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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Impact of Junior Physicians' Resignation on Palliative Sedation Practices: A Retrospective Single-Center Study in South Korea.

Hong M, Lee SW, Jung M · 2026 · Journal of hospice and palliative care

Purpose This study aimed to evaluate changes in the proportion of patients receiving palliative sedation (PS) before and after the mass resignation of junior physicians in South Korea. Methods This single-center retrospective chart review…

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Negative / Null Result ReportOpen accessMedicine

Mitigation of salinity stress in Mentha piperita L. through foliar application of chitosan-salicylic acid encapsulated ZnO nanoparticles.

Al-Obaidi MHR, Mehrabani LV, Hassanpouraghdam MB et al. · 2026 · Scientific reports

Salinity stress harms plant growth and physiological characteristics. To investigate the effect of NaCl salinity stress (without salinity stress and 100 mM salinity) and foliar spray with: control (distilled water), zinc oxide…

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Negative / Null Result ReportMedicine

Factors Associated With Surgical Outcomes in Medial Orbital Wall Fracture Reconstruction With Absorbable Plates.

Li B · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Preoperative imaging factors associated with absorbable plate reconstruction outcomes for medial orbital wall fractures are not well-established. The role of muscle cone integrity on computed tomography (CT) has not been…

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Negative / Null Result ReportOpen accessMedicine

The effect of <i>Lactiplantibacillus plantarum</i> probiotic supplement on rainbow trout challenged with <i>Aeromonas salmonicida</i>.

Mikulikova I, Lepkova Z, Bandouchova H et al. · 2026 · Veterinarni medicina

Two probiotic ( Lactiplantibacillus plantarum ) supplementation strategies (continuous and cyclic) were evaluated for their ability to enhance resistance of rainbow trout ( Oncorhynchus mykiss ) to Aeromonas salmonicida infection. Neither…

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Negative / Null Result ReportMedicine

[Efficacy of photodynamic therapy in extrahepatic cholangiocarcinoma].

Chen C, Liu HC, Wang RF et al. · 2026 · Zhonghua wai ke za zhi [Chinese journal of surgery]

Objective: To investigate the safety and efficacy of photodynamic therapy(PDT) combined with biliary stent implantation in the treatment of extrahepatic cholangiocarcinoma. Methods: A retrospective cohort analysis was conducted based on…

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Negative / Null Result ReportOpen accessMedicine

Finite element analysis of the pedicle screw in lumbar transpedicular dynamic stabilization that penetrates the lateral cortex of the vertebral pedicle.

Zhao C, Zhang M, Li P et al. · 2026 · BMC musculoskeletal disorders

BACKGROUND: The mechanical stability of lumbar transpedicular dynamic stabilization (LTDS) was determined by simulating the degree to which the pedicle screws penetrated the lateral pedicle cortex. METHODS: A finite element model of the…

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Negative / Null Result ReportMedicine

Preoperative radiotherapy negatively affects early hypertrophy but has no effect on graft survival and union in patients treated with vascularized fibular grafts for bone tumors.

Bayram S, Atasoy İT, Salduz A et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Preoperative radiotherapy may impair bone healing and remodeling after wide resection and reconstruction using vascularized fibular grafts for bone tumors. This study evaluated whether preoperative radiotherapy affected union,…

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Negative / Null Result ReportOpen accessMedicine

Axial Length Asymmetry in Patients with Unilateral Retinal Detachment.

Wang H, Loke JY, Chan WO et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives: Increased axial length is a major risk factor for retinal detachment. This study explored whether, in individuals presenting with unilateral disease, the longer eye was more likely to have rhegmatogenous disease.…

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Negative / Null Result ReportOpen accessMedicine

Dexmedetomidine and Apigenin Combination Mitigates Memory Deficits Caused by Microglial Activation and Hippocampal Neurogenesis Impairment in Methotrexate-Induced Chemo-Brain in Rats.

Yousef EM, Eldemerdash OM, Senousy MA et al. · 2026 · Neural plasticity

Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, and apigenin (Api), a naturally occurring bioflavonoid, have recently shown neuroprotective effects in experimental models of methotrexate (MTX)-induced neurotoxicity; however, the…

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Negative / Null Result ReportOpen accessMedicine

Can Lactate Values Predict Postoperative Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery? A Prospective Observational Study.

Temiztürk Z, Beyazal OF, Topçu AC et al. · 2026 · Brazilian journal of cardiovascular surgery

Introduction The aim of our study is to investigate the relationship and predictive significance of routinely measured serum lactate values with postoperative atrial fibrillation (POAF) in patients following isolated coronary artery bypass…

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Negative / Null Result ReportMedicine

Computed tomography based distal femoral morphology and comparative multi-implant total knee replacement fit analysis in a South East London population.

Eveson TE, Davis TP, Tindall AJ · 2026 · Journal of orthopaedics

Background Accurate medio-lateral sizing of the distal femur during total knee replacement (TKR) is essential to optimise implant fit and avoid over- or under-hang, which have been associated with suboptimal outcomes. National guidance…

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Negative / Null Result ReportOpen accessMedicine

Survival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data.

Hu Z, Ma R, Wen Y et al. · 2026 · Cancer medicine

Background The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0…

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Negative / Null Result ReportOpen accessMedicine

Effect of diode laser biostimulation on implant stability, post-surgical inflammation, and bone healing in immediate implant in the maxillary premolars. A randomized double-blind trial.

Kassem BA, Osman SM, El-Mahallawy Y · 2026 · Clinical oral investigations

INTRODUCTION: The stimulatory effects of laser Biostimulation on immediate implant clinical wound healing and radiographic bone quality analysis is with insufficient evidence. AIM: To evaluate the effect of low-level diode laser as a…

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Negative / Null Result ReportOpen accessMedicine

Clinical characteristics and prognostic differences between elderly-onset and adult-onset ulcerative colitis: a two-center retrospective cohort study.

Li H, Ding S, Li J et al. · 2026 · Frontiers in medicine

Background The incidence of elderly-onset ulcerative colitis (EO-UC) has been gradually increasing. The unique characteristics of clinical manifestations, therapeutic strategies, and prognosis in EO-UC patients compared with adult-onset…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of prophylactic single-dose IV antibiotic versus postoperative multi-dose oral antibiotic regimen for preventing surgical site infections: A prospective comparative study.

Pusdekar VP, Dare G, Bhojwani P et al. · 2026 · Turkish journal of surgery

Objective Surgical site infections (SSIs) are among the most common postoperative complications, contributing to morbidity, prolonged hospital stays, and healthcare costs. Prophylactic antibiotics are widely used, but the optimal regimen…

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Negative / Null Result ReportMedicine

The effects of repetitive transcranial magnetic stimulation over the lateral parietal region on episodic future thinking and episodic memory.

Toufexis C, Grant JB, van Boxtel JJA et al. · 2026 · Consciousness and cognition

The left angular gyrus (AG) has been implicated in the level of detail elicited during both episodic memory (EM) and episodic future thinking (EFT). This study aimed to investigate whether repetitive transcranial magnetic stimulation…

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Negative / Null Result ReportOpen accessMedicine

Radiation Countermeasure Gamma-Tocotrienol Inhibits Accumulation of Lipid Peroxidation Products in the Serum of Nonhuman Primates Exposed to Partial- or Total-Body Radiation-A Hallmark of Inhibition of Irradiation-Induced Ferroptosis?

Brzóska K, Carpenter AD, Petrus SA et al. · 2026 · International journal of molecular sciences

Gamma-tocotrienol (GT3) is one of the constituents of vitamin E that demonstrated significant radioprotective efficacy in murine and nonhuman primate (NHP) models. Considering the antioxidant activity of GT3 and its role in terminating…

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Negative / Null Result ReportOpen accessMedicine

Robotic-assisted <i>versus</i> laparoscopic cholecystectomy: a matched study in pediatric cases at a single center.

Ha S, Kwon H, Namgoong JM et al. · 2026 · Annals of surgical treatment and research

Purpose In the past decade, advancements in robotic surgery have significantly expanded its application into diverse fields, including urological, gastrointestinal, hepatobiliary, and gynecological procedures. However, comparative outcome…

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Negative / Null Result ReportMedicine

Transanastomotic Tube Use and Anastomotic Stricture: A Multicenter Prospective Randomized Trial in Neonates Undergoing Repair of Type C Esophageal Atresia with Distal Tracheoesophageal Fistula.

Lee J, Russell KW, Smith C et al. · 2026 · Annals of surgery

Objective Anastomotic stricture (AS) is the most common complication following repair of type C esophageal atresia with distal tracheoesophageal fistula (EA/TEF). Retrospective studies suggest transanastomotic tube (TT) use may increase AS…

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