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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Neither the number of feature dimensions nor their task relevance necessarily affect interocular grouping in binocular rivalry.

Pedziwiatr MA, Derda M, Bator W et al. · 2026 · Attention, perception & psychophysics

When one eye views half of stimulus A and half of stimulus B, and the other eye views the respective other halves, perception fluctuates. Among percepts reflecting monocular inputs (indicating typical binocular rivalry), percepts of…

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Negative / Null Result ReportMedicine

Is employment status associated with baseline symptoms, engagement, and outcomes in naturalistic psychotherapy? Evaluation in a large community mental health agency.

Jiwani Z, Xie Q, Curtin JJ et al. · 2025 · Psychotherapy (Chicago, Ill.)

Employment status, an essential socioeconomic factor, may be an important driver of disparities in mental health and access to treatment. However, prior research has been inconclusive and utilized broad employment categories. The present…

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Negative / Null Result ReportOpen accessMedicine

Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.

Ahmad R, Zobel G, Hannaford R et al. · 2026 · Brain, behavior, & immunity - health

Adolescent social isolation is a known risk factor for anxiety and depression related disorders, yet its effects on brain-gut communication and potential sex differences remain unclear. We hypothesised that isolation would heighten…

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Negative / Null Result ReportMedicine

Diverse social environments and 10-year all-cause mortality in a cohort of historically excluded racial/ethnic older adults: A latent class analysis of social integration.

Flores M, Boyd SM, O'Neill RM et al. · 2025 · Annals of epidemiology

Purpose The association between social integration and mortality in older adults from historically excluded groups may not align with the patterns observed in predominately white samples. We modeled latent groups of social integration and…

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Negative / Null Result ReportOpen accessMedicine

Crude protein concentration in feedlot cattle growth performance, carcass merit, and nitrogen status of long-fed feedlot steers in response to dietary protein concentrations: a comparison of industry-average and reduced protein diets.

Pittaluga AM, Relling AE · 2026 · Translational animal science

Angus × SimAngus-crossbred steers ( n = 93; body weight [BW] = 342 ± 29 kg) were used in a randomized complete block design to examine the effect of feeding finishing diets with crude protein (CP) contents similar or below industry…

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Negative / Null Result ReportMedicine

Dual-Energy X-Ray Absorptiometry Does Not Confirm Validity of the Craig's Test.

Clark KA, Nielsen S, Heywood T et al. · 2024 · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

The Craig's test is a clinical assessment used to quantify femoral version. The validity of the Craig's test has been called into question due to instances where the test exhibits relatively poor correlation with three-dimensional imaging.…

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Negative / Null Result ReportOpen accessMedicine

Does the number of pages received per hour affect resident productivity?

Mangino A, Stenson BA, Leventhal EL et al. · 2023 · Journal of the American College of Emergency Physicians open

Background Workflow interruptions are common for emergency physicians and are shown to have downstream consequences such as patient dissatisfaction, delay in clinical response, and increase in medical error. However, the impact of passive…

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Negative / Null Result ReportMedicine

Actigraphy-based sleep and muscle sympathetic nerve activity in humans.

Bigalke JA, Greenlund IM, Bigalke JR et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology

Short and insufficient sleep are prevalent and associated with cardiovascular disease, with the sympathetic nervous system as a suspected mediator. The purpose of the present study was to investigate the association between objective,…

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Negative / Null Result ReportMedicine

Food processing according to the NOVA classification is not associated with glycemic index and glycemic load: results from an analysis of 1995 food items.

Basile AJ, Ruiz-Tejada A, Mohr AE et al. · 2024 · The American journal of clinical nutrition

Background Ultraprocessed foods (UPFs) comprise most calories in the United States diet. Glycemic index (GI) and glycemic load (GL) are measures of the quality and quantity of carbohydrates in food based on their effect on postprandial…

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Negative / Null Result ReportMedicine

Daily exposure to combat-related cues and posttraumatic stress symptoms among veterans: Moderating effects of peri- and postdeployment experiences.

Mojallal M, Simons RM, Simons JS et al. · 2024 · Journal of traumatic stress

One of the central symptoms of posttraumatic stress disorder (PTSD) is a heightened reactivity to trauma cues. The current study used experience sampling to investigate the associations between exposure to combat-related cues and PTSD…

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Negative / Null Result ReportOpen accessMedicine

Altering visual feedback during reaching: no mitigating effect on pain for individuals with complex regional pain syndrome, but visuomotor adaptation is preserved.

Dagenais M, Sutter C, Brun C et al. · 2025 · Frontiers in human neuroscience

Introduction Complex regional pain syndrome (CRPS) is often associated with pain-related fear of movement, and virtual reality has been proposed as a potential rehabilitation intervention to overcome this issue. Therefore, this…

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Negative / Null Result ReportMedicine

Primary Care Physicians' and Hospitalists' Experience with Advance Care Planning with South Asian Canadian Older Adults before and during COVID-19.

Vashisht A, Gutman G, Mackey D et al. · 2024 · Canadian journal on aging = La revue canadienne du vieillissement

Few older adults discuss their end-of-life care wishes with their physician, and even fewer minorities do this. We explored physicians' experience with advance care planning (ACP) including the barriers/facilitating factors encountered…

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Negative / Null Result ReportOpen accessMedicine

Association of LR treatment response category with outcome of patients with hepatocellular carcinoma on explant pathology.

Khurana A, Chai N, Gibson A et al. · 2025 · Abdominal radiology (New York)

Objectives Liver transplant (LT) is an effective treatment for hepatocellular carcinoma (HCC) in appropriately selected patients. Locoregional therapy (LRT) is often performed to extend a patient's eligibility for LT. Imaging has a modest…

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Negative / Null Result ReportMedicine

Neonatal hyperoxia exposure does not exacerbate hypertension programmed by maternal obesity.

do Carmo JM, Hall JE, Dai X et al. · 2026 · American journal of physiology. Regulatory, integrative and comparative physiology

Maternal obesity increases the risk of preterm delivery and rapid transition of offspring from a hypoxemic environment to a normal or elevated oxygen environment, especially if the baby receives oxygen therapy. Maternal obesity may also…

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Negative / Null Result ReportOpen accessMedicine

Duration and mode of delivery: Does maternal sleep matter?

Parttimaa H, Paavonen EJ, Perasto L et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective Poor sleep quality in late pregnancy has been identified as a risk factor for operative deliveries. In this study, we investigated the associations between maternal sleep throughout pregnancy and its impact on both the duration…

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Negative / Null Result ReportMedicine

HeartWare Left Ventricular Assist Device Exercise Hemodynamics With Speed Adjustment Based on Left Ventricular Filling Pressures.

Ali O, Arnold AC, Cysyk J et al. · 2024 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

Functional capacity remains limited in heart failure patients with left ventricular assist devices (LVADs) due to fixed pump speed and inability to offload the left ventricle adequately. We hypothesized that manually adjusting LVAD speed…

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Negative / Null Result ReportOpen accessMedicine

A family history of suicide in bipolar disorders: powerful, powerless

Sagué Vilavella M, Fico G, Anmella G et al. · 2023 · European psychiatry : the journal of the Association of European Psychiatrists

Introduction When completing the medical record of a patient with bipolar disoder (BD), hardly anything is more impacting than a family history of completed suicide (FHS). In fact, FHS is a main risk factor for personal suicide attempts…

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Negative / Null Result ReportMedicine

Distress tolerance, coping motives, and alcohol craving and consumption: Two experiments testing momentary responses to a mood induction.

Augur IF, Wolkowicz NR, Ham LS · 2023 · Drug and alcohol dependence

Background The current studies examined the relationship between state and trait distress tolerance (DT), drinking-related variables (alcohol craving and consumption), and the moderating role of drinking to cope with negative affect (i.e.,…

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Negative / Null Result ReportOpen accessMedicine

The Role of Screentime and Family Resiliency in Overweight/Obesity in Children and Children with Developmental Disabilities Before and During COVID-19.

Mudnal PS, Chuang E, Lindly OJ et al. · 2025 · Children (Basel, Switzerland)

Background/objectives This study examines factors associated with child overweight/obesity (OW/OB), pre-COVID-19 and during the COVID-19 pandemic, among all U.S. children aged 10-17 years, with or without developmental disabilities (DD)…

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Negative / Null Result ReportOpen accessMedicine

The independent and combined effect of price increase and price labelling on sugar-sweetened beverage vending machine sales in an Australian university: a factorial randomised controlled trial.

Blake MR, Dancey J, Cameron AJ et al. · 2026 · The international journal of behavioral nutrition and physical activity

BACKGROUND: No studies have examined how price increases on unhealthy drinks in university vending machines impact customer purchasing or vendor financial implications. Vending machines often display prices only upon product selection,…

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Negative / Null Result ReportOpen accessMedicine

Variations of sex-hormones in reproductive aged females do not impact the repeated bout effect following maximal unaccustomed eccentric exercise of the elbow flexors.

Rilling A, Power GA · 2025 · Biology of sport

Neuromuscular function is impaired following unaccustomed eccentric exercise, the repeated bout effect (RBE) however, protects from damage following a subsequent bout. Muscle damage may be mitigated in females due to protective effects of…

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