11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Roman TS, Gray SM, Sneddon TP et al. · 2026 · HGG advances
The impact of clinical exome and genome sequencing (ES/GS) depends on the clinical setting. In the sequencing arm of a multifactor randomized clinical trial to evaluate broadening access, we assessed the diagnostic and inconclusive…
View details →Bölük S, Bölük S · 2025 · Cureus
Background In breast cancer surgery, sentinel lymph node biopsy (SLNB) is routinely utilized for axillary assessment. Frozen section examination of the sentinel lymph node (SLN) is used to guide the decision for axillary dissection.…
View details →Triantafyllidou O, Panagodimou E, Chasiakou S et al. · 2026 · Cureus
Objective To evaluate whether the addition of clomiphene citrate (CC) to a low-dose recombinant follicle-stimulating hormone (FSH) (r-FSH) gonadotropin-releasing hormone (GnRH)-antagonist protocol improves clinical outcomes in women with…
View details →Buteau JP, Moon D, Fahey MT et al. · 2026 · The Lancet. Oncology
Background MRI is recommended for men with clinical suspicion of significant prostate cancer. Those with high clinical risk but non-suspicious or equivocal MRI often undergo prostate biopsy, but have a low likelihood of clinically…
View details →Paturu T, Shukla A, Shivan SG et al. · 2024 · Journal of cataract and refractive surgery
Evidence-based decision-making is generally based on published evidence. Therefore, if the published evidence is biased, so will the decision-making. One possible bias is the "positive-results" publication bias. This study attempts to…
View details →Lydia S, Blaise G · 2024 · Journal of travel medicine
Background When malaria is suspected in case of fever after travel in endemic areas, the current recommendation is to repeat the malaria test at 24-hour intervals, with up to two additional tests, as long as the test result is negative. A…
View details →Teixeira J, Teixeira D, Coelho A et al. · 2026 · Dermatology practical & conceptual
Introduction Systemic amyloidosis is a rare disorder characterized by extracellular amyloid deposition in tissues, leading to variable organ dysfunction. Abdominal wall fat pad biopsy is widely used as a minimally invasive diagnostic…
View details →Jean J, Sukhanova M, Dittmann D et al. · 2024 · Case reports in hematology
Chronic myeloid leukemia (CML) is associated with several breakpoint regions that result in different BCR::ABL1 fusion transcripts. These include the major breakpoint region (M-BCR), minor breakpoint region (m-BCR), and mu breakpoint…
View details →Mateuszczyk MK, Łyko M, Bieniek A et al. · 2025 · Clinics and practice
Background: Adverse reactions to tattoo pigments are increasingly recognized, yet severe systemic complications remain rare and poorly characterized. Red tattoo ink, in particular, is associated with delayed hypersensitivity reactions, but…
View details →Chunkul S, Sathirapatya T, Dangklao P et al. · 2025 · Forensic science international. Synergy
Sexual assault is a terrible crime that demands a comprehensive and skilled investigation to gather the perpetrator's biological material. To collect all possible physical and biological evidence, forensic investigation is crucial and…
View details →Liu Q, Liu X, Chang L et al. · 2025 · Clinica chimica acta; international journal of clinical chemistry
Introduction Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated…
View details →Ma F, Hu J, Bai M et al. · 2024 · Clinical laboratory
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection typically relies on reverse transcription-polymerase chain reaction (RT-PCR) technology. However, there is a certain rate of missed detection of SARS-CoV-2…
View details →Lauffer P, van Weelden W, van Haelst MM et al. · 2025 · Journal of community genetics
Polygenic risk scores (PRS) have emerged as a potential tool for predicting complex genetic traits and disorders, which may complement traditional rare variant testing. As genome-wide association studies (GWAS) expand, PRS predictive…
View details →Cassileth LB, Killeen K, York A et al. · 2026 · Aesthetic surgery journal. Open forum
Background Mastectomy skin flap necrosis (MSFN) is a critical postoperation complication in postmastectomy breast reconstruction. High replacement tissue expander fill volume and large mastectomy specimen size are commonly assumed to…
View details →Akella JS, Onken BD, Sedore CA et al. · 2026 · microPublication biology
The Caenorhabditis Intervention Testing Program aims to identify lifespan-extending interventions that are effective across diverse genetic backgrounds. Previous studies identified a role for anticonvulsants in lifespan extension in the…
View details →Jones GT, Bennett AN, Sengupta R et al. · 2025 · Arthritis care & research
Objective Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, there is no consistent guidance on whether patients should temporarily stop…
View details →Karlsen KL, Clausen CL, Kahiyah RAS et al. · 2026 · Open forum infectious diseases
Background Adults hospitalized with respiratory syncytial virus (RSV) face mortality risks comparable to or higher than those with influenza A or B. However, studies on the impact of bacterial co-infections on mortality are inconsistent.…
View details →Kocaaslan H, Ceylan C, Sümer F et al. · 2026 · BMC surgery
PURPOSE: In non-metastatic advanced gastric cancer, gastrectomy with D2 lymph node dissection is the main curative treatment. The clinical benefit of omentectomy in gastric cancer surgery is still controversial. We planned to investigate…
View details →Domche A, Nomo A, Yemele RD et al. · 2026 · BMC ophthalmology
BACKGROUND: Loiasis is a parasitic disease caused by the filarial nematode Loa loa. CASE PRESENTATION: This report describes loiasis in a 6-year-old child presented to a public hospital in Yaoundé, Cameroon, with an immobile worm located…
View details →Trka J, Fronkova E · 2025 · British journal of haematology
Can peripheral blood be used to detect residual disease in acute lymphoblastic leukaemia (ALL) when we increase the sensitivity of the method used? Bendig et al. found that a larger amount of material and the use of next-generation…
View details →Lykkegaard J, Olsen JK, Wehberg S et al. · 2024 · Scandinavian journal of primary health care
Objective Patients previously examined for cancer with a negative result may present in general practice with ongoing or new symptoms or signs suggestive of cancer. This paper explores the potential existence of a relatively safe period…
View details →Bellott TR, Luz FB, Fausto da Silva AK et al. · 2024 · Anais brasileiros de dermatologia
Background Merkel cell polyomavirus (MCPyV), a human polyomavirus that is unequivocally linked to merkel cell carcinoma (MCC), has been found in association with keratinocytes carcinomas (KC), especially basal cell carcinoma (BCC) and…
View details →Lund A, Nielsen CK, Jensen RB et al. · 2026 · International journal of pediatric otorhinolaryngology
Background Newborn hearing screening programmes aim to identify hearing loss early; however, infants with recognised risk factors may have different screening outcomes, including false-negative results. This study evaluates screening…
View details →Tao Y, Zheng A, Li X et al. · 2026 · Surgical oncology
Objective To construct and validate a nomogram for predicting false-negative results of axillary lymph node (ALN) fine needle aspiration (FNA) in breast cancer (BC). Methods Using the surgical pathological results of axillary lymph nodes…
View details →Shukla A, Paturu T, Shivan S et al. · 2026 · Southern medical journal
Objective The objective of our study was to determine the extent of publication bias of clinical trials pertaining to the treatment of coronary artery disease. Specifically, studies are more likely to be published if the results are…
View details →Uchida S, Mizuguchi Y, Sato S et al. · 2026 · Journal of human genetics
Non-invasive prenatal testing (NIPT) is widely used for fetal aneuploidy screening; however, most evaluations of test accuracy rely on pregnancy outcomes rather than cytogenetic confirmation after birth, and evidence regarding the…
View details →Abi Kheir DJ, Moriles K, Carr AL et al. · 2026 · The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians
Background: The (1,3)-β-D-glucan (BDG) test can be used as a stewardship approach to decrease antifungal overutilization, development of resistance, and excess costs. Objective: This study assessed the impact that a BDG algorithm has on…
View details →Auer A, Settypalli TBK, Rozstalnyy A et al. · 2026 · BMC veterinary research
Background Rapid diagnosis is critical for the early detection and control of transboundary animal diseases such as African Swine Fever (ASF) and Avian Influenza (AI), particularly because it enables timely containment measures at the farm…
View details →Saliba M, Haddad E · 2026 · International journal of surgery case reports
Introduction The most common type of vulvar cancer is squamous cell carcinoma. The management of early-stage vulvar squamous cell carcinoma includes radical local excision of the primary tumor. Evaluation of sentinel nodes for metastases…
View details →Lindsley IC, Juman MM, Seifert SN et al. · 2026 · PLoS neglected tropical diseases
Large host-virus association databases are increasingly used to explore broad questions in disease ecology, particularly around host range, pathogen diversity, and the potential for spillover. While these databases have been instrumental…
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