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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Intraperitoneal Polypropylene Mesh in Clean, Potentially Septic, and Controlled Contamination Fields: An Experimental Rat Study.

Makrantonakis A, Mantzoros I, Ioannidis O et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Intraperitoneal onlay mesh (IPOM) reduces ventral/incisional hernia recurrence but raises concern for adhesions and infection, particularly when the operative field is not strictly clean. We aimed to determine…

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Negative / Null Result ReportOpen accessMedicine

Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Acute Coronary Syndrome and Its Correlation With Angiographic Findings.

Seetharama DB, Prasad K, Prakash VR et al. · 2026 · Cureus

Introduction Acute coronary syndrome (ACS) is a major manifestation of coronary heart disease and is associated with significant morbidity and mortality. Inflammatory and thrombotic mechanisms play an important role in its pathogenesis.…

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Negative / Null Result ReportMedicine

The effect of three different root canal filling materials on postoperative pain in teeth with irreversible pulpitis: a randomized clinical trial.

Eminsoy Avcı AT, Yavuz B, Karakaya B et al. · 2026 · BMC oral health

Background This randomized clinical trial aimed to compare postoperative pain (PP) and analgesic consumption following single-visit root canal treatment using two calcium silicate-based sealers (BioMTA + and Well-Root PT) and one epoxy…

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Negative / Null Result ReportOpen accessMedicine

The Reciprocal Risk Relationship of Dental Caries with NAFLD and Liver Fibrosis: Combined Evidence from the NHANES Study and Mendelian Randomization Analysis.

Xu L, Wang X, Meng X et al. · 2026 · Oral health & preventive dentistry

Purpose To explore the relationship between dental caries and non-alcoholic fatty liver disease (NAFLD) and its advanced stage of liver fibrosis, and to confirm causality by employing a bidirectional two-sample Mendelian Randomization (MR)…

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Negative / Null Result ReportMedicine

Analysis of US Pediatric Pharmacists Incomes: A Gender Comparison Survey Study by the Pediatric Pharmacy Association, Practice-Based Research Network.

Popovici I, Carvajal MJ, Higgins T et al. · 2026 · The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Objectives While gender disparities in the US workforce have received substantial attention, income inequalities among subspecialty pharmacists remain understudied. This study aimed to develop a professional profile of pediatric…

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Negative / Null Result ReportOpen accessMedicine

The potential clinical significance of immunomodulation of immune and inflammatory responses involving selected adipokines in patients with ovarian cancer - preliminary studies.

Stępień S, Morawiec ML, Smycz-Kubańska M et al. · 2026 · Frontiers in oncology

Ovarian cancer (OC) is a major clinical problem in gynaecological oncology, characterised by difficulties in early diagnosis, which contributes to the high mortality rate from OC. Therefore, the search for new biological markers continues,…

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Negative / Null Result ReportOpen accessMedicine

Validation of the C-WATCH score for predicting severity in patients with upper gastrointestinal bleeding at a tertiary public hospital in Lima, Peru.

Espinoza-Ríos J, Ruiz-Cortez R, Santiago B et al. · 2026 · BMC gastroenterology

Background Upper gastrointestinal bleeding (UGIB) remains one of the most common emergencies in gastroenterology, with mortality rates reaching 14% in some settings. Despite advances in management, mortality has remained relatively…

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Negative / Null Result ReportOpen accessMedicine

Cytomorphometric and Clinical Analysis of the Effects of Azithromycin and Platelet-Rich Fibrin on Wound Healing After Surgical Removal of an Impacted Mandibular Third Molar.

Spasić M, Todorović K, Živković N et al. · 2026 · Journal of functional biomaterials

Impacted mandibular third molars present a common challenge in oral surgery, often associated with postoperative complications such as delayed healing and periodontal defects; therefore, optimizing adjunctive therapies is clinically…

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Negative / Null Result ReportOpen accessMedicine

A Comparative Study of Intra-articular Steroid Injection Alone Versus Steroid Injection Combined with Hydroplasty and Manipulation in the Treatment of Frozen Shoulder.

Thakur A, Singh BP, Parihar YS · 2026 · Cureus

Background Frozen shoulder (adhesive capsulitis) is a common cause of shoulder pain and disability in middle-aged adults, characterized by progressive pain and restriction of both active and passive range of motion. Despite multiple…

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Negative / Null Result ReportOpen accessMedicine

Bony Path Assisted Suturing and Tendon-to-Tendon Suturing Technique for External Rotator Repair After Hip Arthroplasty: A Randomized-Controlled Trial.

Wen Z, Ye Y, Chen H et al. · 2026 · Indian journal of orthopaedics

Objective To compare and verify the effectiveness of tendon-to-bone suture technique for the repair of external rotator injuries after hip arthroplasty. Methods This was a prospective, randomized, controlled study including 178 patients…

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Negative / Null Result ReportMedicine

Which Residual Symptoms Predict Relapse in major Depression? A Scoping Review: Quels symptômes résiduels constituent des prédicteurs de rechute de dépression majeure? Un examen de la portée.

Borghgraef D, Sienaert P, Lambrichts S · 2026 · Canadian journal of psychiatry. Revue canadienne de psychiatrie

BackgroundPreventing relapse following a successful acute treatment of major depressive disorder (MDD) remains a clinical challenge. The presence of residual depressive symptoms seems to be a reliable predictor of relapse. However, few…

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Negative / Null Result ReportOpen accessMedicine

Comparison of the Effects of Intranasal and Oral Midazolam Premedication on Sedation and Separation From Parents for Pediatric Patients.

Metin Yamac D, Erguven N, Ozenc E · 2026 · Anesthesiology research and practice

Aim The aim of this study is to compare the effect of intranasal and oral midazolam administered for premedication to children of preschool age on hemodynamic parameters, sedation, and separation from parents. Method A prospective,…

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Negative / Null Result ReportMedicine

Electromyographic and Handheld Dynamometry Assessment of Lumbo-Abdominal Function in Elite Acrobatic Military Parachutists: An Exploratory Cross-Sectional Study.

Reina Abellán J, Bonato F, Ángel García D · 2026 · Military medicine

Background Elite acrobatic military parachutists are exposed to extreme repetitive axial loads and high gravitational forces, and low back pain (LBP) is common; however, the relationship between LBP and trunk neuromuscular function in this…

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Negative / Null Result ReportMedicine

A randomised controlled trial comparing effectiveness of audio-visual aid and ai-personalised video self-modelling interventions to reduce dental fear and anxiety in paediatric patients.

Tasgaonkar A, Rathi N, Tasgaonkar M et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Purpose Paediatric dental anxiety remains a significant challenge in clinical practice, often impacting co-operation and treatment outcomes. This randomised controlled trial compares the anxiety-reducing effects of AI-based self-modelling…

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Negative / Null Result ReportOpen accessMedicine

Translating Evidence into Obstetric Care: Developing a Best Practice-Informed Stepped-Care Clinical Algorithm for the Management of Gestational Insomnia.

Zhao FY, Yue LP, Ho YS et al. · 2026 · Nature and science of sleep

Background and aims Insomnia during pregnancy is potentially associated with adverse outcomes, including gestational diabetes mellitus, pre-eclampsia, cesarean delivery, preterm birth, and depression. This study aimed to synthesize…

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Negative / Null Result ReportMedicine

Electroacupuncture for essential hypertension: Mechanistic insights, current clinical evidence, and translational challenges.

Zhou Y, Qin S, Ma Y · 2026 · Clinical and experimental hypertension (New York, N.Y. : 1993)

Background Essential hypertension (EH) remains a leading modifiable risk factor for cardiovascular morbidity and mortality worldwide. Electroacupuncture (EA), combining traditional acupuncture with pulsed electrical stimulation at specific…

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Negative / Null Result ReportOpen accessMedicine

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms.

Sun Y, Yang X, Zhu Q et al. · 2026 · Drug design, development and therapy

Autoimmune thyroiditis (AIT) is a chronic immune-mediated thyroid disorder characterized by lymphocytic infiltration, follicular epithelial injury, autoantibody production, and variable progression to thyroid dysfunction. Because current…

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Negative / Null Result ReportMedicine

Why evidence struggles to shape musculoskeletal health care and surgical practice in Australia: insights from an Australian clinician survey.

Yu J, Eyles JP, Moreti Cabral Silveira A et al. · 2026 · BMC health services research

Background Evidence based medicine is a critical cornerstone in contemporary medicine, yet uptake and adoption of evidence remain suboptimal. This is prominent in many fields of healthcare, including musculoskeletal health and surgery.…

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