11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Sitbon O, Boucly A, Weatherald J et al. · 2025 · The European respiratory journal
Over the past three decades, several drugs have been developed to target three major dysfunctional pathways in pulmonary arterial hypertension (PAH), including the prostacyclin, endothelin and nitric oxide pathways. Despite these advances,…
View details →Paavonen J, Brunham RC · 2024 · Frontiers in cellular and infection microbiology
Localized provoked vulvodynia (LPV), also called vulvar vestibulitis or provoked vestibulodynia, is a major cause of dyspareunia that severely impacts sexual health. At the tissue level, lymphocytic inflammation and hyperinnervation are…
View details →Le Pallec C, Cerasuolo D, Cauvin JC et al. · 2025 · European journal of pediatrics
The respiratory rate-oxygenation index (ROXi) has been shown to be a reliable tool for predicting the risk of high-flow nasal cannula (HFNC) failure in adult patients with lower respiratory tract infections. However, the usefulness of the…
View details →Linz MS, Wang T, Friberg J et al. · 2026 · Trauma case reports
Introduction Traumatic hemipelvectomy is a rare operation, often performed for injuries caused by a high force mechanism such as a traffic or industrial accident, and often fatal. Most often performed emergently, here we report a traumatic…
View details →Wu TC, Lin CC · 2025 · Cancer prevention research (Philadelphia, Pa.)
The study by Downs and colleagues targets patients with non-muscle-invasive bladder cancer (NMIBC) to explore secondary/tertiary cancer prevention strategies. Utilizing a "window-of-opportunity" design, erlotinib was evaluated for its…
View details →Moon RE, Mitchell SJ · 2025 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g. breath-hold ascent by divers), veins (venous gas embolism, VGE) as a result of tissue bubble formation due to…
View details →Yalcin Y, Yalcin SE, Demir BC et al. · 2026 · BMC surgery
OBJECTIVE: The therapeutic role of lymphadenectomy in endometrial cancer remains controversial. Although systematic pelvic and para-aortic lymphadenectomy (PPLND) has been suggested to improve survival in certain patients, randomized…
View details →Regidor E, Dionigi C, Ghoraishi M et al. · 2026 · Journal of periodontal research
Aims To evaluate the adjunctive effect of enamel matrix derivative (EMD) in the reconstructive surgical therapy of peri-implantitis. Methods Forty subjects (44 implants) affected by peri-implantitis (PPD ≥ 5 mm, positive BOP/SOP,…
View details →Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology
Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…
View details →Marchetti M, Pinzi V, Gemma M et al. · 2025 · International journal of radiation oncology, biology, physics
Purpose During the last decades, in addition to tumor control, hearing preservation has become an important priority in the treatment of vestibular schwannoma (VS). Given that the potential advantages of hypofractionated radiosurgery (hRS)…
View details →Xu J, Wang H, Chen J et al. · 2025 · International journal of surgery (London, England)
Background Autoimmune rheumatic diseases (ARDs), including rheumatoid arthritis and osteoarthritis, are debilitating conditions with limited curative options. Stem cell therapy offers promising regenerative and immunomodulatory benefits.…
View details →Harris LR, Jörges B, Bury N et al. · 2025 · Experimental brain research
Under the microgravity of the International Space Station, many of the normal processes that determine the perceptual upright on Earth are disrupted. For example, somatosensory cues are absent and an applied physical linear acceleration…
View details →Faghihian R, Tofighi MM, Ziaei S et al. · 2025 · European oral research
Purpose A way to reduce the pain of injection is applying of external cold or vibrations with BUZZY, along with spinal cord gate control systems. We aimed to evaluate the effectiveness of this method in reducing children's pain and anxiety…
View details →Costa TE, Lauar JC, Innecchi MLR et al. · 2026 · Journal of the Endocrine Society
Introduction New evidence has emerged linking uric acid levels to Chronic Kidney Disease and Mineral and Bone Disorder (CKD-MBD). However, interventional studies remain scarce. We evaluated the effect of allopurinol on CKD-MBD biomarkers.…
View details →Ru X, Wu L, Guo Y et al. · 2025 · Medicine
Given that homocysteine (Hey) may be a viable target for intervention and that there is uncertainty regarding the causal relationship between plasma Hcy levels and colorectal cancer (CRC), this study used Mendelian randomization (MR) to…
View details →Crespo R, Poudel I, Malheiros DM et al. · 2024 · Journal of Applied Poultry Research.
This study aimed to compare the performance of 2 quantitative ultrasound (QUS) devices and to investigate the possible relationship between bone density, measured by speed of sound (SOS), and the biomechanical properties of bone. The bone…
View details →Aziz YN, Aragon Garcia R, Plummer P et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized trials showed no benefit of mechanical thrombectomy (MT) for ischemic stroke due to distal medium vessel occlusion (DMVO). We sought to understand the use of MT for DMVO stroke treatment before and after the…
View details →Kim Y, Salazar-Marioni S, Abdelkhaleq R et al. · 2025 · Scientific reports
The role of intravenous thrombolysis (IVT) in combination with endovascular thrombectomy (EVT) for the treatment of large vessel occlusion acute ischemic stroke has been evaluated exclusively outside the US, in randomized clinical trials…
View details →Santucci J, Hua C, Chong L et al. · 2025 · ANZ journal of surgery
Background Data on optimal extent of resection for various stages of gallbladder cancer are lacking. This study aims to evaluate disease-free (DFS) and overall survival (OS) after simple (SC) versus radical cholecystectomy (RC) for…
View details →Byrne RA, Hahn JY, O'Kane P et al. · 2025 · JACC. Cardiovascular interventions
Background In recent years, drug-coated balloon (DCB) angioplasty has become an established treatment option for the treatment of coronary in-stent restenosis (ISR). Objectives The aim of this study was to compare the angiographic and…
View details →Morgenthaler J, Trommer M, Khor R et al. · 2024 · Oral oncology
Oropharyngeal carcinomas linked to high-risk types of human papillomavirus (HPV + OPC) as a distinct tumor entity, have a better prognosis than HPV - OPC. Current treatment approaches do not differentiate between HPV-positive and negative…
View details →Šostakaitė G, Jauniškytė M, Budrys D et al. · 2025 · Nutrition (Burbank, Los Angeles County, Calif.)
Background and aims Muscle wasting is a prevalent issue among long-term critically ill patients and is associated with adverse clinical outcomes. Evaluating muscle mass in the ICU presents challenges due to the lack of a consistent…
View details →Jaffee S, Kusyk DM, Onyiah C et al. · 2026 · Surgical neurology international
Background Neuropsychological assessment is crucial in the presurgical evaluation of patients with Parkinson's disease (PD) who are contemplating deep-brain stimulation (DBS). No standardized screening test battery currently exists. Our…
View details →Adam AS, Marcélis L, Fage D et al. · 2026 · JIMD reports
Hereditary tyrosinemia type I (HT-1) is a rare metabolic disorder treated by NTBC, requiring careful therapeutic and nutritional monitoring. While follow-up traditionally relies on urinary succinylacetone, plasma NTBC and plasma amino…
View details →Chen Y, Ma Y, Yuan H et al. · 2025 · BMC cancer
OBJECTIVES: To investigate clinicopathological predictors and evaluate the impact of adjuvant therapy on survival outcomes in patients with early-stage (FIGO 2023 Stage I-II) endometrial clear cell carcinoma (ECCC). METHODS: This…
View details →GamalEl Din SF, Nabil NI, Khalil MA et al. · 2025 · Urology research & practice
Objective The present study examined the impact of measuring penile girth and length in the erect state on reassuring individuals with small penis anxiety (SPA) in the flaccid state. Methods This study included 200 potent men aged 25-40…
View details →Sköld C, Hailer NP, Mallmin H · 2026 · Acta orthopaedica
Background and purpose Denosumab may preserve periprosthetic bone mineral density (pBMD) around uncemented total hip arthroplasty (THA) components. This exploratory analysis of a previously published randomized controlled trial (RCT) aimed…
View details →Lin YH, Tsai IJ, Chang YA et al. · 2026 · Therapeutics and clinical risk management
Background Traumatic brain injury (TBI) is a major risk factor for subsequent neurodegenerative disorders. Emerging evidence suggests that statins may mitigate neuroinflammation and lipid dysregulation after TBI. This study aimed to…
View details →Dos Santos LC, da Cunha VB, Ribeiro JM et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
Cocaine use disorder (CUD) remains a major public health challenge with limited effective therapeutic options. Cannabidiol (CBD) has been proposed as a potential treatment due to its neuroprotective and anti-craving properties. This…
View details →Samson T, Aali M, McBride D et al. · 2026 · Current oncology (Toronto, Ont.)
Surgical resection combined with chemotherapy offers the best chance of survival in pancreatic ductal adenocarcinoma (PDAC), but many will experience recurrence and early mortality. We examined soluble AXL (sAXL), a blood protein, for its…
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