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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The use of a urine lipoarabinomannan test in clinical decision-making regarding empiric tuberculosis treatment among HIV-positive patients suspected to have tuberculosis.

Makgoka TR, De Villiers M, Van Zyl DG · 2025 · South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Background Tuberculosis (TB) is a major contributor to mortality among patients affected by HIV. TB diagnosis can be challenging, especially in those who are severely ill and unable to produce sputum. Urine lipoarabinomannan (LAM) is a…

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Negative / Null Result ReportMedicine

Application of Diagnostic Stewardship to Fungal Polymerase Chain Reaction: Low Yield of Follow-up Testing on Plasma and Bronchoalveolar Lavage After a Negative Result.

Wang T, Park B, Anderson G et al. · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Early diagnosis of invasive fungal disease is essential for optimizing management. Although the clinical utility of fungal polymerase chain reaction (PCR) testing on plasma and bronchoalveolar lavage (BAL) has been established,…

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Negative / Null Result ReportOpen accessMedicine

Combination of bacteriophage and antibiofilm compounds from phyllosphere bacteria as a comprehensive strategy for aquaculture and food pathogen control.

May J, Waturangi DE, Tan WA et al. · 2026 · Scientific reports

Biofilm-forming bacteria, such as Bacillus cereus and Vibrio harveyi are major contributors to food contamination and problems in aquaculture. This study aimed to evaluate the antibiofilm compounds of the phyllosphere bacterial…

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Negative / Null Result ReportMedicine

Is it necessary for patients with a positive urine culture to achieve a negative result after antimicrobial treatment before undergoing percutaneous nephrolithotomy?

Zheng J, Guo Q, Yue G et al. · 2025 · World journal of urology

Objective There is ongoing debate regarding whether patients with a positive urine culture (UC) need to wait for the culture to turn negative following antimicrobial treatment before undergoing percutaneous nephrolithotomy (PCNL). This…

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Negative / Null Result ReportMedicine

Association between sleep disturbances and gray matter volume in individuals at clinical high-risk for psychosis and healthy controls: A longitudinal MRI study (NAPLS-3).

Wezenberg BN, Koster M, van Wingen G et al. · 2025 · Schizophrenia research

Objective Sleep disturbances and brain alterations are common in psychotic disorders and individuals at clinical high risk for psychosis (CHR-P). It remains unclear whether gray matter volume changes are inherent to psychosis or partly…

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Negative / Null Result ReportOpen accessMedicine

Evaluating algorithmic approaches to rare disease case-finding: a retrospective validation study using electronic health records.

Boardman-Pretty F, Kumar J, Grant C et al. · 2026 · Orphanet journal of rare diseases

BACKGROUND: Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of…

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Negative / Null Result ReportMedicine

Diagnostic discrepancies: A retrospective analysis of two antinuclear antibody platforms.

Ali M, Baban Y, Kumar G · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

To retrospectively examine the outcome of the antinuclear antibody (ANA) screen by comparing the performance of BioPlex 2200 and immunofluorescence assay (IFA). We reviewed the ANA screening results performed on the BioPlex 2200 using…

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Negative / Null Result ReportMedicine

Low-Dose Aspirin Continuation During Gastric Endoscopic Submucosal Dissection in Patients With Low Thrombotic Risk: A Randomized Trial.

Uedo N, Gotoda T, Takizawa K et al. · 2026 · The American journal of gastroenterology

Introduction The recommendation to discontinue low-dose aspirin (LDA) during the periprocedural period of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) remains controversial in patients at low thrombotic risk. If…

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Negative / Null Result ReportOpen accessMedicine

Seasonality and clinical characteristics of influenza-like illness and severe acute respiratory infection in children under 5 years in Cox's Bazar, Bangladesh (2021-2023).

Zabir MOH, Habib MA, Monalisa et al. · 2026 · IJID regions

Objectives Acute respiratory infections (ARIs) such as influenza-like illness (ILI) and severe acute respiratory infection (SARI) are leading causes of morbidity among children aged under 5 years (under-5) in Bangladesh. In Cox's Bazar,…

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Negative / Null Result ReportMedicine

[Analysis of a twin pregnancy with false negative result for 22q11.2 deletion syndrome by expanded non-invasive prenatal testing].

Zhao G, Jiao Z, Dai P et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To explore the cause for a twin pregnancy with false negative result for 22q11.2 deletion syndrome by expanded non-invasive prenatal testing (NIPT-plus). Methods A pregnant woman with twin pregnancy through in-vitro fertilization…

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Negative / Null Result ReportOpen accessMedicine

Comparative efficacy of once-daily versus twice-daily doxycycline regimens in dogs naturally infected with <i>Ehrlichia canis</i>: A randomized clinical trial.

Taechikantaphat M, Kongchareon A, Julapanthong P et al. · 2026 · Veterinary and animal science

This prospective, randomized clinical trial compared the therapeutic efficacy and rate of platelet recovery of doxycycline 10 mg/kg once daily (SID) (Group A, n=17) versus 5 mg/kg twice daily (BID) (Group B, n=12) in 29 dogs naturally…

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Negative / Null Result ReportOpen accessMedicine

Raw Equid Milk: A Potential Risk for Q Fever?

Mazzotta E, Natale A, Bellinati L et al. · 2025 · Animals : an open access journal from MDPI

Equid milk (donkey or mare) has traditionally been consumed raw or fermented due to its distinctive chemical composition, which closely resembles human milk, and its nutritional benefits. Nowadays, interest in it is increasing, despite…

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Negative / Null Result ReportOpen accessMedicine

Comparison of boiling versus magnetic bead techniques in nucleic acid extraction for human papillomavirus detection: evidence based 17,179 cases.

Bai M, Li Y, Gao Q et al. · 2025 · Virology journal

Purpose Present study aimed to compare the boiling and magnetic bead nucleic acid extraction method for HPV genotypes detection. Methods By mixing hemoglobin with HPV positive quality control products, the anti-interference ability of two…

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Negative / Null Result ReportOpen accessMedicine

Cytomegalovirus (CMV)-Specific Cell-Mediated Immunity for Prediction of Postprophylaxis CMV Disease in a Phase 3 Trial of Letermovir Versus Valganciclovir Prophylaxis in Donor CMV-Seropositive/Recipient CMV-Seronegative Kidney Transplant Recipients.

Limaye AP, Crespo M, Kamar N et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background QuantiFERON-cytomegalovirus (QFT-CMV) is a standardized assay for the evaluation of cytomegalovirus-specific cell-mediated immunity (CMV-CMI). Objectives The purpose of this study was to assess the evolution of CMV-CMI…

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Negative / Null Result ReportOpen accessMedicine

Identification of Factors Predicting False-Negative Results in Sentinel Lymph Node Biopsy in Patients Undergoing Surgery for Breast Cancer: A Single-Center Retrospective Study.

Bölük S, Bölük S · 2025 · Cureus

Background In breast cancer surgery, sentinel lymph node biopsy (SLNB) is routinely utilized for axillary assessment. Frozen section examination of the sentinel lymph node (SLN) is used to guide the decision for axillary dissection.…

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