e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The effects of marine fatty acid omega-3 supplements on incident fractures and bone mineral density in generally healthy adults.

LeBoff MS, Chou SH, Ratnarajah DM et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Although preclinical studies suggest that omega-3 fatty acids may benefit skeletal health, there are few randomized controlled trials investigating effects of supplemental omega-3 on bone outcomes. This VITamin D and OmegA-3 TriaL (VITAL)…

View details →
Negative / Null Result ReportOpen accessMedicine

Reducing Noise Induced by Cardiac Pulsatility in Brain Maps of R<sub>2</sub>* and Magnetic Susceptibility Using Tailored k-space Sampling.

Raynaud Q, Dardano T, Oliveira R et al. · 2026 · NMR in biomedicine

Maps of the transverse relaxation rate R 2 * and magnetic susceptibility (χ) are computed from gradient-echo data and are sensitive to signal instabilities induced by cardiac pulsation. Here, we introduce two k-space sampling strategies…

View details →
Negative / Null Result ReportMedicine

Common channel length and implications to the weight loss.

Santoro S, Mota FC, de Aquino CGG et al. · 2025 · Updates in surgery

To present and analyze the results of sleeve gastrectomy with transit bipartition (SG + TB) with three different lengths of common channel (CC) and its implications for the weight loss and signals of residual malabsorption. A total of 790…

View details →
Negative / Null Result ReportMedicine

Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial.

Shu W, Wan J, Xu H et al. · 2025 · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Background Although previous studies have shown the potential advantages of albumin administration in critically ill patients, it has not been tested in patients with severe acute pancreatitis. Methods In this single-center trial, we…

View details →
Negative / Null Result ReportMedicine

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial.

Cariou B, Thys A, Oliveira AR et al. · 2025 · Diabetes, obesity & metabolism

Aims Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to…

View details →
Negative / Null Result ReportMedicine

Impact of an electronic clinical decision support algorithm (eCDSA) on antibiotic prescribing in primary care in Cambodia: A cluster randomised controlled trial.

Wynberg E, Mishra A, Liverani M et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Poorly targeted antibiotic use in primary care is a driver of antimicrobial resistance. Electronic clinical decision support algorithms (eCDSAs) integrating point-of-care tests may improve prescribing. We evaluated the impact of…

View details →
Negative / Null Result ReportMedicine

Proactive versus standard support of labor in the latent phase - A randomized, controlled clinical trial.

Larsen M, Underdal M, Salvesen Ø et al. · 2025 · Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives

Objective Long latent phase of labor with subsequent prolonged total labor duration increases the risk of obstetric interventions and complications. We explored whether Proactive Support of Labor (PSL) compared to Standard Support of Labor…

View details →
Negative / Null Result ReportMedicine

Enhancing Removable Partial Denture Hygiene: Investigating Mucolytic Agents and Biocides for Disrupting Biofilms and Improving Antimicrobial Efficacy.

Moraes LGDS, Oliveira VC, Macedo AP et al. · 2025 · The International journal of prosthodontics

Purpose To evaluate the antibiofilm action of 2.5 mg/mL peracetic acid (PA), 0.5 mg/mL cetylpyridinium chloride (CPC), and 160 mg/mL N-acetylcysteine (NAC) against multispecies biofilm of Streptococcus mutans, Staphylococcus aureus,…

View details →
Negative / Null Result ReportOpen accessMedicine

Effect of virtual reality distraction on anxiety, pain and discomfort during unsedated gastroscopy: Randomized controlled trial.

Bouman Z, De Vries F, De Ruiter M et al. · 2026 · Endoscopy international open

Background and study aims Esophagogastroduodenoscopy is a widely used medical examination. Despite the short duration of this procedure, many patients experience anxiety, pain, and discomfort. The aim of this study was to examine effects…

View details →
Negative / Null Result ReportMedicine

Hyaluronidase activity of Indian ornamental tarantula (Poecilotheria regalis) venom is significantly reduced by commercial Latrodectus mactans and American scorpion antivenoms.

García-García M, Mosqueda J, Escobar-Cabrera JE et al. · 2025 · Toxicon : official journal of the International Society on Toxinology

A recent clinical case involving a Poecilotheria regalis bite was treated with Mexican L. mactans antivenom (Aracmyn Plus, Silanes, Mexico), resulting in the improvement of some of the symptoms. This could be attributed to cross-reactivity…

View details →
Negative / Null Result ReportMedicine

Assessing the Comparative Ability of Early Postoperative T4-L1PA Mismatch versus L1PA or T4PA Alone for Predicting Mechanical Complications or Spinal Reoperations: A Retrospective Analysis.

Baumann AN, Chatzis K, Son E et al. · 2026 · Spine

Study design Retrospective single-center study. Objective We aim to compare the prognostic capacity of postoperative T4-L1PA mismatch versus T4PA and L1PA alone. Summary of background data The assessment of T4-L1PA mismatch, the difference…

View details →
Negative / Null Result ReportMedicine

Optimizing a Multimodal Large Language Model for Ultrasound-Based Thyroid Nodule Malignancy Classification: A Comparative Study of Few-Shot Learning, Prompt Engineering, and Fine-Tuning.

Li YH, Cheng YC, Chang CY et al. · 2026 · Diagnostics (Basel, Switzerland)

Objectives: Multimodal large language models (MLLMs) have shown potential for medical image classification. We evaluated four optimization strategies in two MLLMs-GPT-4o (gpt-4o-2024-08-06) and Gemini 2.5 Flash-Lite-for ultrasound-based…

View details →
Negative / Null Result ReportMedicine

CT-derived hepatic extracellular volume fraction for the assessment of graft rejection after liver transplantation: a retrospective observational study.

Asmundo L, Pansini V, Monti CB et al. · 2026 · Abdominal radiology (New York)

To evaluate the diagnostic performance of hepatic extracellular volume (ECV) fraction derived from delayed single-energy CT for identifying graft rejection in liver transplant recipients and its added value over clinical parameters. This…

View details →
Negative / Null Result ReportMedicine

Predictive value of ultrasound-measured tongue base thickness for upper airway obstruction during monitored anesthesia care: a single-center prospective observational study.

Kikkawa K, Takeuchi M, Sakaguchi D et al. · 2026 · Journal of anesthesia

Purpose Monitored anesthesia care (MAC) is increasingly used for various procedures, but sedation-related upper airway obstruction may lead to hypoxemia or conversion to general anesthesia. This study evaluated whether preoperative tongue…

View details →
Negative / Null Result ReportOpen accessMedicine

Admission Physiology Appeared More Informative Than Small-for-Gestational-Age Status for Predicting Severe In-Hospital Disposition in Preterm Infants Born at 28-36 Weeks: A Retrospective Single-Center NICU Cohort Study.

Ghorooneh Z, Mohammadzadeh A, Farhat AS et al. · 2026 · BMC pediatrics

BACKGROUND: Whether small for gestational age adds prognostic information after NICU admission physiology is known remains uncertain in preterm infants. This distinction is clinically important because SGA is an anthropometric birth-size…

View details →
Negative / Null Result ReportMedicine

Substantial Operative and Nonoperative Mortality Persists in Neonatal Ebstein Anomaly: A 20-Year Multi-Institutional Analysis.

Turner D, Mehdizadeh-Shrifi A, Faateh M et al. · 2026 · World journal for pediatric & congenital heart surgery

BackgroundWe sought to characterize the epidemiology, treatment patterns, and outcomes of neonatal Ebstein anomaly using a national database.MethodsIn this descriptive analysis, the pediatric health information system (PHIS) database was…

View details →