11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Paavonen J, Brunham RC · 2024 · Frontiers in cellular and infection microbiology
Localized provoked vulvodynia (LPV), also called vulvar vestibulitis or provoked vestibulodynia, is a major cause of dyspareunia that severely impacts sexual health. At the tissue level, lymphocytic inflammation and hyperinnervation are…
View details →Le Pallec C, Cerasuolo D, Cauvin JC et al. · 2025 · European journal of pediatrics
The respiratory rate-oxygenation index (ROXi) has been shown to be a reliable tool for predicting the risk of high-flow nasal cannula (HFNC) failure in adult patients with lower respiratory tract infections. However, the usefulness of the…
View details →Linz MS, Wang T, Friberg J et al. · 2026 · Trauma case reports
Introduction Traumatic hemipelvectomy is a rare operation, often performed for injuries caused by a high force mechanism such as a traffic or industrial accident, and often fatal. Most often performed emergently, here we report a traumatic…
View details →Wu TC, Lin CC · 2025 · Cancer prevention research (Philadelphia, Pa.)
The study by Downs and colleagues targets patients with non-muscle-invasive bladder cancer (NMIBC) to explore secondary/tertiary cancer prevention strategies. Utilizing a "window-of-opportunity" design, erlotinib was evaluated for its…
View details →Moon RE, Mitchell SJ · 2025 · Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g. breath-hold ascent by divers), veins (venous gas embolism, VGE) as a result of tissue bubble formation due to…
View details →Yalcin Y, Yalcin SE, Demir BC et al. · 2026 · BMC surgery
OBJECTIVE: The therapeutic role of lymphadenectomy in endometrial cancer remains controversial. Although systematic pelvic and para-aortic lymphadenectomy (PPLND) has been suggested to improve survival in certain patients, randomized…
View details →Regidor E, Dionigi C, Ghoraishi M et al. · 2026 · Journal of periodontal research
Aims To evaluate the adjunctive effect of enamel matrix derivative (EMD) in the reconstructive surgical therapy of peri-implantitis. Methods Forty subjects (44 implants) affected by peri-implantitis (PPD ≥ 5 mm, positive BOP/SOP,…
View details →Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology
Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…
View details →Niazi SK · 2024 · International journal of molecular sciences
Although decades of intensive drug discovery efforts to treat neurodegenerative disorders (NDs) have failed, around half a million patients in more than 2000 studies continue being tested, costing over USD 100 billion, despite the…
View details →Nutbeam T · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine
Background Cervical collar application remains prevalent in trauma care despite the absence of evidence of neurological benefit from spinal immobilisation. Clinical behaviour in this area has proven resistant to change, and the persistence…
View details →Struys T, Christiaens V, De Bruyckere T et al. · 2025 · Clinical implant dentistry and related research
Aim To assess the impact of the timing of soft tissue augmentation on soft tissue changes and esthetic outcome following single immediate implant placement (IIP) in the anterior maxilla. Materials and methods Patients with a failing tooth…
View details →Hedberg F, Lindh JD, Mannheimer B et al. · 2026 · Journal of the Endocrine Society
Context Levothyroxine (LT4) is the primary treatment of hypothyroidism. Despite adequate LT4 substitution some patients experience symptoms and the use of adjunct liothyronine (LT3) has increased. Several trials show no clear advantage of…
View details →Matera MG, Calzetta L, Rogliani P et al. · 2025 · International journal of chronic obstructive pulmonary disease
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with limited response to standard anti-inflammatory therapies. Biologics targeting specific inflammatory pathways have emerged as potential treatments,…
View details →De Pascale G, Cutuli SL, Vargas M et al. · 2026 · Intensive care medicine
Purpose The MICROINHALO trial investigated whether personalized management of endotracheal tube cuff pressure (Pcuff) based on exhaled CO 2 measurement combined with automatic subglottic space drainage (SSD) may prevent tracheal…
View details →Bano S, Choudhry N, Numan A et al. · 2026 · Journal of clinical medicine
Background : Circulating cytokines and their soluble receptors in body fluids have been implicated in the pathogenesis of multiple sclerosis (MS). Alterations in serum levels of pro- and anti-inflammatory cytokines and/or their soluble…
View details →Wang Y, Niu Y, Qin B et al. · 2025 · Ecology and evolution
Perlidae represents one of the most diverse and ecologically important groups within the order Plecoptera. However, the phylogenetic relationships within Perlidae remain unresolved due to morphological plasticity and the limited…
View details →Kim Y, Salazar-Marioni S, Abdelkhaleq R et al. · 2025 · Scientific reports
The role of intravenous thrombolysis (IVT) in combination with endovascular thrombectomy (EVT) for the treatment of large vessel occlusion acute ischemic stroke has been evaluated exclusively outside the US, in randomized clinical trials…
View details →Santucci J, Hua C, Chong L et al. · 2025 · ANZ journal of surgery
Background Data on optimal extent of resection for various stages of gallbladder cancer are lacking. This study aims to evaluate disease-free (DFS) and overall survival (OS) after simple (SC) versus radical cholecystectomy (RC) for…
View details →Byrne RA, Hahn JY, O'Kane P et al. · 2025 · JACC. Cardiovascular interventions
Background In recent years, drug-coated balloon (DCB) angioplasty has become an established treatment option for the treatment of coronary in-stent restenosis (ISR). Objectives The aim of this study was to compare the angiographic and…
View details →Morgenthaler J, Trommer M, Khor R et al. · 2024 · Oral oncology
Oropharyngeal carcinomas linked to high-risk types of human papillomavirus (HPV + OPC) as a distinct tumor entity, have a better prognosis than HPV - OPC. Current treatment approaches do not differentiate between HPV-positive and negative…
View details →Šostakaitė G, Jauniškytė M, Budrys D et al. · 2025 · Nutrition (Burbank, Los Angeles County, Calif.)
Background and aims Muscle wasting is a prevalent issue among long-term critically ill patients and is associated with adverse clinical outcomes. Evaluating muscle mass in the ICU presents challenges due to the lack of a consistent…
View details →Jaffee S, Kusyk DM, Onyiah C et al. · 2026 · Surgical neurology international
Background Neuropsychological assessment is crucial in the presurgical evaluation of patients with Parkinson's disease (PD) who are contemplating deep-brain stimulation (DBS). No standardized screening test battery currently exists. Our…
View details →Adam AS, Marcélis L, Fage D et al. · 2026 · JIMD reports
Hereditary tyrosinemia type I (HT-1) is a rare metabolic disorder treated by NTBC, requiring careful therapeutic and nutritional monitoring. While follow-up traditionally relies on urinary succinylacetone, plasma NTBC and plasma amino…
View details →Chen Y, Ma Y, Yuan H et al. · 2025 · BMC cancer
OBJECTIVES: To investigate clinicopathological predictors and evaluate the impact of adjuvant therapy on survival outcomes in patients with early-stage (FIGO 2023 Stage I-II) endometrial clear cell carcinoma (ECCC). METHODS: This…
View details →Kim JH, Song M, Lee KW et al. · 2026 · Life (Basel, Switzerland)
Ubiquitin-specific protease 13 (USP13) is a deubiquitinating enzyme that stabilizes phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a well-established tumor suppressor involved in PI3K/AKT signaling. This study aimed to…
View details →Fields BC, Jain AJ, Prieto VG et al. · 2024 · The American Journal of dermatopathology
Abstract A 45-year-old woman with a history of previously treated left plantar foot melanoma presented with a left thigh mass. Fine needle aspiration findings were concerning for metastatic melanoma (MM). Imaging was remarkable for…
View details →Misawa A, Kimura E, Inoue M et al. · 2025 · Journal of surgical case reports
Tension-free vaginal mesh repair surgery (TVM) has decreased due to complications related to mesh use and the lack of superiority compared to native tissue repair (NTR). In japan it is still performed as a treatment for pelvic organ…
View details →Kasoha M, Findeklee S, Nigdelis MP et al. · 2024 · Biomedicines
Background Serum bone turnover markers might play a role in the prediction of the development of bone metastases in breast cancer (BC) patients. We conducted a retrospective cohort study to address the association of serum bone turnover…
View details →Samatoshenkov I, Zakirova E, Samatoshenkova J et al. · 2026 · Cells
Peripheral arterial disease and critical limb-threatening ischemia remain major clinical challenges, particularly in patients who are not candidates for surgical or endovascular revascularization. These limitations have stimulated…
View details →Sadek Azar R, Ramirez Roldan JF, Nuñez de la Vega JM · 2026 · Cureus
Introduction Perineal tears represent one of the main complications of vaginal delivery, with immediate and long-term consequences for maternal health. Although several factors have been associated with their occurrence, the role of…
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