedicine

Circulating GPER-1, 8-Iso-Prostaglandin F<sub>2</sub>α, and Raftlin-1 in Hypertensive Women During the Menopausal Transition: Associations with BMI and Diagnostic Performance.

Öztürk Ü, Üremiş MM, Kurutaş EB · 2026 · Journal of clinical medicine

Background: Hypertension (HTN) is a multifactorial condition involving alterations in vascular signaling, inflammation, and oxidative stress. Women during the menopausal transition may experience increased cardiovascular risk due to…

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Negative / Null Result ReportMedicine

Mobility measures and waking-day movement behaviour composition among older adults: a compositional data analysis of the McMaster Monitoring My Mobility study.

Hakimi S, Kirkwood R, Phillips SM et al. · 2026 · The international journal of behavioral nutrition and physical activity

Background Mobility is a cornerstone of healthy ageing typically assessed using self-report and performance-based measures. Recent research suggests these measures are poor proxies for real-world mobility. Device-derived measures of…

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Negative / Null Result ReportMedicine

Lipoprotein(a) levels and common LPA gene variants in patients with chronic coronary syndrome: Genetic determinants and clinical associations.

Gómez-Barrado JJ, Porras-Ramos Y, Romero-Castro MJ et al. · 2026 · Journal of clinical lipidology

Background Despite optimal lipoprotein cholesterol control, patients with chronic coronary syndrome (CCS) exhibit substantial residual cardiovascular risk. Lipoprotein(a) (Lp[a]) is an independent cardiovascular risk factor, primarily…

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