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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Folded-flap palatoplasty performed with a needle-tip monopolar cautery: retrospective cohort of 66 brachycephalic dogs.

Miloro R, Mala B, Ceplecha V et al. · 2026 · Journal of the American Veterinary Medical Association

Objective To evaluate short- and long-term patient outcomes retrospectively, investigate anesthetic and surgical times, and assess clinically relevant surgical wound complications associated with the use of needle-tip monopolar…

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Negative / Null Result ReportMedicine

Midazolam versus midazolam-promethazine combination for oral sedation in third molar surgery: A randomized split-mouth trial.

Castanha D, Lessa TC, Martins-de-Araújo ES et al. · 2026 · Medicina oral, patologia oral y cirugia bucal

Background Oral sedation is widely utilized in dental surgical practice for anxiety management during third molar extractions. Midazolam is one of the most frequently employed drugs; however, the clinical benefits of its association with…

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Negative / Null Result ReportMedicine

Comparison of prehospital tidal volume delivery performance between automated transport ventilators and bag-valve devices in out-of-hospital cardiac arrest patients: does the pressure limit matter?

Chen CH, Yu PH, Fan CY et al. · 2026 · Frontiers in medicine

Background Automatic transport ventilators (ATVs) are a potential option for ventilating patients experiencing out-of-hospital cardiac arrest (OHCA); however, their tidal volume delivery performance at different pressure limits compared…

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Negative / Null Result ReportMedicine

Effects of a home-based exercise and physical activity intervention after inpatient rehabilitation on real-world mobility in older adults with cognitive impairment: a secondary analysis of a randomised controlled trial.

Werner C, Ullrich P, Degli Angeli L et al. · 2026 · Age and ageing

Persistent mobility limitations after inpatient rehabilitation are common in older adults with cognitive impairment (CI). Home-based exercise interventions can improve locomotor capacity during this vulnerable period; however, evidence…

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Negative / Null Result ReportMedicine

Patient factors outweigh procedure extent in infection risk after cervical disc arthroplasty.

Mastrokostas PG, Said M, Mastrokostas LE et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose To determine the 90-day incidence of surgical site infection (SSI) after cervical disc arthroplasty (CDA), compare single versus multilevel procedures, and identify independent predictors of SSI. Methods We identified adult…

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Negative / Null Result ReportMedicine

Adrenocorticotropin hormone regulates sphingosine-1-phosphate synthesis via cortisol in bovine adrenocortical cells.

Medina-Moctezuma ZB, Guzmán-Sánchez A, González-Aretia D et al. · 2026 · Biochemical and biophysical research communications

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) stimulate the synthesis of sphingosine-1 phosphate (S1P) in Gs-coupled receptors dependent manner, enabling S1P to mediate specific bioactivities of FSH and LH. Because…

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Negative / Null Result ReportMedicine

Do congenital heart diseases or chromosomal anomalies influence the surgical outcomes of esophagocoloplasty in esophageal atresia patients?

Tannuri ACA, Abe Takahasi BN, de Almeida Estrambk G et al. · 2026 · Journal of pediatric surgery

Background Esophageal atresia (EA) is frequently associated with congenital heart disease (CHD) and chromosomal anomalies, mainly Down syndrome (DS). While these conditions affect outcomes following primary repair, their specific impact on…

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Negative / Null Result ReportMedicine

Application of quinoa oil emulsions in fresh goat cheese: effects on lipid profile, technological properties and microstructure.

Muñoz-Tebar N, Lucas-González R, Muñoz-Bas C et al. · 2026 · Food chemistry

This study investigates the use of quinoa oil emulsion as a novel plant-based ingredient to improve the nutritional quality of fresh goat cheese. Quinoa oil emulsions (3 and 6 g/L) were characterized and incorporated in fresh cheese. The…

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Negative / Null Result ReportMedicine

GnRH Administration Increases Synchronisation of Ovulation in Mares.

Cui B, Liu Y, Wu X et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

The objective of this study was to evaluate the effects of exogenous GnRH administration at the beginning of estrus synchronisation in mares during the spring transitional period. Estrus was synchronised using a progesterone releasing…

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Negative / Null Result ReportMedicine

Physiologic, Psychological, Nutritional, and Rest-Activity Observations During 120 Days of Low-Tech Off-Grid Living in the Baja California Desert: A 2-Participant Field Case Study.

Mauvieux B, Montardy Q, Remilly M et al. · 2026 · Wilderness & environmental medicine

Off-grid low-tech living is increasingly proposed for arid environments, yet longitudinal field data documenting health, nutrition, and rest-activity organization under real-world conditions remain scarce. Our objective was to describe…

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Negative / Null Result ReportMedicine

A description of self-selected treatments and self-reported improvement following treatment among post-9/11 veterans experiencing disruptive dizziness following a comprehensive traumatic brain injury evaluation.

Cheever K, Kalvesmaki A, Swan AA et al. · 2026 · Brain injury

Background This study aimed to explore what treatments were sought by post-9/11 Veterans with and without a formal diagnosis related to their long-term dizziness following completion of a Comprehensive Traumatic Brain Injury Evaluation…

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Negative / Null Result ReportMedicine

Glyphosate exposure did not increase the risk of UVR-induced skin tumors in hairless mice.

Lerche CM, Granborg JR, Al-Chaer RN et al. · 2025 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Glyphosate (GLY) is the most widely used pesticide in the world. Agricultural workers are exposed to GLY via ingestion and skin contact. GLY may generate epigenetic changes that might be carcinogenic. However, whether GLY is carcinogenic…

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Negative / Null Result ReportMedicine

Do intraoperative calcar fractures increase early complications or revisions in short stem total hip arthroplasty? A propensity score matching study.

Suksathien Y, Suarjui J, Tippimanchai T et al. · 2026 · International orthopaedics

Purpose Intraoperative calcar fracture (IOCF) can compromise initial stability, leading to stem subsidence and instability. We aimed to compare 2-year complications and revision rates between patients who sustained IOCF and matched…

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Negative / Null Result ReportMedicine

Perioperative risk factors predicting CSF leak and retethering following tethered cord release for complex spinal lipomas.

Chesney KM, McAbee JH, Balu A et al. · 2026 · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Purpose Tethered cord release (TCR) is typically well tolerated in children, but cerebrospinal fluid (CSF) leaks can occur postoperatively, with rates as high as 33%. The aim of this study was to determine perioperative risk factors…

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Negative / Null Result ReportMedicine

Pregnancy outcomes of gestational diabetes mellitus treated before versus after 24 weeks: A comparison of Carpenter-Coustan and IADPSG criteria.

Gorsagun S, Pruksanusak N, Geater AF · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective To compare pregnancy outcomes between early and standard treatment of gestational diabetes mellitus (GDM) diagnosed using the Carpenter-Coustan criteria and to assess the impact of applying the International Association of…

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Negative / Null Result ReportMedicine

Comparison of surgical safety among different comprehensive treatment models for adenocarcinoma of esophagogastric junction: a single-center cohort study.

Dai H, Wang Y, Shan F et al. · 2026 · BMC gastroenterology

Background Neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (nCRT) are increasingly used to treat adenocarcinoma of the esophagogastric junction (AEG). However, there is insufficient clinical evidence to compare surgical…

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Negative / Null Result ReportMedicine

The impact of coronary artery bypass grafting on the short- and long-term development and progression of diabetic retinopathy: A Danish national matched cohort study.

Maschoreck LG, Stokholm L, Pedersen FN et al. · 2026 · Acta ophthalmologica

Purpose Diabetic retinopathy (DR) is a frequent long-term complication of diabetes. While hemodynamic changes are known risk factors for DR, the effect of coronary artery bypass grafting (CABG) on the development of DR is poorly…

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Negative / Null Result ReportMedicine

Down syndrome birth rate post Dobbs decision: has it changed?

Santoro SL, Alvarado C, Tseng SY et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective In 2022, the U.S. Supreme Court decision on Dobbs v. Jackson Women's Health Organization changed abortion access. We evaluated birth rates of Down syndrome (DS) before and after the Dobbs decision hypothesizing similarity to…

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Negative / Null Result ReportMedicine

Impact of additional left atrial roof ablation for persistent atrial fibrillation using cryoballoon: the ICEBERG trial.

Ukita K, Egami Y, Sugino A et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society

Background Several studies have investigated the efficacy of additional left atrial (LA) roof ablation to pulmonary vein isolation (PVI) using cryoballoon for persistent atrial fibrillation (AF). However, the evidence from randomized…

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