11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Hofherr A, Mäki-Petäjä K, Selvarajah V et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points In 558 adults with type 2 diabetes and CKD, inhibition of IL-33 by tozorakimab was well tolerated. IL-33 signaling was blocked at all doses, eosinophil counts decreased, and urinary CC-chemokine ligand 2 decreased at the high…
View details →Alkaramany E, Gallagher BP, Abbasi P et al. · 2025 · Foot & ankle international
Background Previous investigations have speculated that stiffening the lateral column of the hindfoot in triple arthrodesis can increase lateral plantar pressure with resulting lateral column pain. It is unclear whether sparing of the…
View details →Wang Y, Wang S, Lin J et al. · 2026 · Journal of affective disorders
Objective The current study aimed to explore the effectiveness and mechanisms of mindfulness on alleviating both immediate and delayed negative interpretation biases (NIB). Method A total of 105 college students (female: 84.62 %, age:…
View details →Marckmann M, Henriksen NA, Krarup PM et al. · 2025 · The British journal of surgery
Background The benefit of closed incision negative-pressure therapy (ciNPT) after open incisional hernia repair in reducing surgical-site infection (SSI) is uncertain. Methods The PROPRESS multicentre RCT was conducted from 1 March 2023 to…
View details →Bannink A, Kamstra-Brouwer H, van Wesemael D et al. · 2026 · Journal of dairy science
A feeding trial was conducted with 60 mid-lactation cows that were, on average, 116 DIM, parity 3.5, and with a fat- and protein-corrected milk (FPCM) yield of 34 kg/d. Cows were blocked based on cow traits and milk performance. Cows in…
View details →Hiroki S, Fukasawa T, Yokogawa K et al. · 2025 · Journal of medical virology
Patients with type 2 diabetes have a higher risk of herpes zoster (HZ). Although metformin may reduce this risk via immunomodulatory effects, prior evidence is limited by confounding by indication and an unclear causal estimand. We aimed…
View details →Gulersen M, Berghella V, Bornstein E · 2025 · Journal of clinical medicine
Singleton pregnancies complicated by a short cervical length (≤25 mm) are at significantly increased risk for spontaneous preterm birth. Several treatment strategies aimed at reducing this risk and improving perinatal outcomes have been…
View details →Boff GA, Iepsen LB, Serighelli-Junior G et al. · 2025 · Veterinary research communications
This study aimed to evaluate the effects of magnesium sulfate on propofol requirements and perioperative analgesia in dogs undergoing ovariohysterectomy. Fourteen female dogs (2 ± 1 years, 17 ± 5 kg) were enrolled in this randomized and…
View details →LeBoff MS, Chou SH, Ratnarajah DM et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Although preclinical studies suggest that omega-3 fatty acids may benefit skeletal health, there are few randomized controlled trials investigating effects of supplemental omega-3 on bone outcomes. This VITamin D and OmegA-3 TriaL (VITAL)…
View details →Kimura K, Minagawa R, Iseda N et al. · 2025 · Anticancer research
Background/aim Pseudoaneurysm hemorrhage after pancreatectomy can be fatal. However, effective intraoperative preventive strategies remain unclear. This study evaluated the efficacy of fibrin glue combined with polyglycolic acid (PGA)…
View details →Kapur NK, Mangner N, Aghili N et al. · 2026 · Journal of the American College of Cardiology
Background Despite rapid percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), large infarcts contribute to heart failure and mortality. Left ventricular (LV) wall tension and load are major…
View details →Patel PY, Akhani MK, Rathod R et al. · 2025 · Cureus
Introduction and aim Laparoscopic cholecystectomy (LC) is the gold standard for gallstone disease, but conversion to open surgery may be required in difficult cases. The role of drain placement after cholecystectomy remains controversial.…
View details →Tasci A, Tasci EDK, Turan CA et al. · 2026 · Journal of applied toxicology : JAT
Intravenous lipid emulsion (ILE) is an established antidote for local anesthetic systemic toxicity and has been tested in various lipophilic drug intoxications, but its efficacy in pioglitazone toxicity remains unclear. This study…
View details →Hovgaard HL, Vistisen ST, Enevoldsen J et al. · 2026 · Anesthesiology
Background Esophagectomy is a key treatment for esophageal cancer but carries a high risk of postoperative complications, some of which are potentially preventable through optimized hemodynamic management. Goal-directed fluid therapy…
View details →Yan CL, Erben A, Sarmiento K et al. · 2025 · Quality management in health care
Background Heart failure (HF) readmission rates at our institution were often higher than the expected levels for our institution type. Social work post-discharge telephone calls were identified as an opportunity to address reasons for HF…
View details →Vafaei A, Manavi MA, Toutounchian S et al. · 2025 · Neurochemical research
Status epilepticus (SE) is a severe neurological condition with high morbidity and mortality rates. Despite the availability of treatments, many cases remain refractory to standard therapies. In this study we investigated the possible…
View details →Shoubridge AP, Brass A, Crotty M et al. · 2025 · JAMA internal medicine
Importance Infectious outbreaks of respiratory viruses within long-term care facilities (LTCFs) for older adults are associated with high rates of hospitalization and death. Despite evidence that airborne transmission contributes…
View details →Qiao W, Liu L, Zhang X et al. · 2025 · BMC anesthesiology
Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high block…
View details →Tomazini BM, Besen BAMP, Gales AC et al. · 2026 · Lancet regional health. Americas
Background Critically ill patients are at risk of nosocomial infections, acquisition of multidrug-resistant pathogens, and substantial antimicrobial consumption. We assessed whether bathing with chlorhexidine reduces these outcomes…
View details →Beerse M, Bigelow KE, Barrios JA · 2025 · Exp Brain Res
The uncontrolled manifold analysis (UCM) is a useful technique for motor learning research enabling the classification of movement variability into solutions and errors. Less explored methodological considerations within the UCM framework…
View details →Hald JD, Weir CJ, Keerie C et al. · 2026 · JAMA
Importance Osteogenesis imperfecta causes multiple fractures throughout life, causing substantial morbidity. Objective To determine whether the parathyroid hormone analogue teriparatide followed by zoledronic acid reduces the risk of…
View details →Cancellier EL, Degryse F, da Silva RC et al. · 2025 · The Science of the total environment
The use of petroleum-based coatings in controlled-release fertilizers (CRFs) raises environmental concerns and it is unclear if, and to what extent, CRFs can improve P use efficiency. This study explored the synthesis of bio-based…
View details →van den Brink DP, Hilderink BN, Kleinveld DJB et al. · 2026 · British journal of anaesthesia
Background During shock, neutrophil-mediated glycocalyx degradation can lead to exposure of the procoagulant endothelial surface and consequent organ injury. Resuscitation using crystalloid fluids may augment this endothelial damage, while…
View details →Lopes LF, Favoretto VR, Evangelista AG et al. · 2025 · European food research & technology.
This study evaluated the efficacy of gaseous allyl isothiocyanate (AITC) in inhibiting Aspergillus parasiticus growth and aflatoxin production in soybeans and beans stored at 85% relative humidity for 35d. Samples of 50 g of soybeans or…
View details →Elzawahry S, Elhilali H, Awadein A et al. · 2026 · Journal of pediatric ophthalmology and strabismus
Purpose To investigate whether using an enhanced monofocal intraocular lens (IOL) in the pediatric age group can improve the visual performance at varying distances in comparison to standard monofocal lenses. Methods Forty-five eyes of…
View details →Saint-Etienne A, Hardy A, Miele A et al. · 2025 · Journal of clinical medicine
Background: Arthrofibrosis requiring arthrolysis is a relevant complication after anterior cruciate ligament (ACL) reconstruction. It has been suggested that intercondylar notch impingement may contribute to this outcome. The aim of this…
View details →Alarifi M, Luo J, Jabour A et al. · 2026 · Journal of clinical medicine
Background/Objectives : Immediate patient access to radiology reports has increased the need for communication that patients can understand, yet it remains unclear whether simplifying report language improves comprehension without…
View details →Wisén E, Pivodic A, Skagervik A et al. · 2026 · British journal of anaesthesia
Background Blood loss and blood transfusion are associated with negative short-term and long-term outcomes in hepatic resection. Vasopressin decreases portal blood flow and could reduce bleeding during liver surgery. We compared the…
View details →Malik A, Martin GS · 2024 · Annals of internal medicine
Source citation Turgeon AF, Fergusson DA, Clayton L, et al; HEMOTION Trial Investigators on behalf of the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group, and the Canadian Traumatic Brain…
View details →Tran TN, Kerkhof M, Le TT et al. · 2026 · The journal of allergy and clinical immunology. In practice
Background Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) after exacerbation are limited. Objective To investigate whether stepping up to high-dose ICS after severe exacerbation reduces future asthma exacerbation…
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