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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Mechanisms Linking Bonding and Bridging Social Capital and Self-Rated Health Among U.S. Refugees: A Structural Equation Modeling Approach.

Thapa K, R Iyer A, A Cruz-Gonzalez M et al. · 2026 · Journal of racial and ethnic health disparities

Background Refugees often experience disruptions in social networks after resettlement. This study examined associations between bonding (within-group) and bridging (across-group) social capital and self-rated health among resettled U.S.…

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Negative / Null Result ReportMedicine

Effects of xylazine on blood biochemical, oxidative, and haematological to responses to transport distance stress in day-old broiler chicks.

Abdulameer HS, Zarrinkavyani K, Fathi M et al. · 2026 · Poultry science

Transport of day-old chicks is a major concern in the poultry industry, as it induces stress that can impair performance and health. This study investigated whether xylazine, an alpha-2 adrenergic agonist that reduces metabolic rate, could…

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Negative / Null Result ReportMedicine

Accuracy of full-arch digital implant impression and bite registration: effect of different reference object strategies and intraoral scanners.

Rutkūnas V, Kubilius A, Akulauskas M et al. · 2026 · Journal of dentistry

Objectives This in vitro study evaluated the accuracy of digital impressions for full-arch implantsupported restorations by assessing scan body (SB) positional accuracy and inter-arch registration under different intraoral scanners (IOS)…

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Negative / Null Result ReportMedicine

Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial.

Østergaard AM, Rosenbæk JB, Ejlersen JA et al. · 2026 · Physiological reports

Inorganic nitrate may lower blood pressure (BP) and enhance natriuresis through nitric oxide (NO) mediated mechanisms. Studies have found inconsistent effects of NO on sodium excretion. Nitric oxide synthase (NOS) inhibition suggests…

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Negative / Null Result ReportMedicine

Assessing the impact of an integrated health-system specialty pharmacy model on clinical disease activity index scores in patients with rheumatoid arthritis.

Phan T, Datt P, Zhao L et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune joint disorder necessitating the use of complex, specialty medications. Health-system specialty pharmacies (HSSPs) operate under closed-loop models that have been shown to minimize…

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Negative / Null Result ReportMedicine

Acute Effects of Taurine Supplementation on Energy Metabolism and Aerobic Capacity in Physically Active Young Adults.

Júnior FC, Santos WRD, Cordeiro Feitosa R et al. · 2026 · Research quarterly for exercise and sport

Taurine (TAU) is a conditionally essential amino acid whose consumption has recently increased, particularly among young people, through supplements and energy drinks. It has potential beneficial effects on physical performance; however,…

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Negative / Null Result ReportMedicine

Effect of horizontal and extended platelet-rich fibrin on soft tissue healing and outcomes after impacted mandibular third molar extraction: a controlled trial.

Haskic A, Hadziabdic N, Miron RJ · 2026 · International journal of oral and maxillofacial surgery

Postoperative sequelae such as pain, swelling, and trismus are common following mandibular third molar surgery. This single-blind controlled trial was performed to evaluate the effects of two newer platelet-rich fibrin (PRF) formulations,…

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Negative / Null Result ReportMedicine

Ensuring continuous buprenorphine access: A multi-component quality improvement initiative in a university-affiliated clinic and outpatient pharmacy.

Choo LY, Zheng W, Wen S et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Patients with opioid use disorder encounter challenges obtaining buprenorphine (BUP) at pharmacies, increasing their risk of treatment non-adherence and illicit drug use. Objectives The purpose of this quality improvement (QI)…

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Negative / Null Result ReportMedicine

Stage-specific disruption of host resistance and metabolic pathways following developmental PFAS exposure in marine medaka.

DiBona ER, Elliott J, Labeille RO et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)

Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with immunotoxic potential, yet impacts on immune development remain poorly defined. We examined effects of developmental PFAS exposure on host resistance and…

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Negative / Null Result ReportMedicine

Superinfection risk in critically ill patients with severe COVID-19: a retrospective analysis of pulse steroid therapy with and without tocilizumab.

Gok A, Kavakli AS, Sugur T et al. · 2026 · Expert review of anti-infective therapy

Background This study aimed to assess culture positivity rates and the microbiological profile of intensive care unit (ICU)-acquired superinfections in patients with severe COVID-19 pneumonia treated with pulse-dose methylprednisolone,…

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Negative / Null Result ReportMedicine

A combined Ames and in vivo genotoxicity assessment of dimyricetin-yl-diselenide, a structurally defined organoselenium flavonoid.

Zhang L, Liu X, Zhang C et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Dimyricetin-yl-diselenide (DMS; 3,5,7-trihydroxy-8-[[3,5,7-trihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)chromen-8-yl]diselanyl]-2-(3,4,5-trihydroxyphenyl)chromen-4-one) is a structurally defined organoselenium flavonoid dimer in which two…

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Negative / Null Result ReportMedicine

Adding Self-directed Psychological Support to Usual Rehabilitation Following Anterior Cruciate Ligament Reconstruction Did Not Increase Return-to-Sport Rates at 12 Months. Results From the BAck iN the Game (BANG) Randomized Controlled Trial.

Fältström A, Hedevik H, Ardern CL et al. · 2026 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To evaluate the efficacy of internet-delivered psychological support-the BAck iN the Game (BANG) intervention-after anterior cruciate ligament reconstruction (ACLR) for improving return to sport (RTS). DESIGN: Randomized…

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Negative / Null Result ReportMedicine

Increasing meniscal repair rates during ACL reconstruction did not increase reoperation risk: An analysis of surgical trends from 2015 to 2023.

Kekki C, Essen CV, Cristiani R et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To evaluate surgical trends over time in meniscal procedures during anterior cruciate ligament reconstruction (ACLR) and compare meniscal reoperation rates and subjective outcomes between 2015-2019 and 2020-2023. Methods This study…

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Negative / Null Result ReportMedicine

Donning gloves before patient contact, with or without prior hand hygiene.

Bayhan GI, Aydın Altuntaş C, Cevahir N · 2026 · Journal of infection in developing countries

Objective Hand hygiene (HH) is a fundamental infection prevention measure in healthcare settings, playing a crucial role in reducing healthcare-associated infections (HAIs). Despite its importance, HH compliance remains suboptimal…

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Negative / Null Result ReportMedicine

Differential Expression of Dopamine-Related Genes Across Developmental and Parental Stages in the Burying Beetles, Nicrophorus orbicollis.

Panaitof SC, Kermagi MM · 2026 · Archives of insect biochemistry and physiology

Dopamine has diverse roles in the regulation of reproduction and social behaviors in insects. In the burying beetle, Nicrophorus orbicollis, a species with extended care, our previous work has shown that brain dopamine levels increase…

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Negative / Null Result ReportMedicine

The Association Between Sitting Delivery During the Second Stage of Labor and Pelvic Floor Function in Primiparas: A Prospective Cohort Study.

Gong J, Xie B, Wei Y et al. · 2026 · Healthcare (Basel, Switzerland)

Background/objectives Pregnancy and childbirth are independent risk factors for pelvic floor injury. The choice of delivery position, as an interventionable factor during labor, has received much attention. This study aimed to assess the…

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Negative / Null Result ReportMedicine

Nationwide questionnaire survey on collaboration for the management of chronic kidney disease from the perspective of referrals in Japan.

Hatta T, Kobayashi K, Tatematsu S et al. · 2026 · Clinical and experimental nephrology

Background Preventing end-stage renal failure progression of patients with chronic kidney disease (CKD) requires collaboration between nephrologists and general practitioners. Following the 2013 and 2019 surveys in Japan, a nationwide…

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Negative / Null Result ReportMedicine

Effects of reduced metabolizable protein diets supplemented with rumen-protected His under adequate Met and Lys supply on production, nutrient digestibility, N utilization, and manure ammonia emissions in lactating cows.

Park K, Kim J, Hu H et al. · 2026 · Journal of dairy science

Balancing for limiting AA may prevent reduced production when deficient MP is provided. The objective of the study was to determine the effects of rumen-protected (RP) His supplementation at different levels of MP when Lys and Met supplies…

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