11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Leung A, Koo J · 2026 · CNS drugs
Dermatological delusional disorders, such as delusional infestation (DI), are a unique type of psychosis in which the patient experiences specific delusions, such as parasites or inorganic materials that come out of their skin. Originally,…
View details →Cherif IS, Essis EML, Diallo MA et al. · 2026 · Case reports in infectious diseases
Background Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a…
View details →Columbo JA, Scali ST, Wanhainen A et al. · 2026 · Annals of surgery
Objective To determine the contemporary cost per quality-adjusted life year(QALY) gained for abdominal aortic aneurysm (AAA) repair in current practice and assess the optimal threshold for intervention. Summary background data The widely…
View details →Renard K, Sung HD, Griffis C · 2026 · AANA journal
Gabapentin is widely used in perioperative analgesic protocols. Many clinical studies supporting the safety and analgesic efficacy of gabapentin for postoperative pain have been published over the last two decades. Several studies, many…
View details →Winstén AK, Langén V, Airaksinen KEJ et al. · 2026 · JAMA network open
Importance Anticoagulation for stroke prevention in subclinical, device-detected atrial fibrillation (AF) remains an area of clinical equipoise, and its cost-effectiveness is unknown. Objective To evaluate the cost-effectiveness of direct…
View details →Thomas CA, Blau S, Neuhalfen H et al. · 2026 · JCO oncology practice
Purpose Biomarker testing, including immunohistochemistry (IHC) and next-generation sequencing, is the standard of care in advanced non-small cell lung cancer (NSCLC) for identifying actionable mutations such as EGFR , ALK , and KRAS .…
View details →Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…
View details →Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology
Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…
View details →Campello E, Zanetto A, Ferdinande K et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver
Background and aims Cirrhosis is characterized by progressive immune dysregulation, endothelial dysfunction, and haemostatic imbalance. Circulating extracellular vesicles (EVs) have emerged as potential biomarkers reflecting these…
View details →Yamao S, Chiba Y, Kuniyoshi K et al. · 2026 · Ophthalmology. Retina
Purpose To evaluate surgical outcomes and identify key prognostic factors in retinal detachment associated with morning glory syndrome (MGS-RD). Design Retrospective consecutive case series. Subjects Fifteen consecutive eyes of 15 patients…
View details →Augustin M, Pollak TA, Morrin H · 2026 · NPP - digital psychiatry and neuroscience
AI-associated delusions represent an emerging phenomenon requiring mechanistic understanding. This review, after summarizing key contributions on AI-associated delusions, proposes the "amplification spiral" framework, wherein three…
View details →David P, Oliphant K, Zhou C et al. · 2026 · Pediatric research
Background Fentanyl, an opioid medication commonly given to hospitalized preterm infants, may alter gut microbiome development and subsequent neurodevelopmental outcomes. Methods We compare a cohort of preterm infants with and without…
View details →Merzaei Z, Kazemian H, Bamzadeh Z et al. · 2026 · BMC research notes
Objective Irritable bowel syndrome (IBS) presents with symptoms of pain, abdominal discomfort, and altered bowel habits. Changes in the intestinal microbiota, including an increase in Enterobacteriaceae like E. coli, have been associated…
View details →Siddique S, Wang R, Berardi D et al. · 2026 · Cancer
Background The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50 years, has been increasing. The relationship between demographic, birth, and parental characteristics and risk…
View details →Gallaccio G, Müller A, Wang M et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation
Background and objectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder that overlaps clinically with multiple sclerosis (MS) but immunopathologically distinct. Although…
View details →Kumura Y, Maruta M, Yokota H et al. · 2026 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Background Post-operative delirium (POD) is a common complication in older patients with cancer undergoing surgery, leading to prolonged hospitalisation and cognitive decline. This study examined the relationship between pre-operative…
View details →Xu P, Zhong S, Peng X · 2026 · The Journal of international medical research
Barium-associated intestinal ischemia is a rare but life-threatening complication following upper gastrointestinal barium contrast examinations, with an incidence of less than 0.01%. Hepatic portal venous gas is a condition secondary to…
View details →Qu ZW, Zhang Y, Guo MY · 2026 · The Journal of international medical research
ObjectiveTo investigate the association of preoperative hypoalbuminemia (serum albumin <35 g/L) with clinicopathological characteristics and survival outcomes in patients with gastric cancer undergoing radical gastrectomy and to construct…
View details →Abdulridha GAO, Fadhel AS, Al-Kinany SQ et al. · 2026 · Journal of neuroimmunology
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by leukocyte infiltration, immune activation, demyelination, and axonal injury. This case-control observational study aimed to investigate…
View details →Baltu D, Taş N, Alıcı N et al. · 2026 · Pediatric nephrology (Berlin, Germany)
Background Although acetazolamide is the main medical treatment for idiopathic intracranial hypertension (IIH), data on acetazolamide-induced metabolic acidosis and its long-term outcomes are limited. This study aimed to investigate the…
View details →Rinaldi V, Ridolfi F, Finotello R et al. · 2026 · Veterinary medicine and science
Hypertrophic osteopathy (HO) is a paraneoplastic or parainflammatory syndrome characterised by painful periosteal new bone formation and soft tissue swelling, most commonly associated with thoracic neoplasia. The pathogenesis of HO remains…
View details →Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering
Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…
View details →Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education
This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…
View details →Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)
Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…
View details →Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics
Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…
View details →Liu S, Tan Y, Zang L · 2026 · Healthcare (Basel, Switzerland)
Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether…
View details →Turgut H, Özdemir R, Memişoğlu F · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose This study aimed to characterize pathogen distribution and antimicrobial resistance patterns of gram-negative bloodstream infections in a tertiary neonatal intensive care unit and to determine which factors were associated with…
View details →Hsu LI, Chen JW, Hsu HW et al. · 2026 · Anesthesiology
Background Tranexamic acid (TXA) reduces perioperative blood loss, but comparative effectiveness and safety across administration routes remain uncertain. The authors evaluated topical, IV, and oral TXA in unilateral total hip and knee…
View details →Miyake H, Onishi A, Tsuji H et al. · 2026 · Modern rheumatology
To identify factors associated with flare after glucocorticoid (GC) reduction in systemic lupus erythematosus (SLE) and determine whether belimumab influences this risk. Using the ANSWER-SLE cohort, this retrospective multicentre study…
View details →Deconne TM, Suerken CK, Lipford ME et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundArterial stiffness is an emerging risk factor for Alzheimer's disease (AD) and related dementias (ADRD) and is assessed by measuring pulse wave velocity (PWV). Recent mathematical modeling has allowed for the delineation of…
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