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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

How changes to frequency of treatment and mode of treatment improved paediatric speech-language pathology services: A pragmatic clinical trial.

Van Epps VM, Daur-Schierholz M, Dortenzio M et al. · 2026 · International journal of speech-language pathology

Purpose This pragmatic clinical trial examined the functional impact of a modified speech-language pathology intervention delivery model (including telepractice, reduced therapy frequency, and emphasised home programmes with parent…

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Negative / Null Result ReportMedicine

Evaluation of Short-Term Stall Size Housing on the Behavior and Welfare of Domestic Horses (Equus caballus).

Outouil M, Daugherity EK, Warnick LD et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS

Single-stall housing is a common system used for horses in various settings, including racing stables, riding schools, teaching and research facilities. Adequate stall space is necessary for horses to lie down and make postural…

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Negative / Null Result ReportMedicine

Is multimodal monitoring effective in detecting neurological changes in cases of severe idiopathic scoliosis after halo gravity traction?: a series of 70 patients.

Richard L, Vermersch AI, Saghbini E et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology

Objective Severe scoliosis, defined by a Cobb angle exceeding 80°, requires surgical correction and is associated with a high risk of postoperative neurological complications. These complications may be reduced by halo gravity traction…

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Negative / Null Result ReportMedicine

Pilot Testing a Narrative Psychoeducational Video to Reduce Stigma and Improve Mental Health Literacy and Help-Seeking Among Latinx Adults: Examining Gender Differences and Contextual Insights.

Saravia DH, Silvan YA, Martinez JI · 2026 · Community mental health journal

Despite similar rates of mental illness, non-Latinx Whites (NLW) received care at higher rates compared to Latinxs (National Institute of Mental Health, 2024). Latinx adults report lower mental health literacy (MHL) and higher stigma…

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Negative / Null Result ReportMedicine

Behavioral Incentives for Exercise and Intra-Articular Glucocorticoids for Knee Osteoarthritis: Results From a Factorially Designed Pragmatic Randomized Clinical Trial.

Baker JF, Wysham KD, Quinones M et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)

Objective The purpose of this study was to determine the benefit of a behaviorally designed incentive program and glucocorticoid injections in reducing symptoms and promoting physical activity in patients with knee osteoarthritis (KOA).…

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Negative / Null Result ReportMedicine

Use of Er:YAG Laser for Disinfection of Infected Carious Dentin: Microbiological Evaluation and Scanning Electron Microscopy Analysis.

Marcondes Pinto MO, Arana-Chavez VE, Trevelin LT et al. · 2026 · Photobiomodulation, photomedicine, and laser surgery

Objective To evaluate the antimicrobial efficacy of Er:YAG laser for disinfection of softened carious dentin using subablative parameters. Background Current literature lacks robust scientific evidence supporting the use of Er:YAG laser…

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Negative / Null Result ReportMedicine

Impact of Running Shoe Midsole Properties on Energy Cost of Running: Insights Into Midsole Stiffness and Resilience Properties.

Rodrigo-Carranza V, Alda-Blanco A, Kuzmeski J et al. · 2026 · International journal of sports physiology and performance

Purpose The mechanisms behind improvements in running economy (RE) from shoes with supercritical foams (SCF) compared with a traditional midsole material (ethylene vinyl acetate [EVA]) remain only partially understood. This study aimed to…

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Negative / Null Result ReportMedicine

'Sawa Aqwa' (Stronger Together): A multi-site randomized controlled trial of a brief family systemic intervention for adolescent mental health in Lebanon.

Bosqui T, Brown FL, Farah S et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background There are no evaluated family-based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole-family interventions in low- and middle-income…

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Negative / Null Result ReportMedicine

Treatment with elexacaftor/tezacaftor/ivacaftor does not alter SpiroNose-derived electronic breath profiles in children with cystic fibrosis.

Seidl E, Zikic A, Micic S et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Background Breath profile analysis of volatile organic compounds (VOCs) by electronic nose (eNose) technology can distinguish between healthy individuals and people with cystic fibrosis (pwCF). It remains, however, unclear whether CFTR…

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Negative / Null Result ReportMedicine

Effect of Successive Bleaching Treatments Followed by Staining on Color, Whiteness, and Translucency of Polymer-Based CAD-CAM Materials.

Ramos AC, Mascaro BA, Dos Santos Nunes Reis JM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To evaluate differences in color, whiteness, and translucency of CAD-CAM materials after successive bleaching treatments and coffee immersion. Materials and methods Lava Ultimate (LU) and VITA Enamic (VE) were divided into four…

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Negative / Null Result ReportMedicine

Evaluation of an Immune-guided Prevention Strategy Against CMV Among Intermediate-risk Kidney Transplant Recipients: A Quasi-experimental Study.

Caso JM, Fernández-Ruiz M, González E et al. · 2026 · Transplantation

Background Observational studies have shown that kidney transplant (KT) recipients who are cytomegalovirus (CMV)-seropositive (R+) but lack effective CMV-specific cell-mediated immunity (CMV-CMI) are at increased risk of CMV infection.…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the role of high-dose intravenous thiamine supplementation for lactate clearance in patients with cirrhosis and sepsis.

Ali R, Yazdi A, Collins K et al. · 2026 · International journal of critical illness and injury science

Background Thiamine is a vitamin that plays a role in lactate clearance. Patients with sepsis may present with elevated lactate, and also in cirrhosis, as lactate is hepatically metabolized. Prior studies showed mixed results regarding the…

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Negative / Null Result ReportMedicine

Intraoperative Parathyroid Hormone in Minimally Invasive Parathyroidectomy (MIP) for Primary Hyperparathyroidism With Concordant Localisation.

Chew BMH, Lim SSA, Gan TRX et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective There is increasing use of intraoperative parathyroid hormone (ioPTH) in minimally invasive parathyroidectomy (MIP). While ioPTH has improved cure rate, there is little evidence to suggest effectiveness in primary…

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Negative / Null Result ReportMedicine

Impact of eravacycline on fibrinogen.

Stevenson E, Ponder M, Daniels L et al. · 2026 · The Journal of antimicrobial chemotherapy

Objectives While tigecycline has been associated with hypofibrinogenaemia, limited data with eravacycline suggest this may also occur with this agent. However, the incidence and clinical significance of this finding are not well defined.…

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