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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Addition of Clomiphene Citrate to a Low-Dose Gonadotropin-Releasing Hormone (GnRH)-Antagonist Protocol in Poor Responders: A Prospective Cohort Study.

Triantafyllidou O, Panagodimou E, Chasiakou S et al. · 2026 · Cureus

Objective To evaluate whether the addition of clomiphene citrate (CC) to a low-dose recombinant follicle-stimulating hormone (FSH) (r-FSH) gonadotropin-releasing hormone (GnRH)-antagonist protocol improves clinical outcomes in women with…

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Negative / Null Result ReportMedicine

Effect of [<sup>68</sup>Ga]Ga-PSMA-11 PET-CT in the diagnosis of prostate cancer in men with equivocal or clinically high-risk non-suspicious findings on multiparametric MRI (PRIMARY2): a multicentre, non-inferiority, phase 3, randomised controlled trial.

Buteau JP, Moon D, Fahey MT et al. · 2026 · The Lancet. Oncology

Background MRI is recommended for men with clinical suspicion of significant prostate cancer. Those with high clinical risk but non-suspicious or equivocal MRI often undergo prostate biopsy, but have a low likelihood of clinically…

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Negative / Null Result ReportOpen accessMedicine

A Novel BCR::ABL1 Variant Detected with Multiple Testing Modalities.

Jean J, Sukhanova M, Dittmann D et al. · 2024 · Case reports in hematology

Chronic myeloid leukemia (CML) is associated with several breakpoint regions that result in different BCR::ABL1 fusion transcripts. These include the major breakpoint region (M-BCR), minor breakpoint region (m-BCR), and mu breakpoint…

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Negative / Null Result ReportOpen accessMedicine

Presence of Merkel cell polyomavirus DNA and large-T antigen in keratinocyte carcinomas and its correlation with immunohistochemical markers p16, p53 and ki67.

Bellott TR, Luz FB, Fausto da Silva AK et al. · 2024 · Anais brasileiros de dermatologia

Background Merkel cell polyomavirus (MCPyV), a human polyomavirus that is unequivocally linked to merkel cell carcinoma (MCC), has been found in association with keratinocytes carcinomas (KC), especially basal cell carcinoma (BCC) and…

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Negative / Null Result ReportMedicine

Newborn hearing screening in infants at risk of hearing loss: diagnostic outcomes, false-negative results, and the role of surveillance.

Lund A, Nielsen CK, Jensen RB et al. · 2026 · International journal of pediatric otorhinolaryngology

Background Newborn hearing screening programmes aim to identify hearing loss early; however, infants with recognised risk factors may have different screening outcomes, including false-negative results. This study evaluates screening…

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Negative / Null Result ReportMedicine

Neonatal cytogenetic validation demonstrates high accuracy of single-nucleotide polymorphism-based non-invasive prenatal testing: a 4466-case single-center study.

Uchida S, Mizuguchi Y, Sato S et al. · 2026 · Journal of human genetics

Non-invasive prenatal testing (NIPT) is widely used for fetal aneuploidy screening; however, most evaluations of test accuracy rely on pregnancy outcomes rather than cytogenetic confirmation after birth, and evidence regarding the…

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Negative / Null Result ReportMedicine

Impact of a Pharmacy-Driven (1,3)-β-D-Glucan Algorithm on Micafungin Duration of Therapy in the ICU.

Abi Kheir DJ, Moriles K, Carr AL et al. · 2026 · The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians

Background: The (1,3)-β-D-glucan (BDG) test can be used as a stewardship approach to decrease antifungal overutilization, development of resistance, and excess costs. Objective: This study assessed the impact that a BDG algorithm has on…

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Negative / Null Result ReportMedicine

Comparative analysis of laboratory-based and portable qPCR platforms: CFX, MIC, and Biomeme Franklin for African swine fever and avian influenza detection.

Auer A, Settypalli TBK, Rozstalnyy A et al. · 2026 · BMC veterinary research

Background Rapid diagnosis is critical for the early detection and control of transboundary animal diseases such as African Swine Fever (ASF) and Avian Influenza (AI), particularly because it enables timely containment measures at the farm…

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Negative / Null Result ReportMedicine

Field study using sentinel birds and ELISA for differentiating infected from vaccinated animals (DIVA) in chicken flocks vaccinated with inactivated avian influenza H5 vaccines.

Ibrahim M, Mostafa D, Manie EA et al. · 2026 · British poultry science

1. This study used unvaccinated sentinels plus Avian Influenza Virus (AIV) specific ELISA for differentiating infected from vaccinated animals (DIVA). Birds assessed were from 10 broiler flocks (F1-F10), three layer (F11-F13) and two…

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Negative / Null Result ReportOpen accessMedicine

The impact of symptom duration on D-dimer: results from the Venous Thrombosis Registry in Østfold Hospital.

Tavoly M, Jørgensen CT, Sandblad KG et al. · 2026 · Research and practice in thrombosis and haemostasis

Background It has been suggested that D-dimer testing should be avoided in patients with prolonged symptoms, as results may yield false negatives. However, the evidence supporting this recommendation is limited. Objectives This study…

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Negative / Null Result ReportOpen accessMedicine

Reality check: testing the <i>in silico</i> predictions of false negative results due to mutations in SARS-CoV-2 PCR assays using templates with mismatches <i>in vitro</i>.

Otwell T, Knight B, Coryell M et al. · 2025 · Frontiers in cellular and infection microbiology

Molecular diagnostic assays are critical tools to test, diagnose and treat infectious and other diseases. For example, PCR test results have been extremely valuable during the COVID-19 pandemic, not only to provide appropriate health care…

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Negative / Null Result ReportMedicine

Diagnostic performance of somatostatin receptor positron emission tomography in preoperative evaluation of pancreatic neuroendocrine tumor lymph node metastases.

Gudmundsdottir H, Hernandez-Delima FJ, McDowell BC et al. · 2026 · Surgery

Background Regional lymph node involvement impacts prognosis for patients with pancreatic neuroendocrine tumors and may influence management decisions for small tumors. Conventional cross-sectional imaging modalities have low sensitivity…

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Negative / Null Result ReportOpen accessMedicine

Endogenous Biomarkers Analysis and False-Negative Results for SARSCov2 Using two Commercial RT-PCR Diagnostic Kits.

Khoshakhlagh M, Dehghani T, Alizadeh A et al. · 2026 · Iranian journal of pathology

Background & objective Real-time PCR is widely used to detect SARS-CoV-2, the virus responsible for COVID-19, but false-negative results can occur even with internal controls. This study aimed to investigate the impact of using alternative…

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Negative / Null Result ReportOpen accessMedicine

False-negative results of combined endobronchial and endoscopic ultrasound in mediastinal staging of lung cancer.

Gambuś K, Moszczyński K, Popovchenko S et al. · 2026 · Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

Introduction Accurate assessment of mediastinal lymph node involvement is crucial for treatment planning in lung cancer. Combined endobronchial and endoscopic ultrasound (CUS) offers high sensitivity and negative predictive value (NPV),…

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