11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mirda D, Hao J, Dungan M et al. · 2026 · Cancers
Background : Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC), and colorectal surveillance has been shown to reduce death from CRC in this high-risk population. This study aimed to examine adherence to…
View details →Ito K, Fujii M, Oba Y et al. · 2026 · International orthopaedics
Purpose To determine changes in low back pain (LBP) after total hip arthroplasty (THA), identify preoperative factors associated with residual LBP and LBP improvement, and clarify the association between residual LBP and patient-reported…
View details →Cunningham PM, Hayes JE · 2026 · Appetite
Widespread nutrition advice instructs consumers to drink water with meals to increase fullness and reduce energy intake. However, recent data indicates greater water intake is associated with more food intake at a meal, not less. Switching…
View details →Charoenrat B, Sungkarat S, Phirawatthakul C et al. · 2026 · BMC geriatrics
Background Neck pain is associated with altered postural and gait performance in older adults. Smartphone use may further challenge postural and gait control due to additional cognitive and motor demands. This study aimed to investigate…
View details →Ediz E, Küçükdağ HN, Özel MA · 2026 · Scientific reports
Although high fructose consumption is known to be associated with metabolic disorders, specific intake thresholds and consumption patterns related to hepatic steatosis have not been fully defined. This study aimed to quantify daily…
View details →Millarch AS, Schøning J, Hjulmand VG et al. · 2026 · The journal of trauma and acute care surgery
Background Opioids have a well-known capacity to induce long-term dependency with related increased morbidity and mortality. Usage patterns following traumatic injury are, however, not well studied. We investigated long-term opioid usage…
View details →Melcer T, Robinson MI, Jurick S et al. · 2026 · The journal of trauma and acute care surgery
Background Limited longitudinal research has been conducted on health outcomes during the first 15 years after combat-related lower limb amputation. Methods This retrospective analysis of Departments of Defense and Veterans Affairs health…
View details →Jiang Y, Kong M, Feng T et al. · 2026 · Scientific reports
Emergency department overcrowding places sustained pressure on triage workflows and patient prioritization. Artificial intelligence (AI)-augmented triage systems have been introduced to support emergency decision-making, but frontline…
View details →Yang W, Tan M, Lin H et al. · 2026 · Food & function
Oyster-derived peptides have shown potential for bone protection; yet, the anti-osteoporotic activity of defined sequences remains insufficiently characterized in glucocorticoid-induced osteoporosis (GIOP). Here, DLAGRDLTDYLM (OP4),…
View details →Tegegne DT, Banaszkiewicz S, Bania J et al. · 2026 · Molecules (Basel, Switzerland)
Background: Enterococcus faecalis is one of the most frequent causes of catheter-associated urinary tract infections, largely due to its ability to form biofilms on indwelling urinary catheter surfaces, which enhance bacterial persistence…
View details →Vilaseca A, Villagrán-García M, Farina A et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation
Objectives Ma/Ma2-associated neurologic autoimmunity is characterized by CNS involvement. However, isolated peripheral nervous system (PNS) presentations have been rarely reported. We aimed to describe the frequency and syndromes of…
View details →Wu J, Liang P, He Y et al. · 2026 · Frontiers in cellular and infection microbiology
Background Bladder cancer is one of the most common malignancies worldwide, and only a subset of patients derives durable benefit from immune checkpoint blockade. An immune-cold tumor microenvironment, characterized by limited immune…
View details →Gysan MR, Kastrati K, Pochepnia S et al. · 2026 · Journal of clinical medicine
Background: Systemic autoimmune rheumatic diseases-associated interstitial lung disease (SARD-ILD) presents with varied disease courses, emphasizing the need for reliable predictors of progression. The prognostic utility of bronchoalveolar…
View details →Jennings CJ, Marciniak SJ, Pinton G et al. · 2026 · Discover oncology
Aim To investigate the expression of succinate dehydrogenase B and its potential as a therapeutic target in pleural mesothelioma (PM). Methods The expression of succinate dehydrogenase B was examined in cell lines using PCR. The expression…
View details →Bertholdi Filho SU, Telles JP, Melo IM et al. · 2026 · Critical care science
Objective To evaluate the efficacy of monotherapy versus combination therapy in the treatment of carbapenem-resistant Acinetobacter baumannii infections. Methods A retrospective observational study was conducted in two tertiary hospitals…
View details →Tan Y, Cheng F, Li P et al. · 2026 · Epigenomics
Background Glioblastoma (GBM) is epigenetically heterogeneous, and previous long noncoding RNA (lncRNA) methylation studies have often begun from tumor-wide screens. We asked whether brain-enriched lncRNAs show promoter…
View details →Terrinoni M, Caputo V, Palisciano M et al. · 2026 · Genes
Background/Objectives: Cervical cancer is mainly driven by persistent infection with high-risk human papillomaviruses (HPV), particularly HPV16 and HPV18. Despite advances in cytology, HPV-DNA testing and vaccination, challenges remain in…
View details →Jameson AT, Hur WS · 2026 · Current opinion in hematology
Purpose of review Metabolic diseases, including obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and diabetes, are associated with increased thrombotic risks. Conversely, components of the hemostatic system…
View details →Holleman J, Kåreholt I, Kivipelto M et al. · 2026 · Gerontology
Introduction Physical and cognitive impairment constitute large burdens of disease in older adults, but may be preventable through reduction of modifiable risk factors. While chronic stress has been linked to cognitive and physical…
View details →Ahmadi T, Ghorbanzadeh V, Hosseinnejad E et al. · 2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Doxorubicin remains an indispensable component of many chemotherapy regimens; however, its clinical use is limited by dose-dependent cardiotoxicity that may progress to dilated cardiomyopathy and heart failure. In the present study, we…
View details →Mogoș RA, Carauleanu A, Vasilache IA et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Autoimmune thyroiditis (AIT) is often reported patients with PCOS, and may co-occur with altered metabolic risk markers. The aims of this study were to assess baseline differences according to thyroid…
View details →Han Y, Zhong C, Lu Z et al. · 2026 · Scientific reports
Abdominal massage (AM), a traditional Chinese medicine treatment, is gradually being recognized in clinical practice for its ability to improve the symptoms of obesity and type 2 diabetes mellitus (T2DM) in clinical practice. This study…
View details →Wang J, Soley BDS, Xiao Y et al. · 2026 · Cancer research communications
Cancer-associated fibroblasts (CAFs) display remarkable plasticity, enabling them to adapt to therapeutic and mechanical stress within the tumor microenvironment (TME). Here, we identify a shared mechanotransduction pathway by which BRAF…
View details →Chan SWY, Wang R, Liu J · 2026 · Psychological assessment
Adult-reported surveys are more cost-effective for measuring children's executive function (EF) skills than direct child assessments, which are often resource-intensive. This study examined the extent to which teacher and parent reports…
View details →Tang Z, Huang C, Qiu G et al. · 2026 · Clinical rheumatology
Objective Gout is directly associated with hyperuricemia. This study aims to investigate the adherence rate to urate-lowering therapy (ULT) and its influencing factors among patients with gout in Southwest China. Methods A cross-sectional…
View details →Hashimoto S, Ishiguchi H, Yoshiga Y et al. · 2026 · Heart rhythm
Background Data regarding acute blood pressure (BP) drops during pulsed-field ablation (PFA) for pulmonary vein isolation (PVI) are limited. Objective This study aimed to determine the incidence and risk factors of acute BP drops during…
View details →Richards-Brown M, Castiello de Obeso S, Dennison R et al. · 2026 · Quarterly journal of experimental psychology (2006)
The self-prioritisation effect demonstrates that people have a bias to learn and process self-relevant compared to other-relevant information. This tendency may provide a tool to understand how body image and perception become disrupted in…
View details →Micheli K, Koutra K, Markakis G · 2026 · International journal of aging & human development
This study examines whether aging anxiety (based on terror management theory) or demographic and experiential factors better explain attitudes toward older adults among social work students and professionals. Cross-sectional data were…
View details →Daniel N, Papadimitriou N, Chatziioannou AC et al. · 2026 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Background and aims Recent data suggest a role for the gut microbiome in the development of hepatocellular carcinoma. We investigated associations of gut microbiome abundances and concentrations of circulating bacteria-associated…
View details →Shamani-Aminian A, Adán A, Llorenç V · 2026 · Journal of ophthalmic inflammation and infection
Ocular toxoplasmosis is the most common cause of posterior uveitis worldwide and a major cause of visual impairment. Previous studies suggest that the disease may follow a more aggressive clinical course in patients from Latin America;…
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