11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Toraño P, Balmaseda A, Bordons A et al. · 2025 · Food Microbiology.
Oenococcus oeni is the main species of lactic acid bacteria (LAB) responsible for malolactic fermentation (MLF) in winemaking. MLF development can present difficulties because of the harsh, stressful conditions of wine. Yeast mannoproteins…
View details →Holzhauer CG, Bickar L · 2026 · Alcohol, clinical & experimental research
Background The associations of stress and negative emotion with alcohol use are well established. These associations are mediated by cognitive and psychological mechanisms that may be sex-dependent. This pilot study examined sex…
View details →Kobayashi Y, Hosoda C, Kohda M et al. · 2026 · Journal of ethology
Parental care has a direct and beneficial effect on parental fitness. An important question regarding the evolution of parental care is why parental roles and the amount of care invested are characterized by sexual bias. In species that…
View details →Bourgeois J, Domange C, Celie B · 2026 · International journal of environmental research and public health
Sleep is a fundamental aspect of physiological and psychological functioning, and the beneficial effect of exercise on sleep quality and quantity, depending on training modality, remains underexplored. This study compared the effects of…
View details →Kolli RD, Kasireddy B, Iuspa MA et al. · 2026 · British poultry science
1. This 42 d study further examined the physiological mechanisms underlying responses to a precision biotic (PB) on growth performance and ileal amino acid digestibility. It focussed on fermentation profile, caecal soluble protein levels,…
View details →Fransisca S, Sitepu BRE, Delfi · 2026 · Frontiers in medicine
Background Visual disturbances are a common and often debilitating complication following stroke, significantly impairing patients' functional independence and quality of life. Among various neuroprotective agents, Citicoline…
View details →Omae K, Luo Y, Sahker E et al. · 2026 · World journal of urology
PURPOSE: The smallest worthwhile difference (SWD) represents the minimal beneficial effect of an intervention that patients consider valuable when weighed against its burdens, including potential harms, costs, and inconveniences. We aimed…
View details →Zhiping N, Yuanyuan Y, Qichun Z et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
With the acceleration of China's aging society, how to enhance the subjective well-being of older adults has become a core issue of concern. This study aims to explore the influence mechanisms of socioeconomic status, health, recreation,…
View details →Lamb CJ, Biedermann BM, Lin EH et al. · 2025 · JSES international
Background Spin in scientific literature is defined as bias that overstates efficacy and/or underestimates harms of an experimental treatment. Glenoid augmentation is a technique used to correct glenoid bone deficiency during shoulder…
View details →Bkaily G, Jazzar A, Jacques D · 2026 · Canadian journal of physiology and pharmacology
Generation of reactive oxygen species (ROS) is a physiological product of cell activity that is mainly generated by the mitochondria as well as by transmembrane NADPH oxidases (NOX1-5) present at the plasma and nuclear envelope membranes.…
View details →Zhou HY, Xin ZM, Lu YY · 2026 · Journal of clinical psychology
Objective Theory of mind (ToM), the ability of mental state attribution, is an important aspect of social cognition. The autism-psychosis diametrical model suggests that there is an opposite impact of autistic traits and psychotic-like…
View details →Feola M, Landra F, Greco CA et al. · 2026 · Journal of clinical medicine
Cardiac arrest is a way of demise of patients who are affected by heart failure (HF), being more frequent in those with HF with a reduced left ventricular ejection fraction (HFrEF), and is, as such, responsible for 30-50% of cardiac death.…
View details →Noël A, Picard L · 2025 · Emotion (Washington, D.C.)
Numerous studies have highlighted the beneficial effect of humor on memory in younger adults. While older adults are known to preferentially process positive information and appreciate humor, no study has investigated whether the effect of…
View details →Wei Y, Meade ML, Soderstrom NC · 2025 · Memory (Hove, England)
The present study replicated and extended prior research by comparing the effects of reviewing notes in groups vs. reviewing notes individually on individual final test performance. We also examined the potential interaction between…
View details →Silva AT, Ferreira NM, Vaz F et al. · 2025 · Journal of biomechanical engineering
Pelvic organ prolapse (POP) is a common pelvic floor disorder resulting from weakened supportive muscles and ligaments. Although the demand for surgeries involving surgical meshes is expected to increase, current options remain limited. In…
View details →Wang C, Ren J, Cui Y et al. · 2025 · Journal of Applied Ecology.
Grassland carbon storage depends on microbial‐mediated interactions between grazing and nitrogen (N) addition, which regulates the balance between soil organic carbon (SOC) retention and priming effects. However, uncertainties regarding…
View details →Panopoulos S, Poulia V, Vlachogiannis N et al. · 2026 · Rheumatology international
Randomized trials have demonstrated that nintedanib is beneficial for Systemic Sclerosis-associated interstitial lung disease (SSc-ILD) with an acceptable safety profile. We evaluated the long-term safety and efficacy of nintedanib in a…
View details →Cai Y, Ren X, Ding C · 2026 · Intensive & critical care nursing
Objectives To assess the effects of various non-pharmacological interventions on long-term outcomes associated with Post-Intensive Care Syndrome (PICS) in intensive care unit (ICU) survivors, based on existing systematic reviews and…
View details →Pietersen LC, Broekman N, Broekman N et al. · 2025 · Clinical transplantation
Acute kidney injury (AKI) is a common complication following liver transplantation (LT), with multifactorial etiology. It is believed that perioperative hemodynamic instability could lead to AKI. A temporary portocaval shunt (TPCS) could…
View details →Drost M, Fuhrmann G · 2026 · ACS infectious diseases
Pseudomonas aeruginosa is a notorious bacterial pathogen causing chronic pulmonary infections in people with cystic fibrosis (CF) due to its high tolerance to antibiotics and ability to form recalcitrant biofilms. A newer approach to…
View details →Cheng J, Li F, Zhang B et al. · 2025 · Bulletin of experimental biology and medicine
We compared the therapeutic effects of dietary adjustment and fish oil in rats with experimental non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. The NAFLD rats were either maintained on high-fat diet, or transferred…
View details →Clarke JG, Dutta N, Nickel MS et al. · 2026 · ACS medicinal chemistry letters
Semisynthetic modification of mycothiazole ( 1 ) with Meerwein's salt to generate a more stable and/or potent analog than 8- O -acetylmycothiazole ( 2 ) unexpectedly yielded diastereomers devoid of the diene. Analysis of NMR, HR-LCMS, and…
View details →Doneddu PE, Collet-Vidiella R, Gallo C et al. · 2026 · Journal of the peripheral nervous system : JPNS
Background and aims Rituximab has been proposed as a potential treatment in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but formal evidence regarding its clinical effectiveness is weak. The CIDPRIT trial found no…
View details →Tajika A, Toyomoto R, Sakata M et al. · 2026 · BMJ mental health
Background Depression is a leading cause of global disability, and subthreshold cases contribute substantially to the burden. Cognitive behavioural therapy (CBT) is effective for depressive symptoms, but its impact on social functioning in…
View details →Miletić M, Kovač V, Barišić L et al. · 2025 · Pharmaceutics
Background/Objectives : Resveratrol (RSV) and curcumin (CRC) have antioxidant, anti-inflammatory, photoprotective, and cell-repairing properties. We selected them to investigate the potential role involved in human keratinocyte protection.…
View details →Charles AL, Tetsi L, Quiring G et al. · 2026 · Muscles (Basel, Switzerland)
Peripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia-reperfusion (IR) settings, but whether PDE 4 inhibition protects…
View details →Li J, Yang C, Li K · 2026 · BMC pregnancy and childbirth
BACKGROUND: Restricted gestational weight gain (GWG) following lifestyle interventions for gestational diabetes mellitus (GDM) has been observed in clinical trials but not been explicitly confirmed in real-world clinical settings.…
View details →Stanley M, Huang K, Garlich J et al. · 2025 · Journal of orthopaedic trauma
Objectives To compare time, fluoroscopic utilization, and number of misses for placement of far interlocking screws in tibial and femoral nails using a targeting arm (Targeter) versus perfect circle technique (Control). Methods . Design…
View details →Gewiss C, Gehrdau K, Hischke S et al. · 2025 · Journal of wound care
Objective The application of cold atmospheric plasma (CAP) has been described as a promising therapeutic approach for wound healing. Its use in immunologically mediated wounds such as pyoderma gangrenosum (PG) has not yet been sufficiently…
View details →Avetisian H, Mathew K, Myers A et al. · 2026 · Global spine journal
Study DesignCross-sectional.ObjectivesLaminoplasty (LP) and laminectomy with fusion (LF) are surgical approaches for degenerative cervical myelopathy (DCM), but their comparative effectiveness remains controversial. Systematic reviews and…
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