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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Circulating GPER-1, 8-Iso-Prostaglandin F<sub>2</sub>α, and Raftlin-1 in Hypertensive Women During the Menopausal Transition: Associations with BMI and Diagnostic Performance.

Öztürk Ü, Üremiş MM, Kurutaş EB · 2026 · Journal of clinical medicine

Background: Hypertension (HTN) is a multifactorial condition involving alterations in vascular signaling, inflammation, and oxidative stress. Women during the menopausal transition may experience increased cardiovascular risk due to…

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Negative / Null Result ReportMedicine

Mobility measures and waking-day movement behaviour composition among older adults: a compositional data analysis of the McMaster Monitoring My Mobility study.

Hakimi S, Kirkwood R, Phillips SM et al. · 2026 · The international journal of behavioral nutrition and physical activity

Background Mobility is a cornerstone of healthy ageing typically assessed using self-report and performance-based measures. Recent research suggests these measures are poor proxies for real-world mobility. Device-derived measures of…

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Negative / Null Result ReportMedicine

Lipoprotein(a) levels and common LPA gene variants in patients with chronic coronary syndrome: Genetic determinants and clinical associations.

Gómez-Barrado JJ, Porras-Ramos Y, Romero-Castro MJ et al. · 2026 · Journal of clinical lipidology

Background Despite optimal lipoprotein cholesterol control, patients with chronic coronary syndrome (CCS) exhibit substantial residual cardiovascular risk. Lipoprotein(a) (Lp[a]) is an independent cardiovascular risk factor, primarily…

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Negative / Null Result ReportMedicine

Semiautomatic analysis of retinal ischemia using widefield OCTA in patients with diabetes mellitus with or without diabetic retinopathy.

Lisa T, Maria CA, Luca BB et al. · 2026 · European journal of ophthalmology

PurposeThis study assessed retinal non-perfusion areas (RNPAs) and vascular density (VD) in the superficial (SCP) and deep (DCP) capillary plexuses of diabetic patients across three stages of diabetic retinopathy (DR): no DR (stage 0),…

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Negative / Null Result ReportMedicine

The Lack of Association of Infant Gender with Postpartum Depression and Breastfeeding Duration.

Akkurt B, Bülez A · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

Objective: This study aimed to investigate the association between infant gender and both postpartum depression and breastfeeding duration at multiple time points during the postpartum period. Methods: A prospective longitudinal study was…

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Negative / Null Result ReportOpen accessMedicine

Three-Dimensional Speckle-Tracking Echocardiography-Derived Left Ventricular Volumes Show No Associations with Mitral Annular Plane Systolic Excursion in Healthy Adults (Findings from the MAGYAR-Healthy Study).

Nemes A, Ambrus N, Lengyel C · 2026 · Journal of clinical medicine

Introduction. Left ventricular (LV) function can be characterized by numerous parameters, the most well-known being the ejection fraction (EF), derived from LV end-systolic and end-diastolic volumes (ESV and EDV, respectively) throughout…

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Negative / Null Result ReportMedicine

Heart Rate Variability and Perceived Stress in Normal-Weight Female University Students: The Role of Physical Activity Level.

Santiago MV, Olmedillas H, Sáinz J et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress

Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual…

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Negative / Null Result ReportMedicine

Lack of association between Helicobacter pylori and pediatric atopy: Evidence from a Latin American multicenter cohort.

Gil P, Rojo C, Martín ML et al. · 2026 · Journal of pediatric gastroenterology and nutrition

Objectives Owing to the regulatory effect of the immune response associated with Helicobacter pylori (H. pylori) a protective role for this infection in the development of atopic conditions in children has been postulated. We aim to study…

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Negative / Null Result ReportMedicine

Spatial Association between Air Pollution and Non-communicable Diseases and their Distribution in India.

Sharma AK, Huda RK, Alam SP et al. · 2026 · Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

Background Non-communicable diseases (NCDs) are the fastest-growing global health burden, and air pollution is a major threat to human health. Growing evidence suggests that air pollution especially PM 2.5 is associated with diabetes…

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Negative / Null Result ReportMedicine

Quantitative assessments of ultrasound-based rotator cuff muscle quality.

Nasr AJ, Wang H, Khazzam M et al. · 2026 · PM & R : the journal of injury, function, and rehabilitation

Background Fatty infiltration and muscle atrophy strongly influence clinical outcomes in patients with rotator cuff tears. Emerging quantitative techniques integrated with brightness-mode ultrasound and shear wave elastography (SWE) have…

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Negative / Null Result ReportOpen accessMedicine

Lack of association between G6PD variants and Parkinson disease.

Chifamba LV, Parlar SC, Liu L et al. · 2026 · HGG advances

Oxidative stress has been implicated in Parkinson disease (PD). Genes involved in PD, such as PRKN, PINK1, and PARK7, contribute to oxidative stress in dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate dehydrogenase,…

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Negative / Null Result ReportOpen accessMedicine

Optimal duration of neoadjuvant chemotherapy prior to CRS ± HIPEC for colorectal cancer: An assessment of survival and postoperative outcomes.

Bennett FJ, Oppat KM, Zaidi MY et al. · 2026 · Surgical oncology insight

Background Cytoreductive surgery (CRS) with or without heated intraperitoneal chemotherapy (HIPEC) represents a viable therapy for select patients with colorectal cancer (CRC) peritoneal metastases. Given recurrence rates, challenges…

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Negative / Null Result ReportOpen accessMedicine

Weight and sleep health in OSA: exploring their link.

Beatty CJ, Landry SA, Mann DL et al. · 2026 · Frontiers in sleep

Objectives Weight loss is often recommended for individuals with obesity and OSA, however, weight loss is particularly hard for this population. This study investigates how weight and weight change are associated with sleep health in…

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Negative / Null Result ReportMedicine

Unveiling connections: bisphenol A and vitamin D dynamics in breast milk among healthy lactating mothers.

Cinkilli Aktağ E, Yalçin SS, Yіrün A et al. · 2025 · International journal of environmental health research

Bisphenol A (BPA) has negative impact on human health. This study aims to explore the association between the levels of BPA and 25(OH) vitamin D in breastmilk. BPA exposure and vitamin D sources were recorded on the study form. Breastmilk…

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Negative / Null Result ReportOpen accessMedicine

Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population: the Swedish CArdioPulmonary BioImage Study.

Emilsson ÖI, Malinovschi A, Johnsson Å et al. · 2025 · Thorax

Background Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known. Aim Investigate the association between nGER and pulmonary abnormalities on…

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Negative / Null Result ReportOpen accessMedicine

Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease.

Bratseth V, Kindberg KM, Warlo EMK et al. · 2026 · Frontiers in cardiovascular medicine

Introduction Coronary artery disease (CAD) is the clinical manifestation of atherosclerosis, an inflammatory disorder of the coronary arteries, characterized by endothelial dysfunction, lipid accumulation, immune activation, and formation…

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Negative / Null Result ReportMedicine

Lack of Association Between Dietary Fiber Intake and Kidney Failure Among Patients With Chronic Kidney Disease: The Chronic Kidney Disease-Japan Cohort Study.

Hattori K, Sakaguchi Y, Isaka Y et al. · 2025 · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

Objective It remains unclear whether dietary fiber intake improves kidney outcome. The objective of our study was to examine the association between dietary fiber intake and the risk of kidney failure among patients with proteinuric…

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