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11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Long-Term Outcomes After Percutaneous Coronary Intervention With the Polymer-Free Biolimus-Coated BioFreedom Stent Versus the Biodegradable-Polymer Sirolimus-Eluting Orsiro Stent in Patients With Acute Coronary Syndromes.

Noori M, Christiansen EH, Hougaard M et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background The polymer-free biolimus A9-coated BioFreedom stent (BF-BCS) releases a lipophilic drug that may provide a potent anti-inflammatory effect in patients with acute coronary syndromes (ACS). Five-year efficacy and safety of BF-BCS…

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Negative / Null Result ReportMedicine

Neural Correlates for Anticipating and Observing Goal-Directed Actions in Autism.

Krol MA, Skodova T, Jellema T · 2026 · Autism research : official journal of the International Society for Autism Research

We investigated possible atypicalities in activation of cortical motor-related circuits in young adults with Autism Spectrum Conditions (ASC) and typical-development (TD) when observing others' actions. Activation of these circuits is…

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Negative / Null Result ReportMedicine

Rhythmic movements mimicking tremor under different metronome conditions.

Uzunçakmak-Uyanık H, Yıldız FG, Yalçın-Çakmaklı G et al. · 2026 · Scientific reports

Rhythmic movements mimicking tremor are commonly used as a control condition in tremor physiology studies, yet the influence of different metronome modalities on performance has not been systematically examined. We compared auditory,…

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Negative / Null Result ReportMedicine

MicroRNA Dysregulation and Hepatic Involvement in Alcohol-Related Macrocytic Anaemia: Links to Severity Without Predictive Value for Treatment Response.

Porr C, Vidrighin A, Ichim C et al. · 2026 · Life (Basel, Switzerland)

Background Alcohol-related macrocytic anemia remains insufficiently characterized, particularly regarding molecular correlates of disease severity and treatment response. We evaluated the hepatic, inflammatory and microRNA profile of…

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Negative / Null Result ReportMedicine

Epidural thickness of the dura sealants HEMOPATCH® and TACHOSIL® after elective supratentorial craniotomy: A comparative retrospective monocentric cohort study.

Rossmann J, Schicho A, Höhne J et al. · 2026 · Journal of biomaterials applications

This study compares the in vivo behavior (epidural thickness and complication rate including the development of cerebrospinal fluid fistula, CSF-fistula) of the newer dura sealant HEMOPATCH® (HP) with that of the well-established patch…

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Negative / Null Result ReportMedicine

Challenging the standard: comparison of outcomes between laparoscopically assisted anorectoplasty (LAARP) and posterior sagittal anorectoplasty (PSARP) in the correction of rectobulbar fistula in pediatric patients.

Carreño Sanchez MA, Ruiz J, Siffredi J et al. · 2026 · Pediatric surgery international

Background Posterior sagittal anorectoplasty (PSARP) remains the standard surgical approach for rectobulbar fistula in patients with anorectal malformations (ARM). Laparoscopically assisted anorectoplasty (LAARP) has emerged as an…

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Negative / Null Result ReportMedicine

Determinants of Patient-Reported Experience After Interhospital Transfer Within an Integrated Health System.

Howick V JF, Lugo-Fagundo NS, Umadat G et al. · 2026 · Journal for healthcare quality : official publication of the National Association for Healthcare Quality

Objective To evaluate patient-reported experiences after interhospital transfer (IHT) within an integrated health system and identify communication and coordination domains associated with overall satisfaction. Methods This retrospective…

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Negative / Null Result ReportMedicine

Microfluidic sperm selection versus density gradient centrifugation in ICSI cycles with abnormal semen parameters: a randomized sibling-oocyte study.

Thanapongpibul C, Niransuk P, Sassanarakkit S et al. · 2026 · Scientific reports

Microfluidic sperm selection (MSS) is a centrifugation-free alternative to density gradient centrifugation (DGC) for sperm preparation in intracytoplasmic sperm injection (ICSI). This prospective, randomized sibling-oocyte study included…

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Negative / Null Result ReportMedicine

Association of the mitochondrial regulator PGC-1α with diabetes mellitus and myocardial ischemia-reperfusion injury in coronary artery bypass grafting.

Yildiz A, Yazici S, Yildiz Z · 2026 · BMC cardiovascular disorders

Objectives This study aimed to evaluate whether peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) could serve as a marker of myocardial ischemia by examining its association with cross-clamp time, which reflects…

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Negative / Null Result ReportOpen accessMedicine

Low-flow oxygen delivery in patients with disturbed consciousness.

Yamada SM · 2026 · Surgical neurology international

Background When low-flow oxygen (O2) delivery is required, a nasal cannula is commonly used. However, no reports have described arterial blood gas analysis in actual patients receiving O2 simultaneously through a mask and a nasal cannula.…

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Negative / Null Result ReportMedicine

Susceptibility of sorghum to infestation by Oryzaephilus surinamensis (Coleoptera: Silvanidae) and Trogoderma variabile (Coleoptera: Dermestidae): influence of variety and temperature.

Gourgouta M, Athanassiou CG, Arthur FH et al. · 2026 · Journal of economic entomology

This study evaluated the effects of sorghum variety and temperature on the population growth, frass production, kernel damage, and weight loss caused by Oryzaephilus surinamensis (L.) and Trogoderma variabile, Ballion, two common…

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Negative / Null Result ReportOpen accessMedicine

Influence of sport mouth-formed type mouthguards on saliva secretion and composition during jaw activity: a pilot study.

van Vliet KE, Lobbezoo F, van Splunter AP et al. · 2026 · BMC oral health

BACKGROUND: We hypothesized that wearing a mouthguard may affect salivary flow and composition. Therefore, we investigated the impact of mouthguard use on saliva secretion rate and some salivary constituents under different jaw activities.…

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Negative / Null Result ReportMedicine

Sacral positioning and interface pressure in the beach-chair position during shoulder surgery: a retrospective, observational study.

Takatori N, Uchiyama Y, Ito H et al. · 2026 · Journal of tissue viability

Background Intraoperative pressure-related skin injuries remain a concern during surgery under general anaesthesia. Although interface pressures have been evaluated in various surgical positions, sacral pressure in the beach-chair position…

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Negative / Null Result ReportMedicine

Migraine is Associated With Altered Preoperative Endodontic Pain Perception and Mechanical Sensory Function but Not Short-Term Postoperative Pain: A Prospective Clinical Study.

Harun AS, Shikder AHMZH, Moni SD et al. · 2026 · Journal of oral rehabilitation

Background Migraine has been associated with altered nociceptive processing and may influence the clinical presentation of odontogenic pain. This study evaluated whether migraine is associated with preoperative endodontic pain,…

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Negative / Null Result ReportMedicine

Source- and land-use-dependent controls on black carbon accumulation in urban soils: A comparison between an industrial city and a megacity in central China.

Zhan C, Liu S, Kang W et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Black carbon (BC) is an important component of soil organic carbon (SOC), with implications for carbon sequestration and environmental quality, yet its variability across contrasting urban systems remains insufficiently understood. This…

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Negative / Null Result ReportMedicine

Clinical and radiographic outcomes of cannulated cancellous screw osteosynthesis with and without side-plate for nondisplaced femoral neck fractures: a multicenter propensity score-matched study.

Maeda K, Funahashi H, Tokutake K et al. · 2026 · International orthopaedics

Purpose This study aimed to evaluate postoperative outcomes, including clinical results, radiological assessments, and complications, in patients over 50 years old with nondisplaced femoral neck fractures (Garden classification I-II)…

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Negative / Null Result ReportMedicine

Efficacy and Safety of Denosumab versus Zoledronic Acid in the Treatment of Hypercalcemia in Primary Hyperparathyroidism: A Retrospective Comparative Study.

Liu Y, Liu L, Wang J et al. · 2026 · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Objective Nephrotoxicity of bisphosphonates limits their utility in the management of severe hypercalcemia among patients with primary hyperparathyroidism (PHPT) and impaired renal function. It remains unclear whether denosumab is an…

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Negative / Null Result ReportMedicine

Clinical outcomes of a Locator-bilateral segmental bar concept versus a conventional rigid bar concept for maxillary implant-supported overdentures: a retrospective cohort study.

Zheng J, Chen M, Fu J · 2026 · BMC oral health

Background This retrospective cohort study evaluated a Locator-bilateral segmental bar concept (LBSB) for maxillary implant-supported overdentures and compared it with a conventional rigid bar concept (CRB) in terms of implant survival,…

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Negative / Null Result ReportMedicine

Effectiveness of Audiovisual Distraction During Dental Treatment Under Nitrous Oxide/Oxygen Conscious Sedation in Paediatric Patients: A Randomized Crossover Clinical Trial.

Gentile T, Vanacore S, Caputo M et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Dental anxiety represents a major challenge in paediatric dentistry and is a frequent cause of non-cooperative behaviour during dental treatment. Nitrous oxide/oxygen inhalation conscious sedation is widely used to…

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Negative / Null Result ReportMedicine

The trajectories of relative concentrations of antirhodococcal immunoglobulin A differ from those of immunoglobulin G subisotypes in bronchoalveolar lavage fluid but not serum of foals.

Aucoin AA, Zhidkov V, Legere RM et al. · 2026 · American journal of veterinary research

Objective To characterize age-related trajectories of the relative concentrations of anti-virulence-associated protein A (VapA) immunoglobulin (Ig)-G1, IgG3/5, IgG4/7, and IgA in serum and bronchoalveolar lavage fluid (BALF) as indicators…

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Negative / Null Result ReportMedicine

Combined Pain Neuroscience Education and Progressive Muscle Relaxation for Post-Thoracoscopic Pain.

Wang X, Li W, Wang F et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Purpose The objective of this study was to evaluate whether combining pain neuroscience education (PNE) with progressive muscle relaxation (PMR) could reduce acute pain after thoracoscopic lung resection, alleviate psychological distress,…

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Negative / Null Result ReportMedicine

Comparing Spinal and General Anesthesia for Prone Percutaneous Nephrolithotomy: A Propensity Score-Matched Study.

Chen L, Xu D, Hou L · 2026 · Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Background/objective Prone percutaneous nephrolithotomy (PCNL) is commonly performed under general anesthesia (GA); however, increasing evidence supports the feasibility of PCNL under spinal anesthesia (SA). This study presents our…

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