490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Nakamura K, Sakai N, Hirai H et al. · 2026 · British journal of clinical pharmacology
Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long-term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their…
View details →Hennigar SR, Miller KM, Murphy RD et al. · 2026 · The Journal of nutrition
Background Iron deficiency (ID) is associated with decreased appetite and altered mood, which can contribute to feelings of early satiety and reduced overall well-being. Few studies have examined differences in appetite, satiety, and mood…
View details →Portero-Prados FJ, Pabón-Carrasco M, Ponce-Blandón JA · 2026 · Intensive & critical care nursing
Objectives To compare the effectiveness and dermatological safety of chlorhexidine gluconate (CHG)-impregnated dressings versus conventional transparent dressings in preventing central line-associated bloodstream infection (CLABSI) in…
View details →Apostolopoulos V, Mahdal M, Kubíček M et al. · 2026 · SICOT-J
Background Distal femoral megaprosthetic reconstruction is a standard limb-salvage procedure after tumor resection. This study aimed to evaluate implant survival and associated factors, the incidence of mechanical failure, and functional…
View details →Rao LH, Yang ZX, Huang L et al. · 2026 · Journal of pain research
Objective This study aimed to compare the effects of oliceridine and sufentanil on the quality of postoperative recovery in patients undergoing laparoscopic cholecystectomy (LC). Methods This study is of single-center, randomized,…
View details →Chandra S, Rai PJ, Singh N et al. · 2026 · Cureus
Background Streptokinase is widely used for thrombolysis in acute myocardial infarction (AMI), but concerns about complications have led to its underutilization in elderly patients. This study aimed to compare the efficacy and safety of…
View details →Wikkeling OR, VAN Rijn MJ, Witte ME et al. · 2026 · The Journal of cardiovascular surgery
Background Pelvic venous disease (PeVD) and lymphedema are traditionally regarded as distinct clinical entities and are usually investigated and managed within separate clinical frameworks. However, both conditions may coexist in patients…
View details →Huang J, Deng X, Zhou L et al. · 2026 · BMC medical research methodology
Background Evidence quality assessment is critical for informed public health decision-making, but manual approaches are time-consuming and subject to variability. Automated support tools have been proposed to improve efficiency and…
View details →Melendez Vassall I, Mannino JE, Watters P et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses
Metabolic bone disease (MBD) is a disorder affecting bone mineralization that leads to short and long-term consequences. A daily exercise regimen consisting of passive range of motion (ROM) and gentle compression of upper and lower…
View details →Williams T, Phillips NJ, Stein DJ et al. · 2026 · The Cochrane database of systematic reviews
Background Posttraumatic stress disorder (PTSD) is a prevalent and disabling disorder. Evidence that PTSD is characterised by specific psychobiological dysfunctions has contributed to a growing interest in the use of medication in its…
View details →Petri AC, Martins TB, Martins TB et al. · 2026 · Sports medicine - open
Background Gait retraining has been proposed as a strategy to modify running biomechanics and reduce symptoms in runners with patellofemoral pain (PFP). However, review-level evidence remains heterogeneous regarding clinical effects,…
View details →Kloc K, Toumi M, Łukomska E et al. · 2026 · Journal of market access & health policy
The Joint Clinical Assessment (JCA) evaluates the relative effectiveness (RE) of interventions over comparators. While randomised control trials (RCTs) are considered the gold standard, single-arm trials (SATs) require an external control…
View details →Zaher F, Ahrens J, Raucher-Chéné D et al. · 2026 · Bipolar disorders
Clinicians aspire to predict the emergence of Bipolar Disorder (BD) in a timely manner. To accomplish this, markers reflecting mental states that can be gathered non-invasively and at large scale are needed. Here, we systematically…
View details →Nuss ZJ, DeYoung C, Gross D · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
ObjectiveTo evaluate current pharmacotherapeutic strategies for H3 K27M-mutant diffuse midline glioma (DMG), with emphasis on the clinical evidence for dordaviprone, its place in therapy, and its implications for oncology practice.Study…
View details →Bellissimo J, Hall B, Hali K et al. · 2026 · The Journal of arthroplasty
Background Orthobiologic therapies such as platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and hyaluronic acid (HA) are increasingly offered for orthopaedic conditions, but their online promotion may not accurately…
View details →Taylor AJ, Miller BP, Copeland A · 2026 · Journal of the experimental analysis of behavior
Behavioral economic accounts posit that distorted valuation processes underlie cannabis decisions; however, less is known about the moment-to-moment dynamics through which value influences observable choice behavior. This study explored…
View details →Anarna K, Fiander M, Mitra S · 2026 · The Cochrane database of systematic reviews
Rationale Preterm and low-birthweight infants are at risk of anemia due to a variety of factors, including low levels of erythropoietin. They may therefore benefit from erythropoiesis-stimulating agents (ESAs). However, controversy remains…
View details →Clucas K, Saito A · 2026 · The Physician and sportsmedicine
Background Medial elbow injuries occur in approximately one-third of all young baseball players and are characterized by injuries to the bone and cartilaginous growth plates. Bone mineral mass, a representative of bone strength, may show…
View details →Adams R, Deroche MLD · 2025 · The Journal of the Acoustical Society of America
To extract a voice from a background of competing speakers, the human brain exploits voice pitch (harmonic cues) and spatial location (binaural cues) to separate speakers perceptually, and effectively attenuates the background (anything…
View details →LeBlanc MR, Zhou X, Baggett CD et al. · 2026 · Cancer medicine
Background This study aims to describe time to treatment initiation for Black and White older adults with multiple myeloma (MM), and to test the hypothesis that Black/White disparities in treatment initiation have increased over time.…
View details →Ogawa K, Shimatani K, Endo K et al. · 2026 · Public health
Objectives This study examined the association between individual housing cost burden and depressive symptoms, hypothesizing stronger associations particularly in primary breadwinner men who may bear disproportionate financial…
View details →Song J, Pennartz KJ, Caldwell JT et al. · 2026 · European journal of applied physiology
Purpose Near-infrared spectroscopy (NIRS) with vascular occlusion testing (VOT) is used to assess skeletal muscle tissue oxygenation (StO 2 ) responses. Differences in NIRS-VOT outcomes exist between trained and untrained groups; however,…
View details →Ogawa M, Matsumoto K, Aoyama K et al. · 2025 · IEEE transactions on visualization and computer graphics
Virtual reality (VR) enables beyond-real interactions (BRI) that transcend physical constraints, offering effective user experiences like extending a hand to grasp distant objects. However, adapting to novel mappings of BRI often reduces…
View details →Cong YQ, Yurdum L, Fischer A et al. · 2025 · Journal of nonverbal behavior
The ingroup advantage refers to the phenomenon of emotions being more accurately recognised when expressors and perceivers share the same cultural background. Though well-documented in studies using posed facial expressions, whether the…
View details →Sabino-Carvalho JL, Guerrero RV, Teixeira AL et al. · 2025 · Autonomic neuroscience : basic & clinical
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by non-motor symptoms and marked altered sympathetic and parasympathetic activity. However, it is currently unclear if inappropriate autonomic adjustments are…
View details →Højsgaard Chow H, Talbot J, Lundell H et al. · 2023 · Multiple sclerosis and related disorders
Introduction Dimethyl fumarate treatment is approved in Europe for patients with relapsing-remitting multiple sclerosis (MS) and in the US for relapsing forms of MS. We recently published the results of the first randomized…
View details →Goel S, Jovanović B, Chu X et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Cyclin-dependent kinase 4/6 inhibitors can significantly extend survival when given in combination with endocrine therapy in patients with hormone receptor-positive metastatic breast cancer. However, their activity has been…
View details →Buchtele N, Schörgenhofer C, Schwameis M et al. · 2022 · American journal of respiratory and critical care medicine
Rationale: Prostaglandin E 1 (alprostadil; PGE 1 ), in addition to low-dose unfractionated heparin, increases the biocompatibility of extracorporeal systems and enhances the efficacy of artificial organs without increasing bleeding risk.…
View details →Fabbroni C, Grignani G, Vincenzi B et al. · 2024 · ESMO open
Background This is a multicentre, single-arm, phase II study aimed at further exploring the activity of trabectedin as second-/further-line treatment in retroperitoneal leiomyosarcoma (LMS) and well-differentiated/dedifferentiated…
View details →Joshi I, Devine AJ, Joshi R et al. · 2023 · Scientific reports
Progressive emphysema often leads to end-stage lung disease. Most mouse models of emphysema are typically modest (i.e. cigarette smoke exposure), and changes over time are difficult to quantify. The tracheal porcine pancreatic elastase…
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