11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
He JD, Parker JD · 2023 · British journal of clinical pharmacology
Aims To mediate its pharmacodynamic effects, glyceryl trinitrate (GTN) requires bioactivation, by which it releases nitric oxide or a nitric oxide moiety. The exact mechanism of GTN bioactivation remains uncertain. Mitochondrial aldehyde…
View details →Alizo Vera V, Childs JE, Kim J et al. · 2025 · eNeuro
Histone deacetylase 3 (HDAC3) is one of the most highly expressed HDACs in the brain shown to be a negative regulator of long-term memory formation. HDAC3 has also been shown to be involved in cocaine-associated behaviors, demonstrated by…
View details →Sabino-Carvalho JL, Li S, Mekonnen E et al. · 2025 · Medicine and science in sports and exercise
Purpose Parasympathetic reactivation is essential for the rapid decrease in heart rate following exercise and delayed heart rate recovery (HRR) post-exercise is linked to poor clinical outcomes. Chronic kidney disease (CKD) is associated…
View details →Volpe LJ, Zugelder M, Kotarinos R et al. · 2023 · Urogynecology (Philadelphia, Pa.)
Importance Although pelvic floor physical therapy (PFPT) is effective in treating high-tone pelvic floor dysfunction (HTPFD), data on the mechanism of improvement are limited. Objectives This study aimed to compare squeeze intravaginal…
View details →Domin M, Lindenberg R, Lotze M · 2025 · Scientific reports
Evaluating the integrity of the corticospinal tract at the height of the posterior limb of the internal capsule with a lateralization index has been applied to predict upper limb motor recovery after stroke in numerous diffusion tensor…
View details →Lind CM, Agugliaro J, Ortega J et al. · 2024 · The Journal of experimental biology
Disease may be both a cause and a consequence of stress, and physiological responses to infectious disease may involve stress coping mechanisms that have important fitness consequences. For example, glucocorticoid and glycemic responses…
View details →Bogon J, Jagorska C, Steinecker I et al. · 2024 · Acta psychologica
The perception of time is subject to various environmental influences and exhibits changes across the lifespan. Studies on time perception have often been conducted using abstract stimuli and artificial scenarios, and recent claims for…
View details →Smith A, Lin PD, Rifas-Shiman SL et al. · 2026 · Environmental epidemiology (Philadelphia, Pa.)
Background Per- and polyfluoroalkyl substances (PFAS) and nonessential metals impair immune responses, while essential metals promote immune maintenance. We evaluated associations of childhood PFAS and metal mixtures with measles, mumps,…
View details →Porto IM, do Amaral JV, Pacheco JPG et al. · 2025 · European child & adolescent psychiatry
Many countries implement double-shift schooling systems, offering morning or afternoon shifts. Given attention-deficit/hyperactivity disorder (ADHD) is associated with circadian preference for eveningness, this study hypothesised that…
View details →Vervaecke AJ, Thery C, Housset V et al. · 2026 · JSES international
Background Glenoid concavity plays a critical role in shoulder stability via the concavity-compression mechanism. While the bony glenoid concavity, quantified by the bony shoulder stability ratio (BSSR), is a known determinant of…
View details →LaRosa S, Moore K, Harshaw N et al. · 2024 · The Journal of surgical research
Introduction Trauma bay and emergency department (ED) length of stay (LOS) are important time measures in patient care. The data on this subject are inconclusive or specific to one condition. Our goal was to determine the relationship…
View details →Jacob J, Hesling-Fox J, Yamada M et al. · 2026 · Clinical neurophysiology practice
Objective Stroke survivors often show slower, uncoordinated bimanual performance. This study examined the effects of a single session of bimanual task practice on performance, coordination, motor corticospinal excitability (CSE), and…
View details →Liu HZ, Khanna V, Ayeni OR et al. · 2025 · Cureus
Background Adipose-derived stem cells (ADSCs) hold therapeutic potential for the treatment of orthopedic conditions. However, no surveys to date have evaluated physicians' awareness and receptiveness toward these therapies - an essential…
View details →Attaway CA, Brown TC, McCall MA et al. · 2026 · Investigative ophthalmology & visual science
Purpose Retinitis pigmentosa (RP) causes retinal degeneration and the progressive loss of vision. Here, we evaluated whether enhancing experience-dependent plasticity prolongs vision in a mouse genetic model of autosomal dominant RP.…
View details →Menut A, Brysbaert M, Casalis S · 2024 · Quarterly journal of experimental psychology (2006)
Previous research has shown that languages from nearby families are easier to learn as second languages (L2) than languages from more distant families, attributing this difference to the presence of shared elements between the native…
View details →Papastefan ST, Bian Y, Singh M et al. · 2024 · Prenatal diagnosis
Objective The objective of this study was to evaluate whether patient-level neighborhood deprivation index (NDI) was associated with termination of pregnancy consideration and completion in patients presenting with fetal myelomeningocele.…
View details →Hsiao CC, Chou CY, Fang JT et al. · 2024 · Kidney & blood pressure research
Introduction Disparities in physical fitness between immediately before dialysis (pre-D) and the day following dialysis (non-D) have not been investigated despite potential adverse factors such as fluid status, uremia, and electrolyte…
View details →Motka F, Tan H, Vollstädt-Klein S et al. · 2026 · Scientific reports
Approach bias modification (ApBM), a computerized training designed to retrain involuntary approach action tendencies toward drug-related cues, has been shown to reduce relapse rates when added to treatment-as-usual (TAU) in alcohol use…
View details →Liu Y, Olivers C, Van Lange PAM · 2024 · Cognition & emotion
How may feelings of love and hate impact people's attention? We used a modified Attentional Blink (AB) task in which 300 participants were asked to categorise a name representing a person towards whom they felt either hate, love, or…
View details →Sheena-Peer L, Rafaeli E, Berenson KR et al. · 2025 · Personality disorders
Emptiness is central to borderline personality disorder (BPD), significantly impacts quality of life, and is associated with increased impulsivity. Nevertheless, studies of emptiness in daily life are scarce and little is known about…
View details →O'Donoghue AC, Aikin KJ, Amoozegar JB et al. · 2025 · Journal of the American Board of Family Medicine : JABFM
Purpose Exhibit hall booths at medical conferences are a key avenue for promoting prescription drugs to health care providers (HCPs). Because HCPs spend considerable time interacting with industry representatives at conferences, we…
View details →Clark D, Kikut-Stein A, Jesch E et al. · 2024 · Journal of health communication
Public health communication campaign planners must carefully consider whether misinformation beliefs are important to target and, ideally, correct. Guided by the reasoned action approach, we hypothesized that behavior-specific beliefs…
View details →Grunewald K, Andrews JL, Schweizer S · 2026 · Child development
Little is known about how social network associations are tracked in cognition during adolescence, when social networks change in size and complexity. In 2023, 123 ethnically diverse adolescents and emerging adults (13-24 years; 52.9%…
View details →Lewis MN, Feola N, Watson K et al. · 2025 · PRiMER (Leawood, Kan.)
Introduction Poster displays are commonly used to present scholarly activity. Most current research evaluates posters' visual appeal. Isolated studies looking at knowledge transfer have evaluated standalone posters. The innovation of…
View details →Foster K, Anholm JD, Foster G et al. · 2025 · High altitude medicine & biology
Foster, Katharine, James D. Anholm, Gary Foster, Suman Thapamagar, and Prajan Subedi. Effects of naltrexone on sleep quality and periodic breathing at high altitude. High Alt Med Biol. 26:13-19, 2025. Objective: This study examined the…
View details →Curtis JA, Beam AB, Nam J et al. · 2025 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)
Introduction Breath-holding maneuvers are frequently used to improve airway closure and swallowing safety in people with dysphagia. While their effects on airway closure have been studied in healthy adults, little is known about their…
View details →Shirzad A, Frewen N, Morava A et al. · 2026 · PloS one
Mental fatigue negatively affects the productivity and health of the general population. Mental fatigue manifests following sustained mental activity and is defined by subjective feelings of inhibition and objective decrements in mental…
View details →Wang J, Fu H, Feng X et al. · 2025 · PloS one
In this study, we explored whether nightmare distress mediated the correlation between autobiographical memory specificity and depression. 112 participants provided their most recent dreams that happened within one month, and finished some…
View details →Habersack A, Kruse A, Guggenberger B et al. · 2026 · Children (Basel, Switzerland)
Background/Objectives: Children with cerebral palsy (CP) often develop altered muscle architecture and calf muscle contractures. Orthotic immobilization aims to provide prolonged stretch to lengthen the muscle belly and muscle-tendon unit…
View details →LaRosa SK, Stone XA, Fenninger AA et al. · 2024 · The American surgeon
Background Arriving during "off hours" to the hospital can put patients at greater risk of complications or mortality given lesser staff. Our goal was to investigate this in trauma patients with an Injury Severity Score (ISS) of >15. We…
View details →