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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Association of the mitochondrial regulator PGC-1α with diabetes mellitus and myocardial ischemia-reperfusion injury in coronary artery bypass grafting.

Yildiz A, Yazici S, Yildiz Z · 2026 · BMC cardiovascular disorders

Objectives This study aimed to evaluate whether peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) could serve as a marker of myocardial ischemia by examining its association with cross-clamp time, which reflects…

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Negative / Null Result ReportOpen accessMedicine

Low-flow oxygen delivery in patients with disturbed consciousness.

Yamada SM · 2026 · Surgical neurology international

Background When low-flow oxygen (O2) delivery is required, a nasal cannula is commonly used. However, no reports have described arterial blood gas analysis in actual patients receiving O2 simultaneously through a mask and a nasal cannula.…

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Negative / Null Result ReportMedicine

Susceptibility of sorghum to infestation by Oryzaephilus surinamensis (Coleoptera: Silvanidae) and Trogoderma variabile (Coleoptera: Dermestidae): influence of variety and temperature.

Gourgouta M, Athanassiou CG, Arthur FH et al. · 2026 · Journal of economic entomology

This study evaluated the effects of sorghum variety and temperature on the population growth, frass production, kernel damage, and weight loss caused by Oryzaephilus surinamensis (L.) and Trogoderma variabile, Ballion, two common…

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Negative / Null Result ReportMedicine

Robotic versus laparoscopic rectal resection: impact on primary postoperative ileus and the role of intraoperative fluid balance: a propensity score-matched cohort study.

Urashima T, Yabuno T, Imanishi K et al. · 2026 · Surgical endoscopy

Background Few studies have directly compared the incidence of primary postoperative ileus (primary POI) between robotic surgery (RS) and laparoscopic surgery (LS) for rectal resection. Methods This retrospective cohort study included…

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Negative / Null Result ReportMedicine

Radial Versus Femoral Access for Diagnostic Coronary Angiography: Insights From a Tertiary Academic Center in Johannesburg.

Ntaka KL, Mpanya D, Adamu UG et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Background The radial artery is the preferred access for performing diagnostic coronary angiograms (DCA). However, data on the safety and efficacy of radial compared to femoral access in low- and middle-income countries is limited. Aims…

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Negative / Null Result ReportMedicine

Levels of acylated and deacylated ghrelin are elevated in unmedicated patients with major depressive disorder and obesity: a cross-sectional study.

Lis M, Miłuch T, Krupa R et al. · 2026 · Scientific reports

Major depressive disorder (MDD) frequently co-occurs with obesity, suggesting shared neuroendocrine mechanisms. Ghrelin, a hormone involved in appetite regulation, stress response, and reward processing, has been proposed as a biological…

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Negative / Null Result ReportMedicine

Noninferiority trial of low-dose intravenous dexamethasone on the analgesic effect of caudal block in children undergoing day-case orchiopexy: a randomized clinical trial.

Lee JR, Choi H, Eum D et al. · 2026 · Anesthesia and pain medicine

Background Intravenous (IV) administration of dexamethasone has been reported to prolong the analgesic duration of a caudal block. The aim of this study was to compare the analgesic effects of IV low-dose and high-dose dexamethasone in…

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Negative / Null Result ReportMedicine

Impact of the amotosalen/UVA process to reduce pathogens in platelet concentrates on transfusion efficiency in cardiac surgery.

Bouali B, Rezzaoui A, Hamzeh-Cognasse H et al. · 2026 · Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

Background Pathogen reduction treatment (PRT) of platelet concentrates (PC) is one of the most recent advances in improving blood safety and lowering the risk of transfusion-transmitted diseases. The characteristics of PR-treated PC differ…

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Negative / Null Result ReportMedicine

The Efficacy of Local Treatment for Recurrent Endometrial Cancer.

Igasaki M, Furusawa A, Kunishi M et al. · 2026 · The journal of obstetrics and gynaecology research

Aim This study aimed to evaluate the efficacy of local treatment in patients with sporadic recurrent endometrial cancer. Methods We retrospectively reviewed patients who received treatment for first recurrence of endometrial cancer at our…

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Negative / Null Result ReportMedicine

Hip Fracture Risk Following Lumbar Fusion: A Retrospective Cohort Study of Construct Length and Age-Stratified Outcomes.

Anundson J, Lee L, Bae S et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Introduction Lumbar fusion alters spinal biomechanics and may increase hip loading, especially with long-segment constructs. We used a large administrative database to evaluate hip fracture risk after lumbar fusion and assess whether…

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Negative / Null Result ReportMedicine

Effectiveness of a standardized patient simulation training programme on nursing students' skill in dementia screening in Malawi: A quasi-experimental study.

Chiona BC, Mbakaya BC, Liu MF · 2026 · Nurse education in practice

Aim To evaluate the effectiveness of Standardized Patient Simulation (SPS) compared with lecture-based teaching in improving dementia knowledge, dementia screening skills and mild cognitive impairment (MCI) classification accuracy among…

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Negative / Null Result ReportMedicine

Marginal Bone Loss Around Bone-Level Fully Guided Implants With Direct Implant Connection Versus Intermediate Abutment: A Randomized Clinical Trial.

Gargallo-Albiol J, Zilleruelo-Pozo MJ, Treserra-Parra A et al. · 2026 · Clinical oral implants research

Objective To determine the influence of an intermediate prosthetic abutment on peri-implant marginal bone loss (MBL) around two implant-supported fixed restorations in the posterior area. Material and methods This study included patients…

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Negative / Null Result ReportMedicine

Evaluating junior medical staff confidence in assessment and management of mental health presentations in an Australian paediatric emergency department.

Daoud J, Greenwood J, Botha T et al. · 2026 · Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

ObjectiveTo evaluate confidence levels of junior doctors working in the paediatric emergency department (ED) in the assessment and management of acute mental health presentations.MethodsThis cross-sectional study invited 89 eligible junior…

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Negative / Null Result ReportMedicine

Retrospective study on diagnostic yield and medical impact of diagnostic imaging in dogs with immune-mediated haemolytic anaemia in Belgium.

Vlassenbroek R, Peeters D, Matthewman L et al. · 2026 · The Journal of small animal practice

Objectives To assess the incidence of associative immune-mediated haemolytic anaemia in dogs diagnosed with immune-mediated haemolytic anaemia and to evaluate whether performing diagnostic imaging, specifically thoracic radiographs and…

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