11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Tomblin Murphy G, Sampalli T, Elliott Rose A et al. · 2026 · International journal of nursing studies advances
Introduction Despite the global shortage of nurses, there is limited literature that comprehensively maps interventions to support, stabilize, and enhance the nursing workforce. Purpose This umbrella review aimed to identify structures,…
View details →Kam KW, Mehraban Far P, Yim TW et al. · 2026 · The Cochrane database of systematic reviews
Rationale Blepharitis is a common ocular condition characterized by inflammation of the eyelid margins, which can cause irritating symptoms and ocular surface damage. Conventional treatment of blepharitis consists of eyelid hygiene and…
View details →Garg A, Nakhla O, Steeper M et al. · 2026 · The Cochrane database of systematic reviews
Rationale Assisted reproductive technologies (ART), including in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), combine an egg and sperm outside the body to enhance the probability of fertilisation and pregnancy.…
View details →Weber I, Whelan BM, Bruce JM et al. · 2026 · Sports health
Context There is significant interest in jugular venous compression (JVC) devices from multiple parties, including sports physicians, athletic trainers, athletes, and parents. Objective To examine the effects of JVC on repetitive head…
View details →Mehta V, Galletti C, Mathur A et al. · 2026 · Systematic reviews
Background Oral candidiasis (OC) is among the most prevalent oral infections, frequently associated with immunosuppression, denture wearing, advanced age, and excessive antibiotic use. Given the growing concerns about antifungal…
View details →Wu X, Zhang B, Yu M et al. · 2026 · Photodiagnosis and photodynamic therapy
Repeated low-level red-light therapy (RLRL) has emerged as a promising ocular photobiomodulation strategy for childhood myopia control. Published randomized trials have reported substantial reductions in axial elongation and refractive…
View details →Ordóñez-Riaño S, Jiménez-Leal W · 2026 · Acta psychologica
What motivates people to place trust in strangers-the sense that they ought to trust, or the feeling that they want to? Competing perspectives suggest that trust may be driven either by obligations or by desires. In two studies, we tested…
View details →De Laet H, Nijhof AD, Wiersema JR · 2026 · Autism : the international journal of research and practice
While prevailing theories suggest social interaction difficulties are inherent to autism, the theory of the double empathy problem (DEP) proposes these difficulties arise from a mismatch between different neurotypes. The theory predicts…
View details →Kiang M, Lepock JR, Mizrahi R et al. · 2026 · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Objectives Patients at clinical high risk (CHR) for schizophrenia experience a wide range of clinical outcomes. Given this heterogeneity, long-term prognostic biomarkers are needed. The gamma-frequency EEG auditory steady-state response…
View details →Csigai P, Sparrow L, Maquet L et al. · 2026 · Scientific reports
Resting heart rate variability (HRV) is considered a marker of individuals' capacity to adapt to environmental demands, although direct empirical evidence remains limited. This study examined whether resting HRV predicts subjective and…
View details →Werle D, Sablottny L, Tuschen-Caffier B et al. · 2026 · Appetite
While the hierarchical model of approach-avoidance motivation suggests a heightened food-specific approach behavior for individuals with binge eating disorder (BED), empirical evidence does not confirm the postulated food approach bias.…
View details →Flint RW Jr, Morehouse J, Chown AE et al. · 2026 · Psychological reports
Long-term reactivated memories undergo a time-dependent reconsolidation process during which they are susceptible to modulation. We report the results of an experiment examining the effect of multiple reminder treatments on reconsolidation…
View details →Sharma A, Hanly M, Bhonagiri D · 2026 · Critical care medicine
Objectives This study aims to investigate the effect of culturally and linguistically diverse (CaLD) status on in-hospital mortality in patients admitted to ICUs with sepsis. We hypothesize that diverse cultural and ethnic backgrounds,…
View details →van Doorslaer de Ten Ryen S, Warnier G, Antoine N et al. · 2026 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Satellite cells participate in myogenesis and contribute to skeletal muscle regeneration and hypertrophy. Amongst other stimuli, satellite cells can be activated by exercise and hypoxia. However, the cumulative effect of exercise on…
View details →Tagami U, Imaizumi S · 2026 · Acta psychologica
Visual false pattern perception can increase in response to a lack of control. However, prior studies have manipulated control over relatively long timescales by altering participants' beliefs. We investigated whether short-timescale…
View details →Inamura Y, Miyazaki S, Nitta J et al. · 2026 · Heart rhythm
Background A size-adjustable cryoballoon (SACB, POLARxFIT, Boston Scientific), switching between 28-mm and 31-mm diameters, was introduced for atrial fibrillation ablation; however, its efficacy and safety compared with conventional…
View details →Adami A, Vitacca M, Casaburi R et al. · 2026 · European journal of applied physiology
PURPOSE: Long-term oxygen therapy (LTOT) is an established treatment for patients with chronic obstructive pulmonary disease (COPD) diagnosed with hypoxemia at rest or during activity. Chronic hypoxemia is a potential mediator of loss of…
View details →Pacheco CFO, Costa RF, Silva AEB et al. · 2026 · Forest Ecology and Management.
Mangroves face increasing threats from human degradation and extreme weather events, yet limited information exists on whether they can naturally recover after those disturbances. In this study, we attempted to fill this gap by assessing…
View details →Antonarakis ES, Antonarakis ES, Cao Q et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This multicenter, single-arm, phase II trial evaluated the safety and efficacy of cabazitaxel and carboplatin followed by abiraterone, plus androgen deprivation therapy (ADT), in patients with high-volume metastatic…
View details →Wanner P, Ostermair F, Cristini J et al. · 2026 · Experimental brain research
A single bout of cardiovascular exercise (CVE) can promote neuroplasticity in an intensity-dependent manner. Consequently, performing CVE immediately after encoding may enhance motor memory consolidation, with stronger effects reported for…
View details →Almeida OP, Page A, Etherton-Beer C · 2026 · International psychogeriatrics
Behavioural and psychological disturbances are common among individuals with dementia. It is unclear if the use of antidementia medicines reduces their presence. This study aimed to clarify if the introduction of antidementia medicines…
View details →Getachew ED, Wronski ML, Van De Water AL et al. · 2026 · The International journal of eating disorders
Objective Avoidant/restrictive food intake disorder (ARFID) is an eating disorder characterized by persistent avoidant/restrictive eating unrelated to body image. Sex differences in clinical phenotypes and neurobiology of ARFID are…
View details →Pohjola A, Asikainen A, Kaprio J et al. · 2026 · Neurology
Background and objectives The growing use and improved accessibility of noninvasive imaging modalities have increased the detection of incidental intracranial findings, such as unruptured brain arteriovenous malformations (AVMs). At the…
View details →Crawford M, Leonardi C, Martin MP et al. · 2026 · Journal of surgical orthopaedic advances
This study sought to characterize patient interest in utilizing telemedicine for orthopaedic surgery clinic visits in a primarily Medicaid population. The authors hypothesized that interest in telemedicine would be associated with higher…
View details →Le Blanc-Brillon J, Fortin JS, Lafrance L et al. · 2025 · Frontiers in psychology
Introduction Social networking sites (SNSs) have become an integral part of daily life, raising concerns about their potential impact on mental health. One key mechanism through which SNSs may affect wellbeing is social comparison. The…
View details →Smulligan KL, Lempke LB, Mannix RC et al. · 2026 · The Journal of pediatrics
Objective To investigate whether slower reaction time (RT) was associated with higher concussion odds among middle school female soccer players. Study design We performed a retrospective cohort study, analyzing pre-participation…
View details →Kemp LT, Smeets T, Jansen A et al. · 2026 · Journal of behavior therapy and experimental psychiatry
While studying appetitive and aversive conditioning is common in psychopathology research, studies that measure both types of learning simultaneously are rare. To gain insight into the role of appetitive and aversive learning in the…
View details →Del Grosso SJ, Nichols KL, Delgado JA et al. · 2025 · Nutrient cycling in agroecosystems.
Grassland soils managed with livestock grazing can act as sources and sinks for methane (CH₄) and nitrous oxide (N₂O), but, in aggregate, are typically a source of N₂O and a sink for CH₄. Previously, we observed higher N₂O losses from…
View details →Arriero-Cabañero A, Díaz-Rubio N, Talabán-Rocha C et al. · 2025 · Molecular neurobiology
Pyruvate kinases are key enzymes of glycolytic metabolism of neurons and glia. One of them, pyruvate kinase M2 (PKM2) can also act as a transcriptional regulator and in this function has been implicated in several neurodegenerative…
View details →Moreau AL, Rappaport BI, Saturday ML et al. · 2026 · Journal of psychiatric research
Intolerance of uncertainty (IU) is an individual difference dimension reflecting negative cognitive, emotional, and behavioral responses to uncertainty. IU is an important etiological and maintaining mechanism of internalizing…
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