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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Randomized clinical trial of duplex ultrasound surveillance after endovascular therapy for chronic limb-threatening ischemia.

Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery

Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…

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Negative / Null Result ReportMedicine

Cryotherapy following total knee replacement.

Aggarwal A, Adie S, Harris IA et al. · 2025 · The Cochrane database of systematic reviews

Background Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life within three to six months. It is,…

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Negative / Null Result ReportMedicine

Association of Mechanical Circulatory Support and Cardiac Catheterization Laboratory Procedural Volumes With Outcomes of Cardiogenic Shock.

Tabibian K, Vadlakonda A, Coaston T et al. · 2025 · The American journal of cardiology

Despite advancements in cardiogenic shock (CS) management, mortality remains high. While hospital volume has been linked to reduced mortality across myriad complex procedures, the cross-volume effects of mechanical circulatory support…

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Negative / Null Result ReportMedicine

The effect of astaxanthin supplementation on inflammatory markers, lipid profile, and anthropometric indices in patients with heart failure: a randomized controlled trial.

Ghotboddin Mohammadi S, Shafie D, Feizi A et al. · 2026 · Scientific reports

Chronic inflammation and dyslipidemia are common pathophysiological features of heart failure (HF). Astaxanthin, a potent marine-derived antioxidant, has shown anti-inflammatory and lipid-lowering properties. This study conducted to…

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Negative / Null Result ReportMedicine

Real-time qPCR evaluation of amino acids buffered sodium hypochlorite gel as an adjunct to non-surgical periodontal treatment: a randomized clinical trial.

Dolińska E, Starosz A, Grubczak K et al. · 2026 · Scientific reports

This study aimed to evaluate the effects of non-surgical periodontal therapy (SRP) and SRP with an amino acid-buffered hypochlorite solution (NaOCl/AA + SRP) on subgingival plaque bacteria. Quantitative changes in Porphyromonas gingivalis,…

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Negative / Null Result ReportMedicine

Mandibular Response in Class II Division 1 Growing Subjects: Clear Aligners vs. Rapid Maxillary Expansion Therapy. A Controlled Pilot Study.

Chiara RF, Letizia L, Francesca G et al. · 2026 · Orthodontics & craniofacial research

Objectives The present study aimed to evaluate the skeletal and dental changes in two different groups of mixed dentition Class II division 1 patients treated with Clear Aligners and with Rapid Maxillary Expansion and to assess the…

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Negative / Null Result ReportOpen accessMedicine

Randomized Controlled Pilot Study of Transcutaneous Electrical Nerve Stimulation for Acute Back Pain in Emergency Department Patients.

Moor-Smith M, Kozak N, McCue M et al. · 2026 · The western journal of emergency medicine

Background Musculoskeletal back pain is a common presenting complaint to emergency departments (ED) worldwide. In this study we aimed to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) as an adjunct to…

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Negative / Null Result ReportMedicine

Comparative effects of metformin and lifestyle therapy on bone metabolism markers: A 6-month pilot, open-label randomized-clinical trial.

Almosfer M, Sabico S, Wani K et al. · 2026 · Aging clinical and experimental research

Background The metabolic effects of Metformin (Met) and lifestyle modification in early type 2 diabetes mellitus (T2DM) management are well established, but their influence on bone remodeling remains uncertain in under-investigated…

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Negative / Null Result ReportMedicine

Twelve-month outcomes after open bleb revision for Preserflo<sup>®</sup> microshunt bleb failure in refractory glaucoma patients.

Darmon J, Bastelica P, Huard M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Purpose To evaluate the 12-month efficacy and safety of open bleb revision (OBR) for Preserflo ® MicroShunt (PMS) (Santen, Osaka, Japan) bleb failure. Patients and methods All consecutive patients who underwent PMS OBR for primary bleb…

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Negative / Null Result ReportOpen accessMedicine

Use of vericiguat in the VICTOR trial: a study that is difficult to interpret.

Orso F, Basile C · 2026 · European heart journal supplements : journal of the European Society of Cardiology

Vericiguat is a soluble guanylate cyclase stimulator that acts by restoring the nitric oxide-cyclic guanosine monophosphate pathway, which is markedly impaired in heart failure with reduced ejection fraction (HFrEF). The VICTORIA trial…

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Negative / Null Result ReportOpen accessMedicine

Impact of red propolis addition on the color stability and surface roughness of glass ionomer cements.

Sampaio GKML, Sette-de-Souza PH, Vieira BR et al. · 2026 · Biomaterial investigations in dentistry

Objective The present study aimed to evaluate the surface roughness (SR) and color stability of conventional restorative glass ionomer cements (GICs) modified with the addition of red propolis ethanolic extract (RPEE) as an antimicrobial…

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Negative / Null Result ReportMedicine

Phthalocyanine-based mouth gel as an adjunct to non-surgical periodontal treatment: a randomized controlled trial.

Neto SOP, Rosalen PL, da Cruz Pegoraro JV et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a…

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Negative / Null Result ReportOpen accessMedicine

Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.

Camargo A, Kaya I, Sturchio A et al. · 2026 · Translational psychiatry

Lipid systems play a substantial role in the pathophysiological mechanisms underlying several brain disorders. However, the mechanisms underlying the lipid profile in stress-induced maladaptations and how these changes can impact distinct…

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Negative / Null Result ReportMedicine

Impact of aromatherapy neck massage on resting cardiovascular parameters in patients with chronic kidney disease and secondary hypertension: A self-controlled study.

Deepa Y, Vijay A, Padmavathi K et al. · 2026 · Journal of bodywork and movement therapies

Objective Chronic kidney disease (CKD) is characterized by kidney damage persisting for 3 months or more. Hypertension (HTN) is a common cause of CKD progression. Previous studies had shown that aroma massage can effectively reduce…

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Negative / Null Result ReportMedicine

Transitions to old age: a multidimensional poverty approach for Chile.

Amarante V, Colacce M · 2026 · Longitudinal and life course studies : international journal

Evaluating deprivation among individuals transitioning to older ages requires a multidimensional approach to evaluate their diverse needs. Despite its importance, research on this topic remains limited in the developing world, particularly…

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Negative / Null Result ReportMedicine

Transforming clinical pharmacy practice models: the impact of a transitions of care model on patient outcomes.

Espinoza Ramirez J, Durango M, Santalo O et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Many organizations have developed criteria for pharmacy practice models; however, most of these models are not based on studies evaluating clinical outcomes. Currently, there is no consensus on the ideal pharmacy practice model.…

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Negative / Null Result ReportMedicine

Assessment of the Impact of Two-Jaw Orthognathic Surgery on Three-Dimensional Airway Volume in Patients with Skeletal Class III Patterns.

Chang YJ, Hsu TC, Chan CH et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo evaluate 3-dimensional pharyngeal airway changes following 2-jaw orthognathic surgery in skeletal Class III patients and to assess their association with surgical movements.DesignRetrospective observational study.SettingSingle…

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Negative / Null Result ReportMedicine

The activation of thematic semantic relation representations is intrusive but modulated by thematic association strength: evidence from the Think/No-Think paradigm.

Shi K, Li J · 2026 · Psychological research

This study adopts the Think/No-Think (TNT) paradigm for the first time to examine whether activation of thematic semantic relation representations is intrusive. In Experiment 1, during the learning phase, participants memorized cue–target…

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Negative / Null Result ReportMedicine

Effects of inpatient and outpatient cardiac rehabilitation on the 5-year prognosis in patients with acute myocardial infarction.

Suematsu Y, Minei A, Sumita Y et al. · 2026 · European journal of preventive cardiology

Aims Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among…

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