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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with long COVID: A pilot randomized controlled trial.

Calvani R, Giampaoli O, Marini F et al. · 2024 · Clinical nutrition (Edinburgh, Scotland)

Background & aims Long-term effects of coronavirus disease 2019 (long COVID) develop in a substantial number of people following an acute COVID-19 episode. Red beetroot juice may have positive effects on multiple pathways involved in long…

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Negative / Null Result ReportOpen accessMedicine

One size does not fit all: uncontrolled T2 inflammation on tezepelumab-a case series.

Tardif A, Boulay ME, Côté A et al. · 2026 · Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

BACKGROUND: Tezepelumab is the most recent human monoclonal antibody in the therapeutic arsenal of patients with severe uncontrolled asthma. It neutralizes thymic stromal lymphopoietin (TSLP). Phase 2 and phase 3 studies showed a…

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Negative / Null Result ReportMedicine

M2 macrophage-targeting peptide-modified liposomes enhance the uptake and antitumor efficacy of liposomal IFN-γ in mice with C26 colon carcinoma.

Kateh Shamshiri M, Vakili-Ghartavol R, Aiyelabegan HT et al. · 2025 · Cytokine

While liposomes enhance the safety and pharmacokinetic profile of free drugs, they have not significantly improved therapeutic efficacy. To overcome this challenge, targeted depletion of tumor-associated macrophages (TAMs) shows…

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Negative / Null Result ReportOpen accessMedicine

Nintedanib Lacks Efficacy in a Spirometry-Confirmed and Bleomycin-Induced Mouse Model of Idiopathic Pulmonary Fibrosis.

Bousamaki J, Maciag G, Petersen AG et al. · 2026 · Basic & clinical pharmacology & toxicology

Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three…

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Negative / Null Result ReportOpen accessMedicine

Vitamin D Deficiency as a Risk Factor for Onset and Recurrence of Sudden Sensorineural Hearing Loss: A Prospective Cohort Study With Age-Specific Analysis.

Hui Q, Xiang T, Qinglan X et al. · 2026 · Food science & nutrition

The link between Vitamin D (Vit D) deficiency and sudden sensorineural hearing loss (SSNHL), especially regarding recurrence and age-related disparities, remains unclear. Recurrence and age-specific risks of SSNHL are under addressed,…

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Negative / Null Result ReportMedicine

Neighborhood bonding and bridging social capital, social activity participation, and short-term cognitive variability in later life.

Hyun J, Cerino ES, Katz MJ et al. · 2025 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives Investigating social determinants of health and related outcomes may help identify effective and sustainable intervention targets. This study examined whether contextual-level social capital (bonding and bridging capital) and…

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Negative / Null Result ReportOpen accessMedicine

Urodynamic findings and vibegron effects on neurogenic lower urinary tract dysfunction caused by human T-cell leukemia virus type I-associated myelopathy/tropical spastic paraparesis.

Kumekawa T, Akaihata H, Natsuya H et al. · 2024 · IJU case reports

Introduction Human T-cell lymphotropic virus type 1 infection can cause HTLV-1-associated myelopathy/tropical spastic paraparesis, characterized by spastic paralysis of both lower limbs. More than 90% of HAM/TSP patients show lower urinary…

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Negative / Null Result ReportOpen accessMedicine

Subocclusive ileus following off-label high-dose semaglutide use.

Nikolaeva A, Vandeputte M · 2025 · Endocrinology, diabetes & metabolism case reports

Summary Semaglutide, a GLP-1 receptor agonist (RA), is approved for the treatment of type 2 diabetes and obesity. However, its increasing off-label use, particularly for cosmetic weight loss, raises concerns considering its potential…

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Negative / Null Result ReportMedicine

Venous stenting versus venous ablation.

Alsheekh A, Kibrik P, Marks N et al. · 2025 · Vascular

BackgroundThe minimally invasive procedures of venous ablation and iliac vein stenting are evolving treatment options for venous insufficiency. Yet, there are no studies directly comparing the outcome of these procedures. We performed a…

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Negative / Null Result ReportMedicine

Long-term prognosis at 1.5 years after infection with wild-type strain of SARS-CoV-2 and Alpha, Delta, as well as Omicron variants.

Agergaard J, Gunst JD, Schiøttz-Christensen B et al. · 2023 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Knowledge is limited on how changing SARS-CoV-2 variants may translate into different characteristics and affect the prognosis of patients with long COVID, especially following Omicron variants. We compared long-term prognosis…

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Negative / Null Result ReportOpen accessMedicine

Cost-effectiveness of a victim improvement package: randomised controlled trial for reduction of continued symptoms of depression or anxiety in older victims of community crime.

Panca M, Serfaty M, Satchell J et al. · 2026 · BJPsych open

Background Crime has significant impact on older victims. High rates of anxiety and depression may be associated with crimes. Aims This paper aims to evaluate the cost-effectiveness of a victim improvement package (VIP) for the reduction…

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Negative / Null Result ReportOpen accessMedicine

Endoscopic endonasal approach for resection of odontoid process, decompression of the cervicomedullary junction spinal cord, and resection of pannus.

Fernandes Cabral DT, Fernández-de Thomas RJ, Alattar A et al. · 2024 · Neurosurgical focus: Video

Odontoid pannus is an abnormal collection of degenerative or inflammatory tissue on the C1-dens joint that can result in severe spinal cord compression myelopathy. Treatment options vary depending on severity and etiology. In cases of…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of the shear bond strength between 3D printed acrylic denture base resin and teeth with surface modifications - An in-vitro study.

Sood M, Hegde V, Prabhu N et al. · 2026 · Journal of Indian Prosthodontic Society

Aim This study aimed to assess the shear bond strength between three-dimensional (3D)-printed acrylic denture base resin and 3D-printed teeth with and without ridge lap surface modifications. Materials and methods The investigation…

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Negative / Null Result ReportMedicine

Effects of sildenafil on gas exchange, ventilatory, and sensory responses to exercise in subjects with mild-to-moderate COPD: A randomized cross-over trial.

Gass R, Plachi F, Silva FOB et al. · 2025 · Respiratory physiology & neurobiology

Excess exercise ventilation (high ventilation (V̇ E )/carbon dioxide output (V̇CO 2 )) contributes significantly to dyspnea and exercise intolerance since the earlier stages of chronic obstructive pulmonary disease (COPD). A selective…

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Negative / Null Result ReportMedicine

Phase 2 trial of veliparib, local irradiation, and temozolomide in patients with newly diagnosed high-grade glioma: a Children's Oncology Group study.

Karajannis MA, Onar-Thomas A, Lin T et al. · 2025 · Neuro-oncology

Background The outcome for pediatric patients with high-grade glioma (HGG) remains poor. Veliparib, a potent oral poly(adenosine diphosphate-ribose) polymerase (PARP) 1/2 inhibitor, enhances the activity of radiotherapy and DNA-damaging…

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Negative / Null Result ReportOpen accessMedicine

High-Dose Furmonertinib Management of Advanced NSCLC Harboring an EGFR Exon 14 Missense Mutation: A Case Report and Literature Review.

Luo JY, Xiang J, Hong XL et al. · 2026 · The American journal of case reports

BACKGROUND Epidermal growth factor receptor (EGFR) is a key driver gene in non-small-cell lung cancer (NSCLC), and EGFR tyrosine kinase inhibitors (TKIs) are the standard treatment for classical mutations, including exon 19 deletion and…

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Negative / Null Result ReportMedicine

Influence of short bouts of stair climbing on young adults during prolonged sitting on posture, discomfort, and musculoskeletal performance outcomes: a counterbalanced pilot randomised crossover trial.

Raj AK, Pedersen SJ, Mainsbridge C et al. · 2024 · Ergonomics

Prolonged sitting is postulated to influence musculoskeletal performance (cervical flexor endurance, balance, and agility), discomfort and alter cervical spine angles during work-based computer use. Stair climbing breaks may be a great…

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