11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Vulindlela I, Paca AM, Meyer EL et al. · 2026 · Nanomaterials (Basel, Switzerland)
The increasing global demand for renewable energy has intensified the search for high-efficiency and cost-effective solar cell technologies. Quantum dot-sensitized solar cells (QDSSCs) have emerged as promising candidates due to their…
View details →Srikanchana R, Samuel D, Powell J et al. · 2025 · Annals of biomedical engineering
Purpose The aim of this research was to assess the potential for machine learning to predict clinically significant patient improvement during a four-week interdisciplinary Intensive Outpatient Program (IOP) for traumatic brain injury…
View details →Irmala N, Solehati T, Sukmawati S · 2026 · International journal of women's health
Background Women with cancer frequently experience co-occurring symptoms, including cancer-related fatigue, sleep disturbance, and psychological distress, which negatively impact quality of life. Despite the increasing use of…
View details →Ohta S, Masuda S, Ueda Y et al. · 2026 · Journal of shoulder and elbow surgery
Background The re-tear rate after rotator cuff repair for large to massive tears remains high, and improving postoperative outcomes is a clinical challenge. This study aimed to evaluate the clinical and radiological outcomes of a modified…
View details →Liu D, Turner D, Cadman J et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy
Background Hydroxyapatite (HA) is an osteo-inductive material commonly added to the surface of components to enhance bone implant fixation; however, clinical studies have demonstrated inferior performance of HA coated acetabular cups in…
View details →Singh S, Galperin M, Waghray-Penmetcha T · 2026 · Pain medicine case reports
Background Vertebral compression fractures (VCFs) are a common and debilitating consequence of multiple myeloma (MM). Acute VCFs often benefit from percutaneous vertebral augmentation (PVA), indicated by bone marrow edema (BME) on MRI. We…
View details →Brand J, Hughes M, Turner KE et al. · 2026 · Orthopedics
Background and objective Locked intramedullary (IM) nails are the primary treatment modality for femoral shaft fractures. This study aimed to determine the risk of developing a femur nonunion as a function of nail-to-bone diameter…
View details →Chang HH, Chun YM, Kim SJ et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Purpose To compare clinical and radiologic outcomes among patients undergoing double-row suture bridge (DRSB) repair alone, DRSB with platelet-rich plasma (PRP) augmentation, and DRSB with bone marrow stimulation (BMS) augmentation.…
View details →El Ayat N, Boutalline M, Tannouche A · 2026 · BMC psychiatry
Background Autism Spectrum Disorder (ASD) affects 1 in 100 children globally, yet early detection remains challenging due to reliance on subjective behavioral assessments and limited specialist availability, particularly in…
View details →Schneider BS, Pfaehler CD, Hao KA et al. · 2026 · The Journal of the American Academy of Orthopaedic Surgeons
Background Although os acromiale is often noted on preoperative imaging in patients undergoing reverse total shoulder arthroplasty (rTSA), its clinical significance is ill-defined. The purpose of this study was to compare the clinical…
View details →Cacciatore S, Abbatecola G, Calvani R et al. · 2026 · Medical sciences (Basel, Switzerland)
Background/objectives Ozone therapy has been proposed across multiple clinical conditions based on hormetic, antioxidant, and immunomodulatory effects, but its efficacy and safety remain controversial. We conducted an umbrella review to…
View details →Maseroli E, Alfaroli C, Cirillo M et al. · 2026 · Journal of endocrinological investigation
Purpose To assess whether the Ketogenic Diet (KD) is associated with improvements in biochemical markers of hyperandrogenism in women diagnosed with Polycystic Ovary Syndrome (PCOS) with obesity or overweight. Methods A systematic search…
View details →Clocchiatti-Tuozzo S, Qureshi AI, Rivier CA et al. · 2026 · Neurology
Background and objectives Intensive blood pressure (BP) reduction may reduce the risk of poor functional outcomes in patients with acute intracerebral hemorrhage (ICH). Whether these potential benefits apply similarly to lobar and deep…
View details →Cataldo-Miranda P, Koh HJW, Stub D et al. · 2026 · Current problems in cardiology
Aims Beta-blocker therapy has traditionally been recommended following coronary events based on clinical trials involving patients with systolic dysfunction. Its survival benefit in patients with preserved left ventricular ejection…
View details →Tan W, Chen L, Li X et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Purpose Hydrosalpinx impairs embryo implantation and development, leading to infertility or miscarriage. Therefore, the effective treatment of hydrosalpinx is crucial for improving pregnancy outcomes. Here, we investigated the comparative…
View details →Hosseinzadeh E, Arefnia M, Bayat M et al. · 2026 · Cancer biotherapy & radiopharmaceuticals
Background Intense hepatobiliary uptake of [ 99m Tc]Tc-sestamibi in myocardial perfusion scintigraphy (MPS) often degrades image quality by obscuring the inferior myocardial wall, leading to equivocal studies. While nonpharmacological…
View details →Ren J, Sun X, Zhang Z et al. · 2026 · The American journal of clinical nutrition
Background Body weight is a critical determinant of cardiovascular disease (CVD) risk among people with type 2 diabetes mellitus (T2DM), substantially contributing to the incidence of and outcomes from CVD. However, the impact of body…
View details →Shah S, Kaul A, Pandey P et al. · 2026 · Indian pediatrics
Objectives To evaluate the efficacy of oral Lactobacillus rhamnosus GG (LGG) in reducing neonatal enterocolitis (NEC), sepsis and mortality in very low birth weight (VLBW) infants. Methods This open-label randomized controlled trial…
View details →Guo Z, Liu X, Yu S et al. · 2025 · Journal of neurointerventional surgery
Background and purpose While endovascular therapy (EVT) is established for acute basilar artery occlusion (BAO), the clinical value of remedial angioplasty or stenting (RAS) is debated. This study investigated the efficacy and safety of…
View details →Mimura T, Moghaddamjou A, Badhiwala JH et al. · 2026 · Spinal cord
Study design Cohort study. Objectives Although the effectiveness of methylprednisolone sodium succinate (MPSS) in spinal cord injury (SCI) is controversial, it is hypothesized that the effectiveness and safety profile of MPSS may vary in…
View details →Beshr MS, Shembesh RH, Nounou MV et al. · 2026 · Clinical oncology (Royal College of Radiologists (Great Britain))
Aim This study reconstructed patient-level data to provide updated evidence on survival outcomes across PD-L1 expression subgroups. Materials and methods A systematic search was conducted on March 2, 2025, using PubMed, Embase, Web of…
View details →Yang X, Zhu L, Chen R et al. · 2026 · Human reproduction open
Study question Does adding vaginal estradiol to standard progesterone luteal phase support improve ongoing pregnancy rates in normal-responder IVF/ICSI patients undergoing GnRH antagonist cycles? Summary answer The addition of vaginal…
View details →Ortiz-Gutiérrez S, Serralde-Zúñiga AE, González-Salazar LE et al. · 2026 · Scientific reports
Iron deficiency without anemia (IDNA) may be linked to obesity-related inflammation. Weight reduction and heme-iron intake from red meat are proposed to improve iron status. This randomized controlled trial (NCT06104800) assessed the…
View details →Byun SH, Kim TS, Ahn S et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Leptomeningeal carcinomatosis (LMC) is a rare but highly lethal manifestation of gastric cancer. We sought to describe its clinical features and define prognostic factors in a large single-center cohort. Methods We…
View details →Zeynodini Meimand H, Anbarloui MR, Eslamian M et al. · 2025 · Neurological research
Background Traumatic brain injury (TBI) is one of the most important causes of morbidity and mortality. It is important to have an effective treatment that can improve the quality of life and cognitive functions of these patients.…
View details →Zeng Z, Ye X, He H et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
This study examined the associations of tea, coffee, and alcohol consumption with cognitive function in Chinese adults aged ≥45 years ( n = 1326), using data from the China Health and Nutrition Survey (1997-2006). Multiple linear…
View details →Schonhaut EB, Scherpereel KL, Young AJ · 2026 · IEEE transactions on bio-medical engineering
Objective Accurate, non-invasive methods for estimating joint and muscle physiological states have the potential to greatly enhance control of wearable devices during real-world ambulation. Traditional modeling approaches and current…
View details →Lusilla Lopez A, Fält UA, Buchwald P et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Aim Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the…
View details →Marsh A, Quelch D, Mackonochie M et al. · 2026 · The international journal of neuropsychopharmacology
The incidence of cognitive disorders is rising, and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence…
View details →Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery
Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…
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