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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Acute cholecystitis in the robotic era: comparative safety and feasibility of robotic and laparoscopic cholecystectomy in an acute care surgery service.

Pontecorvo AA, Cornejo J, Tsenteradze T et al. · 2026 · Journal of robotic surgery

This study aimed to evaluate and compare perioperative outcomes of robotic versus laparoscopic cholecystectomy in patients with acute cholecystitis within an Acute Care Surgery setting. A retrospective cohort study was conducted including…

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Negative / Null Result ReportMedicine

Interaction model of client health behavior-based nursing intervention improves outcomes in patients with pressure injury: A quasi-experimental study.

Guan X, Li X, Yue M et al. · 2026 · Scientific reports

Pressure injury (PI) prevention requires sustained nursing behaviors from patients, caregivers, and nurses. This single-center quasi-experimental, non-randomized, non-equivalent control group study enrolled 60 inpatients with PI or high PI…

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Negative / Null Result ReportMedicine

Child maltreatment recognition and reporting attitudes among pediatric nurses and physicians in Türkiye: A cross-sectional comparative study.

Çarikçi F, Girgin BA, Harmanci NF et al. · 2026 · Child abuse & neglect

Aim To examine and compare the proficiency of pediatric physicians and nurses in recognizing the signs of and risk factors for child maltreatment, as well as to determine the relationship between this proficiency and their reporting…

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Negative / Null Result ReportMedicine

Safety and Efficacy of Oral Tacrolimus Induction Therapy in Elderly Patients with Ulcerative Colitis: A Subanalysis of a Large Multicenter Retrospective Cohort Study.

Inokuchi T, Hiraoka S, Oshima N et al. · 2026 · Gerontology

Introduction We previously reported the findings of a multicenter retrospective cohort study investigating the efficacy of oral tacrolimus induction therapy in patients with ulcerative colitis (UC). In this subanalysis, we specifically…

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Negative / Null Result ReportMedicine

Reduced Left Atrial Reservoir Strain Is Associated with Histopathologically Confirmed Atrial Natriuretic Peptide-Amyloid Deposition.

Nishino S, Asada Y, Nishino C et al. · 2026 · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

Background Isolated atrial amyloidosis is characterized by atrial natriuretic peptide- (ANP-) amyloid deposition confined to the atria and has been primarily linked to atrial fibrillation. However, its relationship with atrial mechanical…

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Negative / Null Result ReportOpen accessMedicine

Enamel Microhardness of Resin-Infiltrated White Spot Lesions After Bleaching With and Without ACP: An In Vitro Study.

Hegde P, Acharya SR, Mayya A et al. · 2026 · International journal of dentistry

Background White spot lesions (WSLs) represent the earliest clinical manifestations of enamel demineralization. Resin infiltration (RI) is a minimally invasive method used to mask WSLs for esthetic improvement; however, infiltrated enamel…

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Negative / Null Result ReportMedicine

Comparative Evaluation of Mealworm (Tenebrio molitor) Larvae as an Alternative Diet for the Mass Rearing of Nesidiocoris tenuis.

Lee J, Hwang HS, Li Y et al. · 2026 · Archives of insect biochemistry and physiology

Nesidiocoris tenuis is an important natural enemy widely used for the biological control of small pests in vegetable crop systems. Its successful implementation in commercial programs depends on reliable and cost-effective mass rearing,…

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Negative / Null Result ReportOpen accessMedicine

Early Immune Alterations in Adult Patients with Trauma According to Injury Severity: Cell-Death Patterns and Inflammatory Mediator Profiles.

Park SJ, Kim JY, Yun S et al. · 2026 · Journal of clinical medicine

Background/Objectives : Trauma triggers complex early immune responses. However, the relationship among trauma severity, changes in immune cell survival, and circulating inflammatory mediators remains unclear. This study compared early…

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Negative / Null Result ReportMedicine

Longitudinal Changes in Health Utility Scores During the Perioperative Period Among Patients With Oral Cancer: An Analysis of the Effect of Older Age and Social Background.

Sasaki M, Aoki T, Uchibori M et al. · 2026 · Oral diseases

Objective Many countries have implemented health technology assessment of their public medical insurance programs owing to rising social security costs from ageing populations and expensive emerging medical technologies. Clarifying factors…

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Negative / Null Result ReportOpen accessMedicine

Effects of insect-derived protein form and replacement level on growth performance and skeletal traits in broiler pheasants (Phasianus colchicus).

Osiak-Wicha C, Kras K, Tomaszewska E et al. · 2026 · Poultry science

This study evaluated black soldier fly (Hermetia illucens) products as alternatives to soybean meal protein in broiler pheasants, focusing on growth performance and skeletal traits in both sexes. Birds were assigned to five dietary…

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Negative / Null Result ReportMedicine

Comparison of Dexmedetomidine Administration Strategy for Propofol-Based Pediatric Sedation for Magnetic Resonance Imaging: A Retrospective Study.

Kim TW, Ji SH, Park JB et al. · 2026 · Paediatric anaesthesia

Background Intravenous dexmedetomidine is a safe and effective adjunct in propofol-based sedation. Dexmedetomidine is typically administered as a loading dose, followed by continuous infusion or not. Whether the addition of a maintenance…

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Negative / Null Result ReportMedicine

Immune-impulsivity link: association between peripheral inflammatory ratios and borderline personality disorder.

Raj R, Nabi J, Gidwani S et al. · 2026 · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan

Objectives To determine associations between impulsivity and peripheral inflammatory ratios in patients with borderline personality disorder (BPD). Methods Consecutive patients aged ≥18 years with a diagnosis of BPD who presented to the…

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Negative / Null Result ReportOpen accessMedicine

Comparative Effectiveness of Azithromycin versus Erythromycin for Latency Prolongation in Preterm Prelabor Rupture of Membranes < 34 Weeks of Gestation.

Chawanpaiboon S, Pooliam J · 2026 · International journal of women's health

Objective Preterm prelabor rupture of membranes (PPROM) is a major contributor to preterm birth and neonatal morbidity. Although azithromycin is increasingly used as an alternative to erythromycin for latency antibiotic therapy,…

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Negative / Null Result ReportMedicine

Comparative evaluation of root dentin thickness following hand and rotary instrumentation of primary molar root canals using cone-beam computed tomography - an invitro study.

Thomas RM, Nayak R, Madi M et al. · 2026 · BMC oral health

Remaining Root Dentin Thickness (RRDT) after root canal instrumentation is an important parameter to be assessed with newer file systems. This study aimed to evaluate the root dentin thickness following instrumentation of primary molar…

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Negative / Null Result ReportMedicine

Comparative study of prosthesis implantation, latissimus dorsi flap, and combined reconstruction immediately after breast cancer surgery: A retrospective, single-center, observational cohort study.

Zhang Y, Yu W, Shen W · 2026 · Medicine

This study aimed to explore the effects of 3 immediate reconstruction methods - prosthesis implantation, latissimus dorsi flap (LDF), or their combination - on postoperative outcomes following breast cancer (BC) surgery. A retrospective,…

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Negative / Null Result ReportOpen accessMedicine

Ductus Arteriosus Morphology in Pulmonary Atresia With Ventricular Septal Defect: A Retrospective Case Series Comparing Echocardiography and Digital Subtraction Angiography.

Quan TT, Nguyen HM, Nguyen HT et al. · 2026 · Cureus

Objective This study aims to describe ductus arteriosus (DA) morphology in patients with pulmonary atresia with ventricular septal defect (PA-VSD) and to assess exploratory paired differences between echocardiography and digital…

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