e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Low-Dose Aspirin Continuation During Gastric Endoscopic Submucosal Dissection in Patients With Low Thrombotic Risk: A Randomized Trial.

Uedo N, Gotoda T, Takizawa K et al. · 2026 · The American journal of gastroenterology

Introduction The recommendation to discontinue low-dose aspirin (LDA) during the periprocedural period of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) remains controversial in patients at low thrombotic risk. If…

View details →
Negative / Null Result ReportOpen accessMedicine

Seasonality and clinical characteristics of influenza-like illness and severe acute respiratory infection in children under 5 years in Cox's Bazar, Bangladesh (2021-2023).

Zabir MOH, Habib MA, Monalisa et al. · 2026 · IJID regions

Objectives Acute respiratory infections (ARIs) such as influenza-like illness (ILI) and severe acute respiratory infection (SARI) are leading causes of morbidity among children aged under 5 years (under-5) in Bangladesh. In Cox's Bazar,…

View details →
Negative / Null Result ReportMedicine

[Analysis of a twin pregnancy with false negative result for 22q11.2 deletion syndrome by expanded non-invasive prenatal testing].

Zhao G, Jiao Z, Dai P et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To explore the cause for a twin pregnancy with false negative result for 22q11.2 deletion syndrome by expanded non-invasive prenatal testing (NIPT-plus). Methods A pregnant woman with twin pregnancy through in-vitro fertilization…

View details →
Negative / Null Result ReportOpen accessMedicine

Blood-based biomarkers GFAP/UCH-L1 for the diagnosis of mild traumatic brain injury (mTBI): a single-center implementation experience.

Maegele M, Breidenbach L, Kaufmann J et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Introduction Mild traumatic brain injuries (mTBI) affect millions of people worldwide every year as one of the most common clinical presentations in the emergency department. Diagnosis is mainly based on clinical criteria and computed…

View details →
Negative / Null Result ReportOpen accessMedicine

Abnormal Ultrasonography Overcomes NIPT's Inherent Limitations: Revealing Two Cases of NIPT False Negatives Caused by Trisomy 21 Mosaicism and a Literature Review.

Mu Y, Jing Y, Liu X et al. · 2026 · International journal of women's health

Background Non-invasive prenatal testing (NIPT) is widely adopted for its high sensitivity in detecting chromosomal abnormalities, but its accuracy for placental and fetal mosaicism is limited due to reliance on placental DNA, leading to…

View details →
Negative / Null Result ReportOpen accessMedicine

Correlation between controlled-pressure provocative test duration and electrodiagnostic severity in carpal tunnel syndrome.

Iamchaimongkol A, Leeareekun K, Chira-Adisai W et al. · 2026 · Journal of rehabilitation medicine

Objective To assess the correlation between controlled-pressure provocative test duration and electrodiagnostic severity in carpal tunnel syndrome. Design Cross-sectional correlational study. Patients Patients with clinical symptoms…

View details →
Negative / Null Result ReportOpen accessMedicine

The discrepancy of somatic BRCA1/2 pathogenic variants from two different platforms in epithelial ovarian, fallopian tube, and peritoneal cancer.

Kim JH, Shin JY, Park SY et al. · 2024 · Scientific reports

The somatic BRCA1 or BRCA2 Pathogenic Variant (PV)/Likely PV (LPV) from Next Generation Sequencing (NGS) is the most important biomarker for PARP inhibitor use and maintenance-targeted therapies. A discrepancy in the detection rates of…

View details →
Negative / Null Result ReportOpen accessMedicine

Quality of life, anxiety and cancer worry following hereditary cancer testing: a 6-month Swedish follow-up study.

Heyman Y, Röjlar H, Hawranek C et al. · 2026 · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

PURPOSE: As genetic testing becomes increasingly integrated into routine care, understanding its impact on psychological well-being and health-related quality of life (HRQoL) is essential. This study assessed HRQoL, anxiety and cancer…

View details →
Negative / Null Result ReportOpen accessMedicine

Comparative efficacy of once-daily versus twice-daily doxycycline regimens in dogs naturally infected with <i>Ehrlichia canis</i>: A randomized clinical trial.

Taechikantaphat M, Kongchareon A, Julapanthong P et al. · 2026 · Veterinary and animal science

This prospective, randomized clinical trial compared the therapeutic efficacy and rate of platelet recovery of doxycycline 10 mg/kg once daily (SID) (Group A, n=17) versus 5 mg/kg twice daily (BID) (Group B, n=12) in 29 dogs naturally…

View details →
Negative / Null Result ReportOpen accessMedicine

Raw Equid Milk: A Potential Risk for Q Fever?

Mazzotta E, Natale A, Bellinati L et al. · 2025 · Animals : an open access journal from MDPI

Equid milk (donkey or mare) has traditionally been consumed raw or fermented due to its distinctive chemical composition, which closely resembles human milk, and its nutritional benefits. Nowadays, interest in it is increasing, despite…

View details →
Negative / Null Result ReportOpen accessMedicine

Comparison of boiling versus magnetic bead techniques in nucleic acid extraction for human papillomavirus detection: evidence based 17,179 cases.

Bai M, Li Y, Gao Q et al. · 2025 · Virology journal

Purpose Present study aimed to compare the boiling and magnetic bead nucleic acid extraction method for HPV genotypes detection. Methods By mixing hemoglobin with HPV positive quality control products, the anti-interference ability of two…

View details →
Negative / Null Result ReportOpen accessMedicine

Cytomegalovirus (CMV)-Specific Cell-Mediated Immunity for Prediction of Postprophylaxis CMV Disease in a Phase 3 Trial of Letermovir Versus Valganciclovir Prophylaxis in Donor CMV-Seropositive/Recipient CMV-Seronegative Kidney Transplant Recipients.

Limaye AP, Crespo M, Kamar N et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background QuantiFERON-cytomegalovirus (QFT-CMV) is a standardized assay for the evaluation of cytomegalovirus-specific cell-mediated immunity (CMV-CMI). Objectives The purpose of this study was to assess the evolution of CMV-CMI…

View details →
Negative / Null Result ReportOpen accessMedicine

Identification of Factors Predicting False-Negative Results in Sentinel Lymph Node Biopsy in Patients Undergoing Surgery for Breast Cancer: A Single-Center Retrospective Study.

Bölük S, Bölük S · 2025 · Cureus

Background In breast cancer surgery, sentinel lymph node biopsy (SLNB) is routinely utilized for axillary assessment. Frozen section examination of the sentinel lymph node (SLN) is used to guide the decision for axillary dissection.…

View details →
Negative / Null Result ReportMedicine

Optimizing HIV testing: Comparing diagnostic signatures and assay performance in ART-treated and general screening populations.

Liu Q, Liu X, Chang L et al. · 2025 · Clinica chimica acta; international journal of clinical chemistry

Introduction Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated…

View details →
Negative / Null Result ReportOpen accessMedicine

Polygenic risk scores in routine genetic diagnostics: what lies ahead?

Lauffer P, van Weelden W, van Haelst MM et al. · 2025 · Journal of community genetics

Polygenic risk scores (PRS) have emerged as a potential tool for predicting complex genetic traits and disorders, which may complement traditional rare variant testing. As genome-wide association studies (GWAS) expand, PRS predictive…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of Nonsteroidal Anti-Inflammatory Drugs on Sacroiliac Joint Inflammation, as Seen on Magnetic Resonance Imaging, in Axial Spondyloarthritis.

Jones GT, Bennett AN, Sengupta R et al. · 2025 · Arthritis care & research

Objective Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, there is no consistent guidance on whether patients should temporarily stop…

View details →
Negative / Null Result ReportOpen accessMedicine

Outcomes Related to Bacterial Co-Infection and Antibiotic Use in Adults Hospitalized With Respiratory Syncytial Virus Compared with Influenza.

Karlsen KL, Clausen CL, Kahiyah RAS et al. · 2026 · Open forum infectious diseases

Background Adults hospitalized with respiratory syncytial virus (RSV) face mortality risks comparable to or higher than those with influenza A or B. However, studies on the impact of bacterial co-infections on mortality are inconsistent.…

View details →