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490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Melatonin therapy reverses lead exposure-induced testicular damage in rats despite the lack of effect on serum testosterone levels.

Gallegos-Reyes MA, Antaño-Martínez AR, Alcaraz-Contreras Y et al. · 2023 · The Journal of toxicological sciences

Lead (Pb) exposure induces testicular damage and infertility. The aim of this study was to analyze and compare the therapeutic effects of antioxidants or vitamin D and calcium, which have previously been shown to reduce the toxic effects…

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Failed Experiment ReportOpen accessMedicine

The Inflammatory Response in the Murine Ovalbumin-Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences.

Henriksen IW, Bartholdy C, Koch J et al. · 2026 · Clinical and translational science

Valid pre-clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low-to-moderate inflammatory responses with significant variability, undermining…

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Failed Experiment ReportMedicine

Placebo-controlled three-armed pilot trial of Escitalopram or Nortriptyline for depressive symptoms in Parkinson's disease (ADepT-PD).

Schrag A, Embleton-Thirsk A, Carroll C et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)

Pilot randomised-controlled trial of nortriptyline and escitalopram compared to placebo for depressive symptoms in people with Parkinson's disease (PD). Participants with PD and depressive symptoms received either nortriptyline,…

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Failed Experiment ReportOpen accessMedicine

Preoperative Intravenous Desmopressin and Perioperative Blood Loss in Patients Undergoing Major Spine Surgery : Preoperative Intravenous Desmopressin and Perioperative Blood Loss in Spine Surgery Patients.

Alizadeh A, Moradi M, Vafaeimastanabad M et al. · 2025 · Galen medical journal

Background Major spine surgeries often involve significant blood loss, increasing transfusion risks and postoperative complications. Desmopressin, a synthetic vasopressin analog, may reduce bleeding by enhancing clotting factor release,…

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Failed Experiment ReportMedicine

Impact of the spatial distribution of positive charges on the catalytic activity of NiSOD bioinspired complexes.

Guinard P, Pécaut J, Le-Goff A et al. · 2026 · Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

In order to mitigate superoxide-induced damage, cells rely on superoxide dismutases (SODs), a family of metalloenzymes that catalyze the dismutation of superoxide. These enzymes display a positively-charged substrate entrance channel for…

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Failed Experiment ReportMedicine

Diagnostic challenges in cardiac amyloidosis: a case report of negative initial endomyocardial biopsy.

Mojahedi A, Goldschmidt M, Skopicki H et al. · 2025 · International journal of physiology, pathophysiology and pharmacology

Cardiac amyloidosis (CA) is a challenging acquired heart disease caused by the deposition of β-pleated amyloid proteins, often leading to nonspecific symptoms that complicate the diagnosis. This case report describes an 83-year-old male…

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Failed Experiment ReportOpen accessMedicine

Persistent cognitive deficits in ACL-injured athletes despite of rehabilitation: an observational longitudinal study.

Jiménez-Martínez J, Alarcón-López F, Chirosa-Ríos LJ et al. · 2025 · Frontiers in sports and active living

Background Rehabilitation programs following an anterior cruciate ligament (ACL) injury tend to focus on improving conditional aspects such as biomechanics. Recently, some studies have analyzed the relationship between cognition and ACL…

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Failed Experiment ReportOpen accessMedicine

Cytogenomics and optical genome mapping approaches characterize a derivative interstitial monosomy 18p due to a maternal complex intrachromosomal rearrangement.

Graziani L, Genovese S, Genovesi ML et al. · 2025 · Molecular cytogenetics

Background Monosomy 18p (MIM: 146390) is a well-known chromosomal disorder associated with intellectual disability, short stature, and non-specific craniofacial features resulting from partial or total deletion of the short arm of…

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Failed Experiment ReportMedicine

Evaluation of leukocyte depletion filters for the removal of EpCAM-positive tumor cells during oncologic intraoperative blood salvage using CATUVAB<sup>®</sup>: an exploratory feasibility study.

Mathis S, Putzer G, Schnegg L et al. · 2026 · BMC anesthesiology

Background Intraoperative blood salvage (IBS) reduces exposure to allogeneic blood but is accompanied by concerns in oncologic surgery regarding the potential reinfusion of residual tumor cells and subsequent metastatic dissemination. The…

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Failed Experiment ReportOpen accessMedicine

Dynamic monitoring of antibody drug conjugates targeting TROP2 or HER2 in breast cancer using circulating tumor cells.

Mishra A, Abelman RO, Cunneely Q et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Antibody-drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against TROP2 (Sacituzumab govitecan) or HER2…

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Failed Experiment ReportMedicine

Comparative assessment of behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles in a chronic mouse model.

Rogachev VV, Goltyaev MV, Varlamova EG et al. · 2026 · Biochemical and biophysical research communications

This study presents a comparative evaluation of the behavioral and systemic effects of small (10 nm) and large (100 nm) tellurium nanoparticles (TeNPs) obtained by laser ablation in a chronic in vivo experiment on male BALB/c mice. TeNPs…

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Failed Experiment ReportMedicine

Comparative analysis of the toxicity of fragmented and fibrous microplastics versus natural particles in the sea squirt Ciona intestinalis type A (Ciona robusta).

Saad R, Sekiguchi T, Takai Y et al. · 2026 · Marine environmental research

Microplastics (MPs) are ubiquitous in marine environments and readily ingested by filter-feeding organisms, yet the ecotoxicological effects of irregularly shaped MPs remain poorly understood. This study assessed the accumulation and…

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Failed Experiment ReportMedicine

Gestational timing and vaccine platform shape maternally derived neutralizing immunity and vaccine RNA detection in piglets following maternal vaccination with C-strain or FlagT4G against classical swine fever.

Coronado L, Muñoz-Aguilera A, Puente-Marin S et al. · 2026 · Frontiers in veterinary science

Control of classical swine fever (CSF) in endemic regions relies heavily on vaccination of breeding herds. Optimizing vaccination strategies is essential for sustainable disease control covering pigs belonging to different categories. Data…

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Failed Experiment ReportOpen accessMedicine

Semaglutide

· 2006

Semaglutide was not detectable in the milk of mothers taking the drug subcutaneously. Their breastfed infants experienced no adverse effects. Some brands of oral semaglutide, such as Rybelsus, contain the absorption enhancer salcaprozate…

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Failed Experiment ReportOpen accessMedicine

The Effects of Conservative Fluid Management and Active Deresuscitation on Markers of Tissue Perfusion, Kidney Injury, and Vascular Injury in Critically Ill Adults: A Secondary Analysis of the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) Trial.

McMullan RR, McGrath C, Cody N et al. · 2026 · Critical care explorations

Objectives Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared with usual care.…

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