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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Cholesterol efflux capacity of high-density lipoprotein was not associated with cognitive decline and brain structures in older people with diabetes mellitus.

Wu Y, Tan KC, Shiu SW et al. · 2022 · Journal of diabetes investigation

Aims/introduction To examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. Materials and methods…

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Negative / Null Result ReportMedicine

Three ways to find a fluke: Evaluating diagnostic methods for Fasciola hepatica surveillance in Swedish sheep.

Felländer M, Grandi G, Juremalm M et al. · 2026 · Veterinary parasitology, regional studies and reports

Infections with Fasciola hepatica are most prevalent in south-western Sweden, but climate change may facilitate further spread, as both the parasite and its snail host thrive in humid, mild conditions. Sheep are particularly susceptible,…

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Negative / Null Result ReportMedicine

[The challenge of delabeling antibiotic allergy in Colombian children: do parents trust the negative result of the drug provocation test with the implicated antibiotic?]

Rincón-González AM, Galeano-Tamayo DC, Zuluaga LSD · 2025 · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

Objective To explore the factors associated with the use of the antibiotic implicated in an adverse reaction following a negative challenge test in pediatric patients in a clinical allergology service of a health institution in Medellin.…

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Negative / Null Result ReportMedicine

Cervical length and fetal fibronectin for the identification of true spontaneous onset of labor.

Warintaksa P, Youkhong C, Trikasemmart M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Introduction True labor is characterized by regular uterine contractions and cervical changes. However, the precise diagnosis of the "onset" of true labor is challenging, as the examination of cervical changes requires multiple timepoints,…

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Negative / Null Result ReportMedicine

Suspicious bands in serum and urine protein immunofixation electrophoresis tests in patients with and without a history of monoclonal gammopathies: a retrospective database study.

Dincer M, Aydin O, Karakus V et al. · 2026 · Laboratory medicine

Introduction Electrophoresis tests are reported as negative, positive, or-rarely-as suspicious for monoclonal band (SfMB). This study aimed to determine the fate of patients with SfMB findings in long-term follow-up. Methods Patients with…

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Negative / Null Result ReportOpen accessMedicine

Stage IV Rectal Adenocarcinoma After Negative Multitarget Stool DNA-Fecal Immunochemical Test in a Symptomatic Patient: Misapplication of a Screening Test in a Diagnostic Context.

Omari Y, Nohomovich B, Sallam D et al. · 2026 · Cureus

Multitarget stool DNA-fecal immunochemical testing (mt-sDNA-FIT) is validated for colorectal cancer (CRC) screening in asymptomatic, average-risk adults. However, its application in symptomatic patients represents a misuse of a screening…

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Negative / Null Result ReportOpen accessMedicine

Use of the dual tyrosine kinase inhibitor lapatinib for the treatment of vulvovaginal squamous cell carcinoma in a dog.

Vardanega MJ, Longo T, Aceino A et al. · 2026 · Journal of veterinary internal medicine

Vulvovaginal squamous cell carcinoma (SCC) is an uncommon neoplasm in dogs. An 11-year-old female spayed German Shepherd dog presented with a history of excessive peri-vulvar grooming and a 3 cm × 3 cm irregular mass involving the vagina…

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Negative / Null Result ReportOpen accessMedicine

Phenotypic spectrum and molecular characteristics of variants of uncertain significance in copy number variations associated with fetal cardiac malformations: a case series of 9 patients.

Yin J, Wang Q, Lan T et al. · 2026 · Frontiers in pediatrics

Background Copy number variants of uncertain significance (VUS-CNVs) pose significant challenges in prenatal counseling for congenital heart malformations (CHMs). Their clinical relevance remains poorly defined, particularly in the absence…

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Negative / Null Result ReportOpen accessMedicine

Overall Diagnostic Efficiency of a Noninvasive Diagnostic Strategy Aimed at Early Detection of Advanced Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Cases.

Iwata K, Mori N, Ogasawara K · 2025 · Cureus

Introduction Noninvasive methods for assessing liver fibrosis are increasingly important for early detection of advanced liver fibrosis (ALF), particularly in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Oral Supplementation with a Multi-Strain Probiotic Preparation on Group B Streptococcus (GBS) Carriage in Pregnant Women-A Pilot Study.

Zych-Krekora K, Sylwestrzak O, Krekora M · 2026 · Journal of clinical medicine

Background/Objectives : Maternal rectovaginal carriage of Group B Streptococcus (GBS, Streptococcus agalactiae ) is a major risk factor for vertical transmission and early-onset neonatal infection. Intrapartum antibiotic prophylaxis…

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Negative / Null Result ReportMedicine

Cardiac Channelopathies in the Pediatric Patient: Long QT Syndrome.

Follansbee CW, Landstrom AP, Aziz PF · 2025 · Cardiac electrophysiology clinics

Congenital long QT syndrome is the most common inherited arrhythmia syndrome and is characterized by prolongation of the QT interval in the absence of structural heart disease or external factors. Disease will often manifest during…

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Negative / Null Result ReportOpen accessMedicine

Clinical predictors of enzyme immunoassay accuracy in Clostridioides difficile infection: the impact of immune status and infection predisposing factors.

Duan S, Lv T, Zheng L et al. · 2026 · BMC infectious diseases

BACKGROUND: Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, with increasing prevalence in China and the Asia-Pacific region. Despite its limited sensitivity, the enzyme immunoassay (EIA) is…

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Negative / Null Result ReportOpen accessMedicine

Progressive Supranuclear Palsy (PSP): An Orthoptic Assessment.

Burdon D, Mullin S, Harris C · 2026 · The British and Irish orthoptic journal

Aim Progressive supranuclear palsy (PSP) is an atypical Parkinsonian disorder which, like other atypical Parkinsonian disorders, displays neurological motor and oculomotor signs at different stages along the disease course. The overlap in…

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Negative / Null Result ReportOpen accessMedicine

Evaluating algorithmic approaches to rare disease case-finding: a retrospective validation study using electronic health records.

Boardman-Pretty F, Kumar J, Grant C et al. · 2026 · Orphanet journal of rare diseases

BACKGROUND: Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of…

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