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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Pictures are not always worth a thousand words: Non-probative pictures did not increase the effectiveness of misinformation corrections.

Whitehead PS, Davis CP, Park JS et al. · 2025 · Journal of applied research in memory and cognition

Much research has focused on the language used for debunking false beliefs: communications should lead with facts, label misinformation as false, and reinforce true information. Pictures are used in debunking messages, but it remains…

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Negative / Null Result ReportMedicine

Evaluating Text Messaging Approaches to Promote Enrollment in Smoking Cessation Treatment Among Latino Adults: A Pragmatic Randomized Clinical Trial.

Cartujano-Barrera F, Catley D, Chávez-Iñiguez A et al. · 2026 · Chest

Background Little is known about the use of text messages to promote enrollment in smoking cessation treatment. Research question What is the impact of the number of outreach messages and monetary incentives on enrollment in smoking…

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Negative / Null Result ReportMedicine

Clinical efficacy and safety of long-term treatment, discontinuation, and extended dosing intervals of denosumab treatment for solid cancer bone metastasis: A retrospective study.

Mihara A, Iwanaga R, Muramatsu K et al. · 2025 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Metastatic bone tumors in solid cancer often induce excessive local bone resorption leading to skeletal related events (SRE) which may impact patients' quality of life and survival of the primary cancer. Denosumab, a bone…

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Negative / Null Result ReportMedicine

Development and testing of implementation strategies to increase the use of midline catheters in a paediatric intensive care unit.

Weber MD, Frankenberger W, Ullman AJ et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Paediatric critically ill patients are at risk of harm from central venous catheter overuse. We applied an implementation science approach to promote appropriate use of midline catheters. The aim of this study was to evaluate…

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Negative / Null Result ReportOpen accessMedicine

First report of bilateral Bronchial Rheoplasty for treating chronic bronchitis performed in a single procedure.

Jensen K, Secher EL, Libermann RH et al. · 2025 · European clinical respiratory journal

Introduction The RheOx system delivers brief, high-voltage electrical pulses to the airway lining, promoting the regeneration of healthy tissue and reducing mucus production in COPD patients with chronic bronchitis. The procedure, called…

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Negative / Null Result ReportOpen accessMedicine

Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study.

Tsujio G, Yashiro M, Miki Y et al. · 2026 · PloS one

Background Our group revealed that the combination of intra-operative stamp cytology and peritoneal lavage cytology (CY) improved the identification of individuals with high risk of peritoneal metastasis. In this exploratory Phase II…

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Negative / Null Result ReportMedicine

Associations between paracetamol administration and delayed intravenous antibiotic administration among patients with in-hospital sepsis.

Senangkhanikorn S, Morapun N, Samansee A et al. · 2026 · Journal of hospital medicine

Background Timely antibiotic administration is crucial for improving sepsis outcomes, but delays are common and multifactorial. Fever, a key feature of sepsis, is often treated with paracetamol, which may mask the condition and contribute…

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Negative / Null Result ReportMedicine

Effects of replacing porcine blood meal with rumen-protected lysine, while maintaining metabolizable methionine supply, on performance, nitrogen use efficiency, and nutrient partitioning in dairy cows.

Arshad U, Johnson SJ, Fukumori R et al. · 2026 · Journal of dairy science

The objectives of this experiment were to determine the effects of replacing metabolizable Lys from porcine blood meal (PBM) with rumen-protected (RP) Lys (RPL) on lactation performance, ECM/DMI, N use efficiency (NUE; milk N/N intake),…

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Negative / Null Result ReportMedicine

COVID-19 infection prior to the onset of type 1 diabetes does not impair beta-cell function: a two-year nationwide follow-up study.

Bjerregaard-Andersen M, Hostrup PE, Kolnes KJ et al. · 2026 · BMC endocrine disorders

Background A possible association between infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and type 1 diabetes (T1D) development has been reported. Whether SARS-CoV-2 infection affects beta-cell loss in T1D…

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Negative / Null Result ReportMedicine

Do Preoperative Intra-Articular Steroid Injections Affect the Choice of Surgical Procedures for Thumb Carpometacarpal Osteoarthritis?

Komura S, Hirakawa A, Hirose H et al. · 2026 · The Journal of hand surgery

Purpose This study investigated the influence of preoperative intra-articular steroid injections on surgical outcomes of trapeziectomy with ligament reconstruction and tendon interposition (LRTI) arthroplasty and arthrodesis and aimed to…

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Negative / Null Result ReportOpen accessMedicine

Effects of the combination of brefeldin A and tunicamycin on endoplasmic reticulum stress and apoptosis in human normal hepatocytes.

Yang Y, Hou M, Li M et al. · 2026 · Current research in toxicology

Background Due to its ability to inhibit the growth of hepatoma cells, brefeldin A (BFA) has been considered a promising drug candidate for liver cancer. However, there is limited research on its safety profile and potential impacts when…

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Negative / Null Result ReportMedicine

The effect of concentrate crude protein concentration and replacing imported feed ingredients with locally grown cereals and faba bean on milk production and nitrogen utilization in grazing dairy cows.

McCarthy KM, Pierce KM, McKay ZC et al. · 2026 · Journal of dairy science

Concentrate feeds with a lower CP concentration are an effective means of reducing nitrogen (N) excretion from grazing dairy cows. Typically, imported feedstuffs such as soybean meal and maize are included in concentrate feeds to increase…

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Negative / Null Result ReportMedicine

The impact of very low nicotine cigarettes on cannabis and alcohol use during a 12-week clinical trial.

Hackworth EE, Lastovich J, Carroll DM et al. · 2026 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Introduction In January 2025, the US FDA announced a proposed rule for a reduced nicotine standard (RNS) in cigarettes. Evidence suggests that the use of very low nicotine content (VLNC) cigarettes decreases cigarette use and tobacco…

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Negative / Null Result ReportMedicine

Intravenous tenecteplase is associated with a higher incidence of thrombus movement before endovascular treatment for acute ischemic stroke: a secondary analysis of the AcT randomized controlled trial.

Alhabli I, Ishaque N, Kate M et al. · 2026 · Journal of neurointerventional surgery

Background Thrombus migration can occur in patients receiving IV thrombolysis for acute stroke. This study compared the effects of IV tenecteplase (0.25 mg/kg) versus alteplase (0.9 mg/kg) on thrombus movement in patients undergoing…

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Negative / Null Result ReportMedicine

Using Eye Tracking to Examine Effects of Overt Localization on Referential Processing in German Sign Language Sentence Processing.

Wienholz A, Nuhbalaoglu-Ayan D, Mani N et al. · 2026 · Journal of psycholinguistic research

The processing of referential expressions is influenced by their form, but also by the accessibility of their antecedents. In sign languages, discourse referents are typically assigned to referential loci (R-loci) in the signing space,…

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Negative / Null Result ReportMedicine

Effects of the Paleo diet on resting metabolic rate in handball players.

Pięta A, Mazur-Kurach P, Maciejczyk M et al. · 2026 · Scientific reports

The Paleolithic diet (PD) has positive effects on health status and body composition. The Paleo diet has been also used to assess the effects on handball players performance but the association of adherence to PD and resting metabolic rate…

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Negative / Null Result ReportMedicine

True metabolizable energy, standardized amino acid digestibility, phosphorus digestibility, and phosphorus bioavailability of fermented soybean meal and fermented full-fat soybeans fed to chickens

Cristobal M, Utterback PL, Stein HH et al. · 2025 · Poultry Science

The objective was to evaluate the nutritional value of conventional soybean meal (SBM-CV), fermented SBM-CV (FSBM), full-fat soybeans (FFSB), and fermented FFSB (FFFSB). In Experiments 1 and 2, two precision-fed rooster assays were…

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Negative / Null Result ReportMedicine

The effects of furosemide on pulmonary transmural pressure and exercise-induced pulmonary hemorrhage in supramaximally exercising thoroughbred racehorses.

Massie S, Léguillette R, Jones JH et al. · 2026 · Journal of veterinary internal medicine

Background Maximal intensity exercise in equine athletes induces pulmonary capillary stress failure and exercise-induced pulmonary hemorrhage (EIPH) secondary to excessive transmural pressure (Ptm). Furosemide decreases EIPH severity and…

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