Negative / Null Result ReportOpen accessMedicine
Lei Wang, Tingjun Ye, Lianfu Deng et al. · 2014 · PLoS ONE
Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained bone sections to examine the morphological characteristics of microdamage, bone resorption activity and spatial relationship between microdamage and bone resorption. Di
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Arslan A, Benli E, Yüce A et al. · 2026 · BMC urology
Background Erectile dysfunction (ED) is a vascular disease associated with systemic inflammation and endothelial dysfunction. The role of inflammatory markers in the pathogenesis of ED is gaining increasing importance. This study aimed to…
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Darpan I. Patel, Kira Abuchowski, Bilal Sheikh et al. · 2019 · European Journal of Translational Myology
The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04).
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Jingjing Zhou, Shanshan Wu, Xiaojing Wu et al. · 2023 · PLoS ONE
The cultural landscape in traditional settlements is an important historical and cultural resource created by human beings in the process of historical evolution, and is an important resource for the development of traditional settlement tourism. This paper selected 21 representative traditional settlements for research using online comments from tourists as data and content analytical methods including high-frequency vocabulary, semantic networks and emotional attitudes to explore the public perspective on the connotations of cultural landscape features in traditional settlements. There are f
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Azam Ardeh, Elham Goodarzi, Zahra Madadi et al. · 2025 · BMC Research Notes
Abstract Background Marital relationships, like any other interpersonal bond, encompass both positive and negative dimensions. Central to the success of marriage is the level of satisfaction and commitment experienced by the partners. This study aims to compare the efficacy of cognitive-behavioral couple therapy and schema-based couple therapy in reducing the desire for divorce and marital boredom. Methods This experimental study employed a pre-test-post-test design with a control group. The research sample comprised couples experiencing marital issues who sought counseling at various counseli
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Dandan Chen, Huamin Wu, Feifeng Huang et al. · 2025 · PLoS ONE
Objective This study explored the prognosis of high-grade squamous intraepithelial lesion (HSIL) patients with negative margins, investigating the impact of different distances between lesions and incisal margins in conization specimens. Methods This retrospective cohort study included 240 HSIL patients. Patients with negative incisal margins were divided into 3 groups according to the distance between the lesion and the incisal margin in the conization tissue. Group 1 consisted of a distance of 3 mm (n = 202). For patients with lesions close to the incisal margin (≤3 cm), the decision between
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Van de Vyver A, Taylan O, Peersman G et al. · 2026 · Archives of orthopaedic and trauma surgery
Objectives This study aimed to analyze to what extent a novel intraoperative navigation platform (Next-AR, Medacta) for total knee arthroplasty (TKA) allows to restore the native knee joint kinematics and strains in the medial collateral…
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Sung Hee Lim, Jong-Mu Sun, Joohyun Hong et al. · 2021 · The Korean Journal of Internal Medicine
Background/Aims Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Methods Treatment-naïve patients with stage III/IV (M0) hypopharynx or BOT cancer were randomly assigned to receive CRT alone (CRT arm: cisplatin 100 mg/m2 on D1 3-weekly, two times plus radiotherapy 68.4 Gy/30 fractions on we
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Derya Sivri Aydın · 2019 · İstanbul Medical Journal
Introduction:To evaluate whether neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have diagnostic value in endometrioma, which is a chronic inflammatory disease.Methods:A total of 187 patients who underwent surgery for adnexal mass, 97 patients diagnosed with endometrioma and 90 patients with benign cyst (corpus luteum, serous cysts or functional cysts), were included in this retrospective, comparative case series. NLR and PLR values obtained from preoperative complete blood count parameters were compared between the two groups.Results:There was no statistically significan
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Laura Sterian Ward, Ilda Shizue Kunii, Rui Monteiro de Barros Maciel · 2000 · São Paulo Medical Journal
CONTEXT: Screening programs not only offer the opportunity to trace and treat almost all cases of congenital hypothyroidism but also mean large savings to the health system. However, carefully planned strategies are necessary to extend their benefits and reduce costs. OBJECTIVE: To determine the possible influence of maternal diseases that affect maternal-fetal placenta dynamics on primary thyroid stimulating hormone (TSH) screening for congenital hypothyroidism. DESIGN: Prospective non-randomized clinical trial with at least 3 months of follow-up. SETTING: A public university referral center
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Magdalena Dudek, Marta Kałużna-Oleksy, Jacek Migaj et al. · 2018 · Journal of Medical Science
Background. Coronary artery disease (CAD) is one of the most important causes of death in both men and women. There are many gender differences among patients with CAD, including risk factors and acute coronary syndrome (ACS) outcomes. The latest reports showed that mortality due to CAD is higher in women than in men. Cardiac biomarkers play an important role in risk stratification and choice of treatment strategy in patients with ACS, however some of cardiac biomarkers show worse sensitivity and specificity in women. Aim. The aim was to investigate the sex-related differences in patients with
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Toshiki Saito, Kosuke Motoki, Rui Nouchi et al. · 2019 · PLoS ONE
Emotion plays important and diverse roles across various social relations. Although the social functions of emotion have attracted increased attention, the effects of positive emotions such as pride on impression formation remain poorly understood. Drawing on social projection theory, this study examined how incidental experiences of pride influenced the impressions of those who made a blunder, along with two other characteristics: the person's warmth and competence. Participants were designated randomly to receive inductions of pride, awe, or a neutral emotion. Subsequently, they were asked t
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Nicholas P Carruth, Jairo A Ramos, Akira Miyake · 2023 · PLoS ONE
This article reports a preregistered study in which we attempted to replicate the results of an influential study on the ego-depletion effect reported by Job, Dweck, and Walton in 2010. The original Job et al. study (Study 1, N = 60) provided evidence that the ego-depletion effect-a performance decrease on a self-control task after performing another self-control task-occurs only for individuals who hold a belief that their willpower is limited. This moderation of the ego-depletion effect by one's willpower mindset (limited vs. nonlimited) has been interpreted as evidence against a prevalent l
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Marta Schirripa, Wu Zhang, Dongyun Yang et al. · 2018 · PLoS ONE
BACKGROUND:Macrophages play a crucial role in the interaction between tumor and immune system, and iNOS is known as a surrogate marker of M1 macrophages activation. The goal of the study was to investigate the role of iNOS polymorphisms as prognostic marker in mCRC patients. MATERIALS AND METHODS:Functional significant polymorphisms in the promoter of INOS gene were analyzed by PCR-based and direct DNA sequencing in 4 cohorts of patients receiving bevacizumab based first-line chemotherapy: two evaluation cohorts (TRIBE ARM A and ARM B) and two validation cohorts (FIRE 3 arm A and MOMA). The re
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Nicholas P. Carruth, Jairo A. Ramos, Akira Miyake · 2023 · PLoS ONE
This article reports a preregistered study in which we attempted to replicate the results of an influential study on the ego-depletion effect reported by Job, Dweck, and Walton in 2010. The original Job et al. study (Study 1, N = 60) provided evidence that the ego-depletion effect—a performance decrease on a self-control task after performing another self-control task—occurs only for individuals who hold a belief that their willpower is limited. This moderation of the ego-depletion effect by one’s willpower mindset (limited vs. nonlimited) has been interpreted as evidence against a prevalent l
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Muhammad Muaaz Aslam, Peter John, Kang-Hsien Fan et al. · 2019 · BMC Research Notes
Abstract Objective Type 1 diabetes (T1D) and rheumatoid arthritis (RA) are autoimmune diseases. It is known that certain genetic loci and factors that increase the overall autoimmunity risk can be shared among different autoimmune diseases. We sought to replicate seven T1D-related SNPs (single nucleotide polymorphisms) that have been previously reported to be associated with RA susceptibility in a small set of mixed family-based and case–control Pakistani sample in a relatively large and independent RA case–control sample from the same population. Seven T1D-associated SNPs (GLIS3/rs7020673, BA
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Hailu Wang, Yingying Dai, Wenhai Pan et al. · 2026 · Medicine Advances
ABSTRACT Background Estradiol, the key endogenous estrogen, reduces the risk of urinary obstruction by smooth muscle relaxation but also increases susceptibility to breast cancer (BC). However, whether estradiol serves as a mechanistic mediator linking urinary tract obstruction and BC remains unclear. This study aimed to determine if there is an association between urinary tract obstruction and the risk of BC and to assess the potential mediating role of systemic estradiol. Methods A case‐control study and survival analysis of Cox regression were conducted using clinical data from the United K
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Daniel Selechnik, Andrea J. West, Gregory P. Brown et al. · 2017 · PeerJ
The cane toad (Rhinella marina) has undergone rapid evolution during its invasion of tropical Australia. Toads from invasion front populations (in Western Australia) have been reported to exhibit a stronger baseline phagocytic immune response than do conspecifics from range core populations (in Queensland). To explore this difference, we injected wild-caught toads from both areas with the experimental antigen lipopolysaccharide (LPS, to mimic bacterial infection) and measured whole-blood phagocytosis. Because the hypothalamic-pituitary-adrenal axis is stimulated by infection (and may influence
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Rachel Cassar, Victor Shiramizu, Lisa M DeBruine et al. · 2020 · PLoS ONE
Women's preferences for masculine characteristics in men's faces have been extensively studied. By contrast, little is known about how gay men respond to masculine facial characteristics. One area of disagreement in the emerging literature on this topic is the association between gay men's partnership status and masculinity preference. One study found that partnered gay men showed stronger preferences for masculine faces than did single gay men, while another study found that partnered gay men showed weaker preferences for masculine faces than did single gay men. We re-examined this issue in a
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Fernando Caravaggio, Pontus Plavén-Sigray, Granville James Matheson et al. · 2018 · PLoS ONE
High levels of trait impulsivity are considered a risk factor for substance abuse and drug addiction. We recently found that non-planning trait impulsivity was negatively correlated with post-commissural putamen volumes in men, but not women, using the Karolinska Scales of Personality (KSP). Here, we attempted to replicate this finding in an independent sample using an updated version of the KSP: the Swedish Universities Scales of Personality (SSP). Data from 88 healthy male participants (Mean Age: 28.16±3.34), who provided structural T1-weighted magnetic resonance images (MRIs) and self-repor
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Olivier Senn, Florian Hoesl, Toni Amadeus Bechtold et al. · 2024 · PLoS ONE
There is a broad consensus in groove research that the experience of groove, understood as a pleasurable urge to move in response to music, is to some extent related to the complexity of the rhythm. Specifically, music with medium rhythmic complexity has been found to motivate greater urge to move compared to low or high complexity music (inverted-U hypothesis). Studies that confirmed the inverted-U hypothesis usually based their measure of complexity on the rhythmic phenomenon of syncopation, where rhythms with more and/or stronger syncopation are considered to be more complex than less synco
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Rogier A. Kievit, Delia Fuhrmann, Gesa Sophia Borgeest et al. · 2018 · Wellcome Open Research
Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the U
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Chen X, Wen W, Zheng L · 2026 · Shock (Augusta, Ga.)
Background Sepsis is a clinical syndrome marked by a dysregulated host response to infection, impairing oxygen delivery and utilization and causing organ dysfunction. Hypoxemia, which can cause significant tissue and organ damage, commonly…
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Nicholas Judd, Rogier Kievit · 2025 · eLife
Education is related to a wide variety of beneficial health, behavioral, and societal outcomes. However, whether education causes long-term structural changes in the brain remains unclear. A pressing challenge is that individuals self-select into continued education, thereby introducing a wide variety of environmental and genetic confounders. Fortunately, natural experiments allow us to isolate the causal impact of increased education from individual (and societal) characteristics. Here, we exploit a policy change in the UK (the 1972 ROSLA act) that increased the amount of mandatory schooling
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Seyyed Abolfazl Tabatabaie-Zadeh, Nazanin Mahdavi, Behnaz Mahdaviani et al. · 2024 · PLoS ONE
Purpose Oral cancers are the 6th most common malignancy worldwide and oral squamous cell carcinoma, comprises over 90% of oral cancers. This study investigates the relationship between physical activity level during the lifetime and oral squamous cell carcinoma risk. Methods 100 oral squamous cell carcinoma patients and 200 healthy individuals participated in this case-control study. Physical activity level was evaluated via the Lifetime Physical Activity Questionnaire. The occupational, household, and sports domains of lifetime physical activity were determined. Case and control groups' parti
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Renata Jabłońska, Marta Gralik, Agnieszka Królikowska et al. · 2016 · Pielęgniarstwo Neurologiczne i Neurochirurgiczne
Introduction. In the occupational medicine back pain is treated as a paraoccupational disease, mainly related to specific professional groups. They include those employed in the sector of health care, who are at the highest risk of developing back pain, nurses in particular. Aim. Assessment of back pain occurrence among nurses and determining the factors affecting this condition. Material and Methods. The study group consisted of 76 nurses working in neurology and neurosurgery wards/clinics. The research methodology applied consisted of diagnostic survey method, and as the technique, a survey
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Kataruka M, Sannyashi P, Bhattacharjee S et al. · 2026 · Cureus
Introduction Neuropathic ulcers occur mainly at the plantar aspect and correspond to areas with peak plantar pressure, usually seen in a sensory-deficient foot. Trophic ulcers are seen in diabetic neuropathy, post-leprosy, and any other…
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Elham Tabesh, Farzad Yadmehr, Awat Feizi et al. · 2024 · Health Science Reports
Abstract Backgrounds and Aims This controlled randomized clinical trial was designed to compare effectiveness, side effects, and severity of symptoms before and after therapy between quadruple (QT) and sequential regimens (SQ) for Helicobacter Pylori (H. pylori). Methods Patients were randomly allocated into two groups. Group A received a 14‐day QT including pantoprazole 40 mg q12 h, bismuth subcitrate 240 mg q12 h, clarithromycin 500 mg q12 h, and amoxicillin 1000 mg q12 h and group B received ST including pantoprazole 40 mg q12 h and amoxicillin 1000 mg q12 h for the initial 5 days followed
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Subh Salem Al-Mudallal, Muna Abd Al-Moeen Al- Habbobi · 2016 · The Iraqi Journal of Medical Sciences
Background: Hematological values at birth encompass broader ranges of normal than at any other time in life, and despite advances in perinatology over the past years, the exact influence of perinatal factors on hematological values in cord blood in normal pregnancy is still unclear. Moreover there was a wide variation and overlap in values between normal and abnormal infants with early symptoms and signs of neonatal sepsis. Objectives: 1. To obtain the values of hematological parameters including complete blood picture, red cell indices, nucleated red blood cells and reticulocyte count in heal
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Bruna Cassia Dal Vesco, Ana Carolina de Miranda, Fernanda do Carmo De Stefani et al. · 2026 · Einstein (São Paulo)
ABSTRACT Objective: The causal mechanisms of peripheral hypoperfusion in sepsis have not yet been fully elucidated. Therefore, this study aimed to investigate whether peripheral hypoperfusion in septic patients is associated with serum levels of damage-associated molecular patterns. Methods: A retrospective cohort study was conducted to compare serum levels of damage-associated molecular patterns - histone H3, histone H4, and high-mobility group box-1 protein (HMGB1) - with markers of tissue hypoperfusion - the peripheral perfusion index and the capillary refill time, using a single measuremen
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